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SG11202112407PA - Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators - Google Patents

Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators

Info

Publication number
SG11202112407PA
SG11202112407PA SG11202112407PA SG11202112407PA SG11202112407PA SG 11202112407P A SG11202112407P A SG 11202112407PA SG 11202112407P A SG11202112407P A SG 11202112407PA SG 11202112407P A SG11202112407P A SG 11202112407PA SG 11202112407P A SG11202112407P A SG 11202112407PA
Authority
SG
Singapore
Prior art keywords
receptor modulators
substituted pyrazolo
pyridine amides
glun2b receptor
glun2b
Prior art date
Application number
SG11202112407PA
Inventor
Afton Hiscox
Akinola Soyode-Johnson
Brice Stenne
Christa Chrovian
Christine Gelin
Andrew Samant
Michael A Letavic
Curt Dvorak
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ARP200101623A external-priority patent/AR119125A1/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SG11202112407PA publication Critical patent/SG11202112407PA/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11202112407PA 2019-06-14 2020-06-12 Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators SG11202112407PA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962861656P 2019-06-14 2019-06-14
PK35020 2020-06-03
ARP200101623A AR119125A1 (en) 2019-06-14 2020-06-09 SUBSTITUTED PYRAZOLO-PYRIDINE AMIDES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS
PCT/EP2020/066392 WO2020249792A1 (en) 2019-06-14 2020-06-12 Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators

Publications (1)

Publication Number Publication Date
SG11202112407PA true SG11202112407PA (en) 2021-12-30

Family

ID=73781829

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202112407PA SG11202112407PA (en) 2019-06-14 2020-06-12 Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators

Country Status (20)

Country Link
US (1) US11618750B2 (en)
EP (1) EP3983075A1 (en)
KR (1) KR20220024511A (en)
CN (1) CN113993868A (en)
AU (1) AU2020290016A1 (en)
BR (1) BR112021024856A2 (en)
CA (1) CA3142996A1 (en)
CL (1) CL2021003277A1 (en)
CO (1) CO2021016003A2 (en)
CR (1) CR20210580A (en)
DO (1) DOP2021000251A (en)
EC (1) ECSP21090478A (en)
IL (1) IL288859A (en)
JO (1) JOP20210328A1 (en)
MA (1) MA56196A (en)
MX (1) MX2021015506A (en)
PE (1) PE20220386A1 (en)
SG (1) SG11202112407PA (en)
TW (1) TW202112774A (en)
WO (1) WO2020249792A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201819376A (en) 2016-10-06 2018-06-01 比利時商健生藥品公司 Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GLUN2B receptor modulators
KR20220024403A (en) 2019-06-14 2022-03-03 얀센 파마슈티카 엔.브이. Substituted pyrazolo-pyrazines and their use as GLUN2B receptor modulators
MX2021015508A (en) 2019-06-14 2022-01-31 Janssen Pharmaceutica Nv Pyridine carbamates and their use as glun2b receptor modulators.
CA3142998A1 (en) 2019-06-14 2020-12-17 Janssen Pharmaceutica Nv Pyrazine carbamates and their use as glun2b receptor modulators
JP7667097B2 (en) 2019-06-14 2025-04-22 ヤンセン ファーマシューティカ エヌ.ベー. Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators - Patents.com
BR112021025141A2 (en) 2019-06-14 2022-01-25 Janssen Pharmaceutica Nv Heteroaromatic substituted pyrazole-pyridines and their use as glun2b receptor modulators
US11618750B2 (en) 2019-06-14 2023-04-04 Janssen Pharmaceutica Nv Substituted pyrazolo-pyridine amides and their use as GluN2B receptor modulators
CA3143102A1 (en) 2019-06-14 2020-12-17 Janssen Pharmaceutica Nv Substituted pyrazolo[4,3-b]pyridines and their use as glun2b receptor modulators

