SI21079B - Formulacija, ki povecuje mobilizacijo - Google Patents
Formulacija, ki povecuje mobilizacijo Download PDFInfo
- Publication number
- SI21079B SI21079B SI200120022A SI200120022A SI21079B SI 21079 B SI21079 B SI 21079B SI 200120022 A SI200120022 A SI 200120022A SI 200120022 A SI200120022 A SI 200120022A SI 21079 B SI21079 B SI 21079B
- Authority
- SI
- Slovenia
- Prior art keywords
- stem cells
- formulation
- hematopoietic
- hematopoietic stem
- defibrotide
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title claims 8
- 239000000203 mixture Substances 0.000 title claims 8
- 230000001483 mobilizing effect Effects 0.000 title claims 7
- 230000003394 haemopoietic effect Effects 0.000 claims abstract 8
- JNWFIPVDEINBAI-UHFFFAOYSA-N [5-hydroxy-4-[4-(1-methylindol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-2-propan-2-ylphenyl] dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C(C(C)C)=CC(C=2N(C(=O)NN=2)C=2C=C3C=CN(C)C3=CC=2)=C1O JNWFIPVDEINBAI-UHFFFAOYSA-N 0.000 claims abstract 5
- 229960004120 defibrotide Drugs 0.000 claims abstract 5
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims abstract 4
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims abstract 4
- 210000000130 stem cell Anatomy 0.000 claims abstract 4
- 210000005259 peripheral blood Anatomy 0.000 claims abstract 3
- 239000011886 peripheral blood Substances 0.000 claims abstract 3
- 241000124008 Mammalia Species 0.000 claims abstract 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 7
- 239000000654 additive Substances 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 230000002123 temporal effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Podan je opis metode za povecanje kolicine izvornih celic in zarodnih celic v perifernem krvnem obtoku pri sesalcih. Metoda je oznacena z administracijo defibrotid-a v kombinaciji ali v zaporedju z vsaj enim hematopoetskim faktorjem, prednostno G-CSF, ki ima sposobnost mobilizacije hematopoetskih zarodnih celic.
Claims (8)
- -1/1- SI21079 PATENTNI ZAHTEVKI 1. Formulacija označena s tem, da vsebuje aktivne komponente defibrotid in vsaj enega od hematopoetskih faktorjev s sposobnostjo mobilizacije hematopoetskih izvornih celic.
- 2. Formulacija po zahtevku 1, označena s tem, da je G-CSF hematopoetski faktor s sposobnostjo mobilizacije hematopoetskih izvornih celic.
- 3. Formulacija po zahtevku 1, označena s tem, daje vodna raztopina.
- 4. Formulacija po zahtevku 1, označena s tem, dajo predstavljajo dve ločeni komponenti za administracijo, ena, ki vsebuje hematopoetski faktor s sposobnostjo mobilizacije hematopoetskih izvornih celic, in druga, ki vsebuje defibrotid.
- 5. Formulacija označena s tem, da vsebuje defibrotid in vsaj enega od hematopoetskih faktorjev s sposobnostjo mobilizacije hematopoetskih izvornih celic, prednostno G-CSF, kot kombiniran pripravek za sočasno, ločeno ali zaporedno uporabo za povečanje zarodnih in/ali izvornih celic v periferni krvi sesalcev.
- 6. Formulacija po zahtevkih od 1 do 5, označena s tem, da vsebuje običajne dodatke polnila in/ali koadjuvanse.
- 7. Uporaba defibrotid-a v kombinaciji z vsaj enim od hematopoetskih faktoijev, ki imajo sposobnost mobilizacije hematopoetskih zarodnih celicah za pripravo formulacije sposobne povečati količino izvornih celic in/ali hematopoetskih zarodnih celic v perifernem krvnem obtoku sesalcev.
