[go: up one dir, main page]

SG11201805321YA - Electrosurgical instrument having multiple treatment modalities - Google Patents

Electrosurgical instrument having multiple treatment modalities

Info

Publication number
SG11201805321YA
SG11201805321YA SG11201805321YA SG11201805321YA SG11201805321YA SG 11201805321Y A SG11201805321Y A SG 11201805321YA SG 11201805321Y A SG11201805321Y A SG 11201805321YA SG 11201805321Y A SG11201805321Y A SG 11201805321YA SG 11201805321Y A SG11201805321Y A SG 11201805321YA
Authority
SG
Singapore
Prior art keywords
international
lllll
iii
llll
chepstow
Prior art date
Application number
SG11201805321YA
Other languages
English (en)
Inventor
Christopher Paul Hancock
Shaun Preston
Francis Amoah
Malcolm White
Zacharias Tsiamoulos
Brian Saunders
Original Assignee
Creo Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Creo Medical Ltd filed Critical Creo Medical Ltd
Publication of SG11201805321YA publication Critical patent/SG11201805321YA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/042Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating using additional gas becoming plasma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B18/1477Needle-like probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B18/1482Probes or electrodes therefor having a long rigid shaft for accessing the inner body transcutaneously in minimal invasive surgery, e.g. laparoscopy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00029Cooling or heating of the probe or tissue immediately surrounding the probe with fluids open
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00059Material properties
    • A61B2018/00071Electrical conductivity
    • A61B2018/00077Electrical conductivity high, i.e. electrically conducting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00107Coatings on the energy applicator
    • A61B2018/00113Coatings on the energy applicator with foam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00166Multiple lumina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577Ablation
    • A61B2018/00583Coblation, i.e. ablation using a cold plasma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00589Coagulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00696Controlled or regulated parameters
    • A61B2018/00702Power or energy
    • A61B2018/00708Power or energy switching the power on or off
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00773Sensed parameters
    • A61B2018/00875Resistance or impedance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00994Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combining two or more different kinds of non-mechanical energy or combining one or more non-mechanical energies with ultrasound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B2018/1405Electrodes having a specific shape
    • A61B2018/1435Spiral
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A61B2018/183Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves characterised by the type of antenna
    • A61B2018/1846Helical antennas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A61B2018/1861Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument inserted into a body lumen or cavity, e.g. a catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A61B2018/1869Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument interstitially inserted into the body, e.g. needles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A61B2018/1892Details of electrical isolations of the antenna

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Otolaryngology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Plasma & Fusion (AREA)
  • Electromagnetism (AREA)
  • Surgical Instruments (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201805321YA 2016-03-04 2017-03-02 Electrosurgical instrument having multiple treatment modalities SG11201805321YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1603744.2A GB2547941A (en) 2016-03-04 2016-03-04 Electrosurgical instrument
PCT/EP2017/054899 WO2017149072A2 (fr) 2016-03-04 2017-03-02 Instrument électrochirurgical comportant de multiples modalités de traitement

Publications (1)

Publication Number Publication Date
SG11201805321YA true SG11201805321YA (en) 2018-07-30

Family

ID=55858989

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201805321YA SG11201805321YA (en) 2016-03-04 2017-03-02 Electrosurgical instrument having multiple treatment modalities

Country Status (15)