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9407447D0 (en) 1994-04-14 1994-06-08 Glaxo Group Ltd Chemical compounds
JP3192662B2 (en) 1996-07-31 2001-07-30 日研化学株式会社 6-phenyltetrahydro-1,3-oxazin-2-one derivatives and pharmaceutical compositions containing the same
JP2004501901A (en) 2000-06-26 2004-01-22 メルク エンド カムパニー インコーポレーテッド Iminopyrimidine NMDANR2B receptor antagonist
US6610723B2 (en) 2001-01-29 2003-08-26 Hoffmann-La Roche Inc. Imidazole derivatives
KR20040111445A (en) 2002-03-28 2004-12-31 에자이 가부시키가이샤 7-Azaindoles as Inhibitors of c-Jun N-terminal Kinase for The Treatment of Neurodegenerative Disorders
US7005432B2 (en) 2002-05-16 2006-02-28 Hoffman-La Roche Inc. Substituted imidazol-pyridazine derivatives
TW200406385A (en) 2002-05-31 2004-05-01 Eisai Co Ltd Pyrazole compound and pharmaceutical composition containing the same
BRPI0507501A (en) 2004-02-18 2007-06-26 Astrazeneca Ab compound, pharmaceutical composition, use of the compound, method for treating mglur5-mediated disorders, and method for inhibiting activation of mglur5 receptors
WO2006034473A2 (en) 2004-09-23 2006-03-30 Reddy Us Therapeutics, Inc. Novel pyrimidine compounds, process for their preparation and compositions containing them
WO2007115231A2 (en) 2006-03-30 2007-10-11 Chemocentryx, Inc. Cxcr4 modulators
PE20090717A1 (en) 2007-05-18 2009-07-18 Smithkline Beecham Corp QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS
AU2008257559B2 (en) 2007-05-25 2013-10-10 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (MGLU2 receptor)
WO2009004430A1 (en) 2007-06-29 2009-01-08 Pfizer Inc. N-benzyl oxazolidinones and related heterocycleic compounds as potentiators of glutamate receptors
BRPI0816095A2 (en) 2007-08-30 2015-03-03 Takeda Pharmaceutical COMPOUND OR SALT OF THE SAME, PRODUCT, PHARMACEUTICAL AGENT, METHODS FOR ANTAGONIZING AN ANDROGEN RECEIVER AND FOR PREVENTING / TREATING CANCER, AND, USE OF THE COMPOUND OR PRODUCT OF THE SAME.
EP2215073A4 (en) 2007-10-31 2011-04-06 Merck Sharp & Dohme SLEEP MODULATION WITH NR2B RECEPTOR ANTAGONISTS
BRPI0909378A2 (en) 2008-03-27 2015-10-06 Evotec Neurosciences Gmbh methods for treating disorders using selective nr2b subtype nm antagonist
EP2298731A4 (en) 2008-06-25 2011-09-21 Takeda Pharmaceutical amide
PL2308877T3 (en) 2008-08-05 2014-07-31 Daiichi Sankyo Co Ltd Imidazopyridin-2-one derivatives
US9643922B2 (en) 2008-08-18 2017-05-09 Yale University MIF modulators
US8697689B2 (en) 2008-10-16 2014-04-15 Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
JP5930278B2 (en) 2008-11-25 2016-06-08 ユニバーシティー オブ ロチェスター MLK inhibitors and methods of use
WO2010108187A2 (en) 2009-03-20 2010-09-23 Brandeis University Compounds and methods for treating mammalian gastrointestinal microbial infections
WO2011022348A1 (en) 2009-08-18 2011-02-24 Janssen Pharmaceutica Nv Ethylene diamine modulators of fatty acid amide hydrolase
WO2011156245A2 (en) 2010-06-09 2011-12-15 Merck Sharp & Dohme Corp. Positive allosteric modulators of mglur2
JP2013530180A (en) * 2010-06-16 2013-07-25 パーデュー、ファーマ、リミテッド、パートナーシップ Aryl substituted indoles and uses thereof
US8987473B2 (en) * 2011-01-28 2015-03-24 Sato Pharmaceutical Co., Ltd. Ring-fused compound
JP2012188363A (en) 2011-03-09 2012-10-04 Dainippon Sumitomo Pharma Co Ltd Azabenzoimidazolone derivative
DK2570415T3 (en) 2011-09-19 2015-11-23 Sanofi Sa N- [4- (1H-pyrazolo [3,4-b] pyrazin-6-yl) phenyl] sulfonamides and their use as medicaments
WO2013060029A1 (en) 2011-10-28 2013-05-02 Merck Sharp & Dohme Corp Allosteric modulators of metabotropic glutamate receptors
