SG46413A1 - Substituted 4-phenyl-4-piperdinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation - Google Patents

Substituted 4-phenyl-4-piperdinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation

Info

Publication number: SG46413A1
Authority: SG; Singapore
Prior art keywords: preparation; well; piperdinecarboxamides; phenyl; substituted
Prior art date: 1989-12-21

Application number

SG1996004491A

Other languages

English (en)

Inventor

Lena Askanna

Rune Sandberg

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-21

Filing date

1990-12-17

Publication date

1998-02-20

1990-12-17 Application filed by Astra Ab filed Critical Astra Ab

1998-02-20 Publication of SG46413A1 publication Critical patent/SG46413A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cosmetics (AREA)

SG1996004491A 1989-12-21 1990-12-17 Substituted 4-phenyl-4-piperdinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation SG46413A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8904298A SE8904298D0 (sv)	1989-12-21	1989-12-21	New compounds

Publications (1)

Publication Number	Publication Date
SG46413A1 true SG46413A1 (en)	1998-02-20

Family

ID=20377821

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996004491A SG46413A1 (en)	1989-12-21	1990-12-17	Substituted 4-phenyl-4-piperdinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation

Country Status (40)

Country	Link
US (2)	US5227389A (xx)
EP (1)	EP0506778B1 (xx)
JP (1)	JP2656152B2 (xx)
KR (1)	KR0179382B1 (xx)
CN (1)	CN1037841C (xx)
AT (1)	ATE138650T1 (xx)
AU (1)	AU647068B2 (xx)
BG (1)	BG60912B1 (xx)
BR (1)	BR1100379A (xx)
CA (1)	CA2069608C (xx)
CZ (1)	CZ278035B6 (xx)
DE (1)	DE69027221T2 (xx)
DK (1)	DK0506778T3 (xx)
DZ (1)	DZ1468A1 (xx)
EG (1)	EG19361A (xx)
ES (1)	ES2087280T3 (xx)
FI (1)	FI100881B (xx)
HK (1)	HK22997A (xx)
HR (1)	HRP920591B1 (xx)
HU (1)	HU213110B (xx)
IE (1)	IE74855B1 (xx)
IL (1)	IL96636A (xx)
IS (1)	IS1664B (xx)
LT (1)	LT4005B (xx)
LV (2)	LV10949B (xx)
NO (1)	NO178858C (xx)
NZ (1)	NZ236293A (xx)
PL (1)	PL163591B1 (xx)
PT (1)	PT96303B (xx)
RO (1)	RO112864B1 (xx)
RU (1)	RU2039043C1 (xx)
SA (1)	SA91110209B1 (xx)
SE (1)	SE8904298D0 (xx)
SG (1)	SG46413A1 (xx)
SI (1)	SI9012346B (xx)
SK (1)	SK278283B6 (xx)
UA (1)	UA26403A (xx)
WO (1)	WO1991009845A1 (xx)
YU (1)	YU48086B (xx)
ZA (1)	ZA909903B (xx)

