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SI2575847T2 - Tehnike čiščenja polipeptidov - Google Patents

Tehnike čiščenja polipeptidov

Info

Publication number
SI2575847T2
SI2575847T2 SI201131267T SI201131267T SI2575847T2 SI 2575847 T2 SI2575847 T2 SI 2575847T2 SI 201131267 T SI201131267 T SI 201131267T SI 201131267 T SI201131267 T SI 201131267T SI 2575847 T2 SI2575847 T2 SI 2575847T2
Authority
SI
Slovenia
Prior art keywords
methods
purifying polypeptides
polypeptides
purifying
Prior art date
Application number
SI201131267T
Other languages
English (en)
Other versions
SI2575847T1 (sl
Inventor
Hui F. Liu
Brian David Kelley
Deanna E. Myers
Beth Mccooey
Krista Marie Petty
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45004368&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2575847(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of SI2575847T1 publication Critical patent/SI2575847T1/sl
Publication of SI2575847T2 publication Critical patent/SI2575847T2/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847—Multimodal interactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI201131267T 2010-05-25 2011-05-25 Tehnike čiščenja polipeptidov SI2575847T2 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34814310P 2010-05-25 2010-05-25
PCT/US2011/037977 WO2011150110A1 (en) 2010-05-25 2011-05-25 Methods of purifying polypeptides
EP11787363.8A EP2575847B2 (en) 2010-05-25 2011-05-25 Methods of purifying polypeptides

Publications (2)

Publication Number Publication Date
SI2575847T1 SI2575847T1 (sl) 2017-09-29
SI2575847T2 true SI2575847T2 (sl) 2022-08-31

Family

ID=45004368

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201131267T SI2575847T2 (sl) 2010-05-25 2011-05-25 Tehnike čiščenja polipeptidov

Country Status (21)

