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SI2516433T1 - Substituirane N-(1 H-indazol-4-il)imidazo(1,2-a)piridin-3-karboksamidne spojine kot cFMS inhibitorji - Google Patents

Substituirane N-(1 H-indazol-4-il)imidazo(1,2-a)piridin-3-karboksamidne spojine kot cFMS inhibitorji

Info

Publication number
SI2516433T1
SI2516433T1 SI201030706T SI201030706T SI2516433T1 SI 2516433 T1 SI2516433 T1 SI 2516433T1 SI 201030706 T SI201030706 T SI 201030706T SI 201030706 T SI201030706 T SI 201030706T SI 2516433 T1 SI2516433 T1 SI 2516433T1
Authority
SI
Slovenia
Prior art keywords
imidazoš1
aćpyridine
indazol
substituted
carboxamide compounds
Prior art date
Application number
SI201030706T
Other languages
English (en)
Inventor
Mark Laurence Boys
Michael F. Bradley
Robert Kirk Delisle
D. David Hennings
April L. Kennedy
Fredrik P. Marmsater
Matthew David Medina
Mark C. Munson
Bryson Rast
James P. Rizzi
Martha E. Rodriguez
George T. Topalov
Qian Zhao
Original Assignee
Array Biopharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma, Inc. filed Critical Array Biopharma, Inc.
Publication of SI2516433T1 publication Critical patent/SI2516433T1/sl

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/4161,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI201030706T 2009-12-21 2010-12-20 Substituirane N-(1 H-indazol-4-il)imidazo(1,2-a)piridin-3-karboksamidne spojine kot cFMS inhibitorji SI2516433T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28872909P 2009-12-21 2009-12-21
PCT/US2010/061341 WO2011079076A1 (en) 2009-12-21 2010-12-20 Substituted n-(1h-indazol-4-yl)imidazo[1, 2-a]pyridine-3- carboxamide compounds as cfms inhibitors
EP10798683.8A EP2516433B1 (en) 2009-12-21 2010-12-20 Substituted n-(1h-indazol-4-yl)imidazo[1, 2-a]pyridine-3- carboxamide compounds as cfms inhibitors

Publications (1)

Publication Number Publication Date
SI2516433T1 true SI2516433T1 (sl) 2014-09-30

Family

ID=43568700

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201030706T SI2516433T1 (sl) 2009-12-21 2010-12-20 Substituirane N-(1 H-indazol-4-il)imidazo(1,2-a)piridin-3-karboksamidne spojine kot cFMS inhibitorji

Country Status (31)

Country Link
US (1) US8841455B2 (sl)
EP (1) EP2516433B1 (sl)
JP (2) JP5739448B2 (sl)
KR (1) KR101779630B1 (sl)
CN (1) CN102822170B (sl)
AR (1) AR079541A1 (sl)
AU (1) AU2010333752B2 (sl)
BR (1) BR112012017123B1 (sl)
CA (1) CA2785338C (sl)
CL (1) CL2012001699A1 (sl)
CO (1) CO6561821A2 (sl)
CR (1) CR20120389A (sl)
DK (1) DK2516433T3 (sl)
ES (1) ES2494590T3 (sl)
HR (1) HRP20140770T1 (sl)
IL (1) IL220544A (sl)
ME (1) ME01894B (sl)
MX (1) MX2012007329A (sl)
MY (1) MY163791A (sl)
NZ (1) NZ601376A (sl)
PL (1) PL2516433T3 (sl)
PT (1) PT2516433E (sl)
RS (1) RS53500B1 (sl)
RU (1) RU2562977C2 (sl)
SG (1) SG181861A1 (sl)
SI (1) SI2516433T1 (sl)
SM (1) SMT201400142B (sl)
TW (1) TWI471326B (sl)
UA (1) UA108222C2 (sl)
WO (1) WO2011079076A1 (sl)
ZA (1) ZA201205505B (sl)

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WO2016040185A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
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WO2016040182A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
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US10226453B2 (en) 2015-08-03 2019-03-12 Samumed, Llc 3-(1H-indol-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
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JP2013515070A (ja) 2013-05-02
TWI471326B (zh) 2015-02-01
CO6561821A2 (es) 2012-11-15
HRP20140770T1 (hr) 2014-11-07
KR20120106853A (ko) 2012-09-26
MY163791A (en) 2017-10-31
CA2785338A1 (en) 2011-06-30
PL2516433T3 (pl) 2014-10-31
WO2011079076A1 (en) 2011-06-30
BR112012017123A2 (pt) 2017-10-31
CA2785338C (en) 2018-09-18
CN102822170A (zh) 2012-12-12
RU2562977C2 (ru) 2015-09-10
KR101779630B1 (ko) 2017-09-18
AU2010333752A2 (en) 2012-09-06
HK1176928A1 (en) 2013-08-09
ME01894B (me) 2014-12-20
EP2516433A1 (en) 2012-10-31
SG181861A1 (en) 2012-07-30
US8841455B2 (en) 2014-09-23
TW201121973A (en) 2011-07-01
NZ601376A (en) 2014-03-28
DK2516433T3 (da) 2014-08-11
JP5739448B2 (ja) 2015-06-24
IL220544A (en) 2016-05-31
AU2010333752B2 (en) 2014-12-04
BR112012017123B1 (pt) 2021-07-20
ZA201205505B (en) 2013-04-24
MX2012007329A (es) 2012-10-15
US20120258952A1 (en) 2012-10-11
CN102822170B (zh) 2014-12-10
ES2494590T3 (es) 2014-09-15
IL220544A0 (en) 2012-08-30
RS53500B1 (sr) 2015-02-27
CL2012001699A1 (es) 2013-02-01
PT2516433E (pt) 2014-09-03
SMT201400142B (it) 2014-11-10
AR079541A1 (es) 2012-02-01
AU2010333752A1 (en) 2012-08-09
CR20120389A (es) 2012-08-16
EP2516433B1 (en) 2014-05-21
UA108222C2 (xx) 2015-04-10
JP2015107999A (ja) 2015-06-11
RU2012131129A (ru) 2014-01-27

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