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JP3916092B2 (ja) *	1993-09-17	2007-05-16	杏林製薬株式会社	イミダゾリジノン誘導体とその酸付加塩及び老年性痴呆症の治療薬
SE9400447D0 (sv) *	1994-02-11	1994-02-11	Astra Ab	New compounds
SE9404438D0 (sv) *	1994-12-21	1994-12-21	Astra Ab	New process
US5931809A (en)	1995-07-14	1999-08-03	Depotech Corporation	Epidural administration of therapeutic compounds with sustained rate of release
GB9600235D0 (en) *	1996-01-05	1996-03-06	Pfizer Ltd	Therapeutic agents
DE19642591A1 (de) *	1996-10-15	1998-04-16	Basf Ag	Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung
TW548271B (en) *	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) *	1996-12-20	1996-12-20	Astra Pharma Inc	New compounds
RU2125878C1 (ru) *	1996-12-26	1999-02-10	Новокузнецкий научно-исследовательский химико-фармацевтический институт	Анальгетическое средство
RU2117481C1 (ru) *	1997-07-15	1998-08-20	Государственный научно-исследовательский институт органической химии и технологии	Анальгетическое средство и способ его приготовления
US7799337B2 (en)	1997-07-21	2010-09-21	Levin Bruce H	Method for directed intranasal administration of a composition
US20020102291A1 (en) *	1997-12-15	2002-08-01	Noven Pharmaceuticals, Inc.	Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate
SE9803239D0 (sv) *	1998-09-24	1998-09-24	Diabact Ab	Composition for the treatment of acute pain
SE9803240D0 (sv) *	1998-09-24	1998-09-24	Diabact Ab	A pharmaceutical composition having a rapid action
ATE460163T1 (de) *	2001-04-12	2010-03-15	Pharmacopeia Llc	Arly und diaryl piperidinderivate verwendbar als mch-hemmer
RU2203041C1 (ru) *	2001-12-27	2003-04-27	Закрытое акционерное общество "Брынцалов-А"	Спазмолитические таблетки бралангин
WO2003066590A1 (en) *	2002-02-08	2003-08-14	Ono Pharmaceutical Co., Ltd.	Piperidine derivative compounds and drugs containing the compounds as the active ingredient
CN1744899A (zh) *	2002-12-13	2006-03-08	史密丝克莱恩比彻姆公司	作为ccr5拮抗剂的哌啶衍生物
TW200831497A (en) *	2006-10-12	2008-08-01	Epix Delaware Inc	Carboxamide compounds and their use
CN101925383A (zh)	2007-12-11	2010-12-22	赛特帕斯凡德株式会社	甲酰胺化合物及其作为趋化因子受体激动剂的应用
US8473062B2 (en)	2008-05-01	2013-06-25	Autonomic Technologies, Inc.	Method and device for the treatment of headache
US8412336B2 (en)	2008-12-29	2013-04-02	Autonomic Technologies, Inc.	Integrated delivery and visualization tool for a neuromodulation system
US9320908B2 (en)	2009-01-15	2016-04-26	Autonomic Technologies, Inc.	Approval per use implanted neurostimulator
US8494641B2 (en)	2009-04-22	2013-07-23	Autonomic Technologies, Inc.	Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US20220096452A1 (en)	2019-01-22	2022-03-31	Icm (Institut Du Cerveau Et De La Moelle Épinière)	Local anesthetic for the treatment of neurological symptoms resulting from brain dysfunctions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE96980C1 (xx)
US2486796A (en) *	1943-06-25	1949-11-01	Ciba Pharm Prod Inc	Esters of 1-alkyl-4-hydroxyphenylpiperidyl-4-ketones
US3334106A (en) *	1964-10-20	1967-08-01	Aldrich Chem Co Inc	N(aryl)n(hydrocarbyl)-omega-(4-phenyl-4-piperidinocarbonylheteroamine) alkanoamide
US3539580A (en) *	1967-06-26	1970-11-10	Janssen Pharm	4-aryl-4-aminoalkoxy-piperidines
CH501622A (de) *	1968-12-20	1971-01-15	Ciba Geigy Ag	Verfahren zur Herstellung von neuen Piperidinderivaten
US3737538A (en) *	1968-12-30	1973-06-05	Ciba Geigy Corp	Antitussive compositions and method with isonipecotic acid derivatives
FR2156470A2 (en) *	1971-10-21	1973-06-01	Synthelabo	1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
ZA899436B (en) *	1988-12-12	1990-08-29	Ciba Geigy	Piperidine derivatives
US5100903A (en) *	1989-05-12	1992-03-31	Anaquest, Inc.	N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds

