SI2576556T1 - Postopek za sintezo karbonukleozida in intermediatov za uporabo v tem postopku - Google Patents
Postopek za sintezo karbonukleozida in intermediatov za uporabo v tem postopkuInfo
- Publication number
- SI2576556T1 SI2576556T1 SI201130588T SI201130588T SI2576556T1 SI 2576556 T1 SI2576556 T1 SI 2576556T1 SI 201130588 T SI201130588 T SI 201130588T SI 201130588 T SI201130588 T SI 201130588T SI 2576556 T1 SI2576556 T1 SI 2576556T1
- Authority
- SI
- Slovenia
- Prior art keywords
- carbonucleoside
- intermediates
- synthesis
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2705953A CA2705953C (en) | 2010-05-31 | 2010-05-31 | Carbanucleoside synthesis and intermediate compounds useful therein |
| CA2730622A CA2730622C (en) | 2010-05-31 | 2011-02-03 | Process for the synthesis of carbonucleoside and intermediates for use therein |
| EP11789021.0A EP2576556B1 (en) | 2010-05-31 | 2011-05-30 | Process for the synthesis of carbonucleoside and intermediates for use therein |
| PCT/CA2011/050323 WO2011150512A1 (en) | 2010-05-31 | 2011-05-30 | Process for the synthesis of carbonucleoside and intermediates for use therein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2576556T1 true SI2576556T1 (sl) | 2015-10-30 |
Family
ID=45066001
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201131341T SI2576565T1 (sl) | 2010-05-31 | 2011-05-30 | Sinteza karbanukleozida in njegovi novi uporabni intermediati |
| SI201130588T SI2576556T1 (sl) | 2010-05-31 | 2011-05-30 | Postopek za sintezo karbonukleozida in intermediatov za uporabo v tem postopku |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201131341T SI2576565T1 (sl) | 2010-05-31 | 2011-05-30 | Sinteza karbanukleozida in njegovi novi uporabni intermediati |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9403864B2 (sl) |
| EP (2) | EP2576556B1 (sl) |
| CN (2) | CN102958931B (sl) |
| CA (4) | CA2705953C (sl) |
| SI (2) | SI2576565T1 (sl) |
| WO (2) | WO2011150513A1 (sl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8481728B2 (en) * | 2010-02-16 | 2013-07-09 | Scinopharm Taiwan, Ltd. | Process for preparing entecavir and its intermediates |
| CA2705953C (en) | 2010-05-31 | 2018-05-01 | Alphora Research Inc. | Carbanucleoside synthesis and intermediate compounds useful therein |
| CN102336754B (zh) * | 2010-07-15 | 2017-04-12 | 浙江奥翔药业股份有限公司 | 恩替卡韦的合成方法及其中间体化合物 |
| WO2014000673A1 (en) * | 2012-06-29 | 2014-01-03 | Sunshine Lake Pharma Co., Ltd. | Process for preparation of entecavir |
| CN108203435B (zh) * | 2016-12-16 | 2020-09-04 | 正大天晴药业集团股份有限公司 | 一种利用Boc保护基的恩替卡韦的制备方法 |
| CN112625041A (zh) * | 2020-12-25 | 2021-04-09 | 常州博海威医药科技股份有限公司 | 恩替卡韦的新制备方法以及中间体 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02229192A (ja) * | 1989-03-02 | 1990-09-11 | Kohjin Co Ltd | プリン誘導体の製法 |
| US5206244A (en) * | 1990-10-18 | 1993-04-27 | E. R. Squibb & Sons, Inc. | Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines |
| WO2003051881A1 (en) * | 2001-12-17 | 2003-06-26 | Ribapharm Inc. | Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies |
