SG52618A1 - Heteroaryl amines as novel acetyl cholinesterase inhibitors - Google Patents

Heteroaryl amines as novel acetyl cholinesterase inhibitors

Info

Publication number: SG52618A1
Authority: SG; Singapore
Prior art keywords: cholinesterase inhibitors; acetyl cholinesterase; heteroaryl amines; novel acetyl; novel
Prior art date: 1991-10-03

Application number

SG1996006904A

Other languages

English (en)

Inventor

Arthur A Nagel

Yuhpyng L Chen

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-03

Filing date

1992-08-31

Publication date

1998-09-28

1992-08-31 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

1998-09-28 Publication of SG52618A1 publication Critical patent/SG52618A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Control Of Indicators Other Than Cathode Ray Tubes (AREA)
Control Of El Displays (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SG1996006904A 1991-10-03 1992-08-31 Heteroaryl amines as novel acetyl cholinesterase inhibitors SG52618A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US77128391A	1991-10-03	1991-10-03

Publications (1)

Publication Number	Publication Date
SG52618A1 true SG52618A1 (en)	1998-09-28

Family

ID=25091318

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996006904A SG52618A1 (en)	1991-10-03	1992-08-31	Heteroaryl amines as novel acetyl cholinesterase inhibitors

Country Status (36)

Country	Link
US (4)	US5574046A (fr)
EP (1)	EP0606248B1 (fr)
JP (1)	JP2546785B2 (fr)
KR (1)	KR0170458B1 (fr)
CN (1)	CN1035615C (fr)
AP (1)	AP314A (fr)
AT (1)	ATE235490T1 (fr)
AU (1)	AU667053B2 (fr)
BG (1)	BG61727B1 (fr)
BR (1)	BR9206577A (fr)
CA (1)	CA2119647C (fr)
CZ (1)	CZ290807B6 (fr)
DE (2)	DE9290112U1 (fr)
DK (1)	DK0606248T3 (fr)
EG (1)	EG21481A (fr)
ES (1)	ES2193137T3 (fr)
FI (1)	FI116939B (fr)
HU (1)	HU225049B1 (fr)
IL (1)	IL103274A (fr)
IS (1)	IS1745B (fr)
MA (1)	MA22672A1 (fr)
MX (1)	MX9205678A (fr)
NO (1)	NO308533B1 (fr)
NZ (1)	NZ244601A (fr)
OA (1)	OA09895A (fr)
PH (1)	PH31290A (fr)
PL (3)	PL171984B1 (fr)
PT (1)	PT100917B (fr)
RO (1)	RO112868B1 (fr)
RU (1)	RU2100357C1 (fr)
SG (1)	SG52618A1 (fr)
TW (1)	TW263504B (fr)
UA (1)	UA41290C2 (fr)
UY (1)	UY23484A1 (fr)
WO (1)	WO1993007140A1 (fr)
ZA (1)	ZA927589B (fr)