- 8. Uporaba po zahtevku 7, označena s tem, da je G-CSF hematopoetski faktor s sposobnostjo mobilizacije hematopoetskih izvornih celic.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00830293A EP1147777A1 (en) | 2000-04-18 | 2000-04-18 | Combination of defibrotide and G-CSF and its use to activate haematopoietic progenitors |
| PCT/EP2001/004105 WO2001078761A2 (en) | 2000-04-18 | 2001-04-10 | Mixture of defibrotide and g-csf ant its use for activating haematopoietic progenitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI21079A SI21079A (sl) | 2003-06-30 |
| SI21079B true SI21079B (sl) | 2006-08-31 |
Family
ID=8175292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200120022A SI21079B (sl) | 2000-04-18 | 2001-04-10 | Formulacija, ki povecuje mobilizacijo |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20040131588A1 (sl) |
| EP (3) | EP1147777A1 (sl) |
| JP (1) | JP5205668B2 (sl) |
| KR (1) | KR100849491B1 (sl) |
| CN (1) | CN1183962C (sl) |
| AT (2) | ATE310532T1 (sl) |
| AU (2) | AU5832201A (sl) |
| BG (1) | BG107203A (sl) |
| CA (1) | CA2406179C (sl) |
| CY (1) | CY1104971T1 (sl) |
| CZ (1) | CZ20023426A3 (sl) |
| DE (2) | DE60115222T2 (sl) |
| DK (2) | DK1621207T3 (sl) |
| EE (1) | EE200200596A (sl) |
| ES (2) | ES2252227T3 (sl) |
| HR (1) | HRP20020835A2 (sl) |
| HU (1) | HUP0300560A3 (sl) |
| IL (1) | IL152328A (sl) |
| IS (1) | IS2171B (sl) |
| MX (1) | MXPA02010346A (sl) |
| NO (1) | NO20024988L (sl) |
| NZ (1) | NZ522016A (sl) |
| PL (1) | PL358100A1 (sl) |
| PT (1) | PT1621207E (sl) |
| RO (1) | RO121006B1 (sl) |
| RU (1) | RU2248216C2 (sl) |
| SI (1) | SI21079B (sl) |
| SK (1) | SK14892002A3 (sl) |
| UA (1) | UA73566C2 (sl) |
| WO (1) | WO2001078761A2 (sl) |
| ZA (1) | ZA200208413B (sl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8771663B2 (en) | 2000-04-18 | 2014-07-08 | Gentium Spa | Formulation having mobilising activity |
| RU2351357C2 (ru) * | 2003-07-29 | 2009-04-10 | ДОМПЕ ФА.Р.МА. С.п.А. | Фармацевтическая композиция, используемая для мобилизации стволовых клеток |
| EP1656156A2 (en) | 2003-08-13 | 2006-05-17 | Children's Hospital Medical Center | Mobilization of hematopoietic cells |
| EP1656451A2 (en) | 2003-08-13 | 2006-05-17 | Children's Hospital Medical Center | Chimeric peptides for the regulation of gtpases |
| EP2103689A1 (en) * | 2008-03-19 | 2009-09-23 | Gentium S.p.A. | Synthetic phosphodiester oligonucleotides and therapeutical uses thereof |
| RU2376985C1 (ru) * | 2008-07-17 | 2009-12-27 | Владислав Николаевич Ласкавый | Средство для активации стволовых клеток |
| JP6069209B2 (ja) | 2010-11-12 | 2017-02-01 | ジェンティウム ソシエタ ア レスポンサビリタ リミタータ | 移植片対宿主病（ｇｖｈｄ）の予防および／または治療に使用するためのデフィブロタイド |
| DK2864496T4 (da) | 2012-06-22 | 2021-01-04 | Gentium S R L | Euglobulin-baseret fremgangsmåde til bestemmelse af den biologiske aktivitet af defibrotid |
| EP3026122A1 (en) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
| CN106567694A (zh) * | 2016-11-14 | 2017-04-19 | 北京国泰通源技术有限公司 | 智能控水短节 |
| AU2018400697B2 (en) * | 2018-01-12 | 2020-02-27 | Cellmig Biolabs Inc. | Methods for generation of cytocapsulae and cytocapsular tubes |
| CN114730031B (zh) | 2019-11-13 | 2024-04-12 | 富士胶片株式会社 | 装饰膜、成型物及电子器件 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1043823B (it) * | 1970-11-03 | 1980-02-29 | Prephar | Procedimento per l estrazione di acidi nucleici da organi animali |
| US3899481A (en) | 1970-11-03 | 1975-08-12 | Crinos Industria Farmaco | Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs |
| DE2154279A1 (de) | 1970-11-03 | 1972-05-25 | Crinos Industria Farmaco | Medikamente für das fibrinolytische System |
| IT1206341B (it) | 1984-02-16 | 1989-04-14 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio. |
| US4694134A (en) | 1985-05-28 | 1987-09-15 | Ajax Magnethermic Corporation | Apparatus for overheating edges of skelp for the production of compression welded pipe |
| US5223609A (en) * | 1986-04-17 | 1993-06-29 | Crinos Industria Farmacobiologica S.P.A. | Process for obtaining chemically defined and reproducible polydeoxyribonucleotides |
| IT1190313B (it) | 1986-04-17 | 1988-02-16 | Crinos Industria Farmaco | Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante |
| IT1223322B (it) * | 1987-10-23 | 1990-09-19 | Crinos Industria Farmaco | Metodo per prevenire la formazione di coaguli sanguigni nel circuito extracorporeo di apparecchi di dialisi a composizione utile per esso |
