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SG87053A1 - High melt polymorth of the compound n-(3,4-dimethyl-5-isoxazolyl)-4'- (2-oxazolyl) [1,1'-biphenyl]-2-sulfonamide - Google Patents

High melt polymorth of the compound n-(3,4-dimethyl-5-isoxazolyl)-4'- (2-oxazolyl) [1,1'-biphenyl]-2-sulfonamide

Info

Publication number
SG87053A1
SG87053A1 SG9904601A SG1999004601A SG87053A1 SG 87053 A1 SG87053 A1 SG 87053A1 SG 9904601 A SG9904601 A SG 9904601A SG 1999004601 A SG1999004601 A SG 1999004601A SG 87053 A1 SG87053 A1 SG 87053A1
Authority
SG
Singapore
Prior art keywords
polymorth
isoxazolyl
sulfonamide
oxazolyl
biphenyl
Prior art date
Application number
SG9904601A
Other languages
English (en)
Inventor
P Polniaszek Richard
Wang Xuebao
S Depue Jeffrey
R Pandit Chennagiri
G Gadamasetti Kumar
Pendri Yadagiri
J Martinez Eduardo
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/786,523 external-priority patent/US5856507A/en
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SG87053A1 publication Critical patent/SG87053A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG9904601A 1996-02-20 1997-02-19 High melt polymorth of the compound n-(3,4-dimethyl-5-isoxazolyl)-4'- (2-oxazolyl) [1,1'-biphenyl]-2-sulfonamide SG87053A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1197496P 1996-02-20 1996-02-20
US08/786,523 US5856507A (en) 1997-01-21 1997-01-21 Methods for the preparation of biphenyl isoxazole sulfonamides

Publications (1)

Publication Number Publication Date
SG87053A1 true SG87053A1 (en) 2002-03-19

Family

ID=26682999

Family Applications (3)

Application Number Title Priority Date Filing Date
SG9904595A SG87052A1 (en) 1996-02-20 1997-02-19 Pinacol ester intermediates useful for the preparation of biphenyl isoxazole sulfonamides
SG9904601A SG87053A1 (en) 1996-02-20 1997-02-19 High melt polymorth of the compound n-(3,4-dimethyl-5-isoxazolyl)-4'- (2-oxazolyl) [1,1'-biphenyl]-2-sulfonamide
SG9904589A SG87051A1 (en) 1996-02-20 1997-02-19 Process for preparing biphenyl isoxazole sulfonamide intermediates

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG9904595A SG87052A1 (en) 1996-02-20 1997-02-19 Pinacol ester intermediates useful for the preparation of biphenyl isoxazole sulfonamides

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG9904589A SG87051A1 (en) 1996-02-20 1997-02-19 Process for preparing biphenyl isoxazole sulfonamide intermediates

Country Status (15)

Country Link
US (1) US6515136B1 (fr)
EP (1) EP0904077A4 (fr)
JP (1) JP2001523218A (fr)
KR (1) KR19990087063A (fr)
CN (1) CN1211183A (fr)
AU (1) AU717230B2 (fr)
BR (1) BR9708151A (fr)
CZ (1) CZ263098A3 (fr)
HU (1) HUP0002351A3 (fr)
IL (1) IL124542A (fr)
NO (1) NO311430B1 (fr)
NZ (1) NZ330464A (fr)
PL (1) PL328571A1 (fr)
SG (3) SG87052A1 (fr)
WO (1) WO1997029747A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
CN1100047C (zh) * 1998-04-28 2003-01-29 中国人民解放军空军总医院 N3－(5－甲基异噁唑)基－3,4－二羟基肉桂酰胺及其制法
IL140622A0 (en) 1998-07-06 2002-02-10 Bristol Myers Squibb Co Biphenyl sufonamide derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
DE19858593A1 (de) * 1998-12-18 2000-06-21 Merck Patent Gmbh Sulfonyloxazolamine als therapeutische Wirkstoffe
HUP0201320A2 (en) 1999-03-19 2002-08-28 Bristol Myers Squibb Co Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof
US6639082B2 (en) * 2000-10-17 2003-10-28 Bristol-Myers Squibb Company Methods for the preparation of biphenyl isoxazole sulfonamides
EP1475103A4 (fr) * 2002-01-25 2007-11-07 Taisho Pharmaceutical Co Ltd Medicaments servant au traitement de nephropathies chroniques
CN114262279B (zh) * 2021-12-30 2022-12-16 上海汇禾医疗科技有限公司 一种x射线可显影分子、栓塞微球及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2888455A (en) * 1956-09-04 1959-05-26 Shionogi & Co New sulfonamide and process for producing the same
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
US4661479A (en) * 1982-02-19 1987-04-28 Merck And Co., Inc. Bicyclic lactams as antihypertensives

Family Cites Families (43)