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EP0976404A3 (fr) *	1998-07-30	2001-06-27	Pfizer Products Inc.	Compositions pharmaceutiques pour la prévention et la therapie de troubles cognitifes chez les mammifères
US6218383B1 (en)	1998-08-07	2001-04-17	Targacept, Inc.	Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
NZ510685A (en)	1998-09-30	2003-10-31	Takeda Chemical Industries Ltd	Drugs for improving vesical excretory strength
SE9902268D0 (sv) *	1999-06-16	1999-06-16	Astra Ab	Pharmaceutically active compounds
CN1317276C (zh) *	2000-09-29	2007-05-23	中国科学院上海药物研究所	一类吲哚基哌啶类化合物及其制备方法和用途
WO2002032863A1 (fr) *	2000-10-20	2002-04-25	Biovitrum Ab	N1-(benzensulfonyl)indoles substitues en 2, 3, 4 ou 5 et leur utilisation a des fins de traitement
EP1554271A1 (fr) *	2002-10-15	2005-07-20	Rigel Pharmaceuticals, Inc.	Indoles substitues et leur utilisation en tant qu'inhibiteurs du virus de l'hepatite c (vhc)
US20060014801A1 (en) *	2002-11-22	2006-01-19	The Johns Hopkins University	Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs
US20050267076A1 (en) *	2004-05-14	2005-12-01	Johns Hopkins University	Method for improving cognitive function
EP1600447A1 (fr) *	2004-05-28	2005-11-30	Neuropharma S.A.U.	Inhibiteurs de butyrylcholinestérase selective
WO2005121140A1 (fr)	2004-06-09	2005-12-22	Glaxo Group Limited	Derives de pyrrolopyridine
CN101087618A (zh) *	2004-12-23	2007-12-12	航行药物公司	醋酸亮丙瑞林和乙酰胆碱酯酶抑制剂或nmda受体抑制剂在阿尔茨海默氏病治疗中的应用
CN1808106B (zh) *	2005-01-21	2010-11-24	中国科学院上海药物研究所	一种用核磁共振筛选乙酰胆碱酯酶抑制剂的方法
US8846315B2 (en)	2008-08-12	2014-09-30	Zinfandel Pharmaceuticals, Inc.	Disease risk factors and methods of use
NZ710443A (en)	2008-08-12	2019-03-29	Zinfandel Pharmaceuticals Inc	Method of identifying disease risk factors
CN101503414B (zh) *	2009-03-04	2013-10-30	沈阳药科大学	噻唑并[3,2-b]-1,2,4-三嗪衍生物及其应用
EP2482815B1 (fr)	2009-10-02	2018-05-02	Avexxin AS	2-oxothiazoles et 2-oxooxazoles antiinflammatoires
EA037187B1 (ru)	2010-02-09	2021-02-17	Дзе Джонс Хопкинс Юниверсити	Способ и композиция для лечения когнитивного расстройства
AU2012205798B2 (en)	2011-01-10	2016-02-25	Takeda Pharmaceutical Company Limited	Methods and drug products for treating Alzheimer's disease
US10154988B2 (en)	2012-11-14	2018-12-18	The Johns Hopkins University	Methods and compositions for treating schizophrenia
US20150376161A1 (en)	2013-01-29	2015-12-31	Avexxin As	Antiiflammatory and antitumor 2-oxothiazoles abd 2-oxothiophenes compounds
JP6433482B2 (ja)	2013-03-15	2018-12-05	エージンバイオ，インコーポレイテッド	認知機能を改善するための方法および組成物
US10806717B2 (en)	2013-03-15	2020-10-20	The Johns Hopkins University	Methods and compositions for improving cognitive function
CN103333163A (zh) *	2013-07-09	2013-10-02	广州中医药大学	一种苯并呋喃类衍生物及其制备方法和应用
GB201413695D0 (en)	2014-08-01	2014-09-17	Avexxin As	Compound
AU2016268096B2 (en)	2015-05-22	2021-04-01	Agenebio, Inc.	Extended release pharmaceutical compositions of levetiracetam
GB201604318D0 (en)	2016-03-14	2016-04-27	Avexxin As	Combination therapy
CN107141266B (zh) *	2017-06-28	2019-04-09	佳木斯大学附属第一医院	一种用于治疗阿尔茨海默病的杂环化合物及其制备方法
CN115466211B (zh) *	2022-06-09	2024-02-23	中国人民解放军空军军医大学	一种n-苯基喹啉-4-胺类化合物及其应用

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BE889931A (fr) *	1980-08-12	1982-02-11	Glaxo Group Ltd	Derives indoliques, leur preparation et leurs applications en tant que medicaments
GB8615562D0 (en) *	1986-06-25	1986-07-30	Maggioni Farma	Aminoalcohols
KR910006138B1 (ko) *	1986-09-30	1991-08-16	에자이 가부시끼가이샤	환상아민 유도체
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FR2640266B2 (fr) *	1988-07-12	1992-07-10	Synthelabo	Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
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CA2092112A1 (fr) *	1992-03-23	1993-09-24	Nobuyoshi Iwata	Derives d'indole et d'indazole, mode de preparation et utilisation pour le traitement et la prophylaxie des troubles cerebraux