| JP2907447B2 (ja) * | 1988-08-24 | 1999-06-21 | 中外製薬株式会社 | 抗血栓剤 |
| IT1231509B (it) * | 1989-09-07 | 1991-12-07 | Crinos Industria Farmaco | Composizione farmceutica ad uso topico per la terapia della fragilita' capillare. |
| US5199942A (en) * | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
| US5977083A (en) * | 1991-08-21 | 1999-11-02 | Burcoglu; Arsinur | Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states |
| JP3021906B2 (ja) * | 1992-01-28 | 2000-03-15 | 松下電器産業株式会社 | 電動調理機 |
| RU2136667C1 (ru) * | 1995-04-18 | 1999-09-10 | Научно-исследовательский институт фармакологии РАМН | Производные 2-меркаптобензимидазола, обладающие противоишемической, антиаритмической и противофибрилляторной активностью |
| JPH08127539A (ja) * | 1994-10-31 | 1996-05-21 | Ajinomoto Co Inc | ヒトｉｌ−１１を含有する末梢血幹細胞増加剤 |
| WO1996016987A1 (en) * | 1994-11-30 | 1996-06-06 | Chugai Seiyaku Kabushiki Kaisha | Thrombocytotic factor |
| DE69733694T2 (de) * | 1996-07-10 | 2006-07-06 | Muramatsu, Takashi, Nagoya | Verwendung von proteinen aus der mk familie als hämatopoietischer faktor |
| AU1705599A (en) * | 1997-11-26 | 1999-06-15 | Allegheny University Of The Health Sciences | Methods for mobilizing hematopoietic facilitating cells and hematopoietic stem cells into the peripheral blood |
| US6573372B2 (en) * | 1999-01-07 | 2003-06-03 | Heska Corporation | Feline immunoglobulin E molecules and compositions there of |
-
2000
- 2000-04-18 EP EP00830293A patent/EP1147777A1/en not_active Withdrawn
-
2001
- 2001-04-10 ES ES01931582T patent/ES2252227T3/es not_active Expired - Lifetime
- 2001-04-10 WO PCT/EP2001/004105 patent/WO2001078761A2/en not_active Ceased
- 2001-04-10 CA CA2406179A patent/CA2406179C/en not_active Expired - Fee Related
- 2001-04-10 RO ROA200201305A patent/RO121006B1/ro unknown
- 2001-04-10 DE DE60115222T patent/DE60115222T2/de not_active Expired - Lifetime
- 2001-04-10 KR KR1020027013967A patent/KR100849491B1/ko not_active Expired - Fee Related
- 2001-04-10 CZ CZ20023426A patent/CZ20023426A3/cs unknown
- 2001-04-10 DE DE60140015T patent/DE60140015D1/de not_active Expired - Lifetime
- 2001-04-10 PT PT05108424T patent/PT1621207E/pt unknown
- 2001-04-10 ES ES05108424T patent/ES2335776T3/es not_active Expired - Lifetime
- 2001-04-10 AT AT01931582T patent/ATE310532T1/de active
- 2001-04-10 EP EP01931582A patent/EP1276497B1/en not_active Expired - Lifetime
- 2001-04-10 PL PL01358100A patent/PL358100A1/xx not_active Application Discontinuation
- 2001-04-10 MX MXPA02010346A patent/MXPA02010346A/es active IP Right Grant
- 2001-04-10 AU AU5832201A patent/AU5832201A/xx active Pending
- 2001-04-10 EE EEP200200596A patent/EE200200596A/xx unknown
- 2001-04-10 HU HU0300560A patent/HUP0300560A3/hu unknown
- 2001-04-10 US US10/432,741 patent/US20040131588A1/en not_active Abandoned
- 2001-04-10 AT AT05108424T patent/ATE443524T1/de active
- 2001-04-10 DK DK05108424.2T patent/DK1621207T3/da active
- 2001-04-10 HR HR20020835A patent/HRP20020835A2/xx not_active Application Discontinuation
- 2001-04-10 DK DK01931582T patent/DK1276497T3/da active
- 2001-04-10 IL IL152328A patent/IL152328A/en active IP Right Grant
- 2001-04-10 NZ NZ522016A patent/NZ522016A/en unknown
- 2001-04-10 RU RU2002130719/15A patent/RU2248216C2/ru not_active IP Right Cessation
- 2001-04-10 AU AU2001258322A patent/AU2001258322B2/en not_active Ceased
- 2001-04-10 SI SI200120022A patent/SI21079B/sl not_active IP Right Cessation
- 2001-04-10 EP EP05108424A patent/EP1621207B1/en not_active Expired - Lifetime
- 2001-04-10 SK SK1489-2002A patent/SK14892002A3/sk unknown
- 2001-04-10 CN CNB018082025A patent/CN1183962C/zh not_active Expired - Fee Related
- 2001-04-10 JP JP2001576061A patent/JP5205668B2/ja not_active Expired - Fee Related
- 2001-10-04 UA UA2002119177A patent/UA73566C2/uk unknown
-
2002
- 2002-10-14 IS IS6581A patent/IS2171B/is unknown
- 2002-10-16 NO NO20024988A patent/NO20024988L/no not_active Application Discontinuation
- 2002-10-17 BG BG107203A patent/BG107203A/bg unknown
- 2002-10-17 ZA ZA200208413A patent/ZA200208413B/en unknown
-
2006
- 2006-02-08 CY CY20061100179T patent/CY1104971T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| OU02 | Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims |
Effective date: 20060530 |
|
| KO00 | Lapse of patent |
Effective date: 20091230 |