SG11201810117WA - Human platelet lysate derived extracellular vesicles for use in medicine - Google Patents
Human platelet lysate derived extracellular vesicles for use in medicineInfo
- Publication number
- SG11201810117WA SG11201810117WA SG11201810117WA SG11201810117WA SG11201810117WA SG 11201810117W A SG11201810117W A SG 11201810117WA SG 11201810117W A SG11201810117W A SG 11201810117WA SG 11201810117W A SG11201810117W A SG 11201810117WA SG 11201810117W A SG11201810117W A SG 11201810117WA
- Authority
- SG
- Singapore
- Prior art keywords
- diseases
- international
- human platelet
- platelet lysate
- medicine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111011101111111111111111111111111111111111111111111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/211906 Al 14 December 2017 (14.12.2017) WIP0 I PCT (51) International Patent Classification: A61K 35/19 (2015.01) A61M 1/00 (2006.01) (21) International Application Number: PCT/EP2017/063868 (22) International Filing Date: 07 June 2017 (07.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16173465.2 08 June 2016 (08.06.2016) EP (72) Inventor; and (71) Applicant: DE MIROSCHEDJI, Kyra Natalia Matahari [DE/DE]; Wiedfeldtstr. 60A, 45133 Essen (DE). (74) Agent: DTS PATENT- UND RECHTSANWALTE SCHNEKENBUHL UND PARTNER MBB; St.-An- na-Str. 15, 80538 Miinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, — = = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. _ = = (84) Designated States (unless otherwise indicated, for every = kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, = = KM, ML, MR, NE, SN, TD, TG). = = Published: = — with international search report (Art. 21(3)) 1-1 ..! (54) Title: HUMAN PLATELET LYSATE DERIVED EXTRACELLULAR VESICLES FOR USE IN MEDICINE (57) : The present invention is related to human platelet lysate or a fraction that is enriched for human platelet lysate de- t:N rived extracellular vesicles and their use in medicine, particularly for the prevention and/or treatment of inflammatory driven diseases, 1 -1 neurodegenerative diseases, immune/autoimmune diseases, cardiovascular diseases, dermatologic diseases, orthopedic diseases, tissue 1-1 regenerative medicine, oncologic diseases, infectious diseases, transplant rejections, stroke, ischemia or Graft-versus-Host Disease. ei --.... The present invention is further related to a method of manufacture of a pharmaceutical preparation or a diagnostic preparation or a IN cosmetic preparation comprising the step of adding human platelet lysate or a fraction that is enriched for human platelet lysate derived 1-1 C extracellular vesicles to the pharmaceutical preparation or a diagnostic preparation or a cosmetic preparation. ei C
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16173465.2A EP3254684B1 (en) | 2016-06-08 | 2016-06-08 | Human platelet lysate or fraction enriched in human platelet-derived extracellular vesicles, for use in medicine |
| PCT/EP2017/063868 WO2017211906A1 (en) | 2016-06-08 | 2017-06-07 | Human platelet lysate derived extracellular vesicles for use in medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201810117WA true SG11201810117WA (en) | 2018-12-28 |
Family
ID=56112904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201810117WA SG11201810117WA (en) | 2016-06-08 | 2017-06-07 | Human platelet lysate derived extracellular vesicles for use in medicine |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20190290696A1 (en) |
| EP (2) | EP3254684B1 (en) |
| JP (2) | JP7122976B2 (en) |
| KR (3) | KR20220136461A (en) |
| CN (2) | CN109310712A (en) |
| AU (1) | AU2017276712B2 (en) |
| BR (1) | BR112018075295A2 (en) |
| CA (1) | CA3026004A1 (en) |
| DK (1) | DK3468568T3 (en) |
| ES (1) | ES2832727T3 (en) |
| HU (1) | HUE051792T2 (en) |
| IL (1) | IL263296B (en) |
| MX (1) | MX384202B (en) |
| PL (1) | PL3468568T3 (en) |
| PT (1) | PT3468568T (en) |
| RU (1) | RU2735139C2 (en) |
| SG (1) | SG11201810117WA (en) |
| WO (1) | WO2017211906A1 (en) |
| ZA (1) | ZA201807760B (en) |
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| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| CN107073090A (en) | 2014-04-30 | 2017-08-18 | 哈佛学院董事会 | Combined vaccine device and method of killing cancer cells |
| CN115487351A (en) | 2016-02-06 | 2022-12-20 | 哈佛学院校长同事会 | Remodel Blood Nest to rebuild immunity |
| TWI744300B (en) * | 2016-03-23 | 2021-11-01 | 里爾中央醫學中心 | Use of a modified heat-treated platelet pellet lysate in manufacturing a composition for the treatment of neurological disorders |
