SI1996163T1 - Postopek za izdelavo trdne disperzije aktivne sestavine - Google Patents
Postopek za izdelavo trdne disperzije aktivne sestavineInfo
- Publication number
- SI1996163T1 SI1996163T1 SI200730843T SI200730843T SI1996163T1 SI 1996163 T1 SI1996163 T1 SI 1996163T1 SI 200730843 T SI200730843 T SI 200730843T SI 200730843 T SI200730843 T SI 200730843T SI 1996163 T1 SI1996163 T1 SI 1996163T1
- Authority
- SI
- Slovenia
- Prior art keywords
- active ingredient
- solid dispersion
- section
- producing
- matrix
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/115—Stirrers characterised by the configuration of the stirrers comprising discs or disc-like elements essentially perpendicular to the stirrer shaft axis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B7/00—Mixing; Kneading
- B29B7/30—Mixing; Kneading continuous, with mechanical mixing or kneading devices
- B29B7/34—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices
- B29B7/38—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary
- B29B7/46—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft
- B29B7/48—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws
- B29B7/482—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws provided with screw parts in addition to other mixing parts, e.g. paddles, gears, discs
- B29B7/483—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws provided with screw parts in addition to other mixing parts, e.g. paddles, gears, discs the other mixing parts being discs perpendicular to the screw axis
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- B29B7/30—Mixing; Kneading continuous, with mechanical mixing or kneading devices
- B29B7/34—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices
- B29B7/38—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary
- B29B7/46—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft
- B29B7/48—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws
- B29B7/488—Parts, e.g. casings, sealings; Accessories, e.g. flow controlling or throttling devices
- B29B7/489—Screws
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B29B7/82—Heating or cooling
- B29B7/826—Apparatus therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B29C31/00—Handling, e.g. feeding of the material to be shaped, storage of plastics material before moulding; Automation, i.e. automated handling lines in plastics processing plants, e.g. using manipulators or robots
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/022—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the choice of material
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/04—Particle-shaped
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/07—Flat, e.g. panels
- B29C48/08—Flat, e.g. panels flexible, e.g. films
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
- B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
- B29C48/402—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders the screws having intermeshing parts
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
- B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
- B29C48/405—Intermeshing co-rotating screws
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
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- B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
- B29C48/41—Intermeshing counter-rotating screws
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B29C48/80—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling at the plasticising zone, e.g. by heating cylinders
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- B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B—PERFORMING OPERATIONS; TRANSPORTING
