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SI1572169T1 - Odkrivanje in modulacija slit in robo posredovane angiogeneze ter njuni načini uporabe - Google Patents

Odkrivanje in modulacija slit in robo posredovane angiogeneze ter njuni načini uporabe

Info

Publication number
SI1572169T1
SI1572169T1 SI200332312T SI200332312T SI1572169T1 SI 1572169 T1 SI1572169 T1 SI 1572169T1 SI 200332312 T SI200332312 T SI 200332312T SI 200332312 T SI200332312 T SI 200332312T SI 1572169 T1 SI1572169 T1 SI 1572169T1
Authority
SI
Slovenia
Prior art keywords
roundabount
robo
slit
modulation
detection
Prior art date
Application number
SI200332312T
Other languages
English (en)
Inventor
Jian-Guo Geng
Original Assignee
Shanghai Institutes For Biological Sciences, Cas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Institutes For Biological Sciences, Cas filed Critical Shanghai Institutes For Biological Sciences, Cas
Publication of SI1572169T1 publication Critical patent/SI1572169T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Eye Examination Apparatus (AREA)
SI200332312T 2002-03-08 2003-03-10 Odkrivanje in modulacija slit in robo posredovane angiogeneze ter njuni načini uporabe SI1572169T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36248502P 2002-03-08 2002-03-08
EP03716469.6A EP1572169B1 (en) 2002-03-08 2003-03-10 Detection and modulation of slit and roundabount (robo) mediated angiogenesis and uses thereof
PCT/US2003/007458 WO2003075860A2 (en) 2002-03-08 2003-03-10 Detection and modulation of slit and roundabount (robo) mediated angiogenesis and uses thereof

Publications (1)

Publication Number Publication Date
SI1572169T1 true SI1572169T1 (sl) 2013-12-31

Family

ID=27805180

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200332312T SI1572169T1 (sl) 2002-03-08 2003-03-10 Odkrivanje in modulacija slit in robo posredovane angiogeneze ter njuni načini uporabe

Country Status (8)