Country Link
US (1) US10820937B2 (fr)
EP (1) EP3422981B1 (fr)
JP (1) JP6960165B2 (fr)
KR (1) KR102414547B1 (fr)
CN (1) CN108697464B (fr)
AU (1) AU2017228015B2 (fr)
BR (1) BR112018012747A2 (fr)
CA (1) CA3008347A1 (fr)
DK (1) DK3422981T3 (fr)
ES (1) ES2779801T3 (fr)
GB (1) GB2547941A (fr)
PT (1) PT3422981T (fr)
SG (1) SG11201805321YA (fr)
WO (1) WO2017149072A2 (fr)
ZA (1) ZA201803424B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201308558D0 (en) * 2013-05-13 2013-06-19 Creo Medical Ltd Electrosurgical apparatus
GB2550414A (en) * 2016-05-20 2017-11-22 Creo Medical Ltd Antenna structure
GB2559604A (en) * 2017-02-13 2018-08-15 Creo Medical Ltd Microwave energy transfer component for electrosurgical apparatus
GB2563377A (en) * 2017-05-04 2018-12-19 Creo Medical Ltd Electrosurgical apparatus and method of tissue ablation
GB2562110A (en) * 2017-05-05 2018-11-07 Creo Medical Ltd Apparatus for sterilising an instrument channel of a surgical scoping device
GB2563203A (en) * 2017-06-01 2018-12-12 Creo Medical Ltd Electrosurgical apparatus
CN109953816A (zh) * 2017-12-25 2019-07-02 四川锦江电子科技有限公司 一种多极等离子消融装置
CN109953819A (zh) * 2017-12-25 2019-07-02 四川锦江电子科技有限公司 一种多极等离子消融导管
CN109953815A (zh) * 2017-12-25 2019-07-02 四川锦江电子科技有限公司 一种多极等离子消融导管管体
US11925308B2 (en) * 2018-02-16 2024-03-12 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Ionizing radiation-free dental imaging by near-infrared fluorescence, and related systems
US11197708B2 (en) 2018-02-28 2021-12-14 Gyrus Acmi, Inc. Plasma generator configured for use with an auxiliary device
GB2574365A (en) * 2018-03-16 2019-12-11 Creo Medical Ltd Sterilization apparatus
GB2576477B (en) 2018-05-01 2022-02-16 Creo Medical Ltd Apparatus for treating urinary tract infections
GB2573823A (en) * 2018-05-19 2019-11-20 Creo Medical Ltd Electrosurgical ablation instrument
GB2574219A (en) * 2018-05-30 2019-12-04 Creo Medical Ltd Electrosurgical instrument
GB2577706A (en) 2018-10-03 2020-04-08 Creo Medical Ltd Electrosurgical instrument
GB2579644A (en) * 2018-12-10 2020-07-01 Creo Medical Ltd A modular electrosurgical system, and modules for said system
EP3695798A1 (fr) * 2019-02-13 2020-08-19 National University of Ireland Galway Sonde d'ablation
JP7418141B2 (ja) * 2019-06-04 2024-01-19 日本特殊陶業株式会社 プラズマ照射装置及び先端デバイス
KR102049483B1 (ko) * 2019-08-07 2019-11-27 주식회사 울트라브이 범용 전기 수술기
GB2589589A (en) * 2019-12-03 2021-06-09 Creo Medical Ltd Electrosurgical instrument
US11660135B2 (en) * 2019-12-05 2023-05-30 Biosense Webster (Israel) Ltd. Generating and interleaving of irreversible-electroporation and radiofrequnecy ablation (IRE/RFA) waveforms
GB2590424A (en) * 2019-12-17 2021-06-30 Creo Medical Ltd Electrosurgical instrument and apparatus
CN115551427B (zh) * 2020-03-19 2025-08-01 卡普斯医疗有限公司 使用等离子产生装置对体内空间的处理
US20230125601A1 (en) * 2020-03-19 2023-04-27 Caps Medical Ltd. Plasma system with adjustable features
CN111772776B (zh) * 2020-07-16 2024-12-17 嘉兴市第二医院 一种射频与化学一体化消融装置
CN111772775A (zh) * 2020-07-16 2020-10-16 嘉兴市第二医院 一种射频与化学一体化消融方法
EP4329653A1 (fr) * 2021-04-28 2024-03-06 Sorbonne Universite Outil pour dispositif de traitement medical par plasma et dispositif correspondant
WO2022240233A1 (fr) * 2021-05-13 2022-11-17 서석배 Appareil appliquant des stimuli à base de courant rf et de plasma
CN114376722B (zh) * 2022-03-24 2022-05-31 北京格瑞朗博科技发展有限公司 一种射频和低温等离子的手术电极
CN115778526B (zh) * 2022-07-11 2023-08-29 南京康友医疗科技有限公司 一种微波、射频和测温一体式消融针
EP4458297A1 (fr) 2023-05-04 2024-11-06 Erbe Elektromedizin GmbH Instrument à plasma avec fenêtres latérales
EP4458296A1 (fr) 2023-05-04 2024-11-06 Erbe Elektromedizin GmbH Instrument à plasma
GB202319378D0 (en) * 2023-12-18 2024-01-31 Creo Medical Ltd Electrosurgical instrument
WO2025132371A1 (fr) * 2023-12-19 2025-06-26 Medtronic Europe Sàrl Procédé d'utilisation d'une sonde ou de sondes d'ablation pour créer une zone d'ablation dans un tissu
WO2025179067A1 (fr) * 2024-02-20 2025-08-28 United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health Systèmes et procédés d'ablation intramyocardique
CN120788721B (zh) * 2025-09-15 2025-12-12 电子科技大学 一种微波钻孔手术装置及方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787730B2 (en) * 1998-07-09 2004-09-07 Damian Coccio Device for plasma incision of matter with a specifically tuned radiofrequency electromagnetic field generator
US7276063B2 (en) * 1998-08-11 2007-10-02 Arthrocare Corporation Instrument for electrosurgical tissue treatment
WO2003049631A1 (fr) * 2001-12-12 2003-06-19 Tissuelink Medical, Inc. Dispositifs, systemes et procedes medicaux utilisant un liquide
US6936048B2 (en) * 2003-01-16 2005-08-30 Charlotte-Mecklenburg Hospital Authority Echogenic needle for transvaginal ultrasound directed reduction of uterine fibroids and an associated method
EP2320820B1 (fr) * 2008-05-16 2014-03-19 Trod Medical Instrument de chirurgie percutanee et laparoscopique
JP4706725B2 (ja) * 2008-06-20 2011-06-22 コニカミノルタビジネステクノロジーズ株式会社 定着装置および画像形成装置
US20140358140A1 (en) * 2008-10-21 2014-12-04 Microcube, Llc Microwave treatment devices and methods
WO2010048335A1 (fr) * 2008-10-21 2010-04-29 Microcube, Llc Procédés et dispositifs d'application d'énergie sur des tissus corporels
DE102009044512B4 (de) * 2009-09-11 2021-08-12 Erbe Elektromedizin Gmbh Karbonisierungsverhinderungsvorrichtung
GB2474058B (en) * 2009-10-02 2014-10-01 Creo Medical Ltd Cosmetic Surgery Apparatus
US9060750B2 (en) * 2009-11-09 2015-06-23 Ionmed Ltd. Plasma head for tissue welding
PL2632359T3 (pl) * 2010-10-26 2019-12-31 Erbe Elektromedizin Gmbh Urządzenie do hemostazy
US9011421B2 (en) * 2011-01-05 2015-04-21 Covidien Lp Energy-delivery devices with flexible fluid-cooled shaft, inflow/outflow junctions suitable for use with same, and systems including same
GB2487199A (en) * 2011-01-11 2012-07-18 Creo Medical Ltd Electrosurgical device with fluid conduit
EP4282363A3 (fr) * 2011-01-19 2024-01-10 Fractyl Health, Inc. Dispositifs pour le traitement de tissus
US20140052125A1 (en) * 2011-04-08 2014-02-20 Coviden Lp Flexible microwave catheters for natural or artificial lumens
AU2012308464B2 (en) * 2011-09-14 2016-10-20 Boston Scientific Scimed, Inc. Ablation device with ionically conductive balloon
GB2503673A (en) * 2012-07-03 2014-01-08 Creo Medical Ltd Electrosurgical device with convex under surface
GB201308558D0 (en) * 2013-05-13 2013-06-19 Creo Medical Ltd Electrosurgical apparatus
GB2521611B (en) * 2013-12-23 2020-02-12 Creo Medical Ltd Electrosurgical apparatus and electrosurgical device
GB2548382B (en) * 2016-03-16 2019-04-03 Fourth State Medicine Ltd Plasma generation

