SI1137411T1 - S paladijem substituirani bakterioklorofilni derivati in njihova uporaba - Google Patents
S paladijem substituirani bakterioklorofilni derivati in njihova uporabaInfo
- Publication number
- SI1137411T1 SI1137411T1 SI9930949T SI9930949T SI1137411T1 SI 1137411 T1 SI1137411 T1 SI 1137411T1 SI 9930949 T SI9930949 T SI 9930949T SI 9930949 T SI9930949 T SI 9930949T SI 1137411 T1 SI1137411 T1 SI 1137411T1
- Authority
- SI
- Slovenia
- Prior art keywords
- palladium
- bacteriochlorophyll derivatives
- ch2oh
- substituted
- substituted bacteriochlorophyll
- Prior art date
Links
- DSJXIQQMORJERS-AGGZHOMASA-M bacteriochlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC([C@H](CC)[C@H]3C)=[N+]4C3=CC3=C(C(C)=O)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 DSJXIQQMORJERS-AGGZHOMASA-M 0.000 title abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98403110 | 1998-12-09 | ||
| PCT/IL1999/000673 WO2000033833A1 (en) | 1998-12-09 | 1999-12-09 | Palladium-substituted bacteriochlorophyll derivatives and use thereof |
| EP99958470A EP1137411B1 (en) | 1998-12-09 | 1999-12-09 | Palladium-substituted bacteriochlorophyll derivatives and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1137411T1 true SI1137411T1 (sl) | 2007-10-31 |
Family
ID=8235584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9930949T SI1137411T1 (sl) | 1998-12-09 | 1999-12-09 | S paladijem substituirani bakterioklorofilni derivati in njihova uporaba |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6569846B1 (sl) |
| EP (1) | EP1137411B1 (sl) |
| JP (1) | JP4796227B2 (sl) |
| CN (1) | CN1160069C (sl) |
| AT (1) | ATE347554T1 (sl) |
| AU (1) | AU771292B2 (sl) |
| BR (1) | BRPI9916096B8 (sl) |
| CA (1) | CA2353554C (sl) |
| CY (1) | CY1106450T1 (sl) |
| DE (1) | DE69934328T2 (sl) |
| DK (1) | DK1137411T3 (sl) |
| ES (1) | ES2277454T3 (sl) |
| HK (1) | HK1040638B (sl) |
| HU (1) | HU228208B1 (sl) |
| IL (1) | IL143591A0 (sl) |
| NO (1) | NO331426B1 (sl) |
| NZ (1) | NZ512093A (sl) |
| PL (1) | PL201172B1 (sl) |
| PT (1) | PT1137411E (sl) |
| RU (1) | RU2234508C2 (sl) |
| SI (1) | SI1137411T1 (sl) |
| WO (1) | WO2000033833A1 (sl) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7166719B2 (en) | 2002-06-27 | 2007-01-23 | Health Research, Inc. | Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy |
| US7897140B2 (en) * | 1999-12-23 | 2011-03-01 | Health Research, Inc. | Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents |
| EP1318807A4 (en) * | 2000-08-11 | 2008-02-20 | Ceramoptec Gmbh | LIGHT-SENSITIVE OINTMENT |
| EP1277470A1 (fr) * | 2001-07-17 | 2003-01-22 | Steba Biotech N.V. | Formulation galénique injectable pour utilisation dans un diagnostic ou une thérapie photodynamique et son procédé de préparation |
| JP2005524461A (ja) | 2002-05-08 | 2005-08-18 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 増感オンラインｂｏｌｄ−ｍｒｉイメージング法 |
| JP4529344B2 (ja) * | 2002-06-03 | 2010-08-25 | ニプロ株式会社 | 腫瘍組織の酸素濃度を上昇させるためのポルフィリン酸素輸液製剤 |
| EP1606291A2 (en) * | 2002-07-02 | 2005-12-21 | Health Research, Inc. | Efficient synthesis of pyropheophorbide a and its dervatives |
| IL152900A0 (en) * | 2002-11-17 | 2003-06-24 | Yeda Res & Dev | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
| RU2257898C1 (ru) * | 2004-03-22 | 2005-08-10 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") | Фотосенсибилизатор, липосомальная форма фотосенсибилизатора и способ проведения фотодинамической терапии |
| MXPA06014326A (es) * | 2004-06-07 | 2007-02-19 | Yeda Res & Dev | Derivados de bacterioclorofila cationica y sus usos. |
| GB2415372A (en) * | 2004-06-23 | 2005-12-28 | Destiny Pharma Ltd | Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent |
| US20060222592A1 (en) * | 2005-04-05 | 2006-10-05 | Clemens Burda | Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications |
