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SI2448968T1 - Protitelesa, selektivna za protofibrile/oligomere na N-koncu skrajšanega amiloida-beta - Google Patents

Protitelesa, selektivna za protofibrile/oligomere na N-koncu skrajšanega amiloida-beta

Info

Publication number
SI2448968T1
SI2448968T1 SI201032068T SI201032068T SI2448968T1 SI 2448968 T1 SI2448968 T1 SI 2448968T1 SI 201032068 T SI201032068 T SI 201032068T SI 201032068 T SI201032068 T SI 201032068T SI 2448968 T1 SI2448968 T1 SI 2448968T1
Authority
SI
Slovenia
Prior art keywords
terminaltruncated
protofibrils
amyloid
oligomers
antibodies selective
Prior art date
Application number
SI201032068T
Other languages
English (en)
Inventor
Par Gellerfors
Lars Lannfelt
Linda Soderberg
Karin Tegerstedt
Original Assignee
Bioarctic Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioarctic Ab filed Critical Bioarctic Ab
Publication of SI2448968T1 publication Critical patent/SI2448968T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
SI201032068T 2009-06-29 2010-06-29 Protitelesa, selektivna za protofibrile/oligomere na N-koncu skrajšanega amiloida-beta SI2448968T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22110509P 2009-06-29 2009-06-29
PCT/IB2010/052947 WO2011001366A1 (en) 2009-06-29 2010-06-29 N-terminal truncated amyloid beta protofibrils/ oligomers for use in therapeutic and diagnostic methods for alzheimer's disease
EP10739701.0A EP2448968B1 (en) 2009-06-29 2010-06-29 ANTIBODIES SELECTIVE FOR N-TERMINALTRUNCATED AMYLOID-p PROTOFIBRILS/OLIGOMERS

Publications (1)

Publication Number Publication Date
SI2448968T1 true SI2448968T1 (sl) 2021-07-30

Family

ID=42832352

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201032068T SI2448968T1 (sl) 2009-06-29 2010-06-29 Protitelesa, selektivna za protofibrile/oligomere na N-koncu skrajšanega amiloida-beta

Country Status (16)

Country Link
US (2) US20120100129A1 (sl)
EP (2) EP3892633A1 (sl)
JP (3) JP2012532094A (sl)
AU (1) AU2010267640B2 (sl)
CA (1) CA2765602C (sl)
CY (1) CY1124034T1 (sl)
DK (1) DK2448968T3 (sl)
ES (1) ES2864049T3 (sl)
HR (1) HRP20210611T1 (sl)
HU (1) HUE053949T2 (sl)
LT (1) LT2448968T (sl)
PL (1) PL2448968T3 (sl)
PT (1) PT2448968T (sl)
SI (1) SI2448968T1 (sl)
SM (1) SMT202100237T1 (sl)
WO (1) WO2011001366A1 (sl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0401601D0 (sv) 2004-06-21 2004-06-21 Bioarctic Neuroscience Ab Protofibril specific antibodies and uses thereof
PL2004688T5 (pl) 2006-03-23 2014-09-30 Bioarctic Neuroscience Ab Ulepszone przeciwciała wobec protofibryli oraz ich zastosowania
CN110655573B (zh) 2010-02-26 2023-07-18 生命北极神经科学公司 原细纤维结合抗体及其治疗和诊断帕金森氏症、路易体痴呆和其他α-共核蛋白病的应用
WO2012123562A1 (en) * 2011-03-16 2012-09-20 Probiodrug Ag Diagnostic antibody assay
JO3537B1 (ar) 2014-07-10 2020-07-05 Bioarctic Neuroscience Ab أجسام مضادة لييفية أولية لاميلويد بيتا الببتيد ab المحسنة
EP3325506A1 (en) 2015-07-21 2018-05-30 BioArctic AB Method for treatment of traumatic brain injury targeting aggregated peptides
CN109476728A (zh) 2016-07-14 2019-03-15 生命北极公司 脑部递送蛋白
US12227567B2 (en) 2017-07-25 2025-02-18 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
CN118924896A (zh) 2018-07-24 2024-11-12 卫材R&D管理有限公司 阿尔茨海默病的治疗及预防方法
CN116063520A (zh) 2019-01-30 2023-05-05 真和制药有限公司 抗gal3抗体及其用途
JPWO2021006212A1 (sl) * 2019-07-08 2021-01-14
WO2021055670A1 (en) 2019-09-20 2021-03-25 Avx Corporation Somatic cell-based electrical biosensor
CN116157151A (zh) 2020-05-26 2023-05-23 真和制药有限公司 通过阻断半乳凝素-3治疗炎性疾病的方法
MA60122B1 (fr) 2020-06-26 2025-07-31 Bioarctic Ab Anticorps se liant à la protofibrille d'alpha-synucléine
TW202317192A (zh) 2021-07-09 2023-05-01 日商衛材R&D企管股份有限公司 用於阿茲海默氏症治療的生物標記物
MX2024002567A (es) 2021-08-30 2024-03-20 Eisai R&D Man Co Ltd Formulaciones subcutaneas de anticuerpo anti protofibrillas de beta-amiloide (abeta) y metodos de uso de las mismas.
US20250377367A1 (en) 2022-02-02 2025-12-11 Eisai R&D Management Co., Ltd. Methods of treatment using p-tau181 level
WO2024133925A1 (en) 2022-12-22 2024-06-27 Bioarctic Ab Antibody which binds to abetape3

