SI1615699T1 - Benzoksazinil-amidociklopentil-heterocikliäśni modulatorji kemokin receptorjev - Google Patents
Benzoksazinil-amidociklopentil-heterocikliäśni modulatorji kemokin receptorjevInfo
- Publication number
- SI1615699T1 SI1615699T1 SI200431410T SI200431410T SI1615699T1 SI 1615699 T1 SI1615699 T1 SI 1615699T1 SI 200431410 T SI200431410 T SI 200431410T SI 200431410 T SI200431410 T SI 200431410T SI 1615699 T1 SI1615699 T1 SI 1615699T1
- Authority
- SI
- Slovenia
- Prior art keywords
- compounds
- benzoxazinyl
- amidocyclopentyl
- chemokine receptors
- diseases
- Prior art date
Links
- 102000009410 Chemokine receptor Human genes 0.000 title 1
- 108050000299 Chemokine receptor Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical compound C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010003645 Atopy Diseases 0.000 abstract 1
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 abstract 1
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 abstract 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 abstract 1
- 206010012434 Dermatitis allergic Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000009961 allergic asthma Diseases 0.000 abstract 1
- 208000002205 allergic conjunctivitis Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000024998 atopic conjunctivitis Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 125000004622 benzoxazinyl group Chemical group O1NC(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000004957 immunoregulator effect Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46311103P | 2003-04-15 | 2003-04-15 | |
| PCT/US2004/011281 WO2004092124A2 (en) | 2003-04-15 | 2004-04-09 | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
| EP04759458A EP1615699B1 (en) | 2003-04-15 | 2004-04-09 | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1615699T1 true SI1615699T1 (sl) | 2010-07-30 |
Family
ID=33300038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200431410T SI1615699T1 (sl) | 2003-04-15 | 2004-04-09 | Benzoksazinil-amidociklopentil-heterocikliäśni modulatorji kemokin receptorjev |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7700591B2 (sl) |
| EP (1) | EP1615699B1 (sl) |
| JP (1) | JP4440257B2 (sl) |
| KR (1) | KR20060003353A (sl) |
| CN (1) | CN1802187B (sl) |
| AT (1) | ATE461929T1 (sl) |
| AU (1) | AU2004231087B2 (sl) |
| BR (1) | BRPI0409393A8 (sl) |
| CA (1) | CA2521950C (sl) |
| CY (1) | CY1110155T1 (sl) |
| DE (1) | DE602004026166D1 (sl) |
| DK (1) | DK1615699T3 (sl) |
| ES (1) | ES2342776T3 (sl) |
| IS (1) | IS8056A (sl) |
| MX (1) | MXPA05011160A (sl) |
| NO (1) | NO20055376L (sl) |
| NZ (1) | NZ543287A (sl) |
| PL (1) | PL1615699T3 (sl) |
| PT (1) | PT1615699E (sl) |
| RU (1) | RU2301802C2 (sl) |
| SI (1) | SI1615699T1 (sl) |
| WO (1) | WO2004092124A2 (sl) |
| ZA (1) | ZA200507796B (sl) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1732552A4 (en) * | 2004-01-20 | 2007-12-19 | Merck & Co Inc | 2,6-DISUBSTITUTED PIPERIDINES AS MODULATORS OF CHEMOKIN RECEPTOR ACTIVITY |
| US20070238723A1 (en) * | 2004-10-15 | 2007-10-11 | Goble Stephen D | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
| US20080194548A1 (en) * | 2005-01-06 | 2008-08-14 | Forrest Michael J | Drug Combination Therapy and Pharmaceutical Compositions for Treating Inflammatory Disorders |
| TW200738701A (en) | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| US8067457B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
| WO2007053499A2 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| WO2007122103A1 (en) * | 2006-04-20 | 2007-11-01 | F. Hoffmann-La Roche Ag | Diazepan derivatives modulators of chemokine receptors |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| WO2009068318A1 (en) * | 2007-11-30 | 2009-06-04 | Noxxon Pharma Ag | Mcp-i binding nucleic acids and use thereof |
| KR100904535B1 (ko) * | 2009-03-09 | 2009-06-29 | 한세이엔씨(주) | 교량의 박스거더 내부 안전진단장치 |
| KR20110136813A (ko) | 2009-03-17 | 2011-12-21 | 다이이찌 산쿄 가부시키가이샤 | 아미드 유도체 |
| SG174463A1 (en) * | 2009-04-07 | 2011-10-28 | Astrazeneca Ab | Isoxazol-3(2h)-one analogs as therapeutic agents |