Country Link
US (5) US20130079272A1 (sl)
EP (3) EP2575847B2 (sl)
JP (3) JP5934190B2 (sl)
KR (1) KR101976853B1 (sl)
CN (2) CN102905718A (sl)
AU (1) AU2011258254B2 (sl)
CA (2) CA2799915C (sl)
ES (2) ES2991883T3 (sl)
HK (1) HK1246328A1 (sl)
HR (2) HRP20241463T1 (sl)
HU (1) HUE068857T2 (sl)
IL (2) IL223029A0 (sl)
MX (2) MX370828B (sl)
MY (1) MY161534A (sl)
NZ (1) NZ603648A (sl)
PL (2) PL3299380T3 (sl)
RU (1) RU2594163C2 (sl)
SG (2) SG10201710439UA (sl)
SI (1) SI2575847T2 (sl)
WO (1) WO2011150110A1 (sl)
ZA (1) ZA201208673B (sl)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011258254B2 (en) 2010-05-25 2016-01-07 Genentech, Inc. Methods of purifying polypeptides
EP2768857B1 (en) * 2011-10-19 2020-01-01 NovImmune SA Methods of purifying antibodies
SG11201403437TA (en) 2011-12-22 2014-07-30 Genentech Inc Ion exchange membrane chromatography
CN102911250B (zh) * 2012-09-29 2014-04-16 浙江海正药业股份有限公司 酸性重组蛋白药物的纯化方法
CN103880947B (zh) * 2012-12-21 2016-01-13 武汉禾元生物科技股份有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
WO2014118685A2 (en) * 2013-01-29 2014-08-07 Dr. Reddy's Laboratories Limited Method of altering the acidic variant content of antibody
EP2971087B1 (en) * 2013-03-14 2017-11-01 Qiagen Sciences, LLC Assessing dna quality using real-time pcr and ct values
CN104236983A (zh) * 2013-06-14 2014-12-24 中国科学院大连化学物理研究所 溶液样品中含长烷基链的离子液体的去除方法
EP3041593B1 (en) * 2013-09-05 2025-01-29 F. Hoffmann-La Roche AG Method of cleaning a chromatography material for its reuse
KR102332302B1 (ko) 2013-09-13 2021-12-01 제넨테크, 인크. 세포주에서 숙주 세포 단백질 및 재조합 폴리펩티드 생성물을 검출 및 정량화하기 위한 조성물 및 방법
KR102373930B1 (ko) 2013-09-13 2022-03-11 제넨테크, 인크. 정제된 재조합 폴리펩티드를 포함하는 방법 및 조성물
CN106170298B (zh) 2013-10-16 2024-01-09 前瞻疗法公司 用于提高抗体稳定性的缓冲液制剂
US8859252B1 (en) 2014-01-02 2014-10-14 Aerial Biopharma, Llc Prostatic acid phosphatase, compositions comprising the same, and methods for producing and/or purifying the same
WO2015105551A1 (en) * 2014-01-09 2015-07-16 Kentucky Bioprocessing, Inc. Method of purifying monoclonal antibodies
DK3116891T3 (da) 2014-03-10 2020-05-04 Richter Gedeon Nyrt Immunglobulinrensning ved hjælp af forrensningstrin
JP6647220B2 (ja) * 2014-05-23 2020-02-14 インスティトゥート・マッソーネ・エセ・ア Ｈｍｇ−ｕｐ（超高純度グレードのヒト閉経期ゴナドトロピン）を得るための方法及び夾雑物を含まない組成物
US20170183376A1 (en) * 2014-06-24 2017-06-29 Insight Biopharmaceuticals Ltd. Methods of purifying antibodies
GB201411802D0 (en) 2014-07-02 2014-08-13 Univ Bradford Effervescent compositions
US10696735B2 (en) * 2015-01-21 2020-06-30 Outlook Therapeutics, Inc. Modulation of charge variants in a monoclonal antibody composition
MX2018009341A (es) 2016-02-03 2019-05-15 Oncobiologics Inc Formulaciones tamponadas para una mayor estabilidad de anticuerpos.
KR20250107275A (ko) 2016-06-17 2025-07-11 제넨테크, 인크. 다중 특이적 항체의 정제
CN115598231B (zh) 2016-08-15 2025-11-18 豪夫迈·罗氏有限公司 定量包含非离子表面活性剂和多肽的组合物中非离子表面活性剂的层析方法
JP6564539B1 (ja) 2018-09-14 2019-08-21 長瀬産業株式会社 スルホン酸化合物によるペプチド精製方法
US20220002688A1 (en) * 2018-12-20 2022-01-06 Armagen, Inc. Purification of iduronate-2-sulfatase immunoglobulin fusion protein
CN109765307B (zh) * 2018-12-24 2021-06-29 山东省科学院海洋仪器仪表研究所 一种水体中六氯环己烷的测量方法
CN111366547A (zh) * 2018-12-26 2020-07-03 贵州中烟工业有限责任公司 一种用连续流动法测定烟草或烟草制品中α-氨基氮的检测方法
US20220098235A1 (en) 2019-01-23 2022-03-31 Daiichi Sankyo Company, Limited Methods for purifying antibodies comprising of a process by using activated carbon materials
KR20250057918A (ko) 2019-05-03 2025-04-29 제넨테크, 인크. 정제 플랫폼으로부터 수득된 조성물의 효소적 가수분해 활성 속도를 감소시키는 방법
AR119264A1 (es) * 2019-06-05 2021-12-09 Genentech Inc Método para reutilización de cromatografía
EP4045917A1 (en) * 2019-10-14 2022-08-24 Pierce Biotechnology, Inc. Peptide purification formulations and methods
WO2021240458A2 (en) * 2020-05-28 2021-12-02 Kashiv Biosciences, Llc An improved process of storing and preparing the protein
US20230251269A1 (en) * 2020-07-15 2023-08-10 The Johns Hopkins University Comprehensive analysis of anti-allergen antibodies using phage display
US20220135620A1 (en) * 2020-10-30 2022-05-05 Genentech, Inc. Purification platforms for obtaining pharmaceutical compositions having a reduced hydrolytic enzyme activity rate
CN112852876B (zh) * 2021-03-04 2022-11-29 西南大学 一种表达人表皮生长因子的家蚕丝腺重组表达载体及其制备方法和应用
JP2024514306A (ja) 2021-03-31 2024-04-01 エフ． ホフマン－ラ ロシュ アーゲー 混合モードクロマトグラフィーによる抗体の精製