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5604102A (en) 1992-04-15 1997-02-18 Athena Neurosciences, Inc. Methods of screening for β-amyloid peptide production inhibitors
JP4796725B2 (ja) * 1999-08-04 2011-10-19 ユニバーシティ オブ サザン カリフォルニア アミロイドβタンパク質（球状アセンブリー及びその使用）
JP5362164B2 (ja) * 2000-07-07 2013-12-11 バイオアークティック ニューロサイエンス アーベー アルツハイマー病の予防及び治療
US7122374B1 (en) * 2002-04-09 2006-10-17 Takaomi Saido Amyloid beta-protein 3(pE)-42 antibodies and uses thereof
CA2487528A1 (en) * 2002-07-24 2004-02-12 Innogenetics N.V. Prevention, treatment and diagnosis of diseases associated with beta-amyloid formation and/or aggregation
WO2005100402A1 (en) * 2004-04-13 2005-10-27 F.Hoffmann-La Roche Ag Anti-p-selectin antibodies
GB0413726D0 (en) * 2004-06-18 2004-07-21 Lauras As Compounds
SE0401601D0 (sv) * 2004-06-21 2004-06-21 Bioarctic Neuroscience Ab Protofibril specific antibodies and uses thereof
SG190665A1 (en) * 2004-07-30 2013-06-28 Rinat Neuroscience Corp Antibodies directed against amyloid-beta peptide and methods using same
PL2004688T5 (pl) * 2006-03-23 2014-09-30 Bioarctic Neuroscience Ab Ulepszone przeciwciała wobec protofibryli oraz ich zastosowania
BRPI0819312A2 (pt) * 2007-11-16 2020-09-15 The Rockefeller University específico anticorpo para a forma protofibril de proteínas amilóide beta
LT2282758T (lt) * 2008-04-29 2019-03-12 Bioarctic Ab Antikūnai ir vakcinos, skirti su alfa sinukleinu susijusių sutrikimų gydymo ir diagnostiniams metodams

Also Published As

Publication number Publication date
CA2765602C (en) 2021-05-25
SMT202100237T1 (it) 2021-05-07
JP6884025B2 (ja) 2021-06-09
JP2017197531A (ja) 2017-11-02
HUE053949T2 (hu) 2021-08-30
AU2010267640B2 (en) 2015-03-05
US20230295283A1 (en) 2023-09-21
US20120100129A1 (en) 2012-04-26
WO2011001366A1 (en) 2011-01-06
LT2448968T (lt) 2021-05-10
CY1124034T1 (el) 2022-05-27
JP2019218362A (ja) 2019-12-26
HRP20210611T1 (hr) 2021-05-28
EP2448968A1 (en) 2012-05-09
EP3892633A1 (en) 2021-10-13
DK2448968T3 (da) 2021-04-12
PT2448968T (pt) 2021-04-30
PL2448968T3 (pl) 2021-09-13
JP2012532094A (ja) 2012-12-13
CA2765602A1 (en) 2011-01-06
EP2448968B1 (en) 2021-01-27
AU2010267640A1 (en) 2012-01-19
ES2864049T3 (es) 2021-10-13

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