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SI1615699T1 - Benzoksazinil-amidociklopentil-heterocikliäśni modulatorji kemokin receptorjev - Google Patents

Benzoksazinil-amidociklopentil-heterocikliäśni modulatorji kemokin receptorjev

Info

Publication number
SI1615699T1
SI1615699T1 SI200431410T SI200431410T SI1615699T1 SI 1615699 T1 SI1615699 T1 SI 1615699T1 SI 200431410 T SI200431410 T SI 200431410T SI 200431410 T SI200431410 T SI 200431410T SI 1615699 T1 SI1615699 T1 SI 1615699T1
Authority
SI
Slovenia
Prior art keywords
compounds
benzoxazinyl
amidocyclopentyl
chemokine receptors
diseases
Prior art date
Application number
SI200431410T
Other languages
English (en)
Inventor
Stephen D Goble
Sander G Mills
Lihu Yang
Alexander Pasternak
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of SI1615699T1 publication Critical patent/SI1615699T1/sl

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI200431410T 2003-04-15 2004-04-09 Benzoksazinil-amidociklopentil-heterocikliäśni modulatorji kemokin receptorjev SI1615699T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46311103P 2003-04-15 2003-04-15
PCT/US2004/011281 WO2004092124A2 (en) 2003-04-15 2004-04-09 Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
EP04759458A EP1615699B1 (en) 2003-04-15 2004-04-09 Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors

Publications (1)

Publication Number Publication Date
SI1615699T1 true SI1615699T1 (sl) 2010-07-30

Family

ID=33300038

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200431410T SI1615699T1 (sl) 2003-04-15 2004-04-09 Benzoksazinil-amidociklopentil-heterocikliäśni modulatorji kemokin receptorjev

Country Status (23)

Country Link
US (1) US7700591B2 (sl)
EP (1) EP1615699B1 (sl)
JP (1) JP4440257B2 (sl)
KR (1) KR20060003353A (sl)
CN (1) CN1802187B (sl)
AT (1) ATE461929T1 (sl)
AU (1) AU2004231087B2 (sl)
BR (1) BRPI0409393A8 (sl)
CA (1) CA2521950C (sl)
CY (1) CY1110155T1 (sl)
DE (1) DE602004026166D1 (sl)
DK (1) DK1615699T3 (sl)
ES (1) ES2342776T3 (sl)
IS (1) IS8056A (sl)
MX (1) MXPA05011160A (sl)
NO (1) NO20055376L (sl)
NZ (1) NZ543287A (sl)
PL (1) PL1615699T3 (sl)
PT (1) PT1615699E (sl)
RU (1) RU2301802C2 (sl)
SI (1) SI1615699T1 (sl)
WO (1) WO2004092124A2 (sl)
ZA (1) ZA200507796B (sl)