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704362A (en) 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
ES2058199T3 (es) 1987-09-23 1994-11-01 Bristol Myers Squibb Co Heteroconjugados de anticuerpos para la eliminacion de celulas infectadas por el vih.
ATE105585T1 (de) 1987-12-21 1994-05-15 Univ Toledo Transformation von keimenden pflanzensamen mit hilfe von agrobacterium.
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
FR2646437B1 (fr) 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
AU641673B2 (en) 1989-06-29 1993-09-30 Medarex, Inc. Bispecific reagents for aids therapy
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
WO1992020373A1 (en) 1991-05-14 1992-11-26 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
JP4124480B2 (ja) 1991-06-14 2008-07-23 ジェネンテック・インコーポレーテッド 免疫グロブリン変異体
IE922437A1 (en) 1991-07-25 1993-01-27 Idec Pharma Corp Recombinant antibodies for human therapy
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
FI941572A7 (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
WO1993011161A1 (en) 1991-11-25 1993-06-10 Enzon, Inc. Multivalent antigen-binding proteins
AU675929B2 (en) 1992-02-06 1997-02-27 Curis, Inc. Biosynthetic binding protein for cancer marker
ATE244763T1 (de) 1992-02-11 2003-07-15 Cell Genesys Inc Erzielen von homozygotem durch zielgerichtete genetische ereignisse
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
CA2140280A1 (en) 1992-08-17 1994-03-03 Avi J. Ashkenazi Bispecific immunoadhesins
DE69303494T2 (de) 1992-11-13 1997-01-16 Idec Pharma Corp Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5545328A (en) * 1993-09-21 1996-08-13 Hemosol Inc. Purification of hemoglobin by displacement chromatography
CA2106612C (en) 1993-09-21 2001-02-06 Diana Pliura Displacement chromatography process
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
CA2242931A1 (en) * 1996-01-31 1997-08-07 David Francis Elgar Production of an immunoglobulin enriched fraction from whey protein solutions
US6037454A (en) 1996-11-27 2000-03-14 Genentech, Inc. Humanized anti-CD11a antibodies
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
ES2261589T3 (es) 1998-05-06 2006-11-16 Genentech, Inc. Composicion de anticuerpos anti-her2.
PT1501369E (pt) 2002-04-26 2015-09-21 Genentech Inc Purificação de proteínas com base na não afinidade
SE526227C2 (sv) 2002-05-15 2005-08-02 North China Pharmaceutical Group Metod för rening av rekombinant humant serumalbumin
NZ604082A (en) 2004-06-04 2014-09-26 Genentech Inc Method for treating multiple sclerosis
ZA200701715B (en) 2004-08-19 2008-07-30 Genentech Inc Polypeptide variants with altered effector function
EP3088004B1 (en) 2004-09-23 2018-03-28 Genentech, Inc. Cysteine engineered antibodies and conjugates
BRPI0518207B1 (pt) † 2004-10-21 2023-05-16 Cytiva Bioprocess R&D Ab Método de separação de um ou mais anticorpos de um ou mais outros compostos em uma amostra líquida
PT1869065T (pt) 2005-03-11 2020-06-18 Wyeth Llc Método de cromatografia de partição fraca
NZ562949A (en) 2005-04-11 2009-05-31 Medarex Inc Protein purification using HCIC and ion exchange chromatography
DE112006001012B4 (de) 2005-04-22 2017-05-18 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Verfahren für eine auf Massenspektrometrie gerichtete Aufbereitung von Biopolymeren
US7691980B2 (en) † 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
ATE526017T1 (de) 2007-01-22 2011-10-15 Genentech Inc Abscheidung von polyelektrolyten und reinigung von antikörpern
US9493548B2 (en) 2007-06-01 2016-11-15 Hoffmann-La Roche Inc. Immunoglobulin purification
US9433922B2 (en) * 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
PE20091434A1 (es) * 2007-10-30 2009-10-17 Genentech Inc Purificacion de anticuerpos por cromatografia de intercambio cationico
EP2265129B1 (en) † 2008-04-08 2015-10-28 Bio-Rad Laboratories, Inc. Chromatography purification of antibodies
US20110105725A1 (en) 2008-05-15 2011-05-05 Novo Nordisk A/S Antibody purification process
PL3604324T3 (pl) 2008-08-14 2024-07-01 Genentech, Inc. Sposoby usuwania zanieczyszczeń za pomocą chromatografii membranowej jonowymiennej z zastąpieniem macierzystego białka
EP2360183B1 (en) 2008-12-19 2016-07-27 Takeda Pharmaceutical Company Limited Antibody purification method by mixed mode chromatography utilizing an arginine-containing loading solution
US20120148576A1 (en) * 2009-03-06 2012-06-14 Medlmmune, Llc Humanized anti-cd 19 antibody formulations
US8536316B2 (en) 2009-08-07 2013-09-17 Emd Millipore Corporation Methods for purifying a target protein from one or more impurities in a sample
WO2011035282A1 (en) 2009-09-21 2011-03-24 Ge Healthcare Bio-Sciences Ab Dual capture separation
EP2480561B1 (en) * 2009-09-23 2016-07-13 E. R. Squibb & Sons, L.L.C. Cation exchange chromatography
AU2011258254B2 (en) 2010-05-25 2016-01-07 Genentech, Inc. Methods of purifying polypeptides
JP2014503495A (ja) 2010-11-15 2014-02-13 バイオジェン アイデック インコーポレイテッド 過負荷結合および溶出クロマトグラフィによる選択生成物アイソフォームの富化および濃縮

