SG11201910085UA - Atropine pharmaceutical compositions - Google Patents
Atropine pharmaceutical compositionsInfo
- Publication number
- SG11201910085UA SG11201910085UA SG11201910085UA SG11201910085UA SG 11201910085U A SG11201910085U A SG 11201910085UA SG 11201910085U A SG11201910085U A SG 11201910085UA SG 11201910085U A SG11201910085U A SG 11201910085UA
- Authority
- SG
- Singapore
- Prior art keywords
- new jersey
- international
- atropine
- pct
- road
- Prior art date
Links
- 229930003347 Atropine Natural products 0.000 title abstract 4
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 title abstract 4
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 title abstract 4
- 229960000396 atropine Drugs 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 5
- 238000009472 formulation Methods 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000003755 preservative agent Substances 0.000 abstract 2
- VBSTXRUAXCTZBQ-UHFFFAOYSA-N 1-hexyl-4-phenylpiperazine Chemical compound C1CN(CCCCCC)CCN1C1=CC=CC=C1 VBSTXRUAXCTZBQ-UHFFFAOYSA-N 0.000 abstract 1
- 241000167854 Bourreria succulenta Species 0.000 abstract 1
- 235000014676 Phragmites communis Nutrition 0.000 abstract 1
- JACRWUWPXAESPB-QMMMGPOBSA-N Tropic acid Natural products OC[C@H](C(O)=O)C1=CC=CC=C1 JACRWUWPXAESPB-QMMMGPOBSA-N 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 235000019693 cherries Nutrition 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/08—Mydriatics or cycloplegics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
WO 18/ 20905 1 Al Tronskr Met.Tarrir le . Cr. POIrrwerSoutom.81,rank Figure 1 coop= ny lra, lor 1.tridlon drrArtxne. cool Gowns, 20-25 . C. CM1clotc Artrual pri Mr, 1.10rachloric um Mydroxice5olar6, =rho: IrdErtssrreinp PARlIGULATE PEOLICnON FILTPAIION irn.rj rminlararre r• r ertle Vor 6aIritiaro Stale Bulk Formulation of Arimpeullato lne.Madan nbnt• rat Ire than 60 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 November 2018 (15.11.2018) WIPO I PCT ~ill IIIIIIIIII1101DIVIIIIIIIHo o Holoiloimollmuoinio oimIE (10) International Publication Number WO 2018/209051 Al (51) International Patent Classification: A61K 9/00 (2006.01) A61K 47/18 (2006.01) A61K 9/08 (2006.01) A61K 31/46 (2006.01) A61K 47/38 (2006.01) A61P 27/02 (2006.01) (21) International Application Number: PCT/US2018/032017 (22) International Filing Date: 10 May 2018 (10.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/505,027 11 May 2017 (11.05.2017) US (71) Applicant: NEVAKAR INC. [US/US]; 1019 Route 202/206, Bldg. K, Bridgewater, New Jersey 08807 (US). (72) Inventors: PURI, Navneet; 40 Still Hollow Road, Lebanon, New Jersey 08833 (US). AKASAPU, Prem Sa- gar; 906 Rivendell Way, Edison, New Jersey 08817 (US). MOHAMMED, Irfan A.; 1900 Frontage Road, Apt. 1113, Cherry Hill, New Jersey 08034 (US). SOPPIMATH, Ku- maresh; 97 Autumn Lane, Skillman, New Jersey 08558 (US). ILITCHEV, bowl V.; 21 Reed Road, Hillsborough, New Jersey 08844 (US). ZHANG, Tao; 52 Douglas Drive, Towaco, New Jersey 07082 (US). (74) Agent: FESSENMAIER, Martin; Umberg Zipser LLP, 1920 Main Street, Suite 750, Irvine, California 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: ATROPINE PHARMACEUTICAL COMPOSITIONS (57) : The inventive subject matter is directed to composi- tions and methods for sterile and storage stable low-dose atropine formulations with improved stability. Most preferably, the compo- sitions presented herein are substantially preservative free and ex- hibit less than 0.35% tropic acid from degradation of atropine. Ad- vantageously, contemplated formulations are also substantially free of preservatives. [Continued on next page] WO 2018/209051 Al MIDEDIM01101DEIRDEIO10010101101MOIREM01111110110111111 Published: — with international search report (Art. 21(3)) with amended claims (Art. 19(1))
