SG11201908273PA - A methylation classifier for detection of hpv-induced invasive cancers, nonhpv- induced gynaecological and anogenital cancers and their high-grade precursor lesions - Google Patents
A methylation classifier for detection of hpv-induced invasive cancers, nonhpv- induced gynaecological and anogenital cancers and their high-grade precursor lesionsInfo
- Publication number
- SG11201908273PA SG11201908273PA SG11201908273PA SG11201908273PA SG 11201908273P A SG11201908273P A SG 11201908273PA SG 11201908273P A SG11201908273P A SG 11201908273PA SG 11201908273P A SG11201908273P A SG 11201908273PA
- Authority
- SG
- Singapore
- Prior art keywords
- induced
- cancers
- hpv
- international
- biothof
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 8
- 230000011987 methylation Effects 0.000 title abstract 5
- 238000007069 methylation reaction Methods 0.000 title abstract 5
- 238000001514 detection method Methods 0.000 title abstract 4
- 230000003902 lesion Effects 0.000 title abstract 4
- 239000002243 precursor Substances 0.000 title abstract 3
- 102100022142 Achaete-scute homolog 1 Human genes 0.000 abstract 3
- 102100029229 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Human genes 0.000 abstract 3
- 101000901099 Homo sapiens Achaete-scute homolog 1 Proteins 0.000 abstract 3
- 101000619912 Homo sapiens LIM/homeobox protein Lhx8 Proteins 0.000 abstract 3
- 108010069296 ST6GalNAc V brain-specific GD1alpha synthase Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 102100022136 LIM/homeobox protein Lhx8 Human genes 0.000 abstract 1
- 230000006607 hypermethylation Effects 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17160346 | 2017-03-10 | ||
| PCT/NL2018/050143 WO2018164577A1 (fr) | 2017-03-10 | 2018-03-09 | Classificateur de méthylation pour la détection de cancers invasifs induits par le hpv, de cancers gynécologiques et anogénitaux non induits par le hpv et de leurs lésions précurseurs de haut grade |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201908273PA true SG11201908273PA (en) | 2019-10-30 |
Family
ID=58266967
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202106932YA SG10202106932YA (en) | 2017-03-10 | 2018-03-09 | A methylation classifier for detection of hpv-induced invasive cancers, nonhpv- induced gynaecological and anogenital cancers and their high-grade precursor lesions |
| SG11201908273P SG11201908273PA (en) | 2017-03-10 | 2018-03-09 | A methylation classifier for detection of hpv-induced invasive cancers, nonhpv- induced gynaecological and anogenital cancers and their high-grade precursor lesions |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202106932YA SG10202106932YA (en) | 2017-03-10 | 2018-03-09 | A methylation classifier for detection of hpv-induced invasive cancers, nonhpv- induced gynaecological and anogenital cancers and their high-grade precursor lesions |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US11932909B2 (fr) |
| EP (2) | EP3592867B1 (fr) |
| JP (1) | JP7299158B2 (fr) |
| KR (1) | KR102542502B1 (fr) |
| CN (1) | CN110753761A (fr) |
| AU (1) | AU2018231578B2 (fr) |
| BR (1) | BR112019018743A2 (fr) |
| CA (1) | CA3055895A1 (fr) |
| DK (1) | DK3592867T3 (fr) |
| EA (1) | EA201991883A1 (fr) |
| ES (1) | ES2928068T3 (fr) |
| MA (1) | MA47821A (fr) |
| MX (1) | MX2019010508A (fr) |
| PH (1) | PH12019550180A1 (fr) |
| PL (1) | PL3592867T3 (fr) |
| PT (1) | PT3592867T (fr) |
| SG (2) | SG10202106932YA (fr) |
| WO (1) | WO2018164577A1 (fr) |
| ZA (1) | ZA201905977B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110753761A (zh) * | 2017-03-10 | 2020-02-04 | 塞尔夫斯库林有限公司 | 检测hpv诱导的浸润性癌症、非hpv诱导的妇科癌症和肛门生殖器癌症以及它们的高级前体病变的甲基化分类器 |
| BR112021010640A2 (pt) * | 2018-12-04 | 2021-09-08 | Hkg Epitherapeutics Limited | Método in-vitro para obter preditores precoces de câncer cervical, painel de biomarcadores de metilação de dna para rastreamento e detecção precoce de câncer cervical, combinação de biomarcadores de metilação de dna para rastreamento e detecção precoce de câncer cervical, kit para detecção de câncer cervical, uso de equação de regressão linear multivariável ou análise de rede neura, uso de ensaios decaracterísticas de operação do receptor (roc), e método implementado por computador para obter biomarcadores de metilação de dna candidatos para detecção precoce dediagnóstico de câncer cervical |
| GB202009220D0 (en) * | 2020-06-17 | 2020-07-29 | Ucl Business Ltd | Methods for detecting and predicting cancer |
| JP2023530984A (ja) * | 2020-06-17 | 2023-07-20 | ユーシーエル ビジネス リミテッド | グレード３子宮頸部上皮腫瘍（ｃｉｎ３）および／またはがんを検出および予測するための方法 |
| KR20230024344A (ko) * | 2020-06-17 | 2023-02-20 | 유씨엘 비즈니스 리미티드 | 암 및/또는 cin3를 검출하고 예측하기 위한 방법 |