Also Published As

Publication number Publication date
EP2575847B1 (en) 2017-06-14
ES2637613T5 (es) 2022-07-20
AU2011258254B2 (en) 2016-01-07
JP2013530156A (ja) 2013-07-25
WO2011150110A1 (en) 2011-12-01
IL223029A0 (en) 2013-02-03
JP2018087192A (ja) 2018-06-07
PL2575847T5 (pl) 2022-07-18
EP3299380A1 (en) 2018-03-28
MX2012013575A (es) 2013-03-21
US20200399307A1 (en) 2020-12-24
US20220064209A1 (en) 2022-03-03
RU2012156271A (ru) 2014-06-27
HK1246328A1 (zh) 2018-09-07
EP3299380C0 (en) 2024-08-28
JP6272941B2 (ja) 2018-01-31
CA2799915C (en) 2023-09-26
HRP20241463T1 (hr) 2025-01-03
ES2991883T3 (es) 2024-12-05
HUE068857T2 (hu) 2025-02-28
US20190300566A1 (en) 2019-10-03
JP2016190851A (ja) 2016-11-10
EP2575847A1 (en) 2013-04-10
ES2637613T3 (es) 2017-10-13
KR20130086544A (ko) 2013-08-02
EP4492053A3 (en) 2025-03-19
CN107365346A (zh) 2017-11-21
RU2594163C2 (ru) 2016-08-10
EP4492053A2 (en) 2025-01-15
ZA201208673B (en) 2016-02-24
CN102905718A (zh) 2013-01-30
US20130079272A1 (en) 2013-03-28
BR112012029904A2 (pt) 2017-08-08
NZ603648A (en) 2014-12-24
MX370828B (es) 2020-01-08
US20250034204A1 (en) 2025-01-30
KR101976853B1 (ko) 2019-05-09
EP3299380B1 (en) 2024-08-28
PL3299380T3 (pl) 2024-12-16
CA2799915A1 (en) 2011-12-01
CA3209878A1 (en) 2011-12-01
MY161534A (en) 2017-04-28
SG185737A1 (en) 2013-01-30
JP5934190B2 (ja) 2016-06-15
US12152054B2 (en) 2024-11-26
EP2575847A4 (en) 2014-10-08
HRP20171095T4 (hr) 2022-07-22
SI2575847T1 (sl) 2017-09-29
HRP20171095T1 (hr) 2017-10-06
AU2011258254A1 (en) 2013-01-10
EP2575847B2 (en) 2022-04-27
SG10201710439UA (en) 2018-01-30
MX344248B (es) 2016-12-09
PL2575847T3 (pl) 2017-10-31
IL261147A (en) 2018-10-31

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