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762505027P | 2017-05-11 | 2017-05-11 | |
| PCT/US2018/032017 WO2018209051A1 (en) | 2017-05-11 | 2018-05-10 | Atropine pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201910085UA true SG11201910085UA (en) | 2019-11-28 |
Family
ID=64096170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201910085U SG11201910085UA (en) | 2017-05-11 | 2018-05-10 | Atropine pharmaceutical compositions |
Country Status (23)
| Country | Link |
|---|---|
| US (14) | US10251875B2 (en) |
| EP (2) | EP3548000B1 (en) |
| JP (5) | JP6557379B2 (en) |
| KR (1) | KR102281667B1 (en) |
| CN (1) | CN110621298B (en) |
| AU (1) | AU2018265257B2 (en) |
| CA (1) | CA3063228C (en) |
| CL (1) | CL2019003228A1 (en) |
| CO (1) | CO2019012893A2 (en) |
| CY (1) | CY1124880T1 (en) |
| ES (1) | ES2901140T3 (en) |
| HR (1) | HRP20212019T1 (en) |
| HU (1) | HUE056595T2 (en) |
| LT (1) | LT3548000T (en) |
| MX (1) | MX392558B (en) |
| PH (1) | PH12019502701A1 (en) |
| PL (1) | PL3548000T3 (en) |
| PT (1) | PT3548000T (en) |
| RS (1) | RS62817B1 (en) |
| RU (1) | RU2745603C1 (en) |
| SG (1) | SG11201910085UA (en) |
| SI (1) | SI3548000T1 (en) |
| WO (1) | WO2018209051A1 (en) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10154923B2 (en) | 2010-07-15 | 2018-12-18 | Eyenovia, Inc. | Drop generating device |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| WO2016172712A2 (en) | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| HK1248570A1 (en) | 2015-05-29 | 2018-10-19 | 西德奈克西斯公司 | D2o stabilized pharmaceutical formulations |
| AR108591A1 (en) * | 2016-05-25 | 2018-09-05 | Singapore Health Serv Pte Ltd | WATER COMPOSITION CONTAINING ATROPINA |
| EP3548000B1 (en) * | 2017-05-11 | 2021-11-10 | Vyluma Inc. | Atropine pharmaceutical compositions |
| AU2018279940B2 (en) | 2017-06-10 | 2023-12-14 | Eyenovia, Inc. | Methods and devices for handling a fluid and delivering the fluid to the eye |
| US11554115B2 (en) * | 2018-03-14 | 2023-01-17 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Quinoline derivative for treatment of triple-negative breast cancer |
| WO2019216395A1 (en) * | 2018-05-11 | 2019-11-14 | 千寿製薬株式会社 | Ophthalmic composition |
| CN110934816B (en) * | 2018-09-25 | 2022-04-08 | 沈阳兴齐眼科医院有限公司 | A kind of method for improving the stability of low-concentration atropine ophthalmic preparation |
| WO2020219707A1 (en) * | 2019-04-24 | 2020-10-29 | Allergan, Inc. | Compositions and methods for treatment of ocular conditions |
| WO2021001806A1 (en) * | 2019-07-04 | 2021-01-07 | Ocular Discovery Ltd. | Stable dipyridamole formulations with reduced impurities |
| CA3164288A1 (en) | 2019-12-11 | 2021-06-17 | Eyenovia, Inc. | Systems and devices for delivering fluids to the eye and methods of use |
| IL293859A (en) * | 2019-12-16 | 2022-08-01 | Sydnexis Inc | Ophthalmic preparations that include d2o |
| CN110917133A (en) * | 2019-12-23 | 2020-03-27 | 河北科技大学 | A kind of eye drops for treating myopia and preparation method thereof |
| EP4146148A1 (en) * | 2020-05-05 | 2023-03-15 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| CN111821259A (en) * | 2020-07-14 | 2020-10-27 | 艾尔健康眼药(辽宁)有限公司 | An ophthalmic pharmaceutical composition |
| CN111840221A (en) * | 2020-08-25 | 2020-10-30 | 安徽博诺美科生物医药有限公司 | Atropine sulfate eye drops |
| WO2022130033A1 (en) * | 2020-12-17 | 2022-06-23 | Sun Pharmaceutical Industries Limited | An aqueous sterile solution of atropine for ophthalmic use |
