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SI1482987T1 - Večvalentni konstrukti za terapevtske in diagnostične aplikacije - Google Patents

Večvalentni konstrukti za terapevtske in diagnostične aplikacije

Info

Publication number
SI1482987T1
SI1482987T1 SI200332395T SI200332395T SI1482987T1 SI 1482987 T1 SI1482987 T1 SI 1482987T1 SI 200332395 T SI200332395 T SI 200332395T SI 200332395 T SI200332395 T SI 200332395T SI 1482987 T1 SI1482987 T1 SI 1482987T1
Authority
SI
Slovenia
Prior art keywords
therapeutic
diagnostic applications
multivalent constructs
multivalent
constructs
Prior art date
Application number
SI200332395T
Other languages
English (en)
Inventor
Christophe Arbogast
Philippe Bussat
Daniel T. Dransfield
Hong Fan
Karen E. Linder
Edmund R. Marinelli
Palaniappa Nanjappan
Adrian D. Nunn
Radhakrishna K. Pillai
Sibylle Pochon
Kondareddiar Ramalingam
Aaron Sato
Ajay Shrivastava
Bo Song
Rolf E. Swenson
Wronski Mathew A. Von
Sharon Michele Walker
Feng Yan
Original Assignee
Bracco Suisse Sa
Dyax Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse Sa, Dyax Corp. filed Critical Bracco Suisse Sa
Publication of SI1482987T1 publication Critical patent/SI1482987T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
SI200332395T 2002-03-01 2003-03-03 Večvalentni konstrukti za terapevtske in diagnostične aplikacije SI1482987T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36082102P 2002-03-01 2002-03-01
US44020103P 2003-01-15 2003-01-15
PCT/US2003/006656 WO2003084574A1 (en) 2002-03-01 2003-03-03 Multivalent constructs for therapeutic and diagnostic applications
EP03726024.7A EP1482987B1 (en) 2002-03-01 2003-03-03 Multivalent constructs for therapeutic and diagnostic applications

Publications (1)

Publication Number Publication Date
SI1482987T1 true SI1482987T1 (sl) 2014-12-31

Family

ID=28794312

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200332395T SI1482987T1 (sl) 2002-03-01 2003-03-03 Večvalentni konstrukti za terapevtske in diagnostične aplikacije

Country Status (7)

Country Link
EP (1) EP1482987B1 (sl)
JP (1) JP2005519980A (sl)
AU (1) AU2003228276B8 (sl)
CA (1) CA2477935C (sl)
ES (1) ES2523654T3 (sl)
SI (1) SI1482987T1 (sl)
WO (1) WO2003084574A1 (sl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
EP1587944A4 (en) 2002-03-01 2007-03-21 Dyax Corp KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7666979B2 (en) * 2002-03-01 2010-02-23 Bracco International B.V. Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same
US20050250700A1 (en) * 2002-03-01 2005-11-10 Sato Aaron K KDR and VEGF/KDR binding peptides
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
WO2004069284A2 (en) 2003-02-04 2004-08-19 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
JP5513708B2 (ja) 2003-12-22 2014-06-04 ブラッコ・シュイス・ソシエテ・アノニム 造影イメージング用の気体封入マイクロベシクル・アセンブリー
DE602005010424D1 (de) 2004-06-03 2008-11-27 Bracco Research Sa Liposomale anordnung für die therapeutische und/oder diagnostische anwendung
CN101005858A (zh) 2004-08-18 2007-07-25 伯拉考开发股份有限公司 用于反差成像的充气微泡组合物
EP1714642A1 (en) 2005-04-18 2006-10-25 Bracco Research S.A. Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery
KR20140083052A (ko) * 2005-12-09 2014-07-03 브라코 스위스 에스.에이. 표적화 벡터-포스포리피드 컨쥬게이트
AU2007293888B2 (en) 2006-09-05 2013-05-02 Bracco Suisse S.A. Gas-filled microvesicles with polymer-modified lipids
EP2117603A2 (en) 2006-12-19 2009-11-18 Bracco International B.V. Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds
US9192685B2 (en) 2008-10-07 2015-11-24 Bracco Suisse S.A. Targeting construct comprising anti-polymer antibody and contrast/therapeutic agents binding to the same
WO2011080401A1 (en) * 2009-12-31 2011-07-07 Licentia Ltd Receptor tyrosine kinase-binding compositions
JP6231263B2 (ja) * 2012-07-17 2017-11-15 株式会社島津製作所 アフィニティ支持体及びそれを用いた物質の捕捉方法
WO2014096165A2 (en) 2012-12-21 2014-06-26 Bracco Suisse Sa Gas-filled microvesicles
CN107206110B (zh) 2014-12-18 2021-07-20 博莱科瑞士股份有限公司 靶向的充气微囊制剂
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
CN114222592A (zh) * 2019-06-14 2022-03-22 爱丁堡分子成像有限公司 化合物和使用方法
WO2025073838A1 (en) 2023-10-04 2025-04-10 Bracco Suisse Sa Freeze-drying process

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL364734A1 (en) * 1998-05-19 2004-12-13 Avidex Limited Soluble t cell receptor
DE60041367D1 (de) * 1999-04-16 2009-02-26 Genentech Inc Vaskuläre Endothelzellen Wachstumsfaktor (VEGF) Varianten und dessen Verwendungen
US7045133B2 (en) * 2000-01-18 2006-05-16 Ludwig Institute For Cancer Research VEGF-D/VEGF-C/VEGF peptidomimetic inhibitor
EP1587944A4 (en) * 2002-03-01 2007-03-21 Dyax Corp KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
WO2003074005A2 (en) * 2002-03-01 2003-09-12 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications

Also Published As

Publication number Publication date
EP1482987A1 (en) 2004-12-08
HK1071999A1 (en) 2005-08-12
EP1482987A4 (en) 2007-03-07
AU2003228276B8 (en) 2010-02-18
EP1482987B1 (en) 2014-08-13
AU2003228276B2 (en) 2009-09-03
CA2477935A1 (en) 2003-10-16
AU2003228276A1 (en) 2003-10-20
JP2005519980A (ja) 2005-07-07
ES2523654T3 (es) 2014-11-28
CA2477935C (en) 2015-01-06
WO2003084574A1 (en) 2003-10-16

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