| EP2244787A1 (en) * | 2008-01-28 | 2010-11-03 | Yeda Research And Development Company Ltd. | Endoscopic imaging photodynamic therapy system and methods of use |
| DK2257309T3 (da) | 2008-02-27 | 2020-01-20 | Yeda Res And Development Company Ltd | Rgd-(bakterie)chlorophyl-konjugater til anvendelse ved diagnose af tumorer, der omfatter nekrotiske domæner |
| US20120034157A1 (en) * | 2010-08-03 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Artificial cells |
| GB0819594D0 (en) | 2008-10-24 | 2008-12-03 | Univ Coimbrra | Process |
| EP2425873A1 (fr) | 2010-09-07 | 2012-03-07 | Steba Maor SA | Modélisation de l'action d'une fibre optique dans un traitement par therapie photodynamique, et assistance à la planification d'un tel traitement |
| CN103405769A (zh) * | 2013-03-07 | 2013-11-27 | 北京亿仁赛博医疗科技研发中心有限公司 | 光敏剂在制备治疗疾病的病毒灭活药物中的应用 |
| BR112015022454B1 (pt) | 2013-03-11 | 2021-09-08 | Tookad Ip Sarl | Método de fermentação em batelada alimentada para a produção de bacterioclorofila a a partir de rhodovulum sulfidophilum |
| CN105377862B (zh) | 2013-03-15 | 2019-09-13 | 希瑞·安·麦克法兰 | 用作光动力化合物的金属基配合物及其用途 |
| CN118304400A (zh) | 2016-04-10 | 2024-07-09 | 耶达研究及发展有限公司 | 包括细菌叶绿素衍生物的用于治疗癌症的联合疗法 |
| US10933134B2 (en) | 2017-03-16 | 2021-03-02 | Memorial Sloan Kettering Cancer Center | Combination therapies for treatment of cancer |
| IL311461A (en) * | 2024-03-13 | 2025-10-01 | Impact Biotech Ltd | Process for preparing bacteriophophorbid derivatives and their alkali metal salts |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5002962A (en) * | 1988-07-20 | 1991-03-26 | Health Research, Inc. | Photosensitizing agents |
| US5171741A (en) * | 1989-04-21 | 1992-12-15 | Health Research, Inc. | Bacteriochlorophyll-a derivatives useful in photodynamic therapy |
| IL102645A (en) * | 1992-07-26 | 1998-02-22 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| RU2063971C1 (ru) * | 1993-11-05 | 1996-07-20 | Московская государственная академия тонкой химической технологии им.М.В.Ломоносова | Способ получения производного гематопорфирина |
| IL115744A (en) * | 1994-10-27 | 2000-07-16 | Akzo Nobel Nv | Peptides comprising a subsequence of human cartilage glycoprotein - 39 |
| IL116126A0 (en) | 1995-11-24 | 1996-01-31 | Yeda Res & Dev | Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them |
-
1999
- 1999-12-09 JP JP2000586326A patent/JP4796227B2/ja not_active Expired - Lifetime
- 1999-12-09 IL IL14359199A patent/IL143591A0/xx active IP Right Grant
- 1999-12-09 AT AT99958470T patent/ATE347554T1/de active
- 1999-12-09 SI SI9930949T patent/SI1137411T1/sl unknown
- 1999-12-09 EP EP99958470A patent/EP1137411B1/en not_active Expired - Lifetime
- 1999-12-09 WO PCT/IL1999/000673 patent/WO2000033833A1/en not_active Ceased
- 1999-12-09 PT PT99958470T patent/PT1137411E/pt unknown
- 1999-12-09 AU AU15834/00A patent/AU771292B2/en not_active Expired
- 1999-12-09 NZ NZ512093A patent/NZ512093A/xx unknown
- 1999-12-09 HK HK02102403.5A patent/HK1040638B/en unknown
- 1999-12-09 US US09/857,772 patent/US6569846B1/en not_active Expired - Lifetime
- 1999-12-09 PL PL348201A patent/PL201172B1/pl unknown
- 1999-12-09 DK DK99958470T patent/DK1137411T3/da active
- 1999-12-09 DE DE69934328T patent/DE69934328T2/de not_active Expired - Lifetime
- 1999-12-09 ES ES99958470T patent/ES2277454T3/es not_active Expired - Lifetime
- 1999-12-09 BR BRPI9916096A patent/BRPI9916096B8/pt not_active IP Right Cessation
- 1999-12-09 CN CNB99816058XA patent/CN1160069C/zh not_active Expired - Lifetime
- 1999-12-09 RU RU2001118842/04A patent/RU2234508C2/ru active
- 1999-12-09 HU HU0105411A patent/HU228208B1/hu unknown
- 1999-12-09 CA CA2353554A patent/CA2353554C/en not_active Expired - Lifetime
-
2001
- 2001-06-07 NO NO20012807A patent/NO331426B1/no not_active IP Right Cessation
-
2007
- 2007-02-15 CY CY20071100207T patent/CY1106450T1/el unknown
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