| UA107938C2 (en) | 2009-08-12 | 2015-03-10 | Syngenta Participations Ag | Heterocycles with microbicidal properties |
| WO2011100227A1 (en) * | 2010-02-09 | 2011-08-18 | Bristol-Myers Squibb Company | Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity |
| CN103694220A (zh) * | 2013-12-30 | 2014-04-02 | 张磊 | 新型吡唑-3-甲酸酯及合成方法 |
| RU2564440C1 (ru) * | 2014-06-03 | 2015-10-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" | 3-ароил-2-гидрокси-2-(2-оксоциклоалкил)пирроло[2,1-с][1,4]бензоксазин-1,4(2н)-дионы, проявляющие анальгетическую активность, и способ их получения |
| JP6660393B2 (ja) | 2015-01-16 | 2020-03-11 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 4−シアノピペリジン塩酸塩を調製する方法 |
| WO2016139165A1 (en) * | 2015-03-05 | 2016-09-09 | Bayer Cropscience Aktiengesellschaft | Process for preparing piperidine-4-carbothioamide hydrochloride |
| SI3297438T1 (sl) | 2015-05-21 | 2022-03-31 | Chemocentryx, Inc. | CCR2 modulatorji |
| MX2018000762A (es) * | 2015-07-23 | 2018-05-15 | Huntsman Advanced Mat Americas Llc | Composiciones curables de benzoxazina. |
| EP3687525B1 (en) | 2017-09-25 | 2025-10-29 | ChemoCentryx, Inc. | Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| ES2991280T3 (es) | 2018-01-08 | 2024-12-03 | Chemocentryx Inc | Antagonistas de CCR2 para el tratamiento del linfoma cutáneo de linfocitos T |
| CR20220310A (es) | 2019-11-27 | 2022-09-23 | Sumitomo Pharma Co Ltd | Derivado de cicloalquilurea |
| US11352357B2 (en) * | 2019-11-27 | 2022-06-07 | Sumitomo Dainippon Pharma Co., Ltd. | Cycloalkylurea derivative |
| CN116730855B (zh) * | 2023-08-08 | 2023-10-20 | 苏州开元民生科技股份有限公司 | 3-氨基-4-氯苯甲酸十六酯的合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3647804A (en) * | 1970-02-27 | 1972-03-07 | Upjohn Co | Cycloalkanecarboxamides |
| US3772308A (en) * | 1972-06-02 | 1973-11-13 | Lilly Co Eli | Cyclopentanecetamides and cyclopentaneacetonitriles |
| US5631363A (en) * | 1992-11-13 | 1997-05-20 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
| GB9812037D0 (en) | 1998-06-04 | 1998-07-29 | Pfizer Ltd | Piperidones |
| US6312689B1 (en) * | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| AU5473400A (en) * | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| MXPA03008109A (es) | 2001-03-07 | 2003-12-12 | Pfizer Prod Inc | Moduladores de la actividad de receptores de quimiocinas. |
| RU2199537C1 (ru) * | 2001-08-08 | 2003-02-27 | Пермский государственный университет | Триазиламиды 4-арил-2-гидрокси-4-оксо-3-(2-оксо-3,4-дигидро-2h-1,4-бензоксазинил)-2-бут еновой кислоты, проявляющие противовоспалительную активность |
| NZ536477A (en) * | 2002-04-29 | 2005-05-27 | Merck & Co Inc | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| US7166614B2 (en) * | 2002-04-29 | 2007-01-23 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity |
| US20060205761A1 (en) | 2003-06-06 | 2006-09-14 | Catherine Abbadie | Ccr-2 antagonists for treatment of neuropathic pain |
| US20070238723A1 (en) * | 2004-10-15 | 2007-10-11 | Goble Stephen D | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
| US20080194548A1 (en) * | 2005-01-06 | 2008-08-14 | Forrest Michael J | Drug Combination Therapy and Pharmaceutical Compositions for Treating Inflammatory Disorders |
-
2004
- 2004-04-08 CA CA002521950A patent/CA2521950C/en not_active Expired - Fee Related
- 2004-04-08 NZ NZ543287A patent/NZ543287A/en not_active IP Right Cessation
- 2004-04-08 AU AU2004231087A patent/AU2004231087B2/en not_active Ceased
- 2004-04-08 RU RU2005135432/05A patent/RU2301802C2/ru not_active IP Right Cessation
- 2004-04-08 KR KR1020057019690A patent/KR20060003353A/ko not_active Ceased
- 2004-04-08 PT PT04759458T patent/PT1615699E/pt unknown
- 2004-04-09 AT AT04759458T patent/ATE461929T1/de active
- 2004-04-09 JP JP2006509950A patent/JP4440257B2/ja not_active Expired - Fee Related
- 2004-04-09 PL PL04759458T patent/PL1615699T3/pl unknown
- 2004-04-09 CN CN2004800160753A patent/CN1802187B/zh not_active Expired - Fee Related
