SI0892793T1 - Substituted tetracyclic tetrahydrofuran derivatives - Google Patents

Substituted tetracyclic tetrahydrofuran derivatives

Info

Publication number: SI0892793T1
Authority: SI; Slovenia
Prior art keywords: 6alkyl; pct; zero; independently; optionally substituted
Prior art date: 1996-04-12

Application number

SI9730551T

Other languages

English (en)

Slovenian (sl)

Inventor

Pilar Gil-Lopetegui

Francisco Javier Fernandez-Gadea

Theo Franz Meert

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-12

Filing date

1997-04-09

Publication date

2003-10-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8223868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI0892793(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-04-09 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2003-10-31 Publication of SI0892793T1 publication Critical patent/SI0892793T1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Addiction (AREA)
Nutrition Science (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Furan Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SI9730551T 1996-04-12 1997-04-09 Substituted tetracyclic tetrahydrofuran derivatives SI0892793T1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP96200990		1996-04-12
EP97920662A EP0892793B1 (fr)	1996-04-12	1997-04-09	Derives tetrahydrofuranes tetracycliques substitues
PCT/EP1997/001829 WO1997038991A1 (fr)	1996-04-12	1997-04-09	Derives tetrahydrofuranes tetracycliques substitues

Publications (1)

Publication Number	Publication Date
SI0892793T1 true SI0892793T1 (en)	2003-10-31

Family

ID=8223868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9730551T SI0892793T1 (en)	1996-04-12	1997-04-09	Substituted tetracyclic tetrahydrofuran derivatives

Country Status (29)

Country	Link
US (3)	US6057441A (fr)
EP (1)	EP0892793B1 (fr)
JP (1)	JP3199751B2 (fr)
KR (1)	KR100389298B1 (fr)
CN (1)	CN1116291C (fr)
AT (1)	ATE236893T1 (fr)
BG (1)	BG63083B1 (fr)
BR (1)	BR9706639A (fr)
CA (1)	CA2232141C (fr)
CY (1)	CY2382B1 (fr)
CZ (1)	CZ288865B6 (fr)
DE (1)	DE69720709T2 (fr)
DK (1)	DK0892793T3 (fr)
EA (1)	EA001002B1 (fr)
EE (1)	EE03612B1 (fr)
ES (1)	ES2196328T3 (fr)
HU (1)	HUP9901613A3 (fr)
IL (1)	IL123655A (fr)
MY (1)	MY119321A (fr)
NO (1)	NO317156B1 (fr)
NZ (1)	NZ329953A (fr)
PL (1)	PL190960B1 (fr)
PT (1)	PT892793E (fr)
SI (1)	SI0892793T1 (fr)
SK (1)	SK283400B6 (fr)
TR (1)	TR199801164T2 (fr)
TW (1)	TW504506B (fr)
WO (1)	WO1997038991A1 (fr)
ZA (1)	ZA973114B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL123655A (en) *	1996-04-12	2001-03-19	Janssen Pharmaceutica Nv	Substituted tetracyclic tetrahydrofuran derivatives and pharmaceutical compositions containing them
UA52778C2 (uk)	1997-10-10	2003-01-15	Янссен Фармацевтика Н.В.	Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі
US20050148018A1 (en)	1999-10-07	2005-07-07	David Weiner	Methods of identifying inverse agonists of the serotonin 2A receptor
HRP20000310A2 (en) *	2000-05-17	2002-02-28	Pliva Farmaceutska Ind Dioniko	New dibenzoazulene compounds as tumor necrosis factor inhibitors
WO2002056873A2 (fr) *	2000-12-22	2002-07-25	Bayer Pharmaceuticals Corporation	Dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulene-8-ones a substitution en 2, comme secretagogues de l'hormone de corsante
UA79248C2 (en) *	2001-11-09	2007-06-11	Janssen Pharmaceutica Nv	Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives
MXPA04005400A (es) *	2001-12-07	2004-10-11	Janssen Pharmaceutica Nv	Preparacion de derivados de 3,3a,8,12b-tetrahidro-2h-dibenzo(3,4:6,7(ciclohepta(1,2-b(furano trans-fusionados.
AU2002352205A1 (en) *	2001-12-07	2003-06-17	Janssen Pharmaceutica N.V.	Preparation of cis-fused 3,3a,8,12b-tetrahydro-2H-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
HRP20020305A8 (en)	2002-04-10	2009-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20030160A2 (en) *	2003-03-06	2005-04-30	Pliva-Istra�iva�ki institut d.o.o.	1-thiadibenzoazulene derivatives and biological action thereof
HRP20030885A2 (en) *	2003-11-03	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030956A2 (en) *	2003-11-21	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20030957A2 (en) *	2003-11-21	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030953A2 (en) *	2003-11-21	2005-10-31	Pliva-Istra�iva�ki institut d.o.o.	PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030955A2 (en) *	2003-11-21	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030958A2 (en) *	2003-11-21	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030954A2 (en) *	2003-11-21	2005-08-31	Pliva D.D.	USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) *	2004-01-30	2005-10-31	Pliva-Istra�iva�ki institut d.o.o.	Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
US20070197525A1 (en) *	2004-06-14	2007-08-23	Cid-Nunez Jose M	Novel tetracyclic tetrahydrofuran derivatives
CA2568752C (fr)	2004-06-23	2013-05-07	Janssen Pharmaceutica N.V.	Nouveaux derives de tetrahydrofurane tetracycliques insatures
CN101115719B (zh) *	2004-12-07	2011-08-31	詹森药业有限公司	取代的四环四氢吡喃、吡咯烷和四氢噻吩衍生物
AU2011202995B2 (en) *	2004-12-07	2012-02-02	Janssen Pharmaceutica N.V.	Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
EP1846415B1 (fr)	2005-01-27	2012-08-01	Janssen Pharmaceutica NV	Dérivés hétérocycliques et tétracycliques du tétrahydrofuranne en tant qu'inhibiteurs de 5ht2 utiles dans le traitement des troubles du système nerveux central
BRPI0611518A2 (pt)	2005-05-19	2010-09-14	Janssen Pharmaceutica Nv	derivados de tetrahidrofurano tetracìclico selecionados contendo uma cadeia lateral de amina cìclica
WO2006125812A1 (fr) *	2005-05-26	2006-11-30	Janssen Pharmaceutica N.V.	Nouveaux derives de tetrahydrothiophene, pyrolidine et tetrahydrofurane tetracyclique substitues et leur utilisation en tant que medicament
CN101228154B (zh) *	2005-06-17	2014-01-29	詹森药业有限公司	包含环状胺侧链的四环四氢呋喃衍生物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7605526A (nl) *	1976-05-24	1977-11-28	Akzo Nv	Nieuwe tetracyclische derivaten.
DE2742794A1 (de) *	1976-11-15	1978-05-18	Dec Int	Vorrichtung zur befoerderung von gemahlenem kaese
DE68924751T2 (de) *	1988-09-26	1996-04-11	Smithkline Beecham Farma	Azacyclische Verbindungen, verwendbar als Arzneimittel.
MY110227A (en) *	1991-08-12	1998-03-31	Ciba Geigy Ag	1-acylpiperindine compounds.
FR2681320B1 (fr) *	1991-09-12	1994-01-14	Synthelabo	Derives de n-(4,7dimethoxyindan-2-yl)-1-(phenylcarbonyl)-n-propyl-piperidine-4-methanamine, leur preparation et leur application en therapeutique.
FR2681325B1 (fr) *	1991-09-16	1993-12-17	Fabre Medicament Pierre	Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
US5981539A (en) *	1995-09-15	1999-11-09	Neurosearch A/S	Piperidine compounds as calcium channel blockers
IL123655A (en) *	1996-04-12	2001-03-19	Janssen Pharmaceutica Nv	Substituted tetracyclic tetrahydrofuran derivatives and pharmaceutical compositions containing them