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EP1732552A4 (en) * 2004-01-20 2007-12-19 Merck & Co Inc 2,6-DISUBSTITUTED PIPERIDINES AS MODULATORS OF CHEMOKIN RECEPTOR ACTIVITY
US20070238723A1 (en) * 2004-10-15 2007-10-11 Goble Stephen D Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
US20080194548A1 (en) * 2005-01-06 2008-08-14 Forrest Michael J Drug Combination Therapy and Pharmaceutical Compositions for Treating Inflammatory Disorders
TW200738701A (en) 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
WO2007053499A2 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
WO2007122103A1 (en) * 2006-04-20 2007-11-01 F. Hoffmann-La Roche Ag Diazepan derivatives modulators of chemokine receptors
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
WO2009068318A1 (en) * 2007-11-30 2009-06-04 Noxxon Pharma Ag Mcp-i binding nucleic acids and use thereof
KR100904535B1 (ko) * 2009-03-09 2009-06-29 한세이엔씨(주) 교량의 박스거더 내부 안전진단장치
KR20110136813A (ko) 2009-03-17 2011-12-21 다이이찌 산쿄 가부시키가이샤 아미드 유도체
SG174463A1 (en) * 2009-04-07 2011-10-28 Astrazeneca Ab Isoxazol-3(2h)-one analogs as therapeutic agents
UA107938C2 (en) 2009-08-12 2015-03-10 Syngenta Participations Ag Heterocycles with microbicidal properties
WO2011100227A1 (en) * 2010-02-09 2011-08-18 Bristol-Myers Squibb Company Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
CN103694220A (zh) * 2013-12-30 2014-04-02 张磊 新型吡唑-3-甲酸酯及合成方法
RU2564440C1 (ru) * 2014-06-03 2015-10-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" 3-ароил-2-гидрокси-2-(2-оксоциклоалкил)пирроло[2,1-с][1,4]бензоксазин-1,4(2н)-дионы, проявляющие анальгетическую активность, и способ их получения
JP6660393B2 (ja) 2015-01-16 2020-03-11 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 4−シアノピペリジン塩酸塩を調製する方法
WO2016139165A1 (en) * 2015-03-05 2016-09-09 Bayer Cropscience Aktiengesellschaft Process for preparing piperidine-4-carbothioamide hydrochloride
SI3297438T1 (sl) 2015-05-21 2022-03-31 Chemocentryx, Inc. CCR2 modulatorji
MX2018000762A (es) * 2015-07-23 2018-05-15 Huntsman Advanced Mat Americas Llc Composiciones curables de benzoxazina.
EP3687525B1 (en) 2017-09-25 2025-10-29 ChemoCentryx, Inc. Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
ES2991280T3 (es) 2018-01-08 2024-12-03 Chemocentryx Inc Antagonistas de CCR2 para el tratamiento del linfoma cutáneo de linfocitos T
CR20220310A (es) 2019-11-27 2022-09-23 Sumitomo Pharma Co Ltd Derivado de cicloalquilurea
US11352357B2 (en) * 2019-11-27 2022-06-07 Sumitomo Dainippon Pharma Co., Ltd. Cycloalkylurea derivative
CN116730855B (zh) * 2023-08-08 2023-10-20 苏州开元民生科技股份有限公司 3-氨基-4-氯苯甲酸十六酯的合成方法

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RU2199537C1 (ru) * 2001-08-08 2003-02-27 Пермский государственный университет Триазиламиды 4-арил-2-гидрокси-4-оксо-3-(2-оксо-3,4-дигидро-2h-1,4-бензоксазинил)-2-бут еновой кислоты, проявляющие противовоспалительную активность
NZ536477A (en) * 2002-04-29 2005-05-27 Merck & Co Inc Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
US7166614B2 (en) * 2002-04-29 2007-01-23 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity
US20060205761A1 (en) 2003-06-06 2006-09-14 Catherine Abbadie Ccr-2 antagonists for treatment of neuropathic pain
US20070238723A1 (en) * 2004-10-15 2007-10-11 Goble Stephen D Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
US20080194548A1 (en) * 2005-01-06 2008-08-14 Forrest Michael J Drug Combination Therapy and Pharmaceutical Compositions for Treating Inflammatory Disorders

Also Published As

Publication number Publication date
KR20060003353A (ko) 2006-01-10
US7700591B2 (en) 2010-04-20
DE602004026166D1 (de) 2010-05-06
EP1615699A4 (en) 2008-03-19
US20060069088A1 (en) 2006-03-30
PL1615699T3 (pl) 2010-08-31
JP4440257B2 (ja) 2010-03-24
WO2004092124A8 (en) 2010-02-25
PT1615699E (pt) 2010-05-21
NZ543287A (en) 2008-08-29
BRPI0409393A8 (pt) 2018-05-08
CY1110155T1 (el) 2015-01-14
CA2521950A1 (en) 2004-10-28
RU2005135432A (ru) 2006-04-27
NO20055376D0 (no) 2005-11-14
MXPA05011160A (es) 2005-12-14
ATE461929T1 (de) 2010-04-15
BRPI0409393A (pt) 2006-04-18
CA2521950C (en) 2009-11-17
ES2342776T3 (es) 2010-07-14
RU2301802C2 (ru) 2007-06-27
WO2004092124A2 (en) 2004-10-28
DK1615699T3 (da) 2010-07-19
EP1615699A2 (en) 2006-01-18
IS8056A (is) 2005-09-29
WO2004092124A3 (en) 2005-04-14
NO20055376L (no) 2006-01-13
ZA200507796B (en) 2007-02-28
AU2004231087B2 (en) 2007-01-04
AU2004231087A1 (en) 2004-10-28
CN1802187A (zh) 2006-07-12
CN1802187B (zh) 2011-09-14
JP2006523702A (ja) 2006-10-19
EP1615699B1 (en) 2010-03-24

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