SG47809A1 - 1'-Aminospiro(isoqunoline-4(1H) ,3'-pyrrolidine)-1, 2',3,'5' (2H9-tetrones and analogs thereof useful as aldose reductase inhibitors - Google Patents
1'-Aminospiro(isoqunoline-4(1H) ,3'-pyrrolidine)-1, 2',3,'5' (2H9-tetrones and analogs thereof useful as aldose reductase inhibitorsInfo
- Publication number
- SG47809A1 SG47809A1 SG1996004510A SG1996004510A SG47809A1 SG 47809 A1 SG47809 A1 SG 47809A1 SG 1996004510 A SG1996004510 A SG 1996004510A SG 1996004510 A SG1996004510 A SG 1996004510A SG 47809 A1 SG47809 A1 SG 47809A1
- Authority
- SG
- Singapore
- Prior art keywords
- carbon atoms
- aryl
- lower alkyl
- alkyl
- tetrones
- Prior art date
Links
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003288 aldose reductase inhibitor Substances 0.000 title 1
- 229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 14
- 125000004432 carbon atom Chemical group C* 0.000 abstract 13
- 125000003118 aryl group Chemical group 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000005332 alkyl sulfoxy group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- -1 arylsulfoxy Chemical group 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/596,266 US5102886A (en) | 1990-10-12 | 1990-10-12 | 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG47809A1 true SG47809A1 (en) | 1998-04-17 |
Family
ID=24386645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG1996004510A SG47809A1 (en) | 1990-10-12 | 1991-10-10 | 1'-Aminospiro(isoqunoline-4(1H) ,3'-pyrrolidine)-1, 2',3,'5' (2H9-tetrones and analogs thereof useful as aldose reductase inhibitors |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5102886A (da) |
| EP (1) | EP0553263B1 (da) |
| JP (1) | JP3115598B2 (da) |
| KR (1) | KR100228842B1 (da) |
| AT (1) | ATE169300T1 (da) |
| AU (1) | AU645865B2 (da) |
| CA (1) | CA2093794C (da) |
| DE (1) | DE69129941T2 (da) |
| DK (1) | DK0553263T3 (da) |
| ES (1) | ES2120966T3 (da) |
| FI (1) | FI103045B1 (da) |
| HU (2) | HU214874B (da) |
| MX (1) | MX9101543A (da) |
| PT (1) | PT99179B (da) |
| RU (1) | RU2110518C1 (da) |
| SG (1) | SG47809A1 (da) |
| TW (1) | TW200484B (da) |
| WO (1) | WO1992006975A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0618917B1 (en) * | 1991-11-25 | 1997-03-26 | American Home Products Corporation | 1'-amino-2- (benzothiazolyl)methyl]spiro isoquinoline-4(1h),3'-pyrrolidine]-1,2',3,5'(2h)-tetrones and analogs thereof useful as aldose reductase inhibitors |
| US5189168A (en) * | 1991-11-25 | 1993-02-23 | American Home Products Corporation | 1'-amino-2[(benzothiazolyl)methyl]spiro-[isoquinoline-4(1H),3'-pyrrolidine]-1,2'3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors |
| EP1400244A1 (en) | 2002-09-17 | 2004-03-24 | Warner-Lambert Company LLC | New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors |
| WO2005068463A1 (en) * | 2004-01-08 | 2005-07-28 | F. Hoffmann-La Roche Ag | Diaza-spiropiperidine derivatives |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4200642A (en) * | 1978-08-21 | 1980-04-29 | Pfizer Inc. | Spiro-oxazolidindiones |