| CA3211874A1 (en) * | 2021-03-16 | 2022-09-22 | Kumaresh Soppimath | Multi-dose container for ophthalmic compositions |
| EP4088713A1 (en) | 2021-05-10 | 2022-11-16 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic pharmaceutical composition comprising atropine |
| EP4088714A1 (en) | 2021-05-10 | 2022-11-16 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic pharmaceutical composition comprising atropine |
| CN113440486B (en) * | 2021-06-02 | 2022-12-20 | 苏州欧康维视生物科技有限公司 | An eye drop composition for preventing or treating ophthalmic diseases, and its preparation method |
| CN117295491A (en) * | 2021-09-13 | 2023-12-26 | 安徽欧普视方医药科技有限公司 | Atropine eye drops and preparation method thereof |
| WO2023086878A1 (en) * | 2021-11-10 | 2023-05-19 | Visus Therapeutics, Inc. | Carbachol formulations to enhance anti-presbyopia effects |
| CN114129511A (en) * | 2021-12-07 | 2022-03-04 | 河南润弘制药股份有限公司 | Atropine sulfate injection with improved stability |
| WO2023152642A1 (en) * | 2022-02-08 | 2023-08-17 | Avaca Pharma Private Limited | Ophthalmic compositions and methods thereof |
| US20230277521A1 (en) * | 2022-03-07 | 2023-09-07 | Harrow Ip, Llc | Extended-release pharmaceutical compositions for treating eye conditions |
| CN114569551A (en) * | 2022-03-21 | 2022-06-03 | 杭州赫尔斯科技有限公司 | Atropine eye drops and preparation method thereof |
| WO2023201315A2 (en) * | 2022-04-14 | 2023-10-19 | TearClear Corp. | Ophthalmic agent in preservative removal device |
| CN115177584A (en) * | 2022-07-14 | 2022-10-14 | 成都市海通药业有限公司 | Preparation method of atropine sulfate injection |
| WO2024091789A1 (en) * | 2022-10-26 | 2024-05-02 | Vyluma Inc. | Childhood atropine for myopia progression |
| CN115998692A (en) * | 2023-02-15 | 2023-04-25 | 苏州欧康维视生物科技有限公司 | Atropine drug product and application thereof |
| WO2025146828A1 (en) * | 2024-01-05 | 2025-07-10 | ロート製薬株式会社 | Ophthalmic composition |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU86521A1 (en) | 1986-07-18 | 1988-02-02 | Oreal | HAIR DYEING PROCESS WITH HYDROXYQUINONIC DYES AND METAL SALTS |
| IL85312A (en) | 1988-02-03 | 1991-08-16 | Israel State | Injectable pharmaceutical compositions having improved stability |
| JP2617508B2 (en) * | 1988-02-05 | 1997-06-04 | エーザイ株式会社 | Stable aqueous solution containing diphenhydramine |
| US5460834A (en) * | 1991-12-13 | 1995-10-24 | Alcon Laboratories, Inc. | Combinations of polymers for use in physiological tear compositions |
| US5716952A (en) * | 1992-03-18 | 1998-02-10 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of muscarinic antagonists |
| SE9401108D0 (en) * | 1994-03-31 | 1994-03-31 | Leiras Oy | Ophthalmic composition I |
| US20030129083A1 (en) | 1997-11-26 | 2003-07-10 | Advanced Medical Optics, Inc. | Multi purpose contact lens care compositions including propylene glycol or glycerin |
| US6164282A (en) | 1999-01-27 | 2000-12-26 | Allergan Sales, Inc. | Methods for restoring and/or enhancing accommodation in pseudo phakia |
| JP2004503593A (en) * | 2000-07-14 | 2004-02-05 | アラーガン、インコーポレイテッド | Compositions comprising a therapeutically active ingredient with increased solubility |
| US20020198209A1 (en) | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Compositions having enhanced pharmacokinetic characteristics |
| US8758816B2 (en) | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
| US7851504B2 (en) | 2005-03-16 | 2010-12-14 | Allergan, Inc. | Enhanced bimatoprost ophthalmic solution |
| CN101049287A (en) | 2006-04-07 | 2007-10-10 | 财团法人长庚纪念医院 | Low-concentration atropine ophthalmic agent for inhibiting myopia increase and its manufacturing method |
