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SG120092A1 - Process for the enzymatic preparation of enantiomer-enriched beta-amino acids - Google Patents

Process for the enzymatic preparation of enantiomer-enriched beta-amino acids

Info

Publication number
SG120092A1
SG120092A1 SG200302077A SG200302077A SG120092A1 SG 120092 A1 SG120092 A1 SG 120092A1 SG 200302077 A SG200302077 A SG 200302077A SG 200302077 A SG200302077 A SG 200302077A SG 120092 A1 SG120092 A1 SG 120092A1
Authority
SG
Singapore
Prior art keywords
enantiomer
amino acids
enzymatic preparation
beta
enriched beta
Prior art date
Application number
SG200302077A
Inventor
Harald Dr Groger
Helge Werner
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of SG120092A1 publication Critical patent/SG120092A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for the production of enantiomer enriched N-unprotected, preferably open chain beta-aminoacids comprises enzymatic hydrolysis of an enantiomer mixture of corresponding beta-aminoacid esters with a hydrolase, whereby the hydrolysis is carried out in a two-phase system of water and an organic solvent that forms a second phase under the reaction conditions.
SG200302077A 2002-05-08 2003-04-09 Process for the enzymatic preparation of enantiomer-enriched beta-amino acids SG120092A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10220740A DE10220740A1 (en) 2002-05-08 2002-05-08 Production of enantiomer enriched N-unprotected beta-aminoacids, useful for production of pharmaceuticals, comprises enzymatic hydrolysis of beta-aminoacid esters with hydrolase in two-phase system of water and organic solvent

Publications (1)

Publication Number Publication Date
SG120092A1 true SG120092A1 (en) 2006-03-28

Family

ID=29285247

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200302077A SG120092A1 (en) 2002-05-08 2003-04-09 Process for the enzymatic preparation of enantiomer-enriched beta-amino acids

Country Status (10)

Country Link
EP (1) EP1367129B1 (en)
JP (1) JP4662694B2 (en)
KR (1) KR101043190B1 (en)
CN (1) CN1327002C (en)
AT (1) ATE435299T1 (en)
CA (1) CA2428163C (en)
DE (2) DE10220740A1 (en)
HR (1) HRP20030356A2 (en)
IL (1) IL155784A (en)
SG (1) SG120092A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2853327B1 (en) * 2003-04-04 2012-07-27 Solvay PROCESS FOR THE PRODUCTION OF ENANTIOPOR BETA-AMINOACID DERIVATIVES AND ENANTIOPA BETA-AMINOACIDIC DERIVATIVES
JP4361094B2 (en) * 2003-12-10 2009-11-11 エボニック デグサ ゲーエムベーハー Method for producing enantiomerically enriched amino acids
WO2005085462A1 (en) * 2004-02-27 2005-09-15 Dsm Ip Assets B.V. Enzymatic preparation of an enantiomerically enriched beta-2-amino acids
JP4608938B2 (en) * 2004-05-12 2011-01-12 宇部興産株式会社 Process for producing optically active 3-alkyl-3-arylpropionic acid and optically active 3-alkyl-3-arylpropionic acid alkyl ester
JP4608963B2 (en) * 2004-06-22 2011-01-12 宇部興産株式会社 Process for producing optically active 3-aryl-3-hydroxypropionic acid and optically active 3-aryl-3-hydroxypropionic acid alkyl ester
CN101040053B (en) * 2004-10-08 2013-04-24 宇部兴产株式会社 Production method of optically active (S or R)-β-amino acid and optically active (R or S)-β-amino acid ester, and β-amino acid 2-alkoxyethyl ester and optically active (S or R)-β- amino acid 2-alkoxyethyl ester
DE102004057966A1 (en) * 2004-11-30 2006-06-01 Degussa Ag Method for asymmetrical enzymatic production of optically active organic compounds in microemulsion
US20090117626A1 (en) * 2005-05-17 2009-05-07 Hiroyuki Miyata Process for preparing carboxylic acid using surfactant-modified enzyme

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439524A (en) * 1979-07-07 1984-03-27 Bayer Aktiengesellschaft Stereoselective resolution of phenylglycine derivatives with enzyme resins
US4636470A (en) * 1984-08-17 1987-01-13 Stauffer Chemical Company Resolution of racemates of amino acids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439524A (en) * 1979-07-07 1984-03-27 Bayer Aktiengesellschaft Stereoselective resolution of phenylglycine derivatives with enzyme resins
US4636470A (en) * 1984-08-17 1987-01-13 Stauffer Chemical Company Resolution of racemates of amino acids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TETRAHEDRON LETTERS. VOL. 41, 2000. PAGES 2697-2681 *

Also Published As

Publication number Publication date
HRP20030356A2 (en) 2004-04-30
CA2428163C (en) 2011-08-09
ATE435299T1 (en) 2009-07-15
EP1367129B1 (en) 2009-07-01
CN1456676A (en) 2003-11-19
DE50311645D1 (en) 2009-08-13
JP4662694B2 (en) 2011-03-30
KR20030087562A (en) 2003-11-14
KR101043190B1 (en) 2011-06-22
JP2003325197A (en) 2003-11-18
EP1367129A2 (en) 2003-12-03
CN1327002C (en) 2007-07-18
CA2428163A1 (en) 2003-11-08
DE10220740A1 (en) 2003-11-27
IL155784A0 (en) 2003-12-23
EP1367129A3 (en) 2003-12-17
IL155784A (en) 2010-06-30

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