1989
- 1989-12-21 SE SE8904298A patent/SE8904298D0/xx unknown
1990
- 1990-11-30 NZ NZ236293A patent/NZ236293A/xx unknown
- 1990-12-10 ZA ZA909903A patent/ZA909903B/xx unknown
- 1990-12-11 IL IL9663690A patent/IL96636A/en not_active IP Right Cessation
- 1990-12-12 YU YU234690A patent/YU48086B/sh unknown
- 1990-12-12 SI SI9012346A patent/SI9012346B/sl not_active IP Right Cessation
- 1990-12-12 DZ DZ900223A patent/DZ1468A1/xx active
- 1990-12-17 HU HU9202044A patent/HU213110B/hu unknown
- 1990-12-17 UA UA5052485A patent/UA26403A/uk unknown
- 1990-12-17 AT AT91901571T patent/ATE138650T1/de not_active IP Right Cessation
- 1990-12-17 SG SG1996004491A patent/SG46413A1/en unknown
- 1990-12-17 EP EP91901571A patent/EP0506778B1/en not_active Expired - Lifetime
- 1990-12-17 WO PCT/SE1990/000818 patent/WO1991009845A1/en not_active Ceased
- 1990-12-17 ES ES91901571T patent/ES2087280T3/es not_active Expired - Lifetime
- 1990-12-17 KR KR1019920701484A patent/KR0179382B1/ko not_active Expired - Fee Related
- 1990-12-17 CA CA002069608A patent/CA2069608C/en not_active Expired - Fee Related
- 1990-12-17 DE DE69027221T patent/DE69027221T2/de not_active Expired - Fee Related
- 1990-12-17 RO RO92-0832A patent/RO112864B1/ro unknown
- 1990-12-17 IS IS3659A patent/IS1664B/is unknown
- 1990-12-17 DK DK91901571.9T patent/DK0506778T3/da active
- 1990-12-17 AU AU69783/91A patent/AU647068B2/en not_active Ceased
- 1990-12-17 JP JP3501896A patent/JP2656152B2/ja not_active Expired - Fee Related
- 1990-12-17 IE IE453490A patent/IE74855B1/en not_active IP Right Cessation
- 1990-12-20 PT PT96303A patent/PT96303B/pt active IP Right Grant
- 1990-12-20 EG EG74690A patent/EG19361A/xx active
- 1990-12-21 SK SK6581-90A patent/SK278283B6/sk unknown
- 1990-12-21 US US07/633,246 patent/US5227389A/en not_active Expired - Lifetime
- 1990-12-21 CZ CS906581A patent/CZ278035B6/cs not_active IP Right Cessation
- 1990-12-21 CN CN90106009A patent/CN1037841C/zh not_active Expired - Fee Related
- 1990-12-21 PL PL90288409A patent/PL163591B1/pl not_active IP Right Cessation
1991
- 1991-01-09 SA SA91110209A patent/SA91110209B1/ar unknown
1992
- 1992-06-17 FI FI922806A patent/FI100881B/fi not_active IP Right Cessation
- 1992-06-17 NO NO922380A patent/NO178858C/no unknown
- 1992-06-19 BG BG96513A patent/BG60912B1/bg unknown
- 1992-06-19 RU SU925052485A patent/RU2039043C1/ru not_active IP Right Cessation
- 1992-09-29 HR HRP-2346/90A patent/HRP920591B1/xx not_active IP Right Cessation
1993
- 1993-07-12 US US08/090,416 patent/US5360805A/en not_active Expired - Lifetime
- 1993-08-27 LV LVP-93-1042A patent/LV10949B/lv unknown
- 1993-12-30 LT LTIP1731A patent/LT4005B/lt not_active IP Right Cessation
1996
- 1996-07-17 LV LV960262A patent/LV5766B4/xx unknown
1997
- 1997-02-27 HK HK22997A patent/HK22997A/en not_active IP Right Cessation
- 1997-04-30 BR BR1100379-0A patent/BR1100379A/pt active IP Right Grant