Also Published As

Publication number Publication date
EP3422981A2 (fr) 2019-01-09
US10820937B2 (en) 2020-11-03
GB201603744D0 (en) 2016-04-20
US20190083159A1 (en) 2019-03-21
EP3422981B1 (fr) 2020-02-05
BR112018012747A2 (pt) 2018-12-04
WO2017149072A2 (fr) 2017-09-08
AU2017228015A1 (en) 2018-06-14
ZA201803424B (en) 2019-08-28
DK3422981T3 (da) 2020-04-20
AU2017228015B2 (en) 2021-05-13
KR20180123005A (ko) 2018-11-14
KR102414547B1 (ko) 2022-06-29
PT3422981T (pt) 2020-03-26
CA3008347A1 (fr) 2017-09-08
JP6960165B2 (ja) 2021-11-05
JP2019509077A (ja) 2019-04-04
CN108697464A (zh) 2018-10-23
CN108697464B (zh) 2020-11-20
WO2017149072A3 (fr) 2017-10-12
ES2779801T3 (es) 2020-08-19
GB2547941A (en) 2017-09-06

Similar Documents

Publication Publication Date Title
SG11201805321YA (en) Electrosurgical instrument having multiple treatment modalities
SG11201906841VA (en) Electrosurgical energy conveying structure and electrosurgical device incorporating the same
SG11201904471WA (en) Electrosurgical instrument
SG11201804604VA (en) Electrosurgical instrument for radiating microwave energy and dispensing liquid at a treatment site
SG11201807138XA (en) Medical ice slurry production and delivery systems and methods
SG11201804942PA (en) Electrosurgical probe for delivering microwave energy
SG11201901566RA (en) Skin treatment apparatus
SG11201906823RA (en) Electrosurgical apparatus for tissue ablation
SG11201909791XA (en) Apparatus for sterilising an instrument channel of a surgical scoping device
SG11201810385TA (en) Electrosurgical device with integrated microwave source
SG11201903882VA (en) Il-2 variants for the treatment of autoimmune diseases
SG11201908076TA (en) Cryotherapies
SG11201804836RA (en) Treatment of fibrosis
SG11201907934YA (en) Devices, methods, and compositions useