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SI0730594T1 - 9-HYDROXY-PYRIDO (1,2-a)PYRIMIDIN-4-ONE ETHER DERIVATIVES - Google Patents

9-HYDROXY-PYRIDO (1,2-a)PYRIMIDIN-4-ONE ETHER DERIVATIVES

Info

Publication number
SI0730594T1
SI0730594T1 SI9430270T SI9430270T SI0730594T1 SI 0730594 T1 SI0730594 T1 SI 0730594T1 SI 9430270 T SI9430270 T SI 9430270T SI 9430270 T SI9430270 T SI 9430270T SI 0730594 T1 SI0730594 T1 SI 0730594T1
Authority
SI
Slovenia
Prior art keywords
pct
novel compounds
date
4alkyl
sec
Prior art date
Application number
SI9430270T
Other languages
English (en)
Slovenian (sl)
Inventor
Jan Vandenberk
Ludo Edmond Josephine Kennis
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of SI0730594T1 publication Critical patent/SI0730594T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI9430270T 1993-11-23 1994-11-16 9-HYDROXY-PYRIDO (1,2-a)PYRIMIDIN-4-ONE ETHER DERIVATIVES SI0730594T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP93203270 1993-11-23
EP95901389A EP0730594B1 (fr) 1993-11-23 1994-11-16 DERIVES DU 9-HYDROXY-PYRIDO [1,2-a]PYRIMIDINE-4-ONE ETHER
PCT/EP1994/003804 WO1995014691A1 (fr) 1993-11-23 1994-11-16 NOUVEAUX DERIVES DU 9-HYDROXY-PYRIDO[1,2-a]PYRIMIDINE-4-ONE ETHER

Publications (1)

Publication Number Publication Date
SI0730594T1 true SI0730594T1 (en) 1999-12-31

Family

ID=8214180

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9430270T SI0730594T1 (en) 1993-11-23 1994-11-16 9-HYDROXY-PYRIDO (1,2-a)PYRIMIDIN-4-ONE ETHER DERIVATIVES

Country Status (14)