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GB804036A (en) 1956-03-02 1958-11-05 Hoffmann La Roche A process for the manufacture of a sulphanilamide of the isoxazole series
DE1059459B (de) 1956-09-04 1959-06-18 Shionogi & Co Verfahren zur Herstellung des therapeutisch wertvollen 3-Sulfanilamido-5-methylisoxazols
CH364506A (de) 1956-09-04 1962-09-30 Shionogi & Co Verfahren zur Herstellung des therapeutisch wirksamen 3-Sulfanilamido-5-methyl-isoxazols
GB897440A (en) 1960-02-08 1962-05-30 Shionogi & Co Improvements in or relating to sulfonamides
GB1473433A (fr) 1975-10-09 1977-05-11 Banyu Pharmaceutical Co Ltd Hi
EP0076072B1 (fr) 1981-09-24 1987-05-13 BEECHAM - WUELFING GmbH & Co. KG Sulfonamides
EP0194548A3 (fr) 1985-03-12 1988-08-17 Dr. Karl Thomae GmbH Composés sulfonylaminoéthyl, médicament contenant ces composés et leur procédé de préparation
US5464853A (en) 1993-05-20 1995-11-07 Immunopharmaceutics, Inc. N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US5591761A (en) 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5594021A (en) 1993-05-20 1997-01-14 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
US5514691A (en) 1993-05-20 1996-05-07 Immunopharmaceutics, Inc. N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5571821A (en) 1993-05-20 1996-11-05 Texas Biotechnology Corporation Sulfonamides and derivatives thereof that modulate the activity of endothelin
CA2005741C (fr) 1988-12-26 1998-06-02 Hiroyoshi Hidaka Sulfonoaminoquinolines ayant une activite de relaxation des muscles lisses des vaisseaux
US5082838A (en) 1989-06-21 1992-01-21 Takeda Chemical Industries, Ltd. Sulfur-containing fused pyrimidine derivatives, their production and use
IL97219A (en) 1990-02-19 1995-12-08 Ciba Geigy Ag Biphenyl substituted aliphatic amino compounds process for their preparation and pharmaceutical compositions containing them
WO1991015479A1 (fr) 1990-03-30 1991-10-17 Merck & Co., Inc. Isoxazoles, isothiazoles et pyrazoles substitues
US5236928A (en) 1991-03-19 1993-08-17 Merck & Co., Inc. Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists
TW270116B (fr) 1991-04-25 1996-02-11 Hoffmann La Roche
RU2086544C1 (ru) 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
ES2164054T3 (es) 1991-11-05 2002-02-16 Smithkline Beecham Corp Antagonistas de receptores de endotelina.
SE9103397D0 (sv) 1991-11-18 1991-11-18 Kabi Pharmacia Ab Nya substituerade salicylsyror
US5378715A (en) 1992-02-24 1995-01-03 Bristol-Myers Squibb Co. Sulfonamide endothelin antagonists
TW224462B (fr) 1992-02-24 1994-06-01 Squibb & Sons Inc
TW215434B (fr) 1992-03-07 1993-11-01 Hoechst Ag
NZ247440A (en) * 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
US5514696A (en) * 1992-05-06 1996-05-07 Bristol-Myers Squibb Co. Phenyl sulfonamide endothelin antagonists
AU4376893A (en) 1992-05-19 1993-12-13 Immunopharmaceutics, Inc. Compounds that modulate endothelin activity
TW287160B (fr) 1992-12-10 1996-10-01 Hoffmann La Roche
ATE189217T1 (de) 1993-03-19 2000-02-15 Merck & Co Inc Phenoxyphenylessigsäurederivate
EP0626174A3 (fr) 1993-04-21 1996-01-03 Takeda Chemical Industries Ltd Procédé et composition de prophylaxie et/ou traitement de la hypofonction d'organes.
TW394761B (en) 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines
EP0634175B1 (fr) 1993-07-15 2001-01-10 F. Hoffmann-La Roche Ag Combinaison pharmaceutique contenant un inhibiteur du système rénin-angiotensin et un antagoniste d'endothéline
US5965732A (en) 1993-08-30 1999-10-12 Bristol-Myers Squibb Co. Sulfonamide endothelin antagonists
GB9504854D0 (en) 1994-03-31 1995-04-26 Zeneca Ltd Nitrogen derivatives
GB9409618D0 (en) 1994-05-13 1994-07-06 Zeneca Ltd Pyridine derivatives
US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
IL116916A (en) * 1995-02-06 2000-09-28 Bristol Myers Squibb Co Substituted biphenyl sulfonamide derivatives and pharmaceutical compositions containing the same
DE19509950A1 (de) 1995-03-18 1996-09-19 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
EP1048657A1 (fr) 1995-04-04 2000-11-02 Texas Biotechnology Corporation Thiényl-, furyl-, pyrrolyl- et biphénylsulfonamides et dérivés de ceux-ci modulant l'activité d'endothéline
UA58494C2 (uk) 1995-06-07 2003-08-15 Зенека Лімітед Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну
GB9512697D0 (en) 1995-06-22 1995-08-23 Zeneca Ltd Heterocyclic compounds
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
US5580894A (en) * 1996-01-11 1996-12-03 Howard University Isoxazolyl enaminones

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2888455A (en) * 1956-09-04 1959-05-26 Shionogi & Co New sulfonamide and process for producing the same
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
US4661479A (en) * 1982-02-19 1987-04-28 Merck And Co., Inc. Bicyclic lactams as antihypertensives

Also Published As

Publication number Publication date
NO983784L (no) 1998-08-19
WO1997029747A1 (fr) 1997-08-21
KR19990087063A (ko) 1999-12-15
EP0904077A4 (fr) 1999-12-22
CN1211183A (zh) 1999-03-17
SG87052A1 (en) 2002-03-19
SG87051A1 (en) 2002-03-19
IL124542A0 (en) 1998-12-06
IL124542A (en) 2003-07-06
HUP0002351A3 (en) 2001-10-29
BR9708151A (pt) 1999-07-27
NO311430B1 (no) 2001-11-26
NO983784D0 (no) 1998-08-19
AU717230B2 (en) 2000-03-23
AU1973797A (en) 1997-09-02
EP0904077A2 (fr) 1999-03-31
US6515136B1 (en) 2003-02-04
HUP0002351A2 (hu) 2001-09-28
NZ330464A (en) 2000-04-28
PL328571A1 (en) 1999-02-01
CZ263098A3 (cs) 1999-05-12
JP2001523218A (ja) 2001-11-20

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