1992
- 1992-08-29 TW TW081106843A patent/TW263504B/zh active
- 1992-08-31 CA CA002119647A patent/CA2119647C/fr not_active Expired - Fee Related
- 1992-08-31 WO PCT/US1992/007230 patent/WO1993007140A1/fr not_active Ceased
- 1992-08-31 DK DK92918761T patent/DK0606248T3/da active
- 1992-08-31 ES ES92918761T patent/ES2193137T3/es not_active Expired - Lifetime
- 1992-08-31 BR BR9206577A patent/BR9206577A/pt not_active Application Discontinuation
- 1992-08-31 US US08/211,044 patent/US5574046A/en not_active Expired - Lifetime
- 1992-08-31 PL PL92312751A patent/PL171984B1/pl not_active IP Right Cessation
- 1992-08-31 DE DE9290112U patent/DE9290112U1/de not_active Expired - Lifetime
- 1992-08-31 PL PL92312752A patent/PL171693B1/pl not_active IP Right Cessation
- 1992-08-31 HU HU9400952A patent/HU225049B1/hu unknown
- 1992-08-31 KR KR1019940701066A patent/KR0170458B1/ko not_active Expired - Fee Related
- 1992-08-31 RO RO94-00533A patent/RO112868B1/ro unknown
- 1992-08-31 EP EP92918761A patent/EP0606248B1/fr not_active Expired - Lifetime
- 1992-08-31 PL PL92303096A patent/PL171669B1/pl not_active IP Right Cessation
- 1992-08-31 JP JP5506442A patent/JP2546785B2/ja not_active Expired - Fee Related
- 1992-08-31 AT AT92918761T patent/ATE235490T1/de not_active IP Right Cessation
- 1992-08-31 UA UA94005424A patent/UA41290C2/uk unknown
- 1992-08-31 RU RU9494019972A patent/RU2100357C1/ru not_active IP Right Cessation
- 1992-08-31 DE DE69232976T patent/DE69232976T2/de not_active Expired - Fee Related
- 1992-08-31 CZ CZ1994785A patent/CZ290807B6/cs not_active IP Right Cessation
- 1992-08-31 SG SG1996006904A patent/SG52618A1/en unknown
- 1992-08-31 AU AU25196/92A patent/AU667053B2/en not_active Ceased
- 1992-09-07 AP APAP/P/1992/000421A patent/AP314A/en active
- 1992-09-15 PH PH44935A patent/PH31290A/en unknown
- 1992-09-24 IL IL10327492A patent/IL103274A/en not_active IP Right Cessation
- 1992-09-25 IS IS3919A patent/IS1745B/is unknown
- 1992-09-30 EG EG58192A patent/EG21481A/xx active
- 1992-09-30 CN CN92112079A patent/CN1035615C/zh not_active Expired - Fee Related
- 1992-10-01 PT PT100917A patent/PT100917B/pt not_active IP Right Cessation
- 1992-10-02 NZ NZ244601A patent/NZ244601A/en not_active IP Right Cessation
- 1992-10-02 ZA ZA927589A patent/ZA927589B/xx unknown
- 1992-10-02 UY UY23484A patent/UY23484A1/es not_active IP Right Cessation
- 1992-10-02 MA MA22956A patent/MA22672A1/fr unknown
- 1992-10-02 MX MX9205678A patent/MX9205678A/es unknown
1994
- 1994-03-18 OA OA60484A patent/OA09895A/en unknown
- 1994-03-30 NO NO941179A patent/NO308533B1/no unknown
- 1994-03-31 FI FI941518A patent/FI116939B/fi active IP Right Grant
- 1994-03-31 BG BG98689A patent/BG61727B1/bg unknown
1997
- 1997-10-24 US US08/957,639 patent/US6124321A/en not_active Expired - Fee Related
1999
- 1999-11-11 US US09/438,712 patent/US6303633B1/en not_active Expired - Fee Related
2001
- 2001-08-23 US US09/935,903 patent/US20020049210A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AP9200421A0 (en)	1992-10-31
FI116939B (fi)	2006-04-13
ZA927589B (en)	1994-04-05
EP0606248A1 (fr)	1994-07-20
BR9206577A (pt)	1995-10-10
RO112868B1 (ro)	1998-01-30
AP314A (en)	1994-02-04
HUT70544A (en)	1995-10-30
CA2119647C (fr)	1998-08-04
IS3919A (is)	1993-04-04
NO941179L (no)	1994-03-30
PL171984B1 (pl)	1997-07-31
PH31290A (en)	1998-07-06
ES2193137T3 (es)	2003-11-01
KR0170458B1 (ko)	1999-02-18
MA22672A1 (fr)	1993-07-01
TW263504B (fr)	1995-11-21
PT100917A (pt)	1993-11-30
NO308533B1 (no)	2000-09-25
IS1745B (is)	2000-05-18
BG61727B1 (bg)	1998-04-30
JPH06510788A (ja)	1994-12-01
AU667053B2 (en)	1996-03-07
MX9205678A (es)	1993-04-01
US20020049210A1 (en)	2002-04-25
HU9400952D0 (en)	1994-06-28
NO941179D0 (no)	1994-03-30
OA09895A (en)	1995-09-15
IL103274A0 (en)	1993-02-21
DE69232976D1 (de)	2003-04-30
CZ78594A3 (en)	1995-07-12
US6303633B1 (en)	2001-10-16
DK0606248T3 (da)	2003-06-23
PL171693B1 (pl)	1997-06-30
HU225049B1 (en)	2006-05-29
ATE235490T1 (de)	2003-04-15
US6124321A (en)	2000-09-26
JP2546785B2 (ja)	1996-10-23
CZ290807B6 (cs)	2002-10-16
CA2119647A1 (fr)	1993-04-15
RU2100357C1 (ru)	1997-12-27
WO1993007140A1 (fr)	1993-04-15
DE69232976T2 (de)	2003-10-02
DE9290112U1 (de)	1994-06-01
CN1071166A (zh)	1993-04-21
EG21481A (en)	2001-11-28
BG98689A (bg)	1995-03-31
PL171669B1 (en)	1997-06-30
FI941518L (fi)	1994-03-31
FI941518A0 (fi)	1994-03-31
PT100917B (pt)	1999-07-30
UY23484A1 (es)	1993-03-11
EP0606248B1 (fr)	2003-03-26
IL103274A (en)	1996-11-14
UA41290C2 (uk)	2001-09-17
AU2519692A (en)	1993-05-03
CN1035615C (zh)	1997-08-13
US5574046A (en)	1996-11-12
NZ244601A (en)	1995-03-28

