SI1338591T1 - NOV POSTOPEK ZA SINTEZO (2S,3aS,7aS)-PERHIDROINDOL-2-KARBOKSILNE KISLINE IN NJENIH ESTROV TER UPORABA PRI SINTEZI PERINDOPRILA - Google Patents
NOV POSTOPEK ZA SINTEZO (2S,3aS,7aS)-PERHIDROINDOL-2-KARBOKSILNE KISLINE IN NJENIH ESTROV TER UPORABA PRI SINTEZI PERINDOPRILAInfo
- Publication number
- SI1338591T1 SI1338591T1 SI200330107T SI200330107T SI1338591T1 SI 1338591 T1 SI1338591 T1 SI 1338591T1 SI 200330107 T SI200330107 T SI 200330107T SI 200330107 T SI200330107 T SI 200330107T SI 1338591 T1 SI1338591 T1 SI 1338591T1
- Authority
- SI
- Slovenia
- Prior art keywords
- synthesis
- perhydroindole
- perindopril
- esters
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03290487A EP1338591B1 (fr) | 2003-02-28 | 2003-02-28 | Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1338591T1 true SI1338591T1 (sl) | 2006-02-28 |
Family
ID=27635945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200330107T SI1338591T1 (sl) | 2003-02-28 | 2003-02-28 | NOV POSTOPEK ZA SINTEZO (2S,3aS,7aS)-PERHIDROINDOL-2-KARBOKSILNE KISLINE IN NJENIH ESTROV TER UPORABA PRI SINTEZI PERINDOPRILA |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7157484B2 (sl) |
| EP (1) | EP1338591B1 (sl) |
| JP (1) | JP4563371B2 (sl) |
| CN (1) | CN100364974C (sl) |
| AR (1) | AR043411A1 (sl) |
| AT (1) | ATE307801T1 (sl) |
| AU (1) | AU2004218200B2 (sl) |
| DE (1) | DE60301980T2 (sl) |
| DK (1) | DK1338591T3 (sl) |
| EA (1) | EA007948B1 (sl) |
| ES (1) | ES2250847T3 (sl) |
| MY (1) | MY135169A (sl) |
| NZ (1) | NZ541422A (sl) |
| PL (1) | PL219733B1 (sl) |
| SI (1) | SI1338591T1 (sl) |
| WO (1) | WO2004078707A2 (sl) |
| ZA (1) | ZA200505779B (sl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004099138A2 (en) * | 2003-05-12 | 2004-11-18 | Cipla Limited | Process for the preparation of perindopril |
| ES2603856T3 (es) * | 2004-03-29 | 2017-03-01 | Les Laboratoires Servier | Procedimiento para preparar una composición farmacéutica sólida |
| SI21800A (sl) | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| ES2366705T3 (es) * | 2004-12-28 | 2011-10-24 | Dsm Ip Assets B.V. | Procedimiento para la preparación de ácido indolin-2-carboxílico enriquecido enantioméricamente. |
| CN100391945C (zh) * | 2005-05-31 | 2008-06-04 | 浙江大学 | 一种s-(-)-吲哚啉-2-羧酸的合成方法 |
| CN116120195B (zh) * | 2022-12-29 | 2025-02-25 | 长兴宜生药物科技有限公司 | 一种催化制备培哚普利中间体的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE55867B1 (en) * | 1981-12-29 | 1991-02-14 | Hoechst Ag | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation |
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| NL1008302C2 (nl) * | 1998-02-13 | 1999-08-16 | Dsm Nv | Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan. |
| FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| FR2827860B1 (fr) * | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
| DE60301774T2 (de) * | 2003-02-28 | 2006-07-20 | Les Laboratoires Servier | Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril |
-
2003
- 2003-02-28 DK DK03290487T patent/DK1338591T3/da active
- 2003-02-28 SI SI200330107T patent/SI1338591T1/sl unknown
- 2003-02-28 ES ES03290487T patent/ES2250847T3/es not_active Expired - Lifetime
- 2003-02-28 DE DE60301980T patent/DE60301980T2/de not_active Expired - Lifetime
- 2003-02-28 EP EP03290487A patent/EP1338591B1/fr not_active Expired - Lifetime
- 2003-02-28 AT AT03290487T patent/ATE307801T1/de active
-
2004
- 2004-02-27 ZA ZA200505779A patent/ZA200505779B/xx unknown
- 2004-02-27 WO PCT/FR2004/000444 patent/WO2004078707A2/fr not_active Ceased
- 2004-02-27 MY MYPI20040683A patent/MY135169A/en unknown
- 2004-02-27 NZ NZ541422A patent/NZ541422A/en not_active IP Right Cessation
- 2004-02-27 PL PL377232A patent/PL219733B1/pl unknown
- 2004-02-27 AR ARP040100611A patent/AR043411A1/es not_active Application Discontinuation
- 2004-02-27 EA EA200501256A patent/EA007948B1/ru not_active IP Right Cessation
- 2004-02-27 US US10/546,967 patent/US7157484B2/en not_active Expired - Fee Related
- 2004-02-27 AU AU2004218200A patent/AU2004218200B2/en not_active Ceased
- 2004-02-27 CN CNB2004800054078A patent/CN100364974C/zh not_active Expired - Fee Related
- 2004-02-27 JP JP2006500161A patent/JP4563371B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK1338591T3 (da) | 2006-01-23 |
| PL219733B1 (pl) | 2015-07-31 |
| WO2004078707A3 (fr) | 2004-10-14 |
| DE60301980D1 (de) | 2005-12-01 |
| EP1338591A1 (fr) | 2003-08-27 |
| CN100364974C (zh) | 2008-01-30 |
| CN1753869A (zh) | 2006-03-29 |
| HK1086262A1 (en) | 2006-09-15 |
| ATE307801T1 (de) | 2005-11-15 |
| NZ541422A (en) | 2008-03-28 |
| JP4563371B2 (ja) | 2010-10-13 |
| JP2006519175A (ja) | 2006-08-24 |
| ES2250847T3 (es) | 2006-04-16 |
| MY135169A (en) | 2008-02-29 |
| EP1338591B1 (fr) | 2005-10-26 |
| AU2004218200B2 (en) | 2009-07-30 |
| DE60301980T2 (de) | 2006-07-27 |
| US7157484B2 (en) | 2007-01-02 |
| AR043411A1 (es) | 2005-07-27 |
| US20060167273A1 (en) | 2006-07-27 |
| WO2004078707A2 (fr) | 2004-09-16 |
| PL377232A1 (pl) | 2006-01-23 |
| EA007948B1 (ru) | 2007-02-27 |
| EA200501256A1 (ru) | 2006-04-28 |
| AU2004218200A1 (en) | 2004-09-16 |
| ZA200505779B (en) | 2006-09-27 |
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