SG11201905788VA - Methods and related compositions for manufacturing food and feed - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIPO I PCT 1111111111110110101011111011010 I 010110 110E10111110# (10) International Publication Number WO 2018/140496 A8 (51) International Patent Classification: A21D 2/00 (2006.01) C12P 1/00 (2006.01) A23C 9/12 (2006.01) C12N 1/12 (2006.01) C12N 1/00 (2006.01) (21) International Application Number: PCT/US2018/015051 (22) International Filing Date: 24 January 2018 (24.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/450,038 24 January 2017 (24.01.2017) US 62/584,011 09 November 2017 (09.11.2017) US (71) Applicant: FLAGSHIP PIONEERING, INC. [US/US]; 55 Cambridge Parkway, 8th Floor 800E, Cambridge, MA 02142 (US). (72) Inventors: MARTINEZ, Ignacio; 36 Moon Hill Rd, Lexington, MA 02421 (US). ARMEN, Zachary, Garo; 1200 Washington St, Unit 412, Boston, MA 02118 (US). CEZAR, Christine; 2454 215 Ave SE, Sammamish, WA 98075 (US). MARTIN, Barry, Andrew; 150 Mount Ver- non St, Boston, MA 02108 (US). AVENDANO AMADO, Maier, Steve; 10 Glassworks Ave, Apt 411, Cambridge, MA 02141 (US). (74) Agent: ELBING, Karen, L. et al.; Clark & Elbing LLP, 101 Federal Street, 15th Floor, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (48) Date of publication of this corrected version: 06 December 2018 (06.12.2018) (15) Information about Correction: see Notice of 06 December 2018 (06.12.2018) Previous Correction: see Notice of 11 October 2018 (11.10.2018) (54) Title: METHODS AND RELATED COMPOSITIONS FOR MANUFACTURING FOOD AND FEED (57) : Provided herein are methods and compositions for food and feed applications, e.g., for targeting one or more microor- ganisms resident in a host insect, the modulation resulting in an increase in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the modulating agent described herein may be used to increase the fitness of a variety of insects utilized in human food or animal feed industries.