SI1260511T1 - Postopek za pripravo 5-kloro-1-(4-fluorofenil)-3-(1,2,3,6-tetrahidropiridin-4-il)indola in postopek za njegovo pripravo - Google Patents
Postopek za pripravo 5-kloro-1-(4-fluorofenil)-3-(1,2,3,6-tetrahidropiridin-4-il)indola in postopek za njegovo pripravoInfo
- Publication number
- SI1260511T1 SI1260511T1 SI9830747T SI9830747T SI1260511T1 SI 1260511 T1 SI1260511 T1 SI 1260511T1 SI 9830747 T SI9830747 T SI 9830747T SI 9830747 T SI9830747 T SI 9830747T SI 1260511 T1 SI1260511 T1 SI 1260511T1
- Authority
- SI
- Slovenia
- Prior art keywords
- fluorophenyl
- indole
- chloro
- tetrahydropyridin
- preparation
- Prior art date
Links
- GZKLJWGUPQBVJQ-UHFFFAOYSA-N sertindole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C(C2CCN(CCN3C(NCC3)=O)CC2)=C1 GZKLJWGUPQBVJQ-UHFFFAOYSA-N 0.000 title abstract 3
- 229960000652 sertindole Drugs 0.000 title abstract 3
- WLQZFXJVVNNEJU-UHFFFAOYSA-N 5-chloro-1-(4-fluorophenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)indole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C(C=2CCNCC=2)=C1 WLQZFXJVVNNEJU-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- VRJHQPZVIGNGMX-UHFFFAOYSA-N 4-piperidinone Chemical compound O=C1CCNCC1 VRJHQPZVIGNGMX-UHFFFAOYSA-N 0.000 abstract 2
- YGSFFDHIYYOVHV-UHFFFAOYSA-N 1-(2-chloroethyl)imidazolidin-2-one Chemical compound ClCCN1CCNC1=O YGSFFDHIYYOVHV-UHFFFAOYSA-N 0.000 abstract 1
- JYEKQDWSLSXYTJ-UHFFFAOYSA-N 5-chloro-1-(4-fluorophenyl)indole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C=C1 JYEKQDWSLSXYTJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Compounds Of Unknown Constitution (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4601197P | 1997-05-09 | 1997-05-09 | |
| DK53697 | 1997-05-09 | ||
| EP98919090A EP0983264B1 (en) | 1997-05-09 | 1998-05-07 | Method of manufacturing sertindole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1260511T1 true SI1260511T1 (sl) | 2005-06-30 |
Family
ID=26064179
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9830608T SI0983264T1 (sl) | 1997-05-09 | 1998-05-07 | Postopek za pripravo sertindola |
| SI9830747T SI1260511T1 (sl) | 1997-05-09 | 1998-05-07 | Postopek za pripravo 5-kloro-1-(4-fluorofenil)-3-(1,2,3,6-tetrahidropiridin-4-il)indola in postopek za njegovo pripravo |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9830608T SI0983264T1 (sl) | 1997-05-09 | 1998-05-07 | Postopek za pripravo sertindola |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6335463B1 (sl) |
| EP (2) | EP1260511B1 (sl) |
| JP (1) | JP2002515904A (sl) |
| KR (2) | KR100546477B1 (sl) |
| CN (2) | CN1301963C (sl) |
| AT (2) | ATE286047T1 (sl) |
| AU (1) | AU731835B2 (sl) |
| BG (1) | BG64007B1 (sl) |
| BR (1) | BR9808740A (sl) |
| CA (1) | CA2288334C (sl) |
| CZ (2) | CZ299015B6 (sl) |
| DE (2) | DE69821477T2 (sl) |
| DK (2) | DK1260511T3 (sl) |
| EA (1) | EA003248B1 (sl) |
| ES (2) | ES2234961T3 (sl) |
| HU (1) | HU226858B1 (sl) |
| IL (1) | IL132461A (sl) |
| IS (2) | IS2158B (sl) |
| NO (2) | NO325918B1 (sl) |
| NZ (1) | NZ500700A (sl) |
| PL (1) | PL191174B1 (sl) |
| PT (2) | PT1260511E (sl) |
| SI (2) | SI0983264T1 (sl) |
| SK (2) | SK285221B6 (sl) |
| TR (2) | TR200003421T2 (sl) |
| UA (1) | UA61105C2 (sl) |
| WO (1) | WO1998051685A1 (sl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6489341B1 (en) | 1999-06-02 | 2002-12-03 | Sepracor Inc. | Methods for the treatment of neuroleptic and related disorders using sertindole derivatives |
| AR039116A1 (es) * | 2002-03-27 | 2005-02-09 | Lundbeck & Co As H | Metodo para la manufactura de sertindol |
| CN1863752A (zh) * | 2002-08-02 | 2006-11-15 | 罗迪亚药业公司 | 铜催化的芳基化 |
| CN1918123A (zh) | 2004-01-30 | 2007-02-21 | 北京佗林医药科技有限公司 | 安络小皮伞提取物,哌啶酮衍生物及其制备抗高血压药物的用途 |
| KR100683274B1 (ko) * | 2004-02-12 | 2007-02-15 | 에스케이케미칼주식회사 | 치환된 벤조피란 화합물의 제조방법 |
| US20070212412A1 (en) * | 2005-09-08 | 2007-09-13 | H. Lundbeck A/S | Stable solid formulation of sertindole |
| TW200821296A (en) * | 2006-06-01 | 2008-05-16 | Lundbeck & Co As H | Use of sertindole for the preventive treatment of suicidal behaviour |
| CN101362704B (zh) * | 2008-09-23 | 2012-04-18 | 上海医药工业研究院 | N-(4-氟苯基)-n-(2-羧基-4-氯苯基)甘氨酸的制备方法 |
| CN101362748B (zh) * | 2008-09-23 | 2012-09-05 | 上海医药工业研究院 | 一种制备舍吲哚的方法 |
| CN101591330B (zh) * | 2009-06-29 | 2013-03-06 | 上海医药工业研究院 | 舍吲哚晶型及其制备方法 |
| CN101899036B (zh) * | 2010-07-22 | 2012-12-19 | 郑州大学 | 以烷基咪唑型离子液体为溶剂制备舍吲哚的方法 |
| CN103214463A (zh) * | 2013-03-30 | 2013-07-24 | 北京德众万全药物技术开发有限公司 | 一种新的舍吲哚制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3131527A1 (de) * | 1981-08-08 | 1983-02-24 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
| IT1271352B (it) * | 1993-04-08 | 1997-05-27 | Boehringer Ingelheim Italia | Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale |
| DE19532054A1 (de) * | 1995-08-31 | 1997-03-06 | Hoechst Ag | Verfahren zur Herstellung von N-Carboxymethylen-4-chlor-anthranilsäure, sowie deren Dialkylestern |
-
1998
- 1998-05-07 SK SK1527-99A patent/SK285221B6/sk not_active IP Right Cessation
- 1998-05-07 AT AT02018748T patent/ATE286047T1/de active
- 1998-05-07 SI SI9830608T patent/SI0983264T1/sl unknown
- 1998-05-07 PT PT02018748T patent/PT1260511E/pt unknown
- 1998-05-07 CN CNB2003101046201A patent/CN1301963C/zh not_active Expired - Fee Related
- 1998-05-07 EA EA199901021A patent/EA003248B1/ru not_active IP Right Cessation
- 1998-05-07 DE DE69821477T patent/DE69821477T2/de not_active Expired - Lifetime
- 1998-05-07 JP JP54871198A patent/JP2002515904A/ja not_active Ceased
- 1998-05-07 US US09/423,096 patent/US6335463B1/en not_active Expired - Fee Related
- 1998-05-07 ES ES02018748T patent/ES2234961T3/es not_active Expired - Lifetime
- 1998-05-07 BR BR9808740-1A patent/BR9808740A/pt not_active Application Discontinuation
- 1998-05-07 NZ NZ500700A patent/NZ500700A/xx not_active IP Right Cessation
- 1998-05-07 PT PT98919090T patent/PT983264E/pt unknown
- 1998-05-07 IL IL13246198A patent/IL132461A/xx not_active IP Right Cessation
- 1998-05-07 AT AT98919090T patent/ATE258929T1/de active
- 1998-05-07 PL PL336578A patent/PL191174B1/pl not_active IP Right Cessation
- 1998-05-07 CZ CZ20050518A patent/CZ299015B6/cs not_active IP Right Cessation
- 1998-05-07 DK DK02018748T patent/DK1260511T3/da active
- 1998-05-07 EP EP02018748A patent/EP1260511B1/en not_active Expired - Lifetime
- 1998-05-07 SK SK54-2006A patent/SK285410B6/sk not_active IP Right Cessation
- 1998-05-07 EP EP98919090A patent/EP0983264B1/en not_active Expired - Lifetime
- 1998-05-07 TR TR2000/03421T patent/TR200003421T2/xx unknown
- 1998-05-07 ES ES98919090T patent/ES2213897T3/es not_active Expired - Lifetime
- 1998-05-07 SI SI9830747T patent/SI1260511T1/sl unknown
- 1998-05-07 AU AU72062/98A patent/AU731835B2/en not_active Ceased
- 1998-05-07 CA CA002288334A patent/CA2288334C/en not_active Expired - Fee Related
- 1998-05-07 CN CNB988048353A patent/CN1243001C/zh not_active Expired - Fee Related
- 1998-05-07 WO PCT/DK1998/000183 patent/WO1998051685A1/en not_active Ceased
- 1998-05-07 HU HU0003365A patent/HU226858B1/hu not_active IP Right Cessation
- 1998-05-07 CZ CZ0396099A patent/CZ298509B6/cs not_active IP Right Cessation
- 1998-05-07 TR TR1999/02759T patent/TR199902759T2/xx unknown
- 1998-05-07 DE DE69828454T patent/DE69828454T2/de not_active Expired - Lifetime
- 1998-05-07 KR KR1019997010319A patent/KR100546477B1/ko not_active Expired - Fee Related
- 1998-05-07 DK DK98919090T patent/DK0983264T3/da active
- 1998-05-07 KR KR1020057015729A patent/KR100627616B1/ko not_active Expired - Fee Related
- 1998-07-05 UA UA99116293A patent/UA61105C2/uk unknown
-
1999
- 1999-10-19 IS IS5222A patent/IS2158B/is unknown
- 1999-11-04 BG BG103857A patent/BG64007B1/bg unknown
- 1999-11-08 NO NO19995457A patent/NO325918B1/no not_active IP Right Cessation
-
2006
- 2006-05-15 IS IS8468A patent/IS2324B/is unknown
-
2007
- 2007-12-03 NO NO20076208A patent/NO331924B1/no not_active IP Right Cessation
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