SG158108A1 - Production of beta-lactam antibiotics by genetically modified non- naturally producing microorganisms - Google Patents
Production of beta-lactam antibiotics by genetically modified non- naturally producing microorganismsInfo
- Publication number
- SG158108A1 SG158108A1 SG200908083-9A SG2009080839A SG158108A1 SG 158108 A1 SG158108 A1 SG 158108A1 SG 2009080839 A SG2009080839 A SG 2009080839A SG 158108 A1 SG158108 A1 SG 158108A1
- Authority
- SG
- Singapore
- Prior art keywords
- beta
- production
- genetically modified
- lactam
- modified non
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000003782 beta lactam antibiotic agent Substances 0.000 title abstract 2
- 239000002132 β-lactam antibiotic Substances 0.000 title abstract 2
- 229940124586 β-lactam antibiotics Drugs 0.000 title abstract 2
- -1 beta-lactam compound Chemical class 0.000 abstract 4
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 101710107944 Isopenicillin N synthase Proteins 0.000 abstract 1
- 241000228150 Penicillium chrysogenum Species 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106471 | 2004-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG158108A1 true SG158108A1 (en) | 2010-01-29 |
Family
ID=34930032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200908083-9A SG158108A1 (en) | 2004-12-10 | 2005-12-08 | Production of beta-lactam antibiotics by genetically modified non- naturally producing microorganisms |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20080131925A1 (fr) |
| EP (1) | EP1819813A2 (fr) |
| KR (1) | KR20070085955A (fr) |
| CN (1) | CN101098963A (fr) |
| BR (1) | BRPI0518399A2 (fr) |
| MX (1) | MX2007006780A (fr) |
| SG (1) | SG158108A1 (fr) |
| WO (1) | WO2006061425A2 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2084270T1 (sl) * | 2006-10-05 | 2014-03-31 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Izdelava beta - laktam antibiotikov |
| EP2080801A1 (fr) * | 2008-01-21 | 2009-07-22 | Technical University of Denmark | Production de peptides non ribosomales dans les saccharomyces |
| EP2123772A1 (fr) * | 2008-04-29 | 2009-11-25 | DSM IP Assets B.V. | Souches produisant des antibiotiques bêta-lactamines |
| EP2376619A4 (fr) | 2008-12-15 | 2012-07-04 | Greenlight Biosciences Inc | Procédés de commande de flux dans des voies métaboliques |
| WO2010074760A1 (fr) * | 2008-12-22 | 2010-07-01 | Greenlight Biosciences | Compositions et procédés pour la production d'un composé |
| US8956833B2 (en) | 2010-05-07 | 2015-02-17 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways through enzyme relocation |
| EP2611922A1 (fr) | 2010-08-31 | 2013-07-10 | Greenlight Biosciences, Inc. | Procédés pour la commande de flux dans des voies métaboliques par manipulation de protéase |
| SG2014014377A (en) | 2011-09-09 | 2014-05-29 | Greenlight Biosciences Inc | Cell-free preparation of carbapenems |
| CA2919383A1 (fr) | 2013-08-05 | 2015-02-12 | Greenlight Biosciences, Inc. | Proteines produites par genie genetique avec site de clivage par les proteases |
| CR20170485A (es) | 2015-03-30 | 2018-02-05 | Greenlight Biosciences Inc | Producción de ácido ribonucleico libre de células |
| US10954541B2 (en) | 2016-04-06 | 2021-03-23 | Greenlight Biosciences, Inc. | Cell-free production of ribonucleic acid |
| MX2019008159A (es) | 2017-01-06 | 2019-12-09 | Greenlight Biosciences Inc | Producción acelular de azúcares. |
| SG11202003192UA (en) | 2017-10-11 | 2020-05-28 | Greenlight Biosciences Inc | Methods and compositions for nucleoside triphosphate and ribonucleic acid production |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL85535A (en) * | 1987-03-04 | 1994-02-27 | Lilly Co Eli | Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase and deacetylcephalosporin c synthetase |
| US6258555B1 (en) * | 1987-12-09 | 2001-07-10 | Beecham Group P.L.C. | DNA encoding ACV synthetase |
| GB8728811D0 (en) * | 1987-12-09 | 1988-01-27 | Beecham Group Plc | Novel substance |
| US5882879A (en) * | 1990-02-28 | 1999-03-16 | Gist-Brocades, N.V. | Method for influencing β-lactam antibiotic production and for isolation of large quantities of ACV synthetase |
-
2005
- 2005-12-08 EP EP05826363A patent/EP1819813A2/fr not_active Withdrawn
- 2005-12-08 MX MX2007006780A patent/MX2007006780A/es not_active Application Discontinuation
- 2005-12-08 BR BRPI0518399-5A patent/BRPI0518399A2/pt not_active IP Right Cessation
- 2005-12-08 WO PCT/EP2005/056619 patent/WO2006061425A2/fr not_active Ceased
- 2005-12-08 KR KR1020077013008A patent/KR20070085955A/ko not_active Withdrawn
- 2005-12-08 CN CNA2005800424915A patent/CN101098963A/zh active Pending
- 2005-12-08 US US11/792,725 patent/US20080131925A1/en not_active Abandoned
- 2005-12-08 SG SG200908083-9A patent/SG158108A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0518399A2 (pt) | 2008-11-18 |
| US20080131925A1 (en) | 2008-06-05 |
| KR20070085955A (ko) | 2007-08-27 |
| WO2006061425A2 (fr) | 2006-06-15 |
| WO2006061425A3 (fr) | 2006-08-03 |
| CN101098963A (zh) | 2008-01-02 |
| EP1819813A2 (fr) | 2007-08-22 |
| MX2007006780A (es) | 2007-08-06 |
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