1997
- 1997-04-09 IL IL12365597A patent/IL123655A/xx not_active IP Right Cessation
- 1997-04-09 EE EE9800326A patent/EE03612B1/xx not_active IP Right Cessation
- 1997-04-09 NZ NZ329953A patent/NZ329953A/xx not_active IP Right Cessation
- 1997-04-09 DK DK97920662T patent/DK0892793T3/da active
- 1997-04-09 CZ CZ19983243A patent/CZ288865B6/cs not_active IP Right Cessation
- 1997-04-09 JP JP53673397A patent/JP3199751B2/ja not_active Expired - Fee Related
- 1997-04-09 ES ES97920662T patent/ES2196328T3/es not_active Expired - Lifetime
- 1997-04-09 PT PT97920662T patent/PT892793E/pt unknown
- 1997-04-09 US US09/155,840 patent/US6057441A/en not_active Expired - Lifetime
- 1997-04-09 BR BR9706639A patent/BR9706639A/pt not_active IP Right Cessation
- 1997-04-09 EP EP97920662A patent/EP0892793B1/fr not_active Expired - Lifetime
- 1997-04-09 TR TR1998/01164T patent/TR199801164T2/xx unknown
- 1997-04-09 KR KR10-1998-0703536A patent/KR100389298B1/ko not_active Expired - Fee Related
- 1997-04-09 WO PCT/EP1997/001829 patent/WO1997038991A1/fr not_active Ceased
- 1997-04-09 SK SK1418-98A patent/SK283400B6/sk unknown
- 1997-04-09 CA CA002232141A patent/CA2232141C/fr not_active Expired - Fee Related
- 1997-04-09 AT AT97920662T patent/ATE236893T1/de active
- 1997-04-09 EA EA199800348A patent/EA001002B1/ru not_active IP Right Cessation
- 1997-04-09 DE DE69720709T patent/DE69720709T2/de not_active Expired - Lifetime
- 1997-04-09 HU HU9901613A patent/HUP9901613A3/hu unknown
- 1997-04-09 PL PL328575A patent/PL190960B1/pl not_active IP Right Cessation
- 1997-04-09 SI SI9730551T patent/SI0892793T1/xx unknown
- 1997-04-09 CN CN97191422A patent/CN1116291C/zh not_active Expired - Fee Related
- 1997-04-10 TW TW086104563A patent/TW504506B/zh not_active IP Right Cessation
- 1997-04-11 ZA ZA973114A patent/ZA973114B/xx unknown
- 1997-04-11 MY MYPI97001598A patent/MY119321A/en unknown
1998
- 1998-03-11 NO NO19981076A patent/NO317156B1/no not_active IP Right Cessation
- 1998-10-07 BG BG102820A patent/BG63083B1/bg unknown
2000
- 2000-03-22 US US09/533,625 patent/US6194405B1/en not_active Expired - Lifetime
- 2000-12-21 US US09/745,517 patent/US6288058B1/en not_active Expired - Fee Related
2003
- 2003-11-04 CY CY0300077A patent/CY2382B1/xx unknown

