SI1189886T1 - Etansulfonil-piperidinski derivati - Google Patents

Etansulfonil-piperidinski derivati

Info

Publication number: SI1189886T1
Authority: SI; Slovenia
Prior art keywords: ethanesulfonyl; piperidine derivatives; piperidine; derivatives
Prior art date: 1999-06-08

Application number

SI200030793T

Other languages

English (en)

Inventor

Alexander Alanine

Serge Burner

Bernd Buettelmann

Neidhart Marie-Paule Heitz

Georg Jaeschke

Emmanuel Pinard

Rene Wyler

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-08

Filing date

2000-05-31

Publication date

2006-04-30

2000-05-31 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2006-04-30 Publication of SI1189886T1 publication Critical patent/SI1189886T1/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SI200030793T 1999-06-08 2000-05-31 Etansulfonil-piperidinski derivati SI1189886T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP99111126		1999-06-08
PCT/EP2000/004953 WO2000075109A1 (en)	1999-06-08	2000-05-31	Ethanesulfonyl-piperidine derivatives
EP00936835A EP1189886B1 (en)	1999-06-08	2000-05-31	Ethanesulfonyl-piperidine derivatives

Publications (1)

Publication Number	Publication Date
SI1189886T1 true SI1189886T1 (sl)	2006-04-30

Family

ID=8238316

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200030793T SI1189886T1 (sl)	1999-06-08	2000-05-31	Etansulfonil-piperidinski derivati

Country Status (38)

Country	Link
US (1)	US6310213B1 (sl)
EP (1)	EP1189886B1 (sl)
JP (1)	JP3645856B2 (sl)
KR (1)	KR100571162B1 (sl)
CN (1)	CN1142141C (sl)
AR (1)	AR024282A1 (sl)
AT (1)	ATE315025T1 (sl)
AU (1)	AU770787B2 (sl)
BR (1)	BR0011419A (sl)
CA (1)	CA2376091C (sl)
CO (1)	CO5160328A1 (sl)
CZ (1)	CZ299483B6 (sl)
DE (1)	DE60025348T2 (sl)
DK (1)	DK1189886T3 (sl)
EG (1)	EG26101A (sl)
ES (1)	ES2254183T3 (sl)
GC (1)	GC0000256A (sl)
GT (1)	GT200000089A (sl)
HK (1)	HK1046412B (sl)
HR (1)	HRP20010885B1 (sl)
HU (1)	HU228591B1 (sl)
IL (2)	IL146750A0 (sl)
JO (1)	JO2260B1 (sl)
MA (1)	MA26797A1 (sl)
MX (1)	MXPA01012585A (sl)
MY (1)	MY128818A (sl)
NO (1)	NO320613B1 (sl)
PA (1)	PA8496601A1 (sl)
PE (1)	PE20010218A1 (sl)
PL (1)	PL196053B1 (sl)
RS (1)	RS50033B (sl)
RU (1)	RU2242464C2 (sl)
SI (1)	SI1189886T1 (sl)
TN (1)	TNSN00125A1 (sl)
TR (1)	TR200103532T2 (sl)
TW (1)	TWI254043B (sl)
WO (1)	WO2000075109A1 (sl)
ZA (1)	ZA200109706B (sl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1136475T3 (da)	2000-03-22	2004-12-27	Hoffmann La Roche	Piperidin- og piperazinderivater til anvendelse i behandlingen af Alzheimer
AU2001273942B2 (en)	2000-04-20	2005-09-01	F. Hoffmann-La Roche Ag	Pyrrolidine and piperidine derivatives and their use for the treament of neurodegenerative disorders
US6407235B1 (en) *	2000-08-21	2002-06-18	Hoffmann-La Roche Inc.	Prodrug acid esters of [2-(4-benzyl-3-hydroxy-piperidin-1-yl)-ethansulfonyl]phenol
JP4228048B2 (ja) *	2000-10-09	2009-02-25	ピーオーダブリューエムアールアイリミテッド	神経変性障害の検出方法
US6951875B2 (en)	2001-10-29	2005-10-04	Hoffmann-La Roche Inc.	Conjugated aromatic compounds with a pyridine substituent
US7005432B2 (en) *	2002-05-16	2006-02-28	Hoffman-La Roche Inc.	Substituted imidazol-pyridazine derivatives
RU2268715C1 (ru) *	2004-06-22	2006-01-27	ГУ "Научно-исследовательский институт экспериментальной медицины" РАМН (ГУ НИИЭМ РАМН)	Нейропротекторное средство
KR20100135847A (ko) *	2008-03-27	2010-12-27	에보텍 뉴로사이언시즈 게엠베하	Ｎｍｄａｎｒ２ｂ―서브타입 선택적 길항제를 사용한 질병 치료 방법
CA2842183A1 (en) *	2011-07-18	2013-01-24	Adolor Corporation	Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
WO2024217539A1 (zh) *	2023-04-20	2024-10-24	纽欧申医药(上海)有限公司	含氮杂环类化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2571904B2 (ja) *	1991-07-17	1997-01-16	フアイザー・インコーポレイテツド	抗虚血剤としての２−（４−ヒドロキシピペリジノ）−１−アルカノール誘導体
DE4410822A1 (de) *	1994-03-24	1995-09-28	Schering Ag	Neue Piperidin-Derivate
ZA9610745B (en) *	1995-12-22	1997-06-24	Warner Lambert Co	4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
TW498067B (en) *	1996-07-19	2002-08-11	Hoffmann La Roche	4-hydroxy-piperidine derivatives

2000
- 2000-05-24 TW TW089109992A patent/TWI254043B/zh not_active IP Right Cessation
- 2000-05-31 KR KR1020017015765A patent/KR100571162B1/ko not_active Expired - Fee Related
- 2000-05-31 RS YUP-865/01A patent/RS50033B/sr unknown
- 2000-05-31 SI SI200030793T patent/SI1189886T1/sl unknown
- 2000-05-31 CZ CZ20014349A patent/CZ299483B6/cs not_active IP Right Cessation
- 2000-05-31 AU AU52181/00A patent/AU770787B2/en not_active Ceased
- 2000-05-31 DE DE60025348T patent/DE60025348T2/de not_active Expired - Lifetime
- 2000-05-31 HR HR20010885A patent/HRP20010885B1/xx not_active IP Right Cessation
- 2000-05-31 BR BR0011419-7A patent/BR0011419A/pt not_active Application Discontinuation
- 2000-05-31 RU RU2001135806/04A patent/RU2242464C2/ru not_active IP Right Cessation
- 2000-05-31 CA CA002376091A patent/CA2376091C/en not_active Expired - Fee Related
- 2000-05-31 HU HU0201916A patent/HU228591B1/hu not_active IP Right Cessation
- 2000-05-31 WO PCT/EP2000/004953 patent/WO2000075109A1/en not_active Ceased
- 2000-05-31 ES ES00936835T patent/ES2254183T3/es not_active Expired - Lifetime
- 2000-05-31 HK HK02108022.3A patent/HK1046412B/zh not_active IP Right Cessation
- 2000-05-31 MX MXPA01012585A patent/MXPA01012585A/es active IP Right Grant
- 2000-05-31 IL IL14675000A patent/IL146750A0/xx active IP Right Grant
- 2000-05-31 DK DK00936835T patent/DK1189886T3/da active
- 2000-05-31 CN CNB008086028A patent/CN1142141C/zh not_active Expired - Fee Related
- 2000-05-31 TR TR2001/03532T patent/TR200103532T2/xx unknown
- 2000-05-31 JP JP2001501590A patent/JP3645856B2/ja not_active Expired - Fee Related
- 2000-05-31 PL PL00352723A patent/PL196053B1/pl unknown
- 2000-05-31 EP EP00936835A patent/EP1189886B1/en not_active Expired - Lifetime
- 2000-05-31 AT AT00936835T patent/ATE315025T1/de active
- 2000-06-02 PE PE2000000547A patent/PE20010218A1/es not_active Application Discontinuation
- 2000-06-02 US US09/585,755 patent/US6310213B1/en not_active Expired - Lifetime
- 2000-06-03 TN TNTNSN00125A patent/TNSN00125A1/fr unknown
- 2000-06-05 PA PA20008496601A patent/PA8496601A1/es unknown
- 2000-06-05 AR ARP000102775A patent/AR024282A1/es active IP Right Grant
- 2000-06-05 EG EG2000060739A patent/EG26101A/en active
- 2000-06-06 MY MYPI20002522A patent/MY128818A/en unknown
- 2000-06-07 CO CO00042340A patent/CO5160328A1/es unknown
- 2000-06-07 JO JO200087A patent/JO2260B1/en active
- 2000-06-07 GC GCP2000702 patent/GC0000256A/en active
- 2000-06-07 GT GT200000089A patent/GT200000089A/es unknown
2001
- 2001-11-26 ZA ZA200109706A patent/ZA200109706B/en unknown
- 2001-11-26 IL IL146750A patent/IL146750A/en not_active IP Right Cessation
- 2001-12-04 NO NO20015920A patent/NO320613B1/no not_active IP Right Cessation
- 2001-12-07 MA MA26438A patent/MA26797A1/fr unknown

