SG11202012554QA - Tertiary amine substituted coumarin compounds and their uses as fluorescent labels - Google Patents
Tertiary amine substituted coumarin compounds and their uses as fluorescent labelsInfo
- Publication number
- SG11202012554QA SG11202012554QA SG11202012554QA SG11202012554QA SG11202012554QA SG 11202012554Q A SG11202012554Q A SG 11202012554QA SG 11202012554Q A SG11202012554Q A SG 11202012554QA SG 11202012554Q A SG11202012554Q A SG 11202012554QA SG 11202012554Q A SG11202012554Q A SG 11202012554QA
- Authority
- SG
- Singapore
- Prior art keywords
- tertiary amine
- fluorescent labels
- amine substituted
- coumarin compounds
- substituted coumarin
- Prior art date
Links
- 125000000332 coumarinyl group Chemical class O1C(=O)C(=CC2=CC=CC=C12)* 0.000 title 1
- 125000001302 tertiary amino group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
- C09B57/02—Coumarine dyes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Chemical Kinetics & Catalysis (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962812732P | 2019-03-01 | 2019-03-01 | |
| PCT/EP2020/055257 WO2020178165A1 (en) | 2019-03-01 | 2020-02-28 | Tertiary amine substituted coumarin compounds and their uses as fluorescent labels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202012554QA true SG11202012554QA (en) | 2021-01-28 |
Family
ID=69723946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202012554QA SG11202012554QA (en) | 2019-03-01 | 2020-02-28 | Tertiary amine substituted coumarin compounds and their uses as fluorescent labels |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US12110546B2 (en) |
| EP (1) | EP3931190A1 (en) |
| JP (2) | JP2022521866A (en) |
| KR (1) | KR102865446B1 (en) |
| CN (1) | CN112654614A (en) |
| AU (1) | AU2020233166B2 (en) |
| BR (1) | BR112020026669A2 (en) |
| CA (1) | CA3103636A1 (en) |
| IL (1) | IL279660B2 (en) |
| MX (1) | MX2020013416A (en) |
| SG (1) | SG11202012554QA (en) |
| WO (1) | WO2020178165A1 (en) |
| ZA (1) | ZA202007843B (en) |
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| US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
| WO2020264182A1 (en) * | 2019-06-25 | 2020-12-30 | Hemex Health, Inc. | Diagnostics systems and methods |
| IL292961B2 (en) | 2019-11-27 | 2024-01-01 | Illumina Cambridge Ltd | Cyclotetraenes contain dyes and their compounds |
| CN120174072A (en) | 2020-06-22 | 2025-06-20 | 伊鲁米纳剑桥有限公司 | Nucleosides and nucleotides with 3' acetal capping groups |
| US11981964B2 (en) | 2020-07-28 | 2024-05-14 | Illumina Cambridge Limited | Substituted coumarin dyes and uses as fluorescent labels |
| US20220195516A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
| US20220195518A1 (en) | 2020-12-22 | 2022-06-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing |
| CN112778235B (en) * | 2021-01-11 | 2024-05-17 | 中国科学技术大学 | Novel FRET donor-acceptor pairs and their applications |
| WO2022243480A1 (en) | 2021-05-20 | 2022-11-24 | Illumina, Inc. | Compositions and methods for sequencing by synthesis |
| US20220403450A1 (en) | 2021-06-03 | 2022-12-22 | Illumina Software, Inc. | Systems and methods for sequencing nucleotides using two optical channels |
| KR20240049214A (en) | 2021-09-01 | 2024-04-16 | 일루미나, 인코포레이티드 | Amplitude modulation for accelerated base calling |
| US20230183799A1 (en) | 2021-12-10 | 2023-06-15 | Illumina, Inc. | Parallel sample and index sequencing |
| WO2023175021A1 (en) | 2022-03-15 | 2023-09-21 | Illumina, Inc. | Methods of preparing loop fork libraries |
| CA3223115A1 (en) | 2022-03-28 | 2023-10-05 | Xiaolin Wu | Labeled avidin and methods for sequencing |
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| EP4499870A1 (en) | 2022-03-31 | 2025-02-05 | Illumina, Inc. | Compositions and methods for improving sequencing signals |