Also Published As

Publication number	Publication date
HK1015771A1 (en)	1999-10-22
NO981076D0 (no)	1998-03-11
EA199800348A1 (ru)	1998-10-29
SK283400B6 (sk)	2003-07-01
EE9800326A (et)	1999-04-15
HUP9901613A3 (en)	2001-08-28
DK0892793T3 (da)	2003-07-21
CY2382B1 (en)	2004-06-04
US6057441A (en)	2000-05-02
CN1205006A (zh)	1999-01-13
EE03612B1 (et)	2002-02-15
DE69720709T2 (de)	2004-03-11
IL123655A (en)	2001-03-19
KR100389298B1 (ko)	2003-10-30
AU712154B2 (en)	1999-10-28
CA2232141A1 (fr)	1997-10-23
MY119321A (en)	2005-05-31
JP3199751B2 (ja)	2001-08-20
PL328575A1 (en)	1999-02-01
ES2196328T3 (es)	2003-12-16
US6194405B1 (en)	2001-02-27
EP0892793B1 (fr)	2003-04-09
ZA973114B (en)	1998-10-12
HUP9901613A2 (hu)	1999-09-28
NZ329953A (en)	1999-06-29
KR19990067514A (ko)	1999-08-25
TW504506B (en)	2002-10-01
BG102820A (en)	1999-08-31
JP2000508327A (ja)	2000-07-04
SK141898A3 (en)	1999-03-12
NO317156B1 (no)	2004-08-30
ATE236893T1 (de)	2003-04-15
IL123655A0 (en)	1998-10-30
EA001002B1 (ru)	2000-08-28
CZ288865B6 (cs)	2001-09-12
PL190960B1 (pl)	2006-02-28
BG63083B1 (bg)	2001-03-30
CN1116291C (zh)	2003-07-30
US6288058B1 (en)	2001-09-11
BR9706639A (pt)	1999-01-12
WO1997038991A1 (fr)	1997-10-23
EP0892793A1 (fr)	1999-01-27
AU2695997A (en)	1997-11-07
NO981076L (no)	1998-10-09
TR199801164T2 (xx)	1998-10-21
PT892793E (pt)	2003-08-29
DE69720709D1 (de)	2003-05-15
CA2232141C (fr)	2006-05-23
CZ324398A3 (cs)	1999-01-13

Publication	Publication Date	Title
CY2382B1 (en)	2004-06-04	Substituted tetracyclic tetrahydrofuran derivatives.
CA2305612A1 (fr)	1999-04-22	Derives de tetracycliques tetrahydrofuraniques halogeno-substitues
TW333532B (en)	1998-06-11	Benzopyrans
NZ329954A (en)	1999-07-29	Isoxazolidine tetracyclic and tricyclic ring system derivatives and medicaments
ATE159255T1 (de)	1997-11-15	Chinuclidine derivate als squalen synthase inhibitoren
MY113325A (en)	2002-01-31	Substituted tetracyclic azepine derivatives
PL319870A1 (en)	1997-09-01	Derivatives of tetracyclic substituted oxazepin and thiazepin exhibiting affinity in respect to 5-ht2 receptors
SE9701396D0 (sv)	1997-04-15	Compounds
CA2232195A1 (fr)	1997-10-23	Derives isoxazolidines
MX9703250A (es)	1997-07-31	Derivados tetraciclicos de oxazepina y tiazepina sustituidos con afinidad al receptor de 5-ht2.