| CA3030427A1 (en) | 2016-07-13 | 2018-01-18 | President And Fellows Of Harvard College | Antigen-presenting cell-mimetic scaffolds and methods for making and using the same |
| JP7274214B2 (en) | 2016-08-02 | 2023-05-16 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Biomaterials for modulating immune responses |
| JP2021509812A (en) | 2018-01-05 | 2021-04-08 | プレートレット バイオジェネシス， インコーポレイテッド | Compositions and Methods for Producing Megakaryocytes |
| CN108715834B (en) * | 2018-06-01 | 2021-09-14 | 天晴干细胞股份有限公司 | Preparation method of platelet lysate rich in CD41+ and CD81+ microcapsules |
| WO2020006539A1 (en) | 2018-06-29 | 2020-01-02 | Platelet Biogenesis, Inc. | Compositions for drug delivery and methods of use thereof |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| US20220118109A1 (en) * | 2018-12-20 | 2022-04-21 | Ohio State Innovation Foundation | Compositions and methods for reprogramming diseased musculoskeletal cells |
| WO2020166700A1 (en) * | 2019-02-15 | 2020-08-20 | テルモ株式会社 | Platelet lysate production method, production system, and bag set |
| TWI722400B (en) | 2019-03-18 | 2021-03-21 | 佛教慈濟醫療財團法人 | Mesenchymal stem cell derived exosomes and uses thereof |
| CN110090310B (en) * | 2019-04-01 | 2021-08-10 | 东南大学 | Platelet membrane self-assembly nanobubble and preparation method and application thereof |
| EP3955939A4 (en) * | 2019-04-15 | 2023-02-01 | Mycomed Technologies LLC | METHODS AND COMPOSITIONS USING EXTRACELLULAR VESICLES FOR THE DETECTION OF DISEASES AND DISORDERS |
| WO2021016368A1 (en) * | 2019-07-22 | 2021-01-28 | Erivan Bio, Llc | Topical exosome compositions and associated methods |
| CN110585243A (en) * | 2019-08-12 | 2019-12-20 | 丰泽康生物医药（深圳）有限公司 | Pluripotent cell active matter and platelet-rich plasma compound for treating glucocorticoid-dependent dermatitis as well as preparation method and application thereof |
| CN110339180B (en) * | 2019-08-12 | 2020-10-09 | 苏州大学 | A kind of anti-inflammatory targeted delivery system and preparation method thereof |
| CN110499287B (en) * | 2019-08-30 | 2021-07-23 | 博雅干细胞科技有限公司 | Method for simply preparing placenta mesenchymal stem cell exosome |
| US20220387505A1 (en) * | 2019-09-13 | 2022-12-08 | Exocure Biosciences, Inc. | Use of ghost nanovesicles as therapeutics |
| US11951134B2 (en) | 2019-09-30 | 2024-04-09 | North Carolina State University | Cationic platelet lysate compositions and related methods |
| JP2023519867A (en) * | 2020-03-27 | 2023-05-15 | プレートレット バイオジェネシス， インコーポレイテッド | Novel anucleate cells and their uses |
| WO2021195544A1 (en) * | 2020-03-27 | 2021-09-30 | Platelet Biogenesis, Inc. | Novel anucleated cells for the treatment of diseases |
| US12377121B2 (en) | 2020-04-10 | 2025-08-05 | Zeo Scientifix, Inc. | Compositions comprising nanoparticles, method of making and uses thereof |
| JP2023525568A (en) * | 2020-05-14 | 2023-06-16 | プレートレット バイオジェネシス， インコーポレイテッド | Novel Anucleated Cells as a Source for the Treatment of Platelet-Rich Plasma Dependent Disorders |
| KR102384368B1 (en) | 2020-06-18 | 2022-04-07 | 경북대학교 산학협력단 | Composition for skin and mucous membrane wound healing comprising extracellular vesicles derived from fibroblast |
| KR102209937B1 (en) * | 2020-06-22 | 2021-02-01 | 주식회사 엑소코바이오 | Manufacturing method of exosomes for increasing their productivity and bioactivity and its application |
| WO2022099093A1 (en) * | 2020-11-06 | 2022-05-12 | President And Fellows Of Harvard College | Scaffolds for enhancing neutrophils and uses thereof |
| CN113332312B (en) * | 2021-02-01 | 2023-02-24 | 浙江大学医学院附属邵逸夫医院 | A self-forming platelet nanovesicle based on physical granulation and its preparation method |
| CN115029309A (en) * | 2021-03-05 | 2022-09-09 | 杭州市萧山区中医院 | Separation method of platelet-rich plasma endogenous exosomes and application thereof |
| JP7025070B1 (en) | 2021-05-14 | 2022-02-24 | セルソース株式会社 | Blood-derived growth factor-containing composition and its preparation method |
| DE102021124752A1 (en) * | 2021-09-24 | 2023-03-30 | Ad Lentus GmbH | Autologous therapeutic and method of making the same |
| WO2023079655A1 (en) * | 2021-11-04 | 2023-05-11 | 株式会社リバティソリューション | Exosome extraction method |
| WO2023108044A1 (en) * | 2021-12-08 | 2023-06-15 | Organicell Regenerative Medicine, Inc. | Compositions and methods for treating pain with extracellular vesicles |
| AU2023215138A1 (en) * | 2022-02-01 | 2024-08-15 | Mitrix Bio, Inc. | Platelet-derived mitochondria-containing extracellular vesicles for use in the treatment of ocular disorders |