| GB202009222D0 (en) * | 2020-06-17 | 2020-07-29 | Ucl Business Plc | Methods for detecting and predicting cancer |
| US20240093318A1 (en) * | 2020-06-23 | 2024-03-21 | The Regents Of The University Of Colorado, A Body Corporate | Method for diagnosing respiratory pathogens and predicting covid-19 related outcomes |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8845535B2 (en) | 2008-02-22 | 2014-09-30 | Herbert Michael Pinedo | Device for detecting a medical condition or disease |
| AU2009344468B2 (en) * | 2009-04-17 | 2015-02-12 | National Defense Medical Center | A method for screening cancer |
| TWI408235B (zh) | 2010-06-03 | 2013-09-11 | Univ China Medical | 用於檢測口腔癌之基因標記及方法 |
| RS56380B1 (sr) * | 2011-09-15 | 2017-12-29 | Self Screen Bv | Postupak za detektovanje kancera grlića materice prouzrokovanog humanim papiloma virusom (hpv) |
| US10233503B2 (en) * | 2012-05-24 | 2019-03-19 | Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) | Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis |
| BR112015008257B1 (pt) * | 2012-10-12 | 2022-05-24 | Self-Screen B.V. | Métodos in vitro para a detecção de lesões pré-cancerosas de alto grau induzidas por hpv ou cânceres invasivos induzidos por hpv, uso de uma combinação de fam19a4 e hsa-mir124-2 para a detecção das ditas lesões ou carcinomas e kit de partes compreendendo meios para a detecção de metilação de fam19a4 e metilação de hsa-mir124-2 |
| US11268151B2 (en) * | 2014-09-22 | 2022-03-08 | Rijksuniversiteit Groningen | Biomarkers for cervical cancer |
| WO2016115354A1 (fr) * | 2015-01-14 | 2016-07-21 | Taipei Medical University | Méthodes de diagnostic et de pronostic du cancer |
| EP3135768A1 (fr) * | 2015-08-26 | 2017-03-01 | Self-screen B.V. | Zic1 et ghsr, marqueurs de diagnostic moléculaire pour cancers invasifs causés par le vph, cancers gynécologiques et anogénitaux non causés par le vph et leurs lésions précancéreuses de haut grade |
| CN110753761A (zh) * | 2017-03-10 | 2020-02-04 | 塞尔夫斯库林有限公司 | 检测hpv诱导的浸润性癌症、非hpv诱导的妇科癌症和肛门生殖器癌症以及它们的高级前体病变的甲基化分类器 |
-
2018
- 2018-03-09 CN CN201880029251.9A patent/CN110753761A/zh active Pending
- 2018-03-09 AU AU2018231578A patent/AU2018231578B2/en active Active
- 2018-03-09 ES ES18710572T patent/ES2928068T3/es active Active
- 2018-03-09 PL PL18710572.1T patent/PL3592867T3/pl unknown
- 2018-03-09 SG SG10202106932YA patent/SG10202106932YA/en unknown
- 2018-03-09 SG SG11201908273P patent/SG11201908273PA/en unknown
- 2018-03-09 US US16/491,182 patent/US11932909B2/en active Active
- 2018-03-09 MA MA047821A patent/MA47821A/fr unknown
- 2018-03-09 EA EA201991883A patent/EA201991883A1/ru unknown
- 2018-03-09 MX MX2019010508A patent/MX2019010508A/es unknown
- 2018-03-09 DK DK18710572.1T patent/DK3592867T3/da active
- 2018-03-09 JP JP2019549400A patent/JP7299158B2/ja active Active
- 2018-03-09 BR BR112019018743A patent/BR112019018743A2/pt not_active IP Right Cessation
- 2018-03-09 WO PCT/NL2018/050143 patent/WO2018164577A1/fr not_active Ceased
- 2018-03-09 PT PT187105721T patent/PT3592867T/pt unknown
- 2018-03-09 EP EP18710572.1A patent/EP3592867B1/fr active Active
- 2018-03-09 EP EP20172435.8A patent/EP3744861B1/fr active Active
- 2018-03-09 CA CA3055895A patent/CA3055895A1/fr active Pending
- 2018-03-09 KR KR1020197027973A patent/KR102542502B1/ko active Active
-
2019
- 2019-09-09 PH PH12019550180A patent/PH12019550180A1/en unknown
- 2019-09-10 ZA ZA2019/05977A patent/ZA201905977B/en unknown
-
2024
- 2024-02-01 US US18/430,518 patent/US12203141B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20190141130A (ko) | 2019-12-23 |
| SG10202106932YA (en) | 2021-08-30 |
| AU2018231578B2 (en) | 2024-01-11 |
| EP3744861B1 (fr) | 2023-12-20 |
| MX2019010508A (es) | 2020-01-20 |
| US20240336974A1 (en) | 2024-10-10 |
| EP3744861C0 (fr) | 2023-12-20 |
| ZA201905977B (en) | 2022-12-21 |
| JP7299158B2 (ja) | 2023-06-27 |
| CN110753761A (zh) | 2020-02-04 |
| BR112019018743A2 (pt) | 2020-05-05 |
| US20200032348A1 (en) | 2020-01-30 |
| KR102542502B1 (ko) | 2023-06-12 |
| US12203141B2 (en) | 2025-01-21 |
| AU2018231578A1 (en) | 2019-09-26 |
| US11932909B2 (en) | 2024-03-19 |
| WO2018164577A1 (fr) | 2018-09-13 |
| DK3592867T3 (da) | 2022-10-17 |
| PH12019550180A1 (en) | 2020-06-29 |
| EP3744861A1 (fr) | 2020-12-02 |
| JP2020509758A (ja) | 2020-04-02 |
| EP3592867B1 (fr) | 2022-08-17 |
| CA3055895A1 (fr) | 2018-09-13 |
| ES2928068T3 (es) | 2022-11-15 |
| EA201991883A1 (ru) | 2020-03-06 |
| MA47821A (fr) | 2020-01-15 |
| EP3592867A1 (fr) | 2020-01-15 |
| PT3592867T (pt) | 2022-10-13 |
| PL3592867T3 (pl) | 2022-11-21 |
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