Country Link
US (1) US7939497B2 (sl)
EP (2) EP1572169B1 (sl)
AU (1) AU2003220173A1 (sl)
DK (1) DK1572169T3 (sl)
ES (1) ES2431040T3 (sl)
PT (1) PT1572169E (sl)
SI (1) SI1572169T1 (sl)
WO (1) WO2003075860A2 (sl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2378402A (en) * 2000-11-06 2002-05-15 Imp Cancer Res Tech Imaging, diagnosis and treatment of disease
EP1534318A4 (en) * 2002-06-27 2009-07-01 Univ Utah Res Found METHOD AND COMPOSITIONS FOR MANIPULATING GUIDED NAVIGATION OF ENDOTHONE TUBES IN THE ANGIOGENESIS
DE60331945D1 (de) * 2002-11-20 2010-05-12 Cancer Rec Tech Ltd An menschliches roundabout bindende antikörper, polypeptide und ihre verwendung zur hemmung der angiogenese
WO2005074556A2 (en) * 2004-01-30 2005-08-18 The General Hospital Corporation Netrin compositions and methods of use thereof
AU2005227598B2 (en) * 2004-03-31 2011-01-20 Hiroyuki Aburatani Cancer diagnosis and treatment using anti-ROBO1 antibody
US8940488B2 (en) 2004-03-31 2015-01-27 Hiroyuki Aburatani Cancer diagnosis and treatment of cancer using anti-robo 1 antibody
EP2104509A4 (en) 2006-12-11 2010-03-24 Univ Utah Res Found COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL ANGIOGENESIS AND VASPERMEABILITY
MX2009008430A (es) * 2007-02-09 2009-10-28 Genentech Inc Anticuerpos anti-robo4 y sus usos.
WO2009129408A2 (en) * 2008-04-16 2009-10-22 University Of Utah Research Foundation Compositions and methods for treating pathologic angiogenesis and vascular permeability
US8535684B2 (en) * 2009-01-06 2013-09-17 Functional Genetics, Inc. Methods of inhibiting HIV infectivity
FR2958936A1 (fr) 2010-04-14 2011-10-21 Sanofi Aventis Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs
CN102233134A (zh) * 2010-04-30 2011-11-09 中国科学院上海生命科学研究院 Slit-robo介导的淋巴管形成及其应用
EP2621511A1 (en) * 2010-09-28 2013-08-07 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical compositions for the treatment of bone density related diseases
CN103703021A (zh) 2010-12-23 2014-04-02 赛诺菲 用于治疗肝癌的Robo1-Fc融合蛋白
BR112014016493A2 (pt) * 2012-01-05 2021-08-10 Boston Medical Center Corporation sinalização slit-robo para diagnóstico e tratamendo de doença renal
KR101897322B1 (ko) * 2015-01-21 2018-09-10 재단법인 아산사회복지재단 원발성 갑상선암 전이의 진단방법 및 이를 이용한 진단키트
CN104711279B (zh) * 2015-03-17 2018-03-02 山东一达启航生物科技有限公司 一种血管内皮生长因子检测试剂盒及其原料制备
JP7018458B2 (ja) 2017-06-02 2022-02-10 ファイザー・インク 組換えｒｏｂｏ２タンパク質、組成物、方法およびそれらの使用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE463851B (sv) * 1988-09-02 1991-02-04 Amsu Ltd Komposition foer behandling av erektil dysfunktion via uretra
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE4221256C2 (de) * 1992-06-26 1997-07-10 Lancaster Group Ag Galenische Zusammensetzung für die topische Anwendung
US5869305A (en) * 1992-12-04 1999-02-09 The University Of Pittsburgh Recombinant viral vector system
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US5741511A (en) * 1995-04-12 1998-04-21 Sam Yang Co., Ltd. Transdermal drug delivery device for treating erectile dysfunction
US5888767A (en) * 1996-11-27 1999-03-30 The Johns Hopkins University School Of Medicine Method of using a conditionally replicating viral vector to express a gene
AU1057097A (en) * 1995-12-22 1997-07-17 Beth Israel Deaconess Medical Center Localized intravascular delivery of growth factors for promotion of angiogenesis
US5736154A (en) * 1996-03-11 1998-04-07 Fuisz Technologies Ltd. Transdermal delivery system
SE9703226D0 (sv) * 1997-09-08 1997-09-08 Astra Ab New pharmaceutical composition
DE69816467T2 (de) * 1997-10-20 2004-04-15 The Regents Of The University Of California, Oakland Robo: eine familie polypeptiden und nukleinesäuren wirksam in nervenzellleitung
US6197801B1 (en) * 1998-01-14 2001-03-06 Usa Doctors Products, Inc. Injectable pharmaceutical composition for treatment and reversal of erectile dysfunction
US5962274A (en) * 1998-03-13 1999-10-05 Wake Forest University Viral vector directed to predetermined target cells
CA2368374A1 (en) * 1999-03-26 2000-10-05 Human Genome Sciences, Inc. 47 human secreted proteins
US6811788B2 (en) * 2000-01-19 2004-11-02 Baofa Yu Combinations and methods for treating neoplasms
DE60331945D1 (de) * 2002-11-20 2010-05-12 Cancer Rec Tech Ltd An menschliches roundabout bindende antikörper, polypeptide und ihre verwendung zur hemmung der angiogenese

Also Published As

Publication number Publication date
DK1572169T3 (da) 2013-10-21
EP2316853A2 (en) 2011-05-04
EP1572169B1 (en) 2013-07-17
PT1572169E (pt) 2013-10-08
WO2003075860A2 (en) 2003-09-18
AU2003220173A8 (en) 2003-09-22
US7939497B2 (en) 2011-05-10
US20030236210A1 (en) 2003-12-25
EP2316853A3 (en) 2011-10-05
EP1572169A4 (en) 2007-07-25
AU2003220173A1 (en) 2003-09-22
ES2431040T3 (es) 2013-11-22
WO2003075860A3 (en) 2006-08-17
EP1572169A2 (en) 2005-09-14

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