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Landscapes
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- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
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- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Extrusion Moulding Of Plastics Or The Like (AREA)
- Formation And Processing Of Food Products (AREA)
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| EP06004999A EP1832281A1 (en) | 2006-03-10 | 2006-03-10 | Process for producing a solid dispersion of an active ingredient |
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| EP (5) | EP1832281A1 (sl) |
| JP (3) | JP5670023B2 (sl) |
| KR (2) | KR101417892B1 (sl) |
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| SI (1) | SI1996163T1 (sl) |
| WO (2) | WO2007104748A2 (sl) |
| ZA (2) | ZA200808563B (sl) |
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| EP1832281A1 (en) | 2006-03-10 | 2007-09-12 | Abbott GmbH & Co. KG | Process for producing a solid dispersion of an active ingredient |
| JP4746014B2 (ja) * | 2007-07-09 | 2011-08-10 | 株式会社日本製鋼所 | 溶融混練脱揮押出機 |
| ES2607814T3 (es) * | 2008-02-28 | 2017-04-04 | Abbvie Inc. | Preparación de tabletas |
| AR073575A1 (es) * | 2008-09-10 | 2010-11-17 | Transcu Ltd | Aparato y metodo para dispensar basados en hpc liquidos viscosos en sustratos porosos por ejemplo proceso continuo basado en bandas |
| JP2012502902A (ja) * | 2008-09-17 | 2012-02-02 | シージェイ チェルジェダン コーポレイション | アデホビルジピボキシルの安定化した固体分散体及びその製造方法 |
| US20110034489A1 (en) * | 2009-07-31 | 2011-02-10 | Ranbaxy Laboratories Limited | Solid dosage forms of hiv protease inhibitors |
| DE102009040047A1 (de) * | 2009-09-04 | 2011-03-17 | Bayer Materialscience Ag | Verfahren zur Einarbeitung von Feststoffen in Polymere |
| EP2627195B1 (en) * | 2010-10-14 | 2014-08-20 | Abbott GmbH & Co. KG | Curcuminoid solid dispersion formulation |
| CA2821659C (en) * | 2010-12-23 | 2019-05-14 | Abbott Gmbh & Co. Kg | Solid retard formulations based on solid dispersions |
| US10968129B1 (en) * | 2011-04-26 | 2021-04-06 | Mansour S. Bader | Minimizing wastes: method for de-oiling, de-scaling and distilling source water |
| WO2012164575A2 (en) | 2011-05-27 | 2012-12-06 | Hetero Research Foundation | Amorphous ritonavir co-precipitated |
| WO2013080148A1 (en) * | 2011-11-28 | 2013-06-06 | Ranbaxy Laboratories Limited | A process for the preparation of solid dispersion of lopinavir and ritonavir |
| US20130172375A1 (en) * | 2011-12-13 | 2013-07-04 | Hoffmann-La Roche Inc. | Pharmaceutical composition |
| GB2503710A (en) * | 2012-07-05 | 2014-01-08 | Res Ct Pharmaceutical Engineering Gmbh | System for producing a solid preparation from a suspension |
| RU2502599C1 (ru) * | 2012-11-14 | 2013-12-27 | Станислав Васильевич Володин | Способ изготовления пластмассовых изделий |
| UA118256C2 (uk) | 2013-01-31 | 2018-12-26 | Гіліад Фармассет Елелсі | Комбінований склад двох противірусних сполук |
| EP3003682B1 (en) * | 2013-05-27 | 2019-11-20 | Steerlife India Private Limited | A hot melt fragmentation extruder and process |
| FR3007685B1 (fr) * | 2013-06-27 | 2016-02-05 | Clextral | Element de vis pour une extrudeuse bivis corotative, ainsi qu'extrudeuse bivis corotative correspondante |
| US20150064253A1 (en) | 2013-08-27 | 2015-03-05 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
| GB201316023D0 (en) * | 2013-09-09 | 2013-10-23 | Res Ct Pharmaceutical Engineering Gmbh | Continuous low dosing of an active ingredient |
| WO2015128853A1 (en) * | 2014-02-28 | 2015-09-03 | Sun Pharmaceutical Industries Limited | Dapagliflozin compositions |
| FR3022823B1 (fr) * | 2014-06-30 | 2017-03-10 | Michelin & Cie | Extrudeuse comportant un fourreau filete |
