[go: up one dir, main page]

SI1664123T1 - Priprava inhibitorja alfa-1 proteinaze v velikem merilu in njegova uporaba - Google Patents

Priprava inhibitorja alfa-1 proteinaze v velikem merilu in njegova uporaba

Info

Publication number
SI1664123T1
SI1664123T1 SI200430759T SI200430759T SI1664123T1 SI 1664123 T1 SI1664123 T1 SI 1664123T1 SI 200430759 T SI200430759 T SI 200430759T SI 200430759 T SI200430759 T SI 200430759T SI 1664123 T1 SI1664123 T1 SI 1664123T1
Authority
SI
Slovenia
Prior art keywords
months
alpha
large scale
api
proteinase inhibitor
Prior art date
Application number
SI200430759T
Other languages
English (en)
Other versions
SI1664123T2 (sl
Inventor
Shabtai Bauer
Original Assignee
Kamada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34379546&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1664123(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IL15805303A external-priority patent/IL158053A0/xx
Application filed by Kamada Ltd filed Critical Kamada Ltd
Publication of SI1664123T1 publication Critical patent/SI1664123T1/sl
Publication of SI1664123T2 publication Critical patent/SI1664123T2/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200430759T 2003-09-22 2004-09-22 Priprava inhibitorja alfa proteinaze v velikem merilu in njegova uporaba SI1664123T2 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50390203P 2003-09-22 2003-09-22
IL15805303A IL158053A0 (en) 2003-09-22 2003-09-22 Process for large scale purification of alpha-1 proteinase inhibitor
PCT/IL2004/000881 WO2005027821A2 (en) 2003-09-22 2004-09-22 Large scale preparation of alpha-1 proteinase inhibitor and use thereof
EP04770552A EP1664123B2 (en) 2003-09-22 2004-09-22 Large scale preparation of alpha-1 proteinase inhibitor and use thereof

Publications (2)

Publication Number Publication Date
SI1664123T1 true SI1664123T1 (sl) 2008-10-31
SI1664123T2 SI1664123T2 (sl) 2012-03-30

Family

ID=34379546

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200430759T SI1664123T2 (sl) 2003-09-22 2004-09-22 Priprava inhibitorja alfa proteinaze v velikem merilu in njegova uporaba

Country Status (12)

Country Link
US (2) US7879800B2 (sl)
EP (1) EP1664123B2 (sl)
AT (1) ATE391730T1 (sl)
CA (1) CA2538998C (sl)
DE (1) DE602004013021T3 (sl)
DK (1) DK1664123T4 (sl)
ES (1) ES2305845T5 (sl)
IL (1) IL174410A0 (sl)
PL (1) PL1664123T5 (sl)
PT (1) PT1664123E (sl)
SI (1) SI1664123T2 (sl)
WO (1) WO2005027821A2 (sl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0524432D0 (en) * 2005-11-30 2006-01-11 Nhs Blood & Transplant Method
US7973005B2 (en) 2006-02-09 2011-07-05 Kamada Ltd. Alpha-1 antitrypsin for treating exacerbation episodes of pulmonary diseases
JP5600061B2 (ja) 2007-08-17 2014-10-01 ツェーエスエル ベーリンク ゲゼルシャフト ミット ベシュレンクテル ハフツング α−１−抗トリプシンおよびアポリポタンパク質Ａ−Ｉを精製する方法
US20110237781A1 (en) * 2008-07-18 2011-09-29 Talecris Biotherapeutics, Inc. Method of preparing alpha-1 proteinase inhibitor
NZ599783A (en) 2009-11-03 2013-10-25 Grifols Therapeutics Inc Composition and use for alpha-1 proteinase inhibitor
KR101567901B1 (ko) 2009-11-24 2015-11-10 그리폴스 테라퓨틱스 인코포레이티드 동결건조 방법, 조성물, 및 키트
CA2836478A1 (en) 2011-05-27 2012-12-06 Baxter International Inc. Therapeutic protein conjugated to water-soluble polymers via reduced cysteine sulfhydryl group
EP2758065B1 (en) 2011-12-30 2021-06-23 Grifols, S.A. Alpha1-proteinase inhibitor for use in delaying the onset or progression of pulmonary exacerbations
TWI629283B (zh) 2012-02-23 2018-07-11 巴克斯歐塔公司 來自血漿中的免疫球蛋白之ｉ-ｉｖ-１部分沉澱
US9353165B2 (en) 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
US20210085764A1 (en) * 2016-12-22 2021-03-25 Kamada Ltd. Dry powder formulations of alpha-1 antitrypsin
WO2018154568A1 (en) * 2017-02-21 2018-08-30 Kamada Ltd. Methods and uses of alpha 1-antitrypsin for early intervention in pulmonary diseases
IL275328B2 (en) 2017-12-12 2024-03-01 Kamada Ltd Methods of inducing immune tolerance and reducing anti-drug antibody response
IL267923B2 (en) 2018-08-02 2023-06-01 Grifols Worldwide Operations Ltd The composition containing the most concentrated alpha-1 type protein inhibitor and a method for obtaining it
WO2020157752A1 (en) * 2019-01-29 2020-08-06 Kamada Ltd Pharmaceutical aerosol composition

