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SG11202111186TA - Process for making drug crystals of desired size distribution and morphology - Google Patents

Process for making drug crystals of desired size distribution and morphology

Info

Publication number
SG11202111186TA
SG11202111186TA SG11202111186TA SG11202111186TA SG11202111186TA SG 11202111186T A SG11202111186T A SG 11202111186TA SG 11202111186T A SG11202111186T A SG 11202111186TA SG 11202111186T A SG11202111186T A SG 11202111186TA SG 11202111186T A SG11202111186T A SG 11202111186TA
Authority
SG
Singapore
Prior art keywords
morphology
size distribution
desired size
drug crystals
making drug
Prior art date
Application number
SG11202111186TA
Inventor
Azadeh Goudarzi
Troy Loss
Michael Gaines
Gina Stetsko
Amanda Malone
Original Assignee
Eupraxia Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eupraxia Pharmaceuticals Inc filed Critical Eupraxia Pharmaceuticals Inc
Publication of SG11202111186TA publication Critical patent/SG11202111186TA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/0059General arrangements of crystallisation plant, e.g. flow sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5026Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089Processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/004Fractional crystallisation; Fractionating or rectifying columns
    • B01D9/0045Washing of crystals, e.g. in wash columns
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B07SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07BSEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
    • B07B13/00Grading or sorting solid materials by dry methods, not otherwise provided for; Sorting articles otherwise than by indirectly controlled devices
    • B07B13/04Grading or sorting solid materials by dry methods, not otherwise provided for; Sorting articles otherwise than by indirectly controlled devices according to size
    • CCHEMISTRY; METALLURGY
    • C30CRYSTAL GROWTH
    • C30BSINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54Organic compounds
    • CCHEMISTRY; METALLURGY
    • C30CRYSTAL GROWTH
    • C30BSINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B33/00After-treatment of single crystals or homogeneous polycrystalline material with defined structure
    • CCHEMISTRY; METALLURGY
    • C30CRYSTAL GROWTH
    • C30BSINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C30B7/02Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent
    • C30B7/06Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent using non-aqueous solvents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Glanulating (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
SG11202111186TA 2019-04-10 2020-04-10 Process for making drug crystals of desired size distribution and morphology SG11202111186TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962832179P 2019-04-10 2019-04-10
PCT/US2020/027797 WO2020210720A1 (en) 2019-04-10 2020-04-10 Process for making drug crystals of desired size distribution and morphology

Publications (1)

Publication Number Publication Date
SG11202111186TA true SG11202111186TA (en) 2021-11-29

Family

ID=72752032

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202111186TA SG11202111186TA (en) 2019-04-10 2020-04-10 Process for making drug crystals of desired size distribution and morphology

Country Status (12)

Country Link
US (1) US20220168665A1 (en)
EP (1) EP3952842A4 (en)
JP (2) JP7547364B2 (en)
KR (1) KR20220025703A (en)
CN (1) CN114040752A (en)
AU (1) AU2020272057B2 (en)
BR (1) BR112021020319A2 (en)
CA (2) CA3275626A1 (en)
IL (1) IL287091A (en)
MX (2) MX2021012364A (en)
SG (1) SG11202111186TA (en)
WO (1) WO2020210720A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119968199A (en) 2022-10-04 2025-05-09 优普顺药物公司 Use of long-acting fluticasone propionate injection suspension for treating and preventing gastrointestinal inflammation

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1329316A (en) * 1970-12-08 1973-09-05 Kerr Mc Gee Chem Corp Process for automatic control of crystal size distribution
JPS50132117A (en) * 1974-04-09 1975-10-20
EP0447858B1 (en) * 1990-03-20 1995-05-24 Asea Brown Boveri Ag Process for producing an oxide dispersion strengthened superalloy article having a coarse grain structure directionally orientated along the length
JP3807086B2 (en) * 1998-03-23 2006-08-09 味の素株式会社 Particle size distribution controlled crystallization method
ATE389455T1 (en) * 2000-05-10 2008-04-15 Jagotec Ag GRINDING BY MEANS OF GRINDING MEDIUM
CN1960708A (en) * 2003-07-22 2007-05-09 巴克斯特国际公司 Small spherical particles of low molecular weight organic molecules and preparation methods and use thereof
US20060078573A1 (en) * 2004-06-11 2006-04-13 Theodore Randolph Methods of modifying crystal habit
JP2006241391A (en) * 2005-03-07 2006-09-14 Polyplastics Co Low dielectric constant organic composite
JP5197564B2 (en) * 2006-03-14 2013-05-15 メルク・シャープ・エンド・ドーム・コーポレイション Method for producing organic crystal fine particle composition by fine grinding and crystallization with fine seeds
CN101757634A (en) * 2008-11-28 2010-06-30 天津金耀集团有限公司 Nasal medicine composition enclosing fluticasone propionate by cyclodextrin
CN103649104A (en) * 2011-07-08 2014-03-19 辉瑞股份有限公司 Process for the preparation of fluticasone propionate form 1
IL287731B2 (en) * 2013-03-21 2025-05-01 Eupraxia Pharmaceuticals USA LLC Injectable sustained release compositions for treating inflammation in joints and pain associated therewith
KR20180038571A (en) * 2014-06-20 2018-04-16 아비라겐 테라퓨틱스, 인코포레이티드 Anhydrous crystalline free base form of [2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy]-3-ethoxy-1,2-benzisoxazole
WO2016044799A1 (en) * 2014-09-19 2016-03-24 Eupraxia Pharmaceuticals Inc. Injectable microparticles for hyper-localized release of therapeutic agents
ES2672993T3 (en) * 2015-10-27 2018-06-19 Eupraxia Pharmaceuticals Inc. Sustained release formulations of local anesthetics

Also Published As

Publication number Publication date
BR112021020319A2 (en) 2021-12-14
JP2024174908A (en) 2024-12-17
AU2020272057A1 (en) 2021-11-04
EP3952842A1 (en) 2022-02-16
MX2024015908A (en) 2025-02-10
AU2020272057B2 (en) 2025-11-13
JP2022526649A (en) 2022-05-25
JP7547364B2 (en) 2024-09-09
CA3136619A1 (en) 2020-10-15
KR20220025703A (en) 2022-03-03
IL287091A (en) 2021-12-01
WO2020210720A1 (en) 2020-10-15
MX2021012364A (en) 2022-01-18
EP3952842A4 (en) 2023-01-11
CA3275626A1 (en) 2025-10-30
CN114040752A (en) 2022-02-11
US20220168665A1 (en) 2022-06-02

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