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SG11202003833TA - Antibody variant and isoform with lowered biological activity - Google Patents

Antibody variant and isoform with lowered biological activity

Info

Publication number
SG11202003833TA
SG11202003833TA SG11202003833TA SG11202003833TA SG11202003833TA SG 11202003833T A SG11202003833T A SG 11202003833TA SG 11202003833T A SG11202003833T A SG 11202003833TA SG 11202003833T A SG11202003833T A SG 11202003833TA SG 11202003833T A SG11202003833T A SG 11202003833TA
Authority
SG
Singapore
Prior art keywords
isoform
biological activity
antibody variant
lowered biological
lowered
Prior art date
Application number
SG11202003833TA
Other languages
English (en)
Inventor
Kensaku Hosoguchi
Maki Kuwayama
Chifumi Seida
Yosuke Watanabe
Nobuyuki Tanaka
Satoshi Saitoh
Masakazu Fukuda
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of SG11202003833TA publication Critical patent/SG11202003833TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11202003833TA 2017-11-01 2018-10-31 Antibody variant and isoform with lowered biological activity SG11202003833TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017212179 2017-11-01
PCT/JP2018/040436 WO2019088143A1 (fr) 2017-11-01 2018-10-31 Variant d'anticorps et isoforme à activité biologique réduite

Publications (1)

Publication Number Publication Date
SG11202003833TA true SG11202003833TA (en) 2020-05-28

Family

ID=66331990

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202003833TA SG11202003833TA (en) 2017-11-01 2018-10-31 Antibody variant and isoform with lowered biological activity

Country Status (18)

Country Link
US (2) US12421322B2 (fr)
EP (1) EP3705496A4 (fr)
JP (2) JPWO2019088143A1 (fr)
KR (1) KR20200074209A (fr)
CN (2) CN111479829B (fr)
AR (1) AR113816A1 (fr)
AU (1) AU2018361430B2 (fr)
BR (1) BR112020008393A2 (fr)
CA (1) CA3079053A1 (fr)
CL (1) CL2020001113A1 (fr)
CR (2) CR20240273A (fr)
IL (1) IL274265B1 (fr)
MA (1) MA50534A (fr)
MX (1) MX2020003472A (fr)
PE (1) PE20210553A1 (fr)
SA (1) SA520411871B1 (fr)
SG (1) SG11202003833TA (fr)
WO (1) WO2019088143A1 (fr)

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EP2006381B1 (fr) 2006-03-31 2016-02-03 Chugai Seiyaku Kabushiki Kaisha Procédé de régulation de la pharmacocinétique sanguine des anticorps
CA2700701C (fr) 2007-09-26 2020-12-29 Chugai Seiyaku Kabushiki Kaisha Procede permettant de modifier le point isoelectrique d'un anticorps par substitution d'acide amine dans une region determinant la complementarite (cdr)
AR080428A1 (es) 2010-01-20 2012-04-11 Chugai Pharmaceutical Co Ltd Formulaciones liquidas estabilizadas contentivas de anticuerpos
TWI700300B (zh) 2014-09-26 2020-08-01 日商中外製藥股份有限公司 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體
WO2016159213A1 (fr) 2015-04-01 2016-10-06 中外製薬株式会社 Procédé pour la production d'un hétéro-oligomère polypeptidique
EP3395835B1 (fr) 2015-12-25 2021-02-03 Chugai Seiyaku Kabushiki Kaisha Anticorps présentant une activité accrue et son procédé de modification
MX2018007781A (es) 2015-12-28 2018-09-05 Chugai Pharmaceutical Co Ltd Metodo para promover la eficiencia de purificacion del polipeptido que contiene la region de fragmento cristalizable (fc).
EP3449940B1 (fr) 2016-04-28 2025-11-19 Chugai Seiyaku Kabushiki Kaisha Préparation contenant un anticorps
CA3035327A1 (fr) 2016-09-06 2018-03-15 Chugai Seiyaku Kabushiki Kaisha Procedes d'utilisation d'un anticorps bispecifique qui reconnait le facteur de coagulation ix et/ou le facteur de coagulation ix active et le facteur de coagulation x et/ou le facteur de coagulation x active
BR112020008393A2 (pt) 2017-11-01 2020-11-03 Chugai Seiyaku Kabushiki Kaisha variante e isoforma de anticorpos com atividade biológica reduzida
WO2021091932A1 (fr) * 2019-11-07 2021-05-14 Amgen Inc. Conditionnement de charge à teneur élevée en sel pendant une chromatographie par échange de cations pour éliminer des impuretés liées au produit
WO2023021311A1 (fr) * 2021-08-20 2023-02-23 Takeda Pharmaceutical Company Limited Mesure sélective du facteur viii humain
JP2023159309A (ja) * 2021-12-22 2023-10-31 中外製薬株式会社 生物活性が低下した抗体バリアント
TW202340249A (zh) * 2021-12-22 2023-10-16 日商中外製藥股份有限公司 生物活性降低之抗體變體
CN114544839B (zh) * 2022-01-20 2024-08-20 未名生物医药有限公司 一种抗人神经生长因子抗体的电荷变异体检测方法

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TW202207984A (zh) 2019-10-11 2022-03-01 日商中外製藥股份有限公司 用於後天性血友病a之預防及/或治療之醫藥組成物、及包含該醫藥組成物之製品

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CN111479829A (zh) 2020-07-31
WO2019088143A1 (fr) 2019-05-09
IL274265A (en) 2020-06-30
JP7777114B2 (ja) 2025-11-27
TW201930352A (zh) 2019-08-01
CN119161488A (zh) 2024-12-20
CA3079053A1 (fr) 2019-05-09
CL2020001113A1 (es) 2020-11-20
RU2020117440A (ru) 2021-12-01
BR112020008393A2 (pt) 2020-11-03
MX2020003472A (es) 2020-08-03
JPWO2019088143A1 (ja) 2020-11-12
AU2018361430A1 (en) 2020-06-11
CR20240273A (es) 2024-08-27
MA50534A (fr) 2020-09-09
US12421322B2 (en) 2025-09-23
CR20200229A (es) 2020-07-12
KR20200074209A (ko) 2020-06-24
AU2018361430B2 (en) 2025-08-14
RU2020117440A3 (fr) 2022-04-01
EP3705496A1 (fr) 2020-09-09
SA520411871B1 (ar) 2023-12-19
JP2024037761A (ja) 2024-03-19
AR113816A1 (es) 2020-06-17
PE20210553A1 (es) 2021-03-17
EP3705496A4 (fr) 2021-12-08
US20250382390A1 (en) 2025-12-18
US20200283544A1 (en) 2020-09-10
CN111479829B (zh) 2024-10-22
IL274265B1 (en) 2025-09-01

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