SI1412328T1 - Derivati dolastatina 10 - Google Patents
Derivati dolastatina 10Info
- Publication number
- SI1412328T1 SI1412328T1 SI200230447T SI200230447T SI1412328T1 SI 1412328 T1 SI1412328 T1 SI 1412328T1 SI 200230447 T SI200230447 T SI 200230447T SI 200230447 T SI200230447 T SI 200230447T SI 1412328 T1 SI1412328 T1 SI 1412328T1
- Authority
- SI
- Slovenia
- Prior art keywords
- dolastatin
- derivatives
- Prior art date
Links
- OFDNQWIFNXBECV-VFSYNPLYSA-N dolastatin 10 Chemical class CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-VFSYNPLYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01117410 | 2001-07-19 | ||
| EP02764710A EP1412328B1 (en) | 2001-07-19 | 2002-07-17 | Dolastatin 10 derivatives |
| PCT/EP2002/007931 WO2003008378A1 (en) | 2001-07-19 | 2002-07-17 | Dolastatin 10 derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1412328T1 true SI1412328T1 (sl) | 2007-02-28 |
Family
ID=8178073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200230447T SI1412328T1 (sl) | 2001-07-19 | 2002-07-17 | Derivati dolastatina 10 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6737409B2 (sl) |
| EP (1) | EP1412328B1 (sl) |
| JP (1) | JP2004534859A (sl) |
| KR (2) | KR100611540B1 (sl) |
| CN (1) | CN1553897A (sl) |
| AR (1) | AR036175A1 (sl) |
| AT (1) | ATE341537T1 (sl) |
| BR (1) | BR0211289A (sl) |
| CA (1) | CA2453987A1 (sl) |
| CO (1) | CO5550462A2 (sl) |
| DE (1) | DE60215179T2 (sl) |
| DK (1) | DK1412328T3 (sl) |
| ES (1) | ES2272763T3 (sl) |
| GT (1) | GT200200154A (sl) |
| HR (1) | HRP20040043A2 (sl) |
| HU (1) | HUP0401253A2 (sl) |
| IL (1) | IL159890A0 (sl) |
| MX (1) | MXPA04000577A (sl) |
| MY (1) | MY127718A (sl) |
| NO (1) | NO20040198L (sl) |
| NZ (1) | NZ530655A (sl) |
| PA (1) | PA8551001A1 (sl) |
| PE (1) | PE20030258A1 (sl) |
| PL (1) | PL367682A1 (sl) |
| PT (1) | PT1412328E (sl) |
| RU (1) | RU2296750C2 (sl) |
| SI (1) | SI1412328T1 (sl) |
| UY (1) | UY27388A1 (sl) |
| WO (1) | WO2003008378A1 (sl) |
| ZA (1) | ZA200400334B (sl) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7256257B2 (en) | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US7064211B2 (en) | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
| KR101208266B1 (ko) | 2002-03-22 | 2012-12-05 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 헤미아스텔린 유도체 및 이의 용도 |
| JP4741838B2 (ja) | 2002-07-31 | 2011-08-10 | シアトル ジェネティクス，インコーポレーテッド | 癌、自己免疫疾患または感染症を治療するための薬物結合体およびその使用 |
| CN104998273A (zh) | 2003-11-06 | 2015-10-28 | 西雅图基因公司 | 能够与配体偶联的单甲基缬氨酸化合物 |
| JP2008501653A (ja) * | 2004-06-02 | 2008-01-24 | エフ．ホフマン−ラ ロシュ アーゲー | アミノ−アルコキシ−ヘプタン酸アルキルエステルの合成 |
| CA2586909A1 (en) | 2004-11-12 | 2006-12-14 | Seattle Genetics, Inc. | Auristatins having an aminobenzoic acid unit at the n terminus |
| WO2006063706A1 (en) * | 2004-12-13 | 2006-06-22 | F. Hoffmann-La Roche Ag | Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives |
| EP1827603A2 (en) * | 2004-12-13 | 2007-09-05 | F. Hoffmann-Roche AG | Novel pharmaceutical composition containing at least one dolastatin 10 derivative |
| US20060189893A1 (en) * | 2005-01-06 | 2006-08-24 | Diamics, Inc. | Systems and methods for detecting abnormal cells |
| US20060161076A1 (en) * | 2005-01-06 | 2006-07-20 | Diamics, Inc. | Systems and methods for collection of cell clusters |
| CN101102993A (zh) * | 2005-01-13 | 2008-01-09 | 霍夫曼-拉罗奇有限公司 | 有用的双取代胺类的新型一步合成 |
| EP1883627B1 (en) | 2005-05-18 | 2018-04-18 | Pharmascience Inc. | Bir domain binding compounds |
| WO2007008848A2 (en) | 2005-07-07 | 2007-01-18 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus |
| CA2614436C (en) * | 2005-07-07 | 2016-05-17 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus |
| US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| SG171682A1 (en) | 2006-05-16 | 2011-06-29 | Aegera Therapeutics Inc | Iap bir domain binding compounds |
| US20080003652A1 (en) * | 2006-06-28 | 2008-01-03 | Hans Iding | Novel enzymatic process for the manufacture of Boc-Dap-Oh priority to related application(s) |
| ES2528922T3 (es) | 2007-07-16 | 2015-02-13 | Genentech, Inc. | Anticuerpos anti-CD79b humanizados e inmunoconjugados y métodos de uso |
| RS53595B1 (sr) | 2007-07-16 | 2015-02-27 | Genentech, Inc. | Anti-cd79b antitela i imunokonjugati i metode upotrebe |