Also Published As

Publication number	Publication date
RS50033B (sr)	2008-11-28
TNSN00125A1 (fr)	2005-11-10
PA8496601A1 (es)	2001-12-14
IL146750A0 (en)	2002-07-25
WO2000075109A1 (en)	2000-12-14
JP3645856B2 (ja)	2005-05-11
HUP0201916A3 (en)	2003-05-28
HK1046412B (zh)	2004-07-09
CO5160328A1 (es)	2002-05-30
EG26101A (en)	2013-02-17
CN1142141C (zh)	2004-03-17
TR200103532T2 (tr)	2002-05-21
AU5218100A (en)	2000-12-28
GT200000089A (es)	2001-11-29
IL146750A (en)	2006-12-10
AU770787B2 (en)	2004-03-04
MY128818A (en)	2007-02-28
KR100571162B1 (ko)	2006-04-17
HU228591B1 (hu)	2013-04-29
NO20015920D0 (no)	2001-12-04
PL352723A1 (en)	2003-09-08
BR0011419A (pt)	2002-02-26
GC0000256A (en)	2006-11-01
US6310213B1 (en)	2001-10-30
DE60025348D1 (de)	2006-03-30
CZ299483B6 (cs)	2008-08-13
TWI254043B (en)	2006-05-01
ATE315025T1 (de)	2006-02-15
HK1046412A1 (en)	2003-01-10
YU86501A (sh)	2004-09-03
EP1189886A1 (en)	2002-03-27
CN1354745A (zh)	2002-06-19
ZA200109706B (en)	2003-02-26
PL196053B1 (pl)	2007-11-30
KR20020008850A (ko)	2002-01-31
NO320613B1 (no)	2005-12-27
CZ20014349A3 (cs)	2002-05-15
RU2242464C2 (ru)	2004-12-20
MXPA01012585A (es)	2002-04-10
DK1189886T3 (da)	2006-05-15
JO2260B1 (en)	2004-10-07
HRP20010885A2 (en)	2004-02-29
NO20015920L (no)	2001-12-04
JP2003501415A (ja)	2003-01-14
DE60025348T2 (de)	2006-08-24
HRP20010885B1 (en)	2010-07-31
CA2376091A1 (en)	2000-12-14
HUP0201916A2 (en)	2002-10-28
ES2254183T3 (es)	2006-06-16
AR024282A1 (es)	2002-09-25
MA26797A1 (fr)	2004-12-20
CA2376091C (en)	2006-03-14
EP1189886B1 (en)	2006-01-04
PE20010218A1 (es)	2001-02-28

Publication	Publication Date	Title
EG23817A (en)	2007-09-19	4-Phenyl-pyridine derivatives
IL148167A0 (en)	2002-09-12	Amino-triazolopyridine derivatives
GC0000183A (en)	2006-03-29	3-Phenyl-pyridine derivatives
GC0000338A (en)	2007-03-31	5-Phenyl-pyrimidine derivatives
IL145739A0 (en)	2002-07-25	13-methyl-erythromycin derivatives
IL148058A0 (en)	2002-09-12	Substituted 2-dialkylaminoalkylbiphenyl derivatives
IL148837A0 (en)	2002-09-12	Isoxazolecarboxamide derivatives
IL149584A0 (en)	2002-11-10	New phenalkyloxy-phenyl derivatives
EG23070A (en)	2004-02-29	Novel propargylether derivatives
GC0000191A (en)	2006-03-29	4-Phenyl-pyrimidine derivatives
GC0000256A (en)	2006-11-01	Ethanesulfonyl-piperidine derivatives
GB9925880D0 (en)	1999-12-29	B-Carboline derivatives
IL147636A0 (en)	2002-08-14	3-amino-2-benzyl-1-phenyl-propane derivatives
IL150132A0 (en)	2002-12-01	Cyclopenteneone derivatives
HUP0204217A3 (en)	2005-11-28	Novel a-500359 derivatives
IL145949A0 (en)	2002-07-25	1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives
PL351407A1 (en)	2003-04-22	Thio-oxindole derivatives
EP1240156A4 (en)	2003-04-16	3-METHYL CHROME OR THIOCHROME DERIVATIVES
IL146282A0 (en)	2002-07-25	Thio-oxindole derivatives
GB9907134D0 (en)	1999-05-19	Antimor napthylcombretastatin derivatives
SI1226131T1 (sl)	2004-04-30	Derivati izoksazolkarboksamida
SI1200445T1 (sl)	2004-02-29	Derivati tienopiran-karboksamida
SI1178984T1 (sl)	2003-08-31	Derivati 1-trifluormetil-4-hidroksi-7-piperidinil-aminometilkromana
SI1237857T1 (sl)	2005-02-28	Novi fenalkiloksi-fenilni derivati
AU139832S (en)	2000-02-18	Ballpen