| US9586371B2 (en) * | 2014-09-02 | 2017-03-07 | Empire Technology Development Llc | Method of bonding material layers in an additive manufacturing process |
| GB201502077D0 (en) | 2015-02-09 | 2015-03-25 | Cubic Pharmaceuticals Ltd And Delta Pharmaceuticals Ltd | Improved hme technology |
| US10086548B2 (en) | 2015-07-29 | 2018-10-02 | The Boeing Company | Extrusion apparatus and method using variable extrusion gate |
| US10933572B2 (en) | 2015-07-29 | 2021-03-02 | The Boeing Company | 2-stage extrusion apparatus and method of extrusion |
| US10195779B2 (en) * | 2015-07-29 | 2019-02-05 | The Boeing Company | Systems and methods for making composite structures |
| US10105889B2 (en) * | 2015-07-29 | 2018-10-23 | The Boeing Company | 2-stage extrusion apparatus and method of extrusion |
| PL3328603T3 (pl) * | 2015-07-31 | 2022-07-25 | Steerlife India Private Limited | Sposób oraz urządzenie do ciągłej granulacji materiału proszkowego |
| RU2619981C2 (ru) * | 2015-08-24 | 2017-05-22 | Федеральное Государственное Бюджетное Научное Учреждение "Аграрный Научный Центр "Донской" | Способ производства экструдированного комбикорма с добавкой зеленой массы кормовых трав и экструдер-измельчитель |
| CN106539689B (zh) | 2015-09-18 | 2020-05-22 | 天士力医药集团股份有限公司 | 一种连续性的液体凝固的智能滴丸机 |
| CN119682170A (zh) * | 2015-12-16 | 2025-03-25 | 科思创德国股份有限公司 | 用于将固体、液体和气体分散在挤出机中的装置和方法 |
| US10327994B2 (en) * | 2016-05-02 | 2019-06-25 | Dose Pack Llc | System and methods for customized medicine dosages in a capsule |
| DE102017114841B4 (de) * | 2017-07-04 | 2022-09-15 | Aim3D Gmbh | Vorrichtung und Verfahren zur Extrusion von thermo-mechanisch verformbaren granulatförmigen Materialien |
| EP3459527B1 (en) | 2017-09-20 | 2022-11-23 | Tillotts Pharma Ag | Method for preparing a solid dosage form comprising antibodies by wet granulation, extrusion and spheronization |
| KR102104257B1 (ko) * | 2018-05-18 | 2020-04-24 | 강원대학교산학협력단 | 열용융압출법을 이용하여 제조된 망간 나노콜로이드 분산체 및 이의 용도 |
| DE102018004355A1 (de) * | 2018-06-01 | 2019-12-05 | Entex Rust & Mitschke Gmbh | Mischen von extrudierbaren Kunststoffen mit geringen Mengen anderer Stoffe |
| KR102786957B1 (ko) * | 2018-09-26 | 2025-03-26 | 뉴트리벤티아 리미티드 | 커큐미노이드 복합물 |
| US20230211537A1 (en) * | 2019-01-30 | 2023-07-06 | Nan Ya Plastics Corporation | Method for manufacturing an lft extrusion member |
| CN111941798A (zh) * | 2020-06-08 | 2020-11-17 | 东南大学 | 一种双螺杆挤出机的双头-三头捏合块的组合 |
| JP2023553010A (ja) | 2020-12-03 | 2023-12-20 | バテル・メモリアル・インスティテュート | 非ウイルス性送達のためのポリマーナノ粒子およびdnaナノ構造組成物ならびに方法 |
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| WO2022216977A1 (en) | 2021-04-07 | 2022-10-13 | Batelle Memorial Institute | Rapid design, build, test, and learn technologies for identifying and using non-viral carriers |
| CN116330616B (zh) * | 2023-05-30 | 2023-08-29 | 河北凯力华维包装科技有限公司 | 一种改性pet材料及其制备方法与应用 |
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| US20050048112A1 (en) * | 2003-08-28 | 2005-03-03 | Jorg Breitenbach | Solid pharmaceutical dosage form |
| US20050186427A1 (en) * | 2004-02-19 | 2005-08-25 | The Procter & Gamble Company | Lubricious coated applicator |
| WO2005115343A2 (de) * | 2004-05-28 | 2005-12-08 | Abbott Gmbh & Co. Kg | Dosierungsform, erhältlich aus einer ein anorganisches pigment umfassenden pulvermischung |
| GB2418854B (en) * | 2004-08-31 | 2009-12-23 | Euro Celtique Sa | Multiparticulates |
| DE102005005173A1 (de) * | 2005-01-31 | 2006-09-14 | Beiersdorf Ag | Wirkstoffhaltige Selbstklebemassen und deren Herstellung |
| US20060193896A1 (en) * | 2005-02-25 | 2006-08-31 | Cadbury Adams Usa Llc | Process for manufacturing a delivery system for active components as part of an edible composition |
