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SG11201807903TA - A bioreactor system and method thereof - Google Patents

A bioreactor system and method thereof

Info

Publication number
SG11201807903TA
SG11201807903TA SG11201807903TA SG11201807903TA SG11201807903TA SG 11201807903T A SG11201807903T A SG 11201807903TA SG 11201807903T A SG11201807903T A SG 11201807903TA SG 11201807903T A SG11201807903T A SG 11201807903TA SG 11201807903T A SG11201807903T A SG 11201807903TA
Authority
SG
Singapore
Prior art keywords
international
discs
rule
central shaft
pct
Prior art date
Application number
SG11201807903TA
Inventor
Ravindrakumar Dhirubhai Patel
Original Assignee
Ravindrakumar Dhirubhai Patel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ravindrakumar Dhirubhai Patel filed Critical Ravindrakumar Dhirubhai Patel
Publication of SG11201807903TA publication Critical patent/SG11201807903TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/06—Plates; Walls; Drawers; Multilayer plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/14—Rotation or movement of the cells support, e.g. rotated hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18—Flow directing inserts
    • C12M27/20—Baffles; Ribs; Ribbons; Auger vanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/14—Incubators; Climatic chambers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/42—Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101111011110110110111011111101111011111 International Bureau 0.. .... .. ..... ..or::,,,, (10) International Publication Number (43) International Publication Date WO 2017/158611 Al 21 September 2017 (21.09.2017) WIP0 I PCT (51) International Patent Classification: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, C12M 1/00 (2006.01) C12M 1/12 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, C12M 3/00 (2006.01) C12M 1/02 (2006.01) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (21) International Application Number: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, PCT/IN2016/050336 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (22) International Filing Date: TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, 4 October 2016 (04.10.2016) ZW. (25) Filing Language: English (8 4 ) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (26) Publication Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (30) Priority Data: TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 201621008865 14 March 2016 (14.03.2016) IN TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventor; and LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (71) Applicant : PATEL, Ravindrakumar Dhirubhai SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, [IN/IN]; B-202, Royal Residency, Nr. Vandematram City, GW, KM, ML, MR, NE, SN, TD, TG). Nr. Gota Railway Crossing, Gota, Ahmedabad, Gujarat 382421 (IN). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(i)) (74) Agents: ACHARYA, Rajeshkumar H. et al.; H K ACHARYA & COMPANY, Advocates•Patent & Trade- — as to applicant's entitlement to apply for and be granted a — marks Attorneys, HK Avenue, 19, Swastik Society Nav- patent (Rule 4.17(U)) — rangpura, Ahmedabad, Gujarat 380009 (IN). — of inventorship (Rule 4.17(iv)) Designated States indicated, (81) (unless otherwise for every Published: kind AE, AG, AL, AM, of national protection available): AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, — with international search report (Art. 21(3)) = BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, = = = (54) Title: A BIOREACTOR SYSTEM AND METHOD THEREOF = N. 2 = = ... ..... .......... = = 4\: '4k.,,,,, 1(b) i I/ 1 . :a ---- 19 = 5 3-, st, \ Il ,0.--,........ ‘‘k, Il 1-1 Fig.1 (a) GC iln (57) : The present invention relates to bioreactor system and method thereof wherein support matrix (2) comprises at last 1-1 --... one central shaft and plurality of peripheral shaft being radially surrounds central shaft. Arrays of discs (11) are mounted along the IN 1-1 shaft by defining interspatial vicinities between two successive plates. Thus, discs mounted on peripheral shafts are rotated within C the interspatial vicinity of discs of central shaft to ensures sufficient mixing and avoid stagnant fluidic zones which is created when N discs are mounted closely apart from each other on shafts. Further, plurality of deflector vanes that are axially provided along the Olength of the central shaft to redirect substantially co-axial direction fluid flow into interior of culture vessel and more specifically ,1. towards the central axis. Thus, bioreactor system provides scalable and disposable bioreactor with efficient mixing and homogen- eous conditions and thereby supports high density growth and maintenance of cells and other biological material.
SG11201807903TA 2016-03-14 2016-10-04 A bioreactor system and method thereof SG11201807903TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201621008865 2016-03-14
PCT/IN2016/050336 WO2017158611A1 (en) 2016-03-14 2016-10-04 A bioreactor system and method thereof

Publications (1)

Publication Number Publication Date
SG11201807903TA true SG11201807903TA (en) 2018-10-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201807903TA SG11201807903TA (en) 2016-03-14 2016-10-04 A bioreactor system and method thereof

Country Status (18)

Country Link
US (1) US11365382B2 (en)
EP (1) EP3430119B1 (en)
JP (1) JP6840219B2 (en)
KR (1) KR102641877B1 (en)
CN (1) CN109196086B (en)
AU (1) AU2016397306B2 (en)
BR (1) BR112018068711B1 (en)
CA (1) CA3017434C (en)
DK (1) DK3430119T3 (en)
ES (1) ES2955959T3 (en)
FI (1) FI3430119T3 (en)
GB (1) GB2563794B (en)
IL (1) IL261716B (en)
MY (1) MY197074A (en)
PL (1) PL3430119T3 (en)
PT (1) PT3430119T (en)
SG (1) SG11201807903TA (en)
WO (1) WO2017158611A1 (en)

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KR102641877B1 (en) 2024-02-27
KR20190128546A (en) 2019-11-18
PT3430119T (en) 2023-09-12
CA3017434A1 (en) 2017-09-21
AU2016397306B2 (en) 2022-02-03
FI3430119T3 (en) 2023-09-11
EP3430119A1 (en) 2019-01-23
IL261716B (en) 2022-03-01
WO2017158611A1 (en) 2017-09-21
PL3430119T3 (en) 2023-11-13
CN109196086B (en) 2022-04-26
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