- 2004-04-09 MX MXPA05011160A patent/MXPA05011160A/es active IP Right Grant
- 2004-04-09 BR BRPI0409393A patent/BRPI0409393A8/pt not_active Application Discontinuation
- 2004-04-09 DE DE602004026166T patent/DE602004026166D1/de not_active Expired - Lifetime
- 2004-04-09 SI SI200431410T patent/SI1615699T1/sl unknown
- 2004-04-09 WO PCT/US2004/011281 patent/WO2004092124A2/en not_active Ceased
- 2004-04-09 EP EP04759458A patent/EP1615699B1/en not_active Expired - Lifetime
- 2004-04-09 DK DK04759458.5T patent/DK1615699T3/da active
- 2004-04-09 ES ES04759458T patent/ES2342776T3/es not_active Expired - Lifetime
-
2005
- 2005-05-13 US US11/129,512 patent/US7700591B2/en not_active Expired - Lifetime
- 2005-09-27 ZA ZA200507796A patent/ZA200507796B/xx unknown
- 2005-09-29 IS IS8056A patent/IS8056A/is unknown
- 2005-11-14 NO NO20055376A patent/NO20055376L/no not_active Application Discontinuation
-
2010
- 2010-06-24 CY CY20101100581T patent/CY1110155T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1110155T1 (el) | Βενζοξαζινυλο-αμιδοκυκλοπεντυλο-ετεροκυκλικοι διαμορφωτες υποδοχεων χημειοκινων | |
| WO2006001958A3 (en) | Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity | |
| MX2010003113A (es) | Compuestos de octahidropentaleno como antagonistas del receptor de quimiocina. | |
| NO20073019L (no) | Pyrasolonforbindelser som metabotrope glutamatreseptor-antagonister for behandlingen av nevrotiske og psykiatriske lidelser | |
| MX2009013169A (es) | Moduladores alostericos positivos del mglur5 benzamida y metodos de elaboracion y uso de los mismos. | |
| NO20070583L (no) | Isoindolonforbindelser og anvendelse derav som metabotrofe glutamatreseptorforsterker | |
| TW200508224A (en) | Cyclic derivatives as modulators of chemokine receptor activity | |
| NO20071660L (no) | Nye pyridinonderivater og deres anvendelse som positive allosteriske modulatorer av MGLUR2-reseptorer | |
| PT1656345E (pt) | Derivados cíclicos como moduladores da actividade de receptores de quimioquinas | |
| NO20083500L (no) | 1,4-disubstituerte 3-cyano-pyridonderivater og deres anvendelse som positiv-allosteriske modulatorer av mGluR2 receptorer | |
| MX2010002538A (es) | 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-disubstituidas. | |
| EA200901160A1 (ru) | Производные 3-циано-4-(4-тетрагидропиранфенил)пиридин-2-она | |
| TNSN06430A1 (en) | Fused pyrimidine derivatives and compositions thereof as cxcr3 receptor modulators, useful in prevention and treatment of inflammatory and immunoregulatory disorders and diseases | |
| MY152078A (en) | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones | |
| JO2907B1 (en) | Pyridine derivatives 1, 2, 4 trisolo [4, 3-A] and their uses as positive LLs for 2MGLUR receptors | |
| IL177291A0 (en) | Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists | |
| MX2007014405A (es) | Novedosos derivados de oxadiazol y su uso como moduladores aloestericos positivos de los receptores de glutamato metabotropicos. | |
| ATE482183T1 (de) | Malonamide und malonamid-derivate als modulatoren der chemokin-rezeptor-aktivität | |
| WO2005105092A3 (en) | 3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity | |
| WO2005120505A3 (en) | Tetrahydropyranyl cyclopentyl tetrahy-dropyridopyridine modulators of chemokine receptor activity | |
| ATE429421T1 (de) | Arylindenopyridin- und arylindenopyrimidinverbindungen und ihre verwendung als adenosin-a2a-rezeptor antagonisten | |
| WO2008037681A8 (en) | 5-{2-[4-(2-methyl-5-quinolinyl)-l-piperidinyl] ethyl} quinolinone derivatives as 5ht1a receptor modulators for treating sexual dysfunction, cognition impairement, psychotic disorders, anxiety, depression, etc. | |
| NO20055752L (no) | N-ureidoalkyl-piperidiner som modulerer forbindelser av kjemokinreseptor-aktivitet | |
| WO2005110409A3 (en) | Tetrahydropyranyl cyclopentyl 1-substituted and 1,1-disubstituted tetrahydroisoquinoline modulators of chemokine receptor activity | |
| WO2005014537A3 (en) | Tetrahydropyran heterocyclic cyclopentyl heteroaryl modulators of chemokine receptor activity |