| US20070254914A1 (en) * | 2006-05-01 | 2007-11-01 | Non-Profit Organization Chang Gung Memorial Hospital | Low-concentration atropine solution for preventing myopia progression and preparing method thereof |
| JP2007308398A (en) * | 2006-05-17 | 2007-11-29 | Chang Gung Memorial Hospital | Eye drops and manufacturing method thereof |
| MX2010003774A (en) * | 2007-10-08 | 2010-04-27 | Fovea Pharmaceuticals Sa | Aqueous ophthalmic formulations. |
| US8883214B2 (en) | 2009-01-13 | 2014-11-11 | The Regents Of The University Of California | Implantable delivery vehicle for ocular delivery of muscarinic antagonists |
| US20120203161A1 (en) | 2009-08-12 | 2012-08-09 | Seros Medical, Llc | Deuterated water and riboflavin solution for extending singlet oxygen lifetimes in treatment of ocular tissue and method of use |
| WO2012161655A1 (en) | 2011-05-23 | 2012-11-29 | Singapore Health Services Pte Ltd | Composition and/or method for reducing and/or preventing myopia progression comprising atropine |
| BR112015017708A2 (en) * | 2013-01-31 | 2017-07-11 | Senju Pharma Co | stable aqueous solution |
| KR102027663B1 (en) | 2013-05-06 | 2019-10-01 | 가오슝 창 궁 메모리얼 하스피털 | Pharmaceutical composition and uses thereof |
| WO2015055301A1 (en) * | 2013-10-15 | 2015-04-23 | Pharmathen S.A. | Preservative free pharmaceutical compositions for ophthalmic administration |
| WO2016172712A2 (en) | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| US9421199B2 (en) * | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| US20160009705A1 (en) * | 2014-06-24 | 2016-01-14 | Sydnexis, Inc. | Ophthalmic composition |
| WO2016013993A1 (en) | 2014-07-25 | 2016-01-28 | Imuneks Farma Llac Sanayi Ve Ticaret A.Ş. | Stable preservative free ophthalmic formulations of opioid antagonists |
| WO2016187426A1 (en) | 2015-05-19 | 2016-11-24 | Amorphex Therapeutics Llc | A device that delivers a sustained low-dose of a myopia-suppressing drug |
| CA2987787C (en) | 2015-06-18 | 2023-06-27 | Presbyopia Therapies, LLC | Compositions for the improvement of distance vision and the treatment of refractive errors of the eye |
| AR108591A1 (en) | 2016-05-25 | 2018-09-05 | Singapore Health Serv Pte Ltd | WATER COMPOSITION CONTAINING ATROPINA |
| EP3548000B1 (en) * | 2017-05-11 | 2021-11-10 | Vyluma Inc. | Atropine pharmaceutical compositions |
| US11191751B1 (en) | 2020-10-08 | 2021-12-07 | Ads Therapeutics Llc | Topical ophthalmological atropine free base compositions |
-
2018
- 2018-05-10 EP EP18798073.5A patent/EP3548000B1/en active Active
- 2018-05-10 US US15/976,279 patent/US10251875B2/en active Active
- 2018-05-10 LT LTEPPCT/US2018/032017T patent/LT3548000T/en unknown
- 2018-05-10 MX MX2019013218A patent/MX392558B/en unknown
- 2018-05-10 JP JP2018091739A patent/JP6557379B2/en active Active
- 2018-05-10 AU AU2018265257A patent/AU2018265257B2/en active Active
- 2018-05-10 SG SG11201910085U patent/SG11201910085UA/en unknown
- 2018-05-10 HR HRP20212019TT patent/HRP20212019T1/en unknown
- 2018-05-10 ES ES18798073T patent/ES2901140T3/en active Active
- 2018-05-10 HU HUE18798073A patent/HUE056595T2/en unknown
- 2018-05-10 RS RS20211580A patent/RS62817B1/en unknown
- 2018-05-10 PL PL18798073T patent/PL3548000T3/en unknown
- 2018-05-10 RU RU2019139290A patent/RU2745603C1/en active
- 2018-05-10 KR KR1020197036249A patent/KR102281667B1/en active Active
- 2018-05-10 SI SI201830521T patent/SI3548000T1/en unknown
- 2018-05-10 CA CA3063228A patent/CA3063228C/en active Active
- 2018-05-10 WO PCT/US2018/032017 patent/WO2018209051A1/en not_active Ceased
- 2018-05-10 CN CN201880031247.6A patent/CN110621298B/en active Active
- 2018-05-10 EP EP21205568.5A patent/EP3970694A1/en active Pending
- 2018-05-10 PT PT187980735T patent/PT3548000T/en unknown