Also Published As

Publication number	Publication date
EG19361A (en)	1994-12-30
EP0506778B1 (en)	1996-05-29
LT4005B (en)	1996-07-25
IL96636A (en)	1994-11-28
ES2087280T3 (es)	1996-07-16
LV10949A (lv)	1995-12-20
SA91110209B1 (ar)	2004-05-08
NO922380L (no)	1992-06-17
CA2069608A1 (en)	1991-06-22
JPH05502869A (ja)	1993-05-20
PL288409A1 (en)	1991-12-02
KR927003531A (ko)	1992-12-18
CN1037841C (zh)	1998-03-25
BG96513A (bg)	1993-12-24
DZ1468A1 (fr)	2004-09-13
UA26403A (uk)	1999-08-30
LV5766B4 (lv)	1997-06-20
ATE138650T1 (de)	1996-06-15
CN1053605A (zh)	1991-08-07
FI922806A0 (fi)	1992-06-17
LV5766A4 (lv)	1996-12-20
US5227389A (en)	1993-07-13
HUT64518A (en)	1994-01-28
CA2069608C (en)	2001-07-10
KR0179382B1 (ko)	1999-03-20
DE69027221D1 (de)	1996-07-04
IE74855B1 (en)	1997-08-13
IS3659A7 (is)	1991-06-22
HU9202044D0 (en)	1992-09-28
DK0506778T3 (da)	1996-10-07
SI9012346A (sl)	1998-08-31
IS1664B (is)	1997-07-04
NO178858B (no)	1996-03-11
LV10949B (en)	1996-06-20
CZ658190A3 (en)	1993-01-13
EP0506778A1 (en)	1992-10-07
SI9012346B (sl)	1999-08-31
DE69027221T2 (de)	1996-10-10
PT96303A (pt)	1991-09-30
IL96636A0 (en)	1991-09-16
PL163591B1 (pl)	1994-04-29
BG60912B1 (bg)	1996-06-28
NZ236293A (en)	1992-10-28
JP2656152B2 (ja)	1997-09-24
HRP920591B1 (en)	1998-12-31
LTIP1731A (en)	1995-07-25
AU6978391A (en)	1991-07-24
US5360805A (en)	1994-11-01
AU647068B2 (en)	1994-03-17
CZ278035B6 (en)	1993-07-14
ZA909903B (en)	1991-08-28
YU234690A (sh)	1993-10-20
SE8904298D0 (sv)	1989-12-21
PT96303B (pt)	1998-07-31
HK22997A (en)	1997-02-27
SK658190A3 (en)	1996-08-07
SK278283B6 (en)	1996-08-07
FI100881B (fi)	1998-03-13
HU213110B (en)	1997-02-28
BR1100379A (pt)	1999-12-07
NO922380D0 (no)	1992-06-17
HRP920591A2 (en)	1997-08-31
IE904534A1 (en)	1991-07-03
FI922806L (fi)	1992-06-17
NO178858C (no)	1996-06-19
WO1991009845A1 (en)	1991-07-11
YU48086B (sh)	1997-01-08
RU2039043C1 (ru)	1995-07-09
RO112864B1 (ro)	1998-01-30

Publication	Publication Date	Title
SG46413A1 (en)	1998-02-20	Substituted 4-phenyl-4-piperdinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation
AU582235B2 (en)	1989-03-16	Quinolylglycinamide derivatives,the process for preparation thereof and their therapeutic application as psychotropic drugs
IL112374A (en)	1999-12-31	Substituted piperidine-4-carboxamides with analgesic and local anaesthetic effect
ZA882854B (en)	1988-12-28	Substituted quinoxalyl-imidazolidine-2,4-diones,processes for their preparation,their use as medicaments and pharmaceutical preparations
SE9401596D0 (sv)	1994-05-06	New compounds
JO1658B1 (en)	1991-11-27	New vehicles
JO1652B1 (en)	1991-11-27	New compounds for local anesthesia and a way to prepare them
IL97780A0 (en)	1992-06-21	Substituted 3-thia-and 3-oxa-alkylflavones,a process for their preparation,the use thereof,medicaments based on these compounds and intermediates
IT1269545B (it)	1997-04-08	Derivati idantoinici
SE8900685D0 (sv)	1989-02-28	New compounds