SG11201912267SA - Nicotinamide riboside derivatives and their uses - Google Patents
Nicotinamide riboside derivatives and their usesInfo
- Publication number
- SG11201912267SA SG11201912267SA SG11201912267SA SG11201912267SA SG11201912267SA SG 11201912267S A SG11201912267S A SG 11201912267SA SG 11201912267S A SG11201912267S A SG 11201912267SA SG 11201912267S A SG11201912267S A SG 11201912267SA SG 11201912267S A SG11201912267S A SG 11201912267SA
- Authority
- SG
- Singapore
- Prior art keywords
- nicotinamide riboside
- riboside derivatives
- derivatives
- nicotinamide
- riboside
- Prior art date
Links
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical class NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762521717P | 2017-06-19 | 2017-06-19 | |
| PCT/US2018/038201 WO2018236814A2 (fr) | 2017-06-19 | 2018-06-19 | Dérivés de nicotinamide riboside et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201912267SA true SG11201912267SA (en) | 2020-01-30 |
Family
ID=62875307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201912267SA SG11201912267SA (en) | 2017-06-19 | 2018-06-19 | Nicotinamide riboside derivatives and their uses |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11286274B2 (fr) |
| EP (1) | EP3642214A2 (fr) |
| SG (1) | SG11201912267SA (fr) |
| WO (1) | WO2018236814A2 (fr) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20200138921A1 (en) * | 2017-06-23 | 2020-05-07 | The Trustees Of Columbia University In The City Of New York | Methods of preventing and treating diseases characterized by synaptic dysfunction and neurodegeneration including alzheimer's disease |
| WO2019089417A1 (fr) * | 2017-10-30 | 2019-05-09 | Elysium Health, Inc. | Méthodes et compositions pour le traitement de la fibrose kystique |
| US20200384004A1 (en) * | 2017-12-01 | 2020-12-10 | Elysium Health, Inc. | Methods and compositions for treating glaucoma |
| CN108841781A (zh) * | 2018-06-13 | 2018-11-20 | 延边大学 | 藏红花素在提高猪卵母细胞抗氧化能力及卵裂率中的应用 |
| US11833167B2 (en) | 2018-12-17 | 2023-12-05 | Mitopower Llc | Nicotinyl riboside compounds and their uses |
| US11266696B2 (en) * | 2019-01-18 | 2022-03-08 | Americord Registry Llc | Method of treating stem cells with NAD |
| CN109674808A (zh) * | 2019-01-30 | 2019-04-26 | 四川大学 | β-烟酰胺单核苷酸或其前体在制备延缓肺衰老药物中的用途 |
| WO2020176445A1 (fr) * | 2019-02-26 | 2020-09-03 | Universitat De Valencia-Estudi General | Méthodes et compositions pour le traitement de maladies des motoneurones |
| WO2020190703A1 (fr) * | 2019-03-21 | 2020-09-24 | Elysium Health, Inc. | Méthodes pour le traitement de plaies |
| US20220125814A1 (en) * | 2019-03-21 | 2022-04-28 | Fred Hutchinson Cancer Research Center | Cancer combination therapies utilizing a nicotinamide phosphoribosyltransferase inhibitor in combination with a nicotinamide adenine dinucleotide salvage pathway precursor |
| EP3946306A2 (fr) * | 2019-03-29 | 2022-02-09 | Société des Produits Nestlé S.A. | Compositions et méthodes d'augmentation de la fonction des lymphocytes t |
| WO2020245187A1 (fr) * | 2019-06-05 | 2020-12-10 | Société des Produits Nestlé S.A. | Nicotinamide ribosides réduits pour traiter ou prévenir une maladie rénale |
| EP3980028A1 (fr) * | 2019-06-05 | 2022-04-13 | Société des Produits Nestlé S.A. | Nicotinamide ribosides réduits pour traiter/prévenir une maladie de muscle squelettique |
| BR112021021726A2 (pt) * | 2019-06-05 | 2021-12-28 | Nestle Sa | Ribosídeos de nicotinamida reduzidos para tratamento/prevenção de doença hepática |