WO2013130855A1 (en) 2012-03-02 2013-09-06 Takeda Pharmaceutical Company Limited Indazole derivatives
JOP20130273B1 (en) 2012-09-11 2021-08-17 Genzyme Corp Glucosylceramide synthase inhibitors
WO2014124651A1 (en) 2013-02-15 2014-08-21 Københavns Universitet Pyrrolidine-2-carboxylic acid derivatives as iglur antagonists
JP2016516710A (en) 2013-03-13 2016-06-09 アッヴィ・インコーポレイテッド Pyridine CDK9 kinase inhibitor
KR102244719B1 (en) 2013-03-15 2021-04-26 플렉시콘 인코퍼레이티드 Heterocyclic compounds and uses thereof
PL3010503T3 (en) 2013-06-21 2020-08-24 Zenith Epigenetics Ltd. Novel bicyclic bromodomain inhibitors
WO2015017502A1 (en) * 2013-07-31 2015-02-05 Merck Patent Gmbh Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof
JP6605020B2 (en) 2014-08-15 2019-11-13 ヤンセン ファーマシューティカルズ,インコーポレーテッド Triazoles as NR2B receptor inhibitors
HUE049278T2 (en) 2014-08-15 2020-09-28 Janssen Pharmaceuticals Inc Pyrazoles
US12006328B2 (en) 2014-11-18 2024-06-11 Emory University Thieno[2,3-d]pyrimidin-4-one derivatives as NMDAR modulators and uses related thereto
MA41803A (en) * 2015-03-24 2018-01-30 Almirall Sa AMINO-INDAZOLES USED AS SODIUM CHANNEL INHIBITORS
SMT202000134T1 (en) 2015-07-09 2020-05-08 Janssen Pharmaceutica Nv Substituted 4-azaindoles and their use as glun2b receptor modulators
BR112018016329A2 (en) 2016-02-10 2018-12-18 Janssen Pharmaceutica Nv 1,2,3-triazoles substituted as nr2b selective nmda modulators
TW201819376A (en) 2016-10-06 2018-06-01 比利時商健生藥品公司 Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GLUN2B receptor modulators
IL271149B2 (en) 2017-06-14 2024-05-01 Trevena Inc Compounds for modulating S1P1 activity and methods of using them
US10766893B2 (en) 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
JP7346441B2 (en) 2018-04-04 2023-09-19 ヤンセン ファーマシューティカ エヌ.ベー. Substituted pyridines and pyrimidines and their use as GLUN2B receptor modulators
CN110294756A (en) * 2019-06-04 2019-10-01 广州市原子高科同位素医药有限公司 GluN2B subunit targeting type central nervous system positive electron tracer and its preparation
BR112021025141A2 (en) 2019-06-14 2022-01-25 Janssen Pharmaceutica Nv Heteroaromatic substituted pyrazole-pyridines and their use as glun2b receptor modulators
CA3143102A1 (en) 2019-06-14 2020-12-17 Janssen Pharmaceutica Nv Substituted pyrazolo[4,3-b]pyridines and their use as glun2b receptor modulators
CA3142998A1 (en) 2019-06-14 2020-12-17 Janssen Pharmaceutica Nv Pyrazine carbamates and their use as glun2b receptor modulators
KR20220024403A (en) 2019-06-14 2022-03-03 얀센 파마슈티카 엔.브이. Substituted pyrazolo-pyrazines and their use as GLUN2B receptor modulators
US11618750B2 (en) 2019-06-14 2023-04-04 Janssen Pharmaceutica Nv Substituted pyrazolo-pyridine amides and their use as GluN2B receptor modulators
MX2021015508A (en) 2019-06-14 2022-01-31 Janssen Pharmaceutica Nv Pyridine carbamates and their use as glun2b receptor modulators.

Also Published As

Publication number Publication date
MX2021015506A (en) 2022-02-10
CO2021016003A2 (en) 2021-12-10
WO2020249792A1 (en) 2020-12-17
AU2020290016A1 (en) 2022-01-06
BR112021024856A2 (en) 2022-01-18
PE20220386A1 (en) 2022-03-18
EP3983075A1 (en) 2022-04-20
CA3142996A1 (en) 2020-12-17
US20210017168A1 (en) 2021-01-21
TW202112774A (en) 2021-04-01
CR20210580A (en) 2022-01-31
JOP20210328A1 (en) 2023-01-30
ECSP21090478A (en) 2022-01-31
DOP2021000251A (en) 2022-04-18
KR20220024511A (en) 2022-03-03
CN113993868A (en) 2022-01-28
MA56196A (en) 2022-04-20
IL288859A (en) 2022-02-01
CL2021003277A1 (en) 2022-08-19
US11618750B2 (en) 2023-04-04

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