| IL287292B (en) | 2008-01-31 | 2022-09-01 | Genentech Inc | Cycteine engineering anti-cd79b antibodies and antibody-drug conjugates |
| EP2842575B1 (en) | 2008-03-18 | 2017-09-27 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
| EP2533810B1 (en) | 2010-02-10 | 2016-10-12 | ImmunoGen, Inc. | Cd20 antibodies and uses thereof |
| EP3263583A1 (en) | 2010-02-12 | 2018-01-03 | Pharmascience Inc. | Iap bir domain binding compounds |
| ES2528956T3 (es) | 2010-06-10 | 2015-02-13 | Seattle Genetics, Inc. | Nuevos derivados de auristatina y su uso |
| WO2012041805A1 (de) | 2010-09-29 | 2012-04-05 | Bayer Pharma Aktiengesellschaft | N-carboxyalkyl-auristatine und ihre verwendung |
| CN103764667B (zh) * | 2011-03-16 | 2017-06-20 | 西雅图基因公司 | N‑羧烷基耳他汀类及其应用 |
| US9796754B2 (en) | 2011-05-27 | 2017-10-24 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
| SG10201605293PA (en) * | 2011-05-27 | 2016-08-30 | Ambrx Inc | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
| ES2604766T3 (es) * | 2012-09-20 | 2017-03-09 | Celltrion, Inc. | Derivado de dolastatina-10, procedimiento de producción del mismo y composición de fármaco anticanceroso que contiene el mismo |
| KR102384740B1 (ko) | 2013-12-27 | 2022-04-07 | 자임워크스 인코포레이티드 | 약물 접합체를 위한 설폰아마이드-함유 연결 시스템 |
| EP3689910A3 (en) | 2014-09-23 | 2020-12-02 | F. Hoffmann-La Roche AG | Method of using anti-cd79b immunoconjugates |
| CN105949277B (zh) * | 2015-05-05 | 2019-03-01 | 成都永泰诺科技有限公司 | 一种抗肿瘤化合物及其用途 |
| HUE062120T2 (hu) * | 2016-03-29 | 2023-09-28 | Toray Industries | Peptid-származék és alkalmazása |
| CN109021065B (zh) * | 2017-06-08 | 2021-10-01 | 复旦大学 | 一种制备海兔毒素Dolastatin10的方法 |
| WO2023033129A1 (ja) | 2021-09-03 | 2023-03-09 | 東レ株式会社 | 癌の治療及び／又は予防用医薬組成物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2700165B1 (fr) * | 1993-01-07 | 1995-02-17 | Rhone Poulenc Rorer Sa | Dérivés de pyrrolidine, leur préparation et les médicaments les contenant. |
| US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
-
2002
- 2002-07-15 US US10/195,698 patent/US6737409B2/en not_active Expired - Fee Related
- 2002-07-17 AT AT02764710T patent/ATE341537T1/de not_active IP Right Cessation
- 2002-07-17 KR KR1020047000854A patent/KR100611540B1/ko not_active Expired - Fee Related
- 2002-07-17 UY UY27388A patent/UY27388A1/es not_active Application Discontinuation
- 2002-07-17 MX MXPA04000577A patent/MXPA04000577A/es active IP Right Grant
- 2002-07-17 RU RU2004105145/04A patent/RU2296750C2/ru not_active IP Right Cessation
- 2002-07-17 CA CA002453987A patent/CA2453987A1/en not_active Abandoned
- 2002-07-17 HR HR20040043A patent/HRP20040043A2/hr not_active Application Discontinuation
- 2002-07-17 EP EP02764710A patent/EP1412328B1/en not_active Expired - Lifetime
- 2002-07-17 NZ NZ530655A patent/NZ530655A/en unknown
- 2002-07-17 PT PT02764710T patent/PT1412328E/pt unknown
- 2002-07-17 HU HU0401253A patent/HUP0401253A2/hu unknown
- 2002-07-17 CN CNA028177622A patent/CN1553897A/zh active Pending
- 2002-07-17 SI SI200230447T patent/SI1412328T1/sl unknown
- 2002-07-17 DE DE60215179T patent/DE60215179T2/de not_active Expired - Fee Related
- 2002-07-17 WO PCT/EP2002/007931 patent/WO2003008378A1/en not_active Ceased
- 2002-07-17 AR ARP020102678A patent/AR036175A1/es not_active Application Discontinuation
- 2002-07-17 KR KR1020067008692A patent/KR20060057652A/ko not_active Ceased
- 2002-07-17 IL IL15989002A patent/IL159890A0/xx unknown
- 2002-07-17 MY MYPI20022704A patent/MY127718A/en unknown
- 2002-07-17 BR BR0211289-2A patent/BR0211289A/pt not_active IP Right Cessation
- 2002-07-17 JP JP2003513938A patent/JP2004534859A/ja active Pending
- 2002-07-17 ES ES02764710T patent/ES2272763T3/es not_active Expired - Lifetime
- 2002-07-17 DK DK02764710T patent/DK1412328T3/da active
- 2002-07-17 PL PL02367682A patent/PL367682A1/xx not_active Application Discontinuation
- 2002-07-18 GT GT200200154A patent/GT200200154A/es unknown
- 2002-07-18 PA PA20028551001A patent/PA8551001A1/es unknown
- 2002-07-19 PE PE2002000643A patent/PE20030258A1/es not_active Application Discontinuation
-
2004
- 2004-01-15 ZA ZA2004/00334A patent/ZA200400334B/en unknown
- 2004-01-16 NO NO20040198A patent/NO20040198L/no not_active Application Discontinuation
- 2004-01-20 CO CO04003736A patent/CO5550462A2/es not_active Application Discontinuation
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