| WO2020257283A1 (fr) * | 2019-06-18 | 2020-12-24 | Mitopower Llc | Composés nicotinyl riboside et leurs utilisations |
| CA3145870A1 (fr) * | 2019-07-26 | 2021-02-04 | Hampar L. Karageozian | Peptides pour le traitement de la degenerescence maculaire non-exsudative et d'autres troubles de l'?il |
| CN110483648A (zh) * | 2019-08-27 | 2019-11-22 | 南京安吉生物科技有限公司 | 一种融合多肽及其应用 |
| FR3102058A1 (fr) * | 2019-10-18 | 2021-04-23 | Nuvamid Sa | Utilisation de NMN pour la prévention et/ou le traitement de la polyarthrite rhumatoïde et compositions correspondantes |
| IL292350A (en) | 2019-10-30 | 2022-06-01 | Perfuse Therapeutics Inc | Treatment of ocular diseases using endothelin receptor antagonists |
| CN113490676A (zh) * | 2019-11-19 | 2021-10-08 | 清华大学 | Nmn衍生物的合成方法和nmn及其衍生物的医学应用 |
| US20230096443A1 (en) * | 2019-12-20 | 2023-03-30 | Nuvamid Sa | Novel nicotinamide di-nucleotide derivatives and use thereof |
| IL294873A (en) | 2020-02-06 | 2022-09-01 | Perfuse Therapeutics Inc | Preparations for the treatment of eye diseases |
| EP4114429A2 (fr) * | 2020-03-06 | 2023-01-11 | Allegro Pharmaceuticals, LLC | Traitements pour améliorer ou diminuer la dégradation de la fonction mitochondriale |
| WO2021180740A1 (fr) * | 2020-03-09 | 2021-09-16 | Société des Produits Nestlé S.A. | Compositions et procédés faisant appel à du nicotinamide riboside réduit pour la prévention et le traitement de maladies et d'affections pulmonaires |
| WO2021180741A1 (fr) * | 2020-03-09 | 2021-09-16 | Société des Produits Nestlé S.A. | Compositions contenant un nicotinamide riboside et méthodes destinées à la prévention et au traitement des maladies et affections pancréatiques |
| FR3108502B1 (fr) * | 2020-03-27 | 2022-09-23 | Nuvamid Sa | Dérivés de nicotinamide mononucléotides dans le traitement et la prévention des infections bactériennes |
| US20230117880A1 (en) * | 2020-03-30 | 2023-04-20 | Oriental Yeast Co., Ltd. | Chromosome-stabilizing agent for stem cells |
| CN111454311B (zh) | 2020-04-03 | 2021-10-19 | 深圳市迪克曼科技开发有限公司 | 烟酰胺核糖的有机酸盐及其组合物与制备方法 |
| US20210353656A1 (en) * | 2020-05-12 | 2021-11-18 | Nuvamid Sa | Combination of nicotinamide mononucleotide derivatives and histamine h2 receptor antagonists for viral infections |
| EP3949964A1 (fr) * | 2020-08-06 | 2022-02-09 | Nuvamid SA | Combinaison de dérivés de nicotinamide mononucléotidique et d'autres agents thérapeutiques pour leur utilisation dans le traitement des infections virales |
| WO2022029275A1 (fr) * | 2020-08-06 | 2022-02-10 | Nuvamid Sa | Combinaison de dérivés de nicotinamide mononucléotide et d'autres agents thérapeutiques destinée à être utilisée dans le traitement d'infections à coronavirus et de la covid-19 |
| CN112500445B (zh) * | 2020-12-04 | 2022-11-29 | 黄冈鲁班药业股份有限公司 | β-烟酰胺核糖的制备方法 |
| CN113274363B (zh) * | 2021-04-29 | 2023-02-10 | 珠海润都制药股份有限公司 | 一种吲达帕胺制剂 |
| EP4329753A4 (fr) | 2021-04-30 | 2025-02-26 | Perfuse Therapeutics, Inc. | Compositions pharmaceutiques et systèmes d'administration intravitréenne de médicament pour le traitement de maladies oculaires |
| CA3224544A1 (fr) * | 2021-06-18 | 2022-12-22 | Mitopower Llc | Traitement de troubles lies a l'immunite, de troubles renaux, de troubles hepatiques, de troubles hemolytiques et de troubles lies au stress oxydatif a l'aide de nrh, narh et de leurs derives reduits |
| WO2022269064A1 (fr) * | 2021-06-24 | 2022-12-29 | Vestlandets Innovasjonsselskap As (Vis) | Traitement d'augmentation de nad pour la maladie de parkinson |
| EP4440590A4 (fr) * | 2021-12-01 | 2025-11-12 | Univ Florida | Approche thérapeutique combinatoire pour l'ataxie de friedreich |