| JP4726491B2 (ja) * | 2002-12-11 | 2011-07-20 | ブリストル−マイヤーズ スクイブ カンパニー | 抗ウイルス剤［１Ｓ−（１α，３α，４β）］−２−アミノ−１，９−ジヒドロ−９−［４−ヒドロキシ−３−（ヒドロキシメチル）−２−メチレンシクロペンチル］−６Ｈ−プリン−６−オンの製造法 |
| CN1289510C (zh) * | 2003-06-27 | 2006-12-13 | 成都地奥制药集团有限公司 | 一种具有抗病毒活性的化合物及其制备方法 |
| CN101235034A (zh) | 2008-02-28 | 2008-08-06 | 陆锦康 | 恩替卡韦的合成方法 |
| CA2639240A1 (en) * | 2008-08-29 | 2010-02-28 | Alphora Research Inc. | Prostaglandin synthesis and intermediates for use therein |
| KR101150254B1 (ko) * | 2008-12-26 | 2012-06-12 | 한미사이언스 주식회사 | 신규 중간체 및 이를 활용한 엔테카비르 제조방법 |
| US8481728B2 (en) * | 2010-02-16 | 2013-07-09 | Scinopharm Taiwan, Ltd. | Process for preparing entecavir and its intermediates |
| CN101805339B (zh) * | 2010-04-12 | 2012-01-11 | 王明 | 一种制备恩替卡韦化合物的方法 |
| US8999246B2 (en) | 2010-05-25 | 2015-04-07 | Exxonmobil Research And Engineering Company | Fluid injection nozzle for fluid bed reactors |
| CA2705953C (en) | 2010-05-31 | 2018-05-01 | Alphora Research Inc. | Carbanucleoside synthesis and intermediate compounds useful therein |
| CN102336754B (zh) | 2010-07-15 | 2017-04-12 | 浙江奥翔药业股份有限公司 | 恩替卡韦的合成方法及其中间体化合物 |
-
2010
- 2010-05-31 CA CA2705953A patent/CA2705953C/en not_active Expired - Fee Related
-
2011
- 2011-02-03 CA CA2730622A patent/CA2730622C/en active Active
- 2011-05-30 CA CA2801128A patent/CA2801128A1/en not_active Abandoned
- 2011-05-30 SI SI201131341T patent/SI2576565T1/sl unknown
- 2011-05-30 SI SI201130588T patent/SI2576556T1/sl unknown
- 2011-05-30 US US13/700,259 patent/US9403864B2/en not_active Expired - Fee Related
- 2011-05-30 US US13/698,886 patent/US8658792B2/en active Active
- 2011-05-30 CN CN201180026821.7A patent/CN102958931B/zh not_active Expired - Fee Related
- 2011-05-30 EP EP11789021.0A patent/EP2576556B1/en not_active Not-in-force
- 2011-05-30 EP EP11789022.8A patent/EP2576565B1/en not_active Not-in-force
- 2011-05-30 CN CN201180026406.1A patent/CN102933585B/zh not_active Expired - Fee Related
- 2011-05-30 WO PCT/CA2011/050324 patent/WO2011150513A1/en not_active Ceased
- 2011-05-30 WO PCT/CA2011/050323 patent/WO2011150512A1/en not_active Ceased
- 2011-05-30 CA CA2800367A patent/CA2800367A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2730622A1 (en) | 2011-11-30 |
| EP2576565B1 (en) | 2017-08-02 |
| US8658792B2 (en) | 2014-02-25 |
| CN102958931A (zh) | 2013-03-06 |
| CA2705953A1 (en) | 2011-11-30 |
| US20130066071A1 (en) | 2013-03-14 |
| CN102958931B (zh) | 2016-04-06 |
| EP2576556B1 (en) | 2015-08-26 |
| CA2730622C (en) | 2018-07-03 |
| WO2011150512A1 (en) | 2011-12-08 |
| SI2576565T1 (sl) | 2018-03-30 |
| CA2705953C (en) | 2018-05-01 |
| EP2576565A1 (en) | 2013-04-10 |
| US20130144058A1 (en) | 2013-06-06 |
| WO2011150513A1 (en) | 2011-12-08 |
| CN102933585B (zh) | 2015-09-02 |
| CA2801128A1 (en) | 2011-12-08 |
| CN102933585A (zh) | 2013-02-13 |
| EP2576565A4 (en) | 2014-01-01 |
| US9403864B2 (en) | 2016-08-02 |
| CA2800367A1 (en) | 2011-12-08 |
| EP2576556A1 (en) | 2013-04-10 |
| EP2576556A4 (en) | 2014-01-01 |
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