-
2019
- 2019-02-20 US US16/280,384 patent/US10568875B2/en active Active
- 2019-02-20 US US16/280,585 patent/US10610525B2/en active Active
- 2019-02-20 US US16/280,552 patent/US11071732B2/en active Active
- 2019-02-20 US US16/280,669 patent/US10576074B2/en not_active Ceased
- 2019-02-20 US US16/280,405 patent/US10583132B2/en active Active
- 2019-07-11 JP JP2019129403A patent/JP6681502B2/en active Active
- 2019-07-11 JP JP2019129396A patent/JP6865476B2/en active Active
- 2019-07-11 JP JP2019129405A patent/JP6681503B2/en active Active
- 2019-11-11 CL CL2019003228A patent/CL2019003228A1/en unknown
- 2019-11-18 CO CONC2019/0012893A patent/CO2019012893A2/en unknown
- 2019-11-28 PH PH12019502701A patent/PH12019502701A1/en unknown
-
2020
- 2020-07-20 US US16/933,642 patent/US11464769B2/en active Active
- 2020-08-31 US US17/007,816 patent/US11730727B2/en active Active
- 2020-08-31 US US17/007,900 patent/US11730728B2/en active Active
- 2020-09-09 US US17/016,186 patent/US11707458B2/en active Active
-
2021
- 2021-01-11 US US17/145,589 patent/US11642338B2/en active Active
- 2021-03-30 JP JP2021056894A patent/JP7332179B2/en active Active
- 2021-12-23 CY CY20211101132T patent/CY1124880T1/en unknown
-
2022
- 2022-03-02 US US17/685,286 patent/USRE50040E1/en active Active
-
2023
- 2023-06-28 US US18/343,636 patent/US12036217B2/en active Active
-
2024
- 2024-06-26 US US18/755,212 patent/US20240342154A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201910085UA (en) | Atropine pharmaceutical compositions | |
| SG11201908540PA (en) | Stable antibody formulation | |
| SG11201811230RA (en) | Compositions and methods for reducing ocular neovascularization | |
| SG11201808799SA (en) | Amine-substituted aryl or heteroaryl compounds as ehmt1 and ehmt2 inhibitors | |
| SG11201809344QA (en) | Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde | |
| SG11201807784SA (en) | 3-desoxy derivative and pharmaceutical compositions thereof | |
| SG11201810161RA (en) | Mesenchymal stem cell and use thereof for treatment of muscle injury and muscle-associated diseases | |
| SG11201807809XA (en) | A transient commensal microorganism for improving gut health | |
| SG11201809499UA (en) | Processes for preparing phosphorodiamidate morpholino oligomers | |
| SG11201909825VA (en) | Hsp90 inhibitor oral formulations and related methods | |
| SG11201810429UA (en) | Anti-cd19 antibody formulations | |
| SG11201900558RA (en) | Spiro-lactam nmda receptor modulators and uses thereof | |
| SG11201900546UA (en) | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof | |
| SG11201900551WA (en) | Spiro-lactam nmda receptor modulators and uses thereof | |
| SG11201809853PA (en) | Multi-material wires for additive manufacturing of titanium alloys | |
| SG11201901438VA (en) | Solid forms of cenicriviroc mesylate and processes of making solid forms of cenicriviroc mesylate | |
| SG11201809497RA (en) | Processes for preparing phosphorodiamidate morpholino oligomers | |
| SG11202000333UA (en) | Bicyclic ketone compounds and methods of use thereof | |
| SG11201908691PA (en) | Compounds and methods for the treatment of parasitic diseases | |
| SG11201807023QA (en) | Compositions and methods for preventing and/or treating vitamin b12 deficiency | |
| SG11201805771XA (en) | Systems and methods for preparation of platelets | |
| SG11201804951SA (en) | Use of tryptophan derivatives for protein formulations | |
| SG11201906164RA (en) | Bicyclic inhibitors of histone deacetylase | |
| SG11202000494UA (en) | Drug delivery composition | |
| SG11201903521XA (en) | Pharmaceutical formulations and methods of making the same |