SG11202111186TA - Process for making drug crystals of desired size distribution and morphology - Google Patents
Process for making drug crystals of desired size distribution and morphologyInfo
- Publication number
- SG11202111186TA SG11202111186TA SG11202111186TA SG11202111186TA SG11202111186TA SG 11202111186T A SG11202111186T A SG 11202111186TA SG 11202111186T A SG11202111186T A SG 11202111186TA SG 11202111186T A SG11202111186T A SG 11202111186TA SG 11202111186T A SG11202111186T A SG 11202111186TA
- Authority
- SG
- Singapore
- Prior art keywords
- morphology
- size distribution
- desired size
- drug crystals
- making drug
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/004—Fractional crystallisation; Fractionating or rectifying columns
- B01D9/0045—Washing of crystals, e.g. in wash columns
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B13/00—Grading or sorting solid materials by dry methods, not otherwise provided for; Sorting articles otherwise than by indirectly controlled devices
- B07B13/04—Grading or sorting solid materials by dry methods, not otherwise provided for; Sorting articles otherwise than by indirectly controlled devices according to size
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B33/00—After-treatment of single crystals or homogeneous polycrystalline material with defined structure
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
- C30B7/02—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent
- C30B7/06—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent using non-aqueous solvents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Glanulating (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962832179P | 2019-04-10 | 2019-04-10 | |
| PCT/US2020/027797 WO2020210720A1 (en) | 2019-04-10 | 2020-04-10 | Process for making drug crystals of desired size distribution and morphology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202111186TA true SG11202111186TA (en) | 2021-11-29 |
Family
ID=72752032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202111186TA SG11202111186TA (en) | 2019-04-10 | 2020-04-10 | Process for making drug crystals of desired size distribution and morphology |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20220168665A1 (en) |
| EP (1) | EP3952842A4 (en) |
| JP (2) | JP7547364B2 (en) |
| KR (1) | KR20220025703A (en) |
| CN (1) | CN114040752A (en) |
| AU (1) | AU2020272057B2 (en) |
| BR (1) | BR112021020319A2 (en) |
| CA (2) | CA3275626A1 (en) |
| IL (1) | IL287091A (en) |
| MX (2) | MX2021012364A (en) |
| SG (1) | SG11202111186TA (en) |
| WO (1) | WO2020210720A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119968199A (en) | 2022-10-04 | 2025-05-09 | 优普顺药物公司 | Use of long-acting fluticasone propionate injection suspension for treating and preventing gastrointestinal inflammation |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1329316A (en) * | 1970-12-08 | 1973-09-05 | Kerr Mc Gee Chem Corp | Process for automatic control of crystal size distribution |
| JPS50132117A (en) * | 1974-04-09 | 1975-10-20 | ||
| EP0447858B1 (en) * | 1990-03-20 | 1995-05-24 | Asea Brown Boveri Ag | Process for producing an oxide dispersion strengthened superalloy article having a coarse grain structure directionally orientated along the length |
| JP3807086B2 (en) * | 1998-03-23 | 2006-08-09 | 味の素株式会社 | Particle size distribution controlled crystallization method |
| ATE389455T1 (en) * | 2000-05-10 | 2008-04-15 | Jagotec Ag | GRINDING BY MEANS OF GRINDING MEDIUM |
| CN1960708A (en) * | 2003-07-22 | 2007-05-09 | 巴克斯特国际公司 | Small spherical particles of low molecular weight organic molecules and preparation methods and use thereof |
| US20060078573A1 (en) * | 2004-06-11 | 2006-04-13 | Theodore Randolph | Methods of modifying crystal habit |
| JP2006241391A (en) * | 2005-03-07 | 2006-09-14 | Polyplastics Co | Low dielectric constant organic composite |
| JP5197564B2 (en) * | 2006-03-14 | 2013-05-15 | メルク・シャープ・エンド・ドーム・コーポレイション | Method for producing organic crystal fine particle composition by fine grinding and crystallization with fine seeds |
| CN101757634A (en) * | 2008-11-28 | 2010-06-30 | 天津金耀集团有限公司 | Nasal medicine composition enclosing fluticasone propionate by cyclodextrin |
| CN103649104A (en) * | 2011-07-08 | 2014-03-19 | 辉瑞股份有限公司 | Process for the preparation of fluticasone propionate form 1 |
| IL287731B2 (en) * | 2013-03-21 | 2025-05-01 | Eupraxia Pharmaceuticals USA LLC | Injectable sustained release compositions for treating inflammation in joints and pain associated therewith |
| KR20180038571A (en) * | 2014-06-20 | 2018-04-16 | 아비라겐 테라퓨틱스, 인코포레이티드 | Anhydrous crystalline free base form of [2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy]-3-ethoxy-1,2-benzisoxazole |
| WO2016044799A1 (en) * | 2014-09-19 | 2016-03-24 | Eupraxia Pharmaceuticals Inc. | Injectable microparticles for hyper-localized release of therapeutic agents |
| ES2672993T3 (en) * | 2015-10-27 | 2018-06-19 | Eupraxia Pharmaceuticals Inc. | Sustained release formulations of local anesthetics |
-
2020
- 2020-04-10 BR BR112021020319A patent/BR112021020319A2/en unknown
- 2020-04-10 CA CA3275626A patent/CA3275626A1/en active Pending
- 2020-04-10 SG SG11202111186TA patent/SG11202111186TA/en unknown
- 2020-04-10 JP JP2021559798A patent/JP7547364B2/en active Active
- 2020-04-10 AU AU2020272057A patent/AU2020272057B2/en active Active
- 2020-04-10 WO PCT/US2020/027797 patent/WO2020210720A1/en not_active Ceased
- 2020-04-10 CA CA3136619A patent/CA3136619A1/en active Pending
- 2020-04-10 CN CN202080028076.9A patent/CN114040752A/en active Pending
- 2020-04-10 US US17/594,208 patent/US20220168665A1/en active Pending
- 2020-04-10 KR KR1020217036473A patent/KR20220025703A/en active Pending
- 2020-04-10 EP EP20786812.6A patent/EP3952842A4/en active Pending
- 2020-04-10 MX MX2021012364A patent/MX2021012364A/en unknown
-
2021
- 2021-10-07 IL IL287091A patent/IL287091A/en unknown
- 2021-10-07 MX MX2024015908A patent/MX2024015908A/en unknown
-
2024
- 2024-08-28 JP JP2024146085A patent/JP2024174908A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021020319A2 (en) | 2021-12-14 |
| JP2024174908A (en) | 2024-12-17 |
| AU2020272057A1 (en) | 2021-11-04 |
| EP3952842A1 (en) | 2022-02-16 |
| MX2024015908A (en) | 2025-02-10 |
| AU2020272057B2 (en) | 2025-11-13 |
| JP2022526649A (en) | 2022-05-25 |
| JP7547364B2 (en) | 2024-09-09 |
| CA3136619A1 (en) | 2020-10-15 |
| KR20220025703A (en) | 2022-03-03 |
| IL287091A (en) | 2021-12-01 |
| WO2020210720A1 (en) | 2020-10-15 |
| MX2021012364A (en) | 2022-01-18 |
| EP3952842A4 (en) | 2023-01-11 |
| CA3275626A1 (en) | 2025-10-30 |
| CN114040752A (en) | 2022-02-11 |
| US20220168665A1 (en) | 2022-06-02 |
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