| CN115232184B (zh) * | 2021-12-06 | 2024-07-05 | 宁波熙健医药科技有限公司 | 呋喃核糖基吡啶衍生物及其药物组合物和用途 |
| CN118922189A (zh) * | 2022-03-02 | 2024-11-08 | 线粒体能量有限公司 | 衍生自烟酸和核糖的新型前药 |
| WO2024050120A2 (fr) * | 2022-09-02 | 2024-03-07 | The Regents Of The University Of California | Combinaisons de nicotinamide-riboside et de ptérostilbène pour traiter l'arthrose |
| WO2024123296A1 (fr) * | 2022-12-07 | 2024-06-13 | Atatürk Üni̇versi̇tesi̇ Rektörlüğü Bi̇li̇msel Araştirma Projeleri̇ (Bap) Koordi̇nasyon Bi̇ri̇mi̇ | Composé contenant du nicotinamide riboside pour inhiber la formation de kystes et induire l'ovulation dans le syndrome des ovaires polykystiques |
| WO2025024484A1 (fr) * | 2023-07-25 | 2025-01-30 | Duke University | Compositions et méthodes pour traiter le cancer du sang |
| WO2025059572A1 (fr) * | 2023-09-15 | 2025-03-20 | University Of Washington | Réparation d'adn à travers l'administration nanothérapeutique de nad+ et de précurseurs de nad+ |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB1190079A (en) | 1966-07-29 | 1970-04-29 | Kyowa Hakko Kogyo Company Ltd | Process for producing Nicotinamide Adenine Dinucleotide |
| US6589948B1 (en) | 2000-11-28 | 2003-07-08 | Eukarion, Inc. | Cyclic salen-metal compounds: reactive oxygen species scavengers useful as antioxidants in the treatment and prevention of diseases |
| CA2530407A1 (fr) | 2003-07-23 | 2005-02-03 | The Regents Of The University Of California | Combinaisons d'amplificateurs de penetration pour administration transdermique |
| EP1723227A4 (fr) | 2004-02-10 | 2007-09-19 | Dartmouth College | Compositions de nicotinamide riboside kinase et procedes d'utilisation |
| US20060229265A1 (en) | 2005-03-30 | 2006-10-12 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| US20070099830A1 (en) * | 2005-04-21 | 2007-05-03 | Massachusetts Institute Of Technology | Sirt4 activities |
| US20130216542A1 (en) | 2005-05-06 | 2013-08-22 | Zymogenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
| EP3369738B1 (fr) | 2005-11-18 | 2020-05-20 | Cornell Research Foundation, Inc. | Procédé de préparation de nicotinates de riboside et de nicotinamide-beta-riboside |
| JP2011518200A (ja) | 2008-04-22 | 2011-06-23 | メルク フロスト カナダ リミテツド | ステアロイル−補酵素aデルタ−9デサチュラーゼの阻害剤としての新規な置換複素環式芳香族化合物 |
| EP2307378A1 (fr) | 2008-06-18 | 2011-04-13 | Pfizer Limited | Dérivés de nicotinamide |
| US20140065099A1 (en) * | 2011-02-15 | 2014-03-06 | Ecole Polytechnique Federale De Lausanne (Epfl) | Methods of Treating Mitochondrial Dysfunction |
| RU2015143836A (ru) | 2013-03-15 | 2017-04-27 | Нусерт Сайенсиз, Инк. | Лейцин и никотиновая кислота для снижения уровня липидов |
| GB201313465D0 (en) | 2013-07-29 | 2013-09-11 | Queens University Of The Belfast | Methods of preparing nicotinamide riboside and derivatives thereof |
| CN105873937A (zh) | 2013-10-30 | 2016-08-17 | 可劳迈戴斯有限公司 | 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物 |
| US10316054B2 (en) | 2014-06-02 | 2019-06-11 | Glaxosmithkline Intellectual Property (No. 2) Limited | Preparation and use of crystalline beta-D-nicotinamide riboside |
| JP6559713B2 (ja) | 2014-06-06 | 2019-08-14 | グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited | ニコチンアミドリボシド類似体ならびにその医薬組成物および使用 |
| CN106715454B (zh) | 2014-07-24 | 2020-06-16 | 格雷斯公司 | 烟酰胺核苷的结晶形式 |
| EP2979706A1 (fr) * | 2014-07-30 | 2016-02-03 | Fundación Centro Nacional De Investigaciones Oncológicas Carlos III | Procédés pour le traitement du cancer du foie ou du pancréas |