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439358A (en) 1982-06-17 1984-03-27 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4379087A (en) 1982-06-17 1983-04-05 Cutter Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4683294A (en) 1985-04-03 1987-07-28 Smith Kline Rit, S.A. Process for the extraction and purification of proteins from culture media producing them
US4697003A (en) * 1985-11-01 1987-09-29 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4656254A (en) 1985-12-02 1987-04-07 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor and antithrombin III
US4629567A (en) 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
US4749783A (en) 1986-07-11 1988-06-07 Miles Laboratories, Inc. Viral inactivation and purification of active proteins
US5114917A (en) 1986-12-24 1992-05-19 John Lezdey Treatment of inflammation using alpha 1-antichymotrypsin
CA2081774A1 (en) 1990-05-01 1991-11-02 John Stephen Haskill Interleukin-1 antagonist and uses thereof
US5814225A (en) 1994-06-09 1998-09-29 Shanbrom Technologies Llc Iodinated gel filtration media for disinfecting protein solutions
US6284874B1 (en) 1994-06-17 2001-09-04 Alpha Therapeutic Corporation Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste
US5610285A (en) 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
AU6884396A (en) 1995-09-07 1997-03-27 Ppl Therapeutics (Scotland) Ltd Purification of alpha-1 proteinase inhibitor
US5780440A (en) 1996-06-17 1998-07-14 Protease Sciences Inc. Treatment of pulmonary disease with protease inhibitors
TW491855B (en) * 1996-08-07 2002-06-21 Csl Ltd Purification of immunoglobulins
AT407114B (de) 1997-06-10 2000-12-27 Immuno Ag Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung
US6093804A (en) * 1998-09-24 2000-07-25 American National Red Cross Method for purification of alpha-1 proteinase inhibitor
US6462180B1 (en) * 1999-11-24 2002-10-08 Bayer Corporation Method of preparing α-1 proteinase inhibitor
EP1343809B2 (en) * 2000-12-14 2023-03-15 Grifols Therapeutics Inc. Method of preparing alpha-1 proteinase inhibitor
JP4319979B2 (ja) 2002-04-26 2009-08-26 ジェネンテック・インコーポレーテッド タンパク質の非アフィニティ精製
US7777006B2 (en) 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
ATE428730T1 (de) 2003-08-12 2009-05-15 Octapharma Ag Verfahren zur herstellung einer alpha-1- antitrypsinlösung
PL1765866T3 (pl) 2004-06-07 2014-06-30 Therapure Biopharma Inc Wydzielanie białek osocza lub surowicy

Also Published As

Publication number Publication date
ES2305845T3 (es) 2008-11-01
DK1664123T3 (da) 2008-07-28
DE602004013021T2 (de) 2009-06-25
EP1664123A2 (en) 2006-06-07
ATE391730T1 (de) 2008-04-15
US20080139465A1 (en) 2008-06-12
US20110092444A1 (en) 2011-04-21
AU2004273696A1 (en) 2005-03-31
SI1664123T2 (sl) 2012-03-30
ES2305845T5 (es) 2012-04-12
WO2005027821A2 (en) 2005-03-31
PL1664123T3 (pl) 2008-11-28
EP1664123A4 (en) 2006-11-02
CA2538998C (en) 2015-11-24
PL1664123T5 (pl) 2012-04-30
DE602004013021D1 (de) 2008-05-21
US7879800B2 (en) 2011-02-01
CA2538998A1 (en) 2005-03-31
PT1664123E (pt) 2008-07-16
WO2005027821A3 (en) 2005-08-04
DK1664123T4 (da) 2012-03-05
EP1664123B1 (en) 2008-04-09
EP1664123B2 (en) 2011-11-30
IL174410A0 (en) 2006-08-01
DE602004013021T3 (de) 2012-04-05

Similar Documents

Publication Publication Date Title
IL174410A0 (en) Large scale preparation of alpha-1 proteinase inhibitor and use thereof
MXPA04004842A (es) Inhibidores de 11-(-hidroxiesteroide deshidrogenasa de tipo 1.
IL161154A0 (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
TW200510391A (en) Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
BRPI0414176A (pt) inibidores de serina proteases, em particular hcv ns3-ns4a protease
WO2005007681A3 (en) Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
DE60233137D1 (de) Transporter mit beabstandeten arginin-teilchen
EA200201271A1 (ru) Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
HUP0401104A2 (hu) Dipeptidil-peptidáz inhibitorként cukorbetegség megelőzésére és kezelésére alkalmazható (béta-aminoacil)-tetrahidroimidazo[1,2-a]pirazinok és - tetrahidrotriazolo[4,3-a]pirazinok, valamint az ezeket tartalmazó gyógyszerkészítmények
ATE381537T1 (de) Formanilid-derivative als beta2-adrenorezeptor- agonisten
SG166791A1 (en) Novel macrocyclic inhibitors of hepatitis c virus replication
GEP20022824B (en) Antipicornaviral Compounds, Pharmaceutical Compositions Containing the Same and Methods for Treatment
ECSP045378A (es) Derivados novedosos de diazabiciclononeno
BR0308765A (pt) Compostos (4,2-dissubstituìdo-tiazol-5-il)amina como inibidores de pde7
SE9904413D0 (sv) Comminuted form
SE9904421D0 (sv) New compounds
MXPA05012675A (es) Compuestos de hidroxiamidina e hidroxiguanidina como inhibidores de urocinasa.
EA200400708A1 (ru) Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
WO2005075471A3 (en) Thiazol-compounds as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
ATE494894T1 (de) Viruzide wirkungen von einer zubereitung enthaltend cetylpyridiniumchlorid und zitronensäure
MXPA04001655A (es) Derivados de acido ascorbico, metodos de sintesis y uso farmaceutico de los mismos.
EA200400707A1 (ru) Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
DE602005020314D1 (de) Bicyclononen-derivate als renin-inhibitoren
SE0101978D0 (sv) New compounds
UA93529C2 (ru) Соли и смеси 9-оксоакридин-10-уксусной кислоты c 1-алкиламино-1-дезоксиполиолами