| US7655728B2 (en) * | 2005-06-27 | 2010-02-02 | Exxonmobil Chemical Patents Inc. | Preparation of thermoplastic elastomers by dynamic vulcanization in multi-screw extruders |
| EP1832281A1 (en) | 2006-03-10 | 2007-09-12 | Abbott GmbH & Co. KG | Process for producing a solid dispersion of an active ingredient |
| WO2009054533A1 (en) | 2007-10-26 | 2009-04-30 | Nippon Steel Engineering Co., Ltd. | Seismic isolation system for structures |
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2006
- 2006-03-10 EP EP06004999A patent/EP1832281A1/en not_active Withdrawn
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2007
- 2007-03-12 WO PCT/EP2007/052315 patent/WO2007104748A2/en not_active Ceased
- 2007-03-12 RU RU2008140040/15A patent/RU2442568C2/ru not_active IP Right Cessation
- 2007-03-12 EP EP07726821.7A patent/EP1996164B1/en not_active Revoked
- 2007-03-12 EP EP11174253A patent/EP2386293A1/en not_active Withdrawn
- 2007-03-12 DK DK07726821.7T patent/DK1996164T3/da active
- 2007-03-12 AT AT07726820T patent/ATE531359T1/de active
- 2007-03-12 MX MX2008010956A patent/MX2008010956A/es active IP Right Grant
- 2007-03-12 SI SI200730843T patent/SI1996163T1/sl unknown
- 2007-03-12 AU AU2007224487A patent/AU2007224487B2/en not_active Ceased
- 2007-03-12 BR BRPI0708709-8A patent/BRPI0708709A2/pt not_active IP Right Cessation
- 2007-03-12 BR BRPI0708734-9A patent/BRPI0708734A2/pt not_active IP Right Cessation
- 2007-03-12 ES ES07726820T patent/ES2376764T3/es active Active
- 2007-03-12 DK DK07726820.9T patent/DK1996163T3/da active
- 2007-03-12 MX MX2008011041A patent/MX2008011041A/es active IP Right Grant
- 2007-03-12 CN CN2007800084626A patent/CN101400341B/zh not_active Expired - Fee Related
- 2007-03-12 CA CA2644035A patent/CA2644035C/en not_active Expired - Fee Related
- 2007-03-12 KR KR1020087024871A patent/KR101417892B1/ko not_active Expired - Fee Related
- 2007-03-12 CN CN2007800084522A patent/CN101400340B/zh not_active Expired - Fee Related
- 2007-03-12 EP EP07726820A patent/EP1996163B1/en not_active Revoked
- 2007-03-12 JP JP2008557771A patent/JP5670023B2/ja not_active Expired - Fee Related
- 2007-03-12 KR KR1020087024874A patent/KR101453399B1/ko not_active Expired - Fee Related
- 2007-03-12 ES ES07726821T patent/ES2425176T3/es active Active
- 2007-03-12 CA CA2644372A patent/CA2644372C/en not_active Expired - Fee Related
- 2007-03-12 EP EP15180069.5A patent/EP2959890A1/en not_active Withdrawn
- 2007-03-12 AU AU2007224486A patent/AU2007224486B2/en not_active Ceased
- 2007-03-12 WO PCT/EP2007/052314 patent/WO2007104747A2/en not_active Ceased
- 2007-03-12 US US12/279,385 patent/US20090302493A1/en not_active Abandoned
- 2007-03-12 JP JP2008557770A patent/JP5512134B2/ja active Active
- 2007-03-12 RU RU2008140039/15A patent/RU2448688C2/ru not_active IP Right Cessation
- 2007-03-12 PT PT07726820T patent/PT1996163E/pt unknown
- 2007-03-12 PL PL07726820T patent/PL1996163T3/pl unknown
- 2007-03-12 US US12/279,415 patent/US20090311414A1/en not_active Abandoned
- 2007-03-12 PL PL07726821T patent/PL1996164T3/pl unknown
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2008
- 2008-10-08 ZA ZA200808563A patent/ZA200808563B/xx unknown
- 2008-10-08 ZA ZA200808564A patent/ZA200808564B/xx unknown
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2009
- 2009-04-03 HK HK16103246.8A patent/HK1215188A1/en unknown
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2012
- 2012-01-31 CY CY20121100107T patent/CY1112273T1/el unknown
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2013
- 2013-12-02 US US14/094,563 patent/US9205027B2/en not_active Expired - Fee Related
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