| WO2016122832A1 (fr) | 2015-01-30 | 2016-08-04 | Natural Formulations | Compositions, méthodes thérapeutiques et prophylactiques pour le traitement de maladies neurodégénératives et de lésions cérébrales |
| FI3268379T3 (fi) | 2015-03-09 | 2023-12-15 | Grace W R & Co | Nikotiiniamidiribosidin kiteinen muoto |
| BR112017019696A2 (pt) | 2015-03-16 | 2018-09-04 | ChromaDex Inc. | composto e usos de um composto |
| AU2016271481A1 (en) | 2015-06-04 | 2017-12-14 | Chromadex, Inc. | Selective solvent free phosphorylation |
| WO2017011788A1 (fr) * | 2015-07-15 | 2017-01-19 | Cornell University | Synthèses, activités et procédés d'utilisation de dérivés du dihydronicotinamide riboside |
| KR102354784B1 (ko) | 2015-08-05 | 2022-01-25 | 메트로 인터내셔널 바이오테크 엘엘씨 | 니코틴아미드 모노뉴클레오티드 유도체 및 그 용도 |
| IL299824B2 (en) | 2015-10-07 | 2024-02-01 | Huizenga Joel | Resetting biological pathways for defending against and repairing deterioration from human aging |
| WO2017079195A1 (fr) | 2015-11-02 | 2017-05-11 | Mitobridge, Inc. | Nicotinamide riboside et dérivés de nicotinamide mononucléotidique utiles dans les traitements de maladies associées aux mitochondries |
| WO2017109195A1 (fr) | 2015-12-24 | 2017-06-29 | Amazentis Sa | Compositions comprenant un riboside de nicotinamide et une urolithine |
| AU2017232930B2 (en) | 2016-03-16 | 2021-03-25 | ChromaDex Inc. | B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof |
| ES2981479T3 (es) | 2016-04-14 | 2024-10-09 | Chromadex Inc | Fórmula para lactantes que comprende ribósido de nicotinamida |
| NZ747693A (en) | 2016-04-20 | 2023-07-28 | Chromadex Inc | Use of nicotinic acid riboside or nicotinamide riboside derivatives, and reduced derivatives thereof, as nad+increasing precursors |
| WO2017218580A1 (fr) | 2016-06-14 | 2017-12-21 | Rejuvenation Therapeutics Corporation | Procédés synthétiques pour la préparation de nicotinamide riboside et de composés apparentés |
| EP3478297A1 (fr) | 2016-06-30 | 2019-05-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions pharmaceutiques pour le traitement de cardiomyopathies |
| GB2553001A (en) | 2016-08-19 | 2018-02-21 | The Queen's Univ Of Belfast | Lactone intermediates of nicotinamide riboside and nicotinate riboside |
| CN109982706A (zh) | 2016-08-22 | 2019-07-05 | 益力舒健康公司 | 用于治疗神经退行性病症的烟酰胺核苷和紫檀芪的组合物和方法 |
| WO2018089830A1 (fr) | 2016-11-11 | 2018-05-17 | The Queen's University Of Belfast | Synthèses efficaces et évolutives de nicotinoyle ribosides et de nicotinoyle ribosides réduits, de leurs dérivés modifiés, de leurs analogues phosphorylés, de leurs conjugués avec de l'adénylyle dinucléotide et de nouvelles formes cristallines de ceux-ci |
| BR112019010607B1 (pt) | 2016-11-29 | 2023-10-31 | University Of Iowa Research Foundation | Uso de precursores de nad e composição compreendendo os referidos precursores |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| CN110769834A (zh) | 2017-03-17 | 2020-02-07 | 益力舒健康公司 | 用于治疗或预防肝损伤的烟酰胺核苷 |
-
2018
- 2018-06-19 EP EP18740009.8A patent/EP3642214A2/fr active Pending
- 2018-06-19 WO PCT/US2018/038201 patent/WO2018236814A2/fr not_active Ceased
- 2018-06-19 US US16/012,004 patent/US11286274B2/en active Active
- 2018-06-19 SG SG11201912267SA patent/SG11201912267SA/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11286274B2 (en) | 2022-03-29 |
| EP3642214A2 (fr) | 2020-04-29 |
| WO2018236814A2 (fr) | 2018-12-27 |
| WO2018236814A3 (fr) | 2019-02-07 |
| US20180362570A1 (en) | 2018-12-20 |
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