| IE52879B1 (en) * | 1981-05-12 | 1988-03-30 | Ici Plc | Pharmaceutical spiro-hydantoin derivatives |
| AU617541B2 (en) * | 1988-10-20 | 1991-11-28 | Wyeth | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
| US4927831A (en) * | 1988-10-20 | 1990-05-22 | American Home Products | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
| JPH0426510A (ja) * | 1990-05-18 | 1992-01-29 | Tonen Corp | 炭素系粒子、その製造方法及びその用途 |
| US5068332A (en) * | 1990-10-12 | 1991-11-26 | American Home Products Corporation | Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors |
-
1990
- 1990-10-12 US US07/596,266 patent/US5102886A/en not_active Expired - Lifetime
-
1991
- 1991-10-08 TW TW080107927A patent/TW200484B/zh active
- 1991-10-09 PT PT99179A patent/PT99179B/pt not_active IP Right Cessation
- 1991-10-10 EP EP91920029A patent/EP0553263B1/en not_active Expired - Lifetime
- 1991-10-10 DK DK91920029T patent/DK0553263T3/da active
- 1991-10-10 ES ES91920029T patent/ES2120966T3/es not_active Expired - Lifetime
- 1991-10-10 AU AU89026/91A patent/AU645865B2/en not_active Ceased
- 1991-10-10 AT AT91920029T patent/ATE169300T1/de not_active IP Right Cessation
- 1991-10-10 HU HU9301042A patent/HU214874B/hu not_active IP Right Cessation
- 1991-10-10 WO PCT/US1991/007473 patent/WO1992006975A1/en not_active Ceased
- 1991-10-10 KR KR1019930701086A patent/KR100228842B1/ko not_active Expired - Fee Related
- 1991-10-10 SG SG1996004510A patent/SG47809A1/en unknown
- 1991-10-10 JP JP03518368A patent/JP3115598B2/ja not_active Expired - Fee Related
- 1991-10-10 CA CA002093794A patent/CA2093794C/en not_active Expired - Fee Related
- 1991-10-10 RU RU93005013A patent/RU2110518C1/ru not_active IP Right Cessation
- 1991-10-10 DE DE69129941T patent/DE69129941T2/de not_active Expired - Fee Related
- 1991-10-11 MX MX9101543A patent/MX9101543A/es unknown
-
1993
- 1993-04-08 FI FI931601A patent/FI103045B1/fi not_active IP Right Cessation
-
1995
- 1995-06-27 HU HU95P/P00451P patent/HU211601A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI931601A0 (fi) | 1993-04-08 |
| EP0553263A1 (en) | 1993-08-04 |
| WO1992006975A1 (en) | 1992-04-30 |
| ATE169300T1 (de) | 1998-08-15 |
| JP3115598B2 (ja) | 2000-12-11 |
| PT99179B (pt) | 1999-04-30 |
| HU211601A9 (en) | 1995-12-28 |
| KR100228842B1 (ko) | 1999-11-01 |
| FI931601L (fi) | 1993-04-08 |
| DE69129941T2 (de) | 1999-02-18 |
| JPH06502175A (ja) | 1994-03-10 |
| RU2110518C1 (ru) | 1998-05-10 |
| HU214874B (hu) | 1998-07-28 |
| AU8902691A (en) | 1992-05-20 |
| AU645865B2 (en) | 1994-01-27 |
| CA2093794C (en) | 2002-01-22 |
| US5102886A (en) | 1992-04-07 |
| DE69129941D1 (de) | 1998-09-10 |
| EP0553263B1 (en) | 1998-08-05 |
| HK1009601A1 (en) | 1999-06-04 |
| DK0553263T3 (da) | 1999-05-10 |
| HU9301042D0 (en) | 1993-07-28 |
| MX9101543A (es) | 1992-06-05 |
| ES2120966T3 (es) | 1998-11-16 |
| HUT67017A (en) | 1995-01-30 |
| TW200484B (da) | 1993-02-21 |
| PT99179A (pt) | 1992-09-30 |
| KR930702346A (ko) | 1993-09-08 |
| FI103045B (fi) | 1999-04-15 |
| FI103045B1 (fi) | 1999-04-15 |
| CA2093794A1 (en) | 1992-04-13 |
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