| EP4499659A1 (en) | 2022-03-31 | 2025-02-05 | Illumina, Inc. | Nucleosides and nucleotides with 3' vinyl blocking group useful in sequencing by synthesis |
| AU2023281871A1 (en) | 2022-05-31 | 2024-11-14 | Illumina, Inc | Compositions and methods for nucleic acid sequencing |
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| JP7721089B2 (en) * | 2022-12-09 | 2025-08-12 | 本田技研工業株式会社 | Sound processing device, sound processing method and program |
| CN119095983A (en) | 2022-12-22 | 2024-12-06 | 伊路米纳有限公司 | Transition metal catalyst compositions and methods for sequencing by synthesis |
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| EP4642931A1 (en) | 2022-12-27 | 2025-11-05 | Illumina, Inc. | Methods of sequencing using 3´ allyl blocked nucleotides |
| CN119452044A (en) | 2023-03-29 | 2025-02-14 | 因美纳公司 | Naphthalimide dyes and their use in nucleic acid sequencing |
| US20240327909A1 (en) | 2023-03-30 | 2024-10-03 | Illumina, Inc. | Compositions and methods for nucleic acid sequencing |
| WO2025049700A1 (en) | 2023-08-31 | 2025-03-06 | Illumina, Inc. | Compositions and methods for nucleic acid sequencing |
| WO2025061922A1 (en) | 2023-09-20 | 2025-03-27 | Illumina, Inc. | Methods for sequencing |
| WO2025061942A1 (en) | 2023-09-20 | 2025-03-27 | Illumina, Inc. | Sequencing error identification and correction |
| WO2025090596A1 (en) | 2023-10-26 | 2025-05-01 | Illumina, Inc. | 4,5-substituted naphthalimide dyes and uses in nucleic acid sequencing |
| WO2025106715A1 (en) | 2023-11-17 | 2025-05-22 | Illumina, Inc. | Conjugated polymers or polymer dots as fluorescent labels |
| WO2025136890A1 (en) | 2023-12-18 | 2025-06-26 | Illumina, Inc. | Hydrogel nanoparticles as labeling scaffold in sequencing |
| WO2025144716A1 (en) | 2023-12-28 | 2025-07-03 | Illumina, Inc. | Nucleotides with enzymatically cleavable 3'-o-glycoside blocking groups for sequencing |
| WO2025184226A1 (en) | 2024-02-28 | 2025-09-04 | Illumina, Inc. | Nucleotides with terminal phosphate capping |
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-
2020
- 2020-02-28 KR KR1020207037219A patent/KR102865446B1/en active Active
- 2020-02-28 SG SG11202012554QA patent/SG11202012554QA/en unknown
- 2020-02-28 MX MX2020013416A patent/MX2020013416A/en unknown
- 2020-02-28 AU AU2020233166A patent/AU2020233166B2/en active Active
- 2020-02-28 JP JP2020572442A patent/JP2022521866A/en active Pending
- 2020-02-28 BR BR112020026669-8A patent/BR112020026669A2/en unknown
- 2020-02-28 CA CA3103636A patent/CA3103636A1/en active Pending
- 2020-02-28 US US16/805,125 patent/US12110546B2/en active Active
- 2020-02-28 IL IL279660A patent/IL279660B2/en unknown
- 2020-02-28 WO PCT/EP2020/055257 patent/WO2020178165A1/en not_active Ceased
- 2020-02-28 CN CN202080003505.7A patent/CN112654614A/en active Pending
- 2020-02-28 EP EP20707631.6A patent/EP3931190A1/en active Pending
- 2020-12-15 ZA ZA2020/07843A patent/ZA202007843B/en unknown
-
2024
- 2024-05-02 JP JP2024074722A patent/JP2024109629A/en active Pending
- 2024-09-11 US US18/882,446 patent/US20250002994A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3931190A1 (en) | 2022-01-05 |
| IL279660B2 (en) | 2024-10-01 |
| US20250002994A1 (en) | 2025-01-02 |
| IL279660B1 (en) | 2024-06-01 |
| CN112654614A (en) | 2021-04-13 |
| KR20210134210A (en) | 2021-11-09 |
| ZA202007843B (en) | 2025-04-30 |
| US20200277670A1 (en) | 2020-09-03 |
| JP2022521866A (en) | 2022-04-13 |
| IL279660A (en) | 2021-03-01 |
| KR102865446B1 (en) | 2025-09-29 |
| CA3103636A1 (en) | 2020-09-10 |
| WO2020178165A1 (en) | 2020-09-10 |
| JP2024109629A (en) | 2024-08-14 |
| AU2020233166A1 (en) | 2021-01-07 |
| BR112020026669A2 (en) | 2021-09-08 |
| US12110546B2 (en) | 2024-10-08 |
| MX2020013416A (en) | 2021-04-28 |
| AU2020233166B2 (en) | 2025-11-13 |
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