SG176100A1 - Modulators of 5-ht receptors and methods of use thereof - Google Patents

Modulators of 5-ht receptors and methods of use thereof Download PDF

Info

Publication number: SG176100A1
Authority: SG; Singapore
Prior art keywords: pyrrolo; trans; hexahydrobenzo; azepin; methyl
Prior art date: 2009-05-22

Application number

SG2011084357A

Other languages

English (en)

Inventor

Irini Akritopoulou-Zanze

Wilfried Braje

Stevan W Djuric

Noel S Wilson

Sean C Turner

Albert W Kruger

Ana-Lucia Relo

Shashank Shekhar

Dennie S Welch

Hongyu Zhao

Jorge Gandarilla

Alan F Gasiecki

Huanqiu Li

Christina M Thompson

Min Zhang

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-05-22

Filing date

2010-05-20

Publication date

2011-12-29

2010-05-20 Application filed by Abbott Lab filed Critical Abbott Lab

2011-12-29 Publication of SG176100A1 publication Critical patent/SG176100A1/en

Links

238000000034 method Methods 0.000 title claims abstract description 116
102000040125 5-hydroxytryptamine receptor family Human genes 0.000 title description 5
108091032151 5-hydroxytryptamine receptor family Proteins 0.000 title description 5
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230000008569 process Effects 0.000 claims abstract description 17
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QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 166
-1 pyrrolo[ 3,4-c]azepin- 2(3H)-yl Chemical group 0.000 claims description 110
229910052739 hydrogen Inorganic materials 0.000 claims description 92
239000001257 hydrogen Substances 0.000 claims description 87
125000000217 alkyl group Chemical group 0.000 claims description 81
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150000003839 salts Chemical class 0.000 claims description 45
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Classifications

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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/16—Peri-condensed systems

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SG2011084357A 2009-05-22 2010-05-20 Modulators of 5-ht receptors and methods of use thereof SG176100A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US18056909P	2009-05-22	2009-05-22
PCT/US2010/035626 WO2010135560A1 (en)	2009-05-22	2010-05-20	Modulators of 5-ht receptors and methods of use thereof

Publications (1)

Publication Number	Publication Date
SG176100A1 true SG176100A1 (en)	2011-12-29

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SG2014014328A SG2014014328A (en)	2009-05-22	2010-05-20	Modulators of 5-ht receptors and methods of use thereof
SG2011084357A SG176100A1 (en)	2009-05-22	2010-05-20	Modulators of 5-ht receptors and methods of use thereof
SG10201706590VA SG10201706590VA (en)	2009-05-22	2010-05-20	Modulators of 5-ht receptors and methods of use thereof

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SG2014014328A SG2014014328A (en)	2009-05-22	2010-05-20	Modulators of 5-ht receptors and methods of use thereof

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SG10201706590VA SG10201706590VA (en)	2009-05-22	2010-05-20	Modulators of 5-ht receptors and methods of use thereof

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US (3)	US9187483B2 (es)
EP (2)	EP2432783B1 (es)
JP (2)	JP5791595B2 (es)
KR (1)	KR101784674B1 (es)
CN (2)	CN102712643B (es)
AU (1)	AU2010249472B2 (es)
BR (1)	BRPI1010604A2 (es)
CA (1)	CA2761961C (es)
ES (2)	ES2423668T3 (es)
IL (1)	IL216193A (es)
MX (1)	MX2011012479A (es)
NZ (2)	NZ596827A (es)
RU (2)	RU2014147175A (es)
SG (3)	SG2014014328A (es)
TW (1)	TWI492947B (es)
WO (1)	WO2010135560A1 (es)
ZA (1)	ZA201601457B (es)

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2010
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- 2010-05-20 RU RU2014147175/04A patent/RU2014147175A/ru not_active Application Discontinuation
- 2010-05-20 KR KR1020117030649A patent/KR101784674B1/ko not_active Expired - Fee Related
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- 2010-05-20 SG SG2011084357A patent/SG176100A1/en unknown
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2011
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2015
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2016
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Also Published As

Publication number	Publication date
JP2016006092A (ja)	2016-01-14
CN102712643A (zh)	2012-10-03
JP6117872B2 (ja)	2017-04-19
JP5791595B2 (ja)	2015-10-07
CA2761961A1 (en)	2010-11-25
KR101784674B1 (ko)	2017-10-12
TWI492947B (zh)	2015-07-21
RU2542103C2 (ru)	2015-02-20
WO2010135560A1 (en)	2010-11-25
KR20120060784A (ko)	2012-06-12
IL216193A0 (en)	2012-01-31
MX2011012479A (es)	2012-03-06
IL216193A (en)	2016-02-29
CN102712643B (zh)	2015-12-16
TW201100434A (en)	2011-01-01
ZA201601457B (en)	2019-04-24
EP2641907A1 (en)	2013-09-25
CN105481864A (zh)	2016-04-13
ES2423668T3 (es)	2013-09-23
BRPI1010604A2 (pt)	2017-05-23
HK1168853A1 (en)	2013-01-11
CA2761961C (en)	2017-10-24
AU2010249472B2 (en)	2015-09-10
NZ596827A (en)	2014-01-31
US9879033B2 (en)	2018-01-30
US20160096851A1 (en)	2016-04-07
US20180346484A1 (en)	2018-12-06
SG10201706590VA (en)	2017-09-28
US9187483B2 (en)	2015-11-17
AU2010249472A1 (en)	2011-12-22
SG2014014328A (en)	2014-07-30
RU2014147175A (ru)	2015-06-27
RU2011152312A (ru)	2013-06-27
EP2641907B1 (en)	2015-01-28
EP2432783B1 (en)	2013-05-01
US20100298292A1 (en)	2010-11-25
JP2012527476A (ja)	2012-11-08
EP2432783A1 (en)	2012-03-28
RU2014147175A3 (es)	2018-06-27
NZ618902A (en)	2015-06-26
ES2535490T3 (es)	2015-05-12

Publication	Publication Date	Title
US9879033B2 (en)	2018-01-30	Modulators of 5-HT receptors and methods of use thereof
AU2010353724B2 (en)	2015-02-12	Modulators of 5-HT receptors and methods of use thereof
AU2015224388B2 (en)	2017-02-02	Modulators of 5-HT receptors and methods of use thereof
HK1168853B (en)	2013-12-06	Modulators of 5-ht receptors and methods of use thereof