Publication	Publication Date	Title
SG52618A1 (en)	1998-09-28	Heteroaryl amines as novel acetyl cholinesterase inhibitors
FI933303L (fi)	1993-08-31	Adenosinkinasinhibitorer
HU9400258D0 (en)	1994-06-28	Quinazoline derivatives as acetylcholinesterase inhibitors
FI945442L (fi)	1994-11-18	Uudet 7beta-substituoidut 4-atsa-5alfa-kolestanonit 5alfa-reduktaasi-inhibiittoreina
FI940573L (fi)	1994-03-28	Geneseriinin johdannaiset koliiniestraasin inhibiittoreina
IL91788A0 (en)	1990-06-10	Novel quinolyloxazole-2-ones useful as proteinkinase c inhibitors
IL97140A0 (en)	1992-05-25	Tricyclic-cyclic amines as novel cholinesterase inhibitors
GB9007751D0 (en)	1990-06-06	Novel platelet-aggregation inhibitors
EP0518672A3 (en)	1993-08-11	Cyclic renin inhibitors
GB9125615D0 (en)	1992-01-29	Amines
EP0415634A3 (en)	1992-06-17	Benzazabicyclic carbamates as cholinesterase inhibitors
EP0518675A3 (en)	1993-08-11	Cyclic renin inhibitors
EP0518676A3 (en)	1993-08-11	Cyclic renin inhibitors
AU113464S (en)	1992-03-13	Dummy clip
DE69420181D1 (de)	1999-09-30	Horizontalsynchronisierungsvorrichtung
GB9110722D0 (en)	1991-07-10	Amine derivatives
AU6593090A (en)	1991-05-30	Novel pyridyloxyazole-2-ones useful as proteinkinase c inhibitors
EP0543936A4 (en)	1993-06-30	Renin inhibitors
GB9026251D0 (en)	1991-01-16	Netalloproteinase inhibitors
ITBS910099V0 (it)	1991-11-22	Basamento per armadi ripartillinea
ITMI922782A1 (it)	1994-06-04	Disposizione per guarnizione
AU113463S (en)	1992-03-13	Dummy
ZA914716B (en)	1992-03-25	Ace inhibitors
ITBO910139U1 (it)	1993-01-04	Sostegno reggimensola specialmente per librerie
ZA925660B (en)	1994-01-28	Quinazoline derivatives as acetylcholinesterase inhibitors