Country Link
US (1) US5688799A (fr)
EP (1) EP0730594B1 (fr)
JP (1) JP3553951B2 (fr)
AT (1) ATE184281T1 (fr)
AU (1) AU687940B2 (fr)
CA (1) CA2175372C (fr)
DE (1) DE69420579T2 (fr)
DK (1) DK0730594T3 (fr)
ES (1) ES2137486T3 (fr)
FI (1) FI112483B (fr)
GR (1) GR3031500T3 (fr)
RU (1) RU2126406C1 (fr)
SI (1) SI0730594T1 (fr)
WO (1) WO1995014691A1 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2141671B1 (es) * 1997-12-26 2001-01-01 Vita Invest Sa Compuesto pirimidinico activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
WO2004009591A1 (fr) * 2002-07-22 2004-01-29 Aurobindo Pharma Ltd. Procede de preparation de risperidone antipsychotique
AU2003256006A1 (en) * 2002-08-30 2004-03-19 Sunil Sadanand Nadkarni Improved process for preparation of risperidone
HUP0401379A3 (en) * 2004-07-08 2006-04-28 Richter Gedeon Vegyeszet Process for the preparation of risperidon
WO2006027370A1 (fr) * 2004-09-09 2006-03-16 Janssen Pharmaceutica N.V. Preparation de 9-hydroxy-3-(2-hydroxyethyl)-2-methyl-4h-pyrido`1,2-a!pyrimidin-4-one et leurs cristaux
HUP0402163A2 (en) * 2004-10-25 2006-05-29 Richter Gedeon Vegyeszet Process for the preparation of risperidone
JP2009524685A (ja) * 2006-08-14 2009-07-02 テバ ファーマシューティカル インダストリーズ リミティド ９−ヒドロキシ−リスペリドン（パリペリドン）の結晶型
EP1945640A2 (fr) 2006-08-14 2008-07-23 Teva Pharmaceutical Industries Ltd. Procédé de synthèse de la 9-hydroxy-rispéridone (palipéridone)
US7820816B2 (en) 2006-08-23 2010-10-26 Teva Pharmaceutical Industries Ltd. Process for the synthesis of CMHTP and intermediates thereof
CN101600716A (zh) * 2007-01-08 2009-12-09 阿特维斯集团公司 用于制备9-羟基-3-(2-氯乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮盐酸盐的改进方法
US20080171876A1 (en) * 2007-05-10 2008-07-17 Santiago Ini Pure paliperidone and processes for preparing thereof
WO2009010988A1 (fr) * 2007-07-19 2009-01-22 Natco Pharma Limited Procédé amélioré, industriellement viable pour la préparation de palipéridone de haute pureté
US20090036470A1 (en) * 2007-07-27 2009-02-05 Jiri Bartl Paliperidone derivatives
PL2079446T3 (pl) * 2007-08-21 2012-04-30 Teva Pharma Preparat paliperidonu o przedłużonym uwalnianiu
US20090061005A1 (en) * 2007-08-21 2009-03-05 Actavis Group Ptc Ehf Paliperidone Polymorphs
WO2009044413A2 (fr) * 2007-10-05 2009-04-09 Matrix Laboratories Limited Procédé amélioré de préparation de palipéridone, nouvelles formes polymorphes et procédé associés
US20090270620A1 (en) * 2007-11-27 2009-10-29 Santiago Ini Processes for preparing crystal forms of 9-hydroxy-risperidone (paliperidone)
WO2009074333A1 (fr) * 2007-12-10 2009-06-18 Synthon B.V. Synthèse de palipéridone
TWI385157B (zh) * 2008-01-16 2013-02-11 Scinopharm Taiwan Ltd 用於製備帕潘立酮（ｐａｌｉｐｅｒｉｄｏｎｅ）之新穎中間體
NZ586930A (en) * 2008-02-05 2012-06-29 Watson Pharma Private Ltd An improved process for preparation of paliperidone
US20090247553A1 (en) * 2008-03-27 2009-10-01 Actavis Group Ptc Ehf Highly Pure Paliperidone or a Pharmaceutically Acceptable Salt Thereof Substantially Free of Keto Impurity
WO2009144288A1 (fr) 2008-05-29 2009-12-03 Inke, S.A. Procédé de fabrication de la palipéridone et d’intermédiaires pour celui-ci
WO2010004578A2 (fr) 2008-06-16 2010-01-14 Msn Laboratories Limited Nouveaux procédés améliorés de préparation de la palipéridone
EP2321311B1 (fr) * 2008-07-11 2012-09-19 Synthon B.V. Synthèse de palipéridone
US7932385B2 (en) * 2008-07-11 2011-04-26 Synthon Bv Paliperidone ketone
WO2010064134A2 (fr) * 2008-12-05 2010-06-10 Cadila Pharmaceuticals Ltd. Procédé de synthèse de la palipéridone
EP2202234A1 (fr) 2008-12-24 2010-06-30 Laboratorios Lesvi, S.L. Purification de la palipéridone
US20120100188A1 (en) 2009-05-28 2012-04-26 Actavis Group Ptc Ehf Solid state forms of paliperidone salts and process for the preparation thereof
WO2011030224A2 (fr) 2009-09-10 2011-03-17 Actavis Group Ptc Ehf Palipéridone ou sel pharmaceutiquement acceptable de celui-ci sensiblement exempt d'impuretés
WO2011073997A2 (fr) * 2009-12-14 2011-06-23 Cadila Healthcare Limited Procédé de préparation de palipéridone et de ses sels pharmaceutiquement acceptables de ces derniers
US8088594B2 (en) * 2010-03-16 2012-01-03 Saladax Biomedical Inc. Risperidone immunoassay
WO2012035554A1 (fr) 2010-09-14 2012-03-22 Megafine Pharma (P) Ltd. Procédé amélioré de préparation de palipéridone très pure
CN103387575A (zh) * 2013-07-22 2013-11-13 江苏万特制药有限公司 帕潘立酮的制备方法及其关键中间体
KR101867988B1 (ko) * 2016-11-02 2018-06-15 주식회사 엔지켐생명과학 팔리페리돈 중간체 및 이를 이용한 팔리페리돈의 제조방법
CN115260190A (zh) * 2022-08-30 2022-11-01 南开大学 一种帕利哌酮前药、制剂及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
CA2000786C (fr) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
US5158952A (en) * 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
GB9008850D0 (en) * 1990-04-19 1990-06-13 Janssen Pharmaceutica Nv Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones

Also Published As

Publication number Publication date
DE69420579T2 (de) 2000-04-27
GR3031500T3 (en) 2000-01-31
DE69420579D1 (de) 1999-10-14
WO1995014691A1 (fr) 1995-06-01
RU2126406C1 (ru) 1999-02-20
US5688799A (en) 1997-11-18
AU687940B2 (en) 1998-03-05
ATE184281T1 (de) 1999-09-15
FI962155L (fi) 1996-05-22
FI112483B (fi) 2003-12-15
AU1065495A (en) 1995-06-13
EP0730594A1 (fr) 1996-09-11
DK0730594T3 (da) 2000-03-27
JP3553951B2 (ja) 2004-08-11
CA2175372C (fr) 2006-02-21
CA2175372A1 (fr) 1995-06-01
ES2137486T3 (es) 1999-12-16
EP0730594B1 (fr) 1999-09-08
FI962155A0 (fi) 1996-05-22
JPH09505574A (ja) 1997-06-03

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Effective date: 20080623