| EP4482469A1 (en) * | 2022-02-24 | 2025-01-01 | Mayo Foundation for Medical Education and Research | Compositions and methods for modulating the immune system |
| KR102674407B1 (en) * | 2022-02-25 | 2024-06-12 | ㈜클리니크후즈후 | A blood-derived exosome manufacturing method, including platelets and blood-derived stem cells, and an exosome manufactured therefrom |
| CN114306384B (en) * | 2022-03-08 | 2022-05-31 | 北京大学口腔医学院 | Application of human platelet apoptosis microvesicle |
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| US20250186498A1 (en) * | 2022-05-16 | 2025-06-12 | Taiwan Mitochondrion Applied Technology Co., Ltd. | Composition for hearing loss mitigation and use thereof |
| WO2024077117A1 (en) * | 2022-10-06 | 2024-04-11 | Capricor, Inc. | Method for making vesicles |
| CN115463154A (en) * | 2022-10-21 | 2022-12-13 | 上海君益禾生物医学科技有限公司 | Preparation method and application of platelet lysate and exosome composite gel |
| CN116637201B (en) * | 2023-06-09 | 2025-10-31 | 天晴干细胞股份有限公司 | SPL nano material for repairing gingival recession and preparation method thereof |
| TW202515588A (en) * | 2023-10-12 | 2025-04-16 | 日商耶迪波席茲股份有限公司 | Method for producing high concentration platelet plasma |
| EP4578454A1 (en) | 2023-12-28 | 2025-07-02 | Lysatpharma GmbH | Compositions comprising platelet derived extracellular vesicles |
| US20250295697A1 (en) * | 2024-03-22 | 2025-09-25 | Dao-Lung Steven LIN | Pharmaceutical composition comprising platelet-derived extracellular vesicles of different sizes activated by freeze-thaw cycles, preparation process thereof, and use in promoting wound healing of respiratory tract-related tissues and alleviating inflammation |
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| CN1313151C (en) * | 2002-11-04 | 2007-05-02 | 杭州浙大康泰生物技术有限公司 | Preparation of high-performance noncellular vaccine and usage |
| JP2008505104A (en) | 2004-07-01 | 2008-02-21 | ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション | Immunosuppressive exosomes |
| IT1392897B1 (en) | 2008-07-18 | 2012-04-02 | Fond Ircss Ca' Granda - Ospedale Maggiore Policlinico | PIASTRINIC FRACTION DERIVING FROM PLACENTED BLOOD |
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| US20130209528A1 (en) | 2010-10-18 | 2013-08-15 | Agency For Science, Technology And Research | Use of exosomes to promote or enhance hair growth |
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| JP2018507916A (en) | 2015-03-11 | 2018-03-22 | ベフファル アタ | Exosome delivery technology |
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2016
- 2016-06-08 EP EP16173465.2A patent/EP3254684B1/en active Active
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2017
- 2017-06-07 RU RU2018141006A patent/RU2735139C2/en active
- 2017-06-07 MX MX2018015123A patent/MX384202B/en unknown
- 2017-06-07 CN CN201780035263.8A patent/CN109310712A/en active Pending
- 2017-06-07 DK DK17727907.2T patent/DK3468568T3/en active
- 2017-06-07 JP JP2018562358A patent/JP7122976B2/en active Active
- 2017-06-07 KR KR1020227032949A patent/KR20220136461A/en not_active Ceased
- 2017-06-07 US US16/307,208 patent/US20190290696A1/en not_active Abandoned
- 2017-06-07 PL PL17727907T patent/PL3468568T3/en unknown
- 2017-06-07 WO PCT/EP2017/063868 patent/WO2017211906A1/en not_active Ceased
- 2017-06-07 BR BR112018075295A patent/BR112018075295A2/en not_active Application Discontinuation
- 2017-06-07 CA CA3026004A patent/CA3026004A1/en active Pending
- 2017-06-07 AU AU2017276712A patent/AU2017276712B2/en active Active
- 2017-06-07 PT PT177279072T patent/PT3468568T/en unknown
- 2017-06-07 KR KR1020197000469A patent/KR20190017896A/en not_active Ceased
- 2017-06-07 HU HUE17727907A patent/HUE051792T2/en unknown
- 2017-06-07 KR KR1020217012339A patent/KR20210047983A/en not_active Ceased
- 2017-06-07 CN CN202211273896.1A patent/CN115710574A/en active Pending
- 2017-06-07 ES ES17727907T patent/ES2832727T3/en active Active
- 2017-06-07 SG SG11201810117WA patent/SG11201810117WA/en unknown
- 2017-06-07 EP EP17727907.2A patent/EP3468568B1/en not_active Revoked
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2018
- 2018-11-19 ZA ZA2018/07760A patent/ZA201807760B/en unknown
- 2018-11-26 IL IL263296A patent/IL263296B/en unknown
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2021
- 2021-09-21 US US17/480,234 patent/US20220000931A1/en active Pending
-
2022
- 2022-05-30 JP JP2022087948A patent/JP2022116227A/en not_active Withdrawn
-
2025
- 2025-04-17 US US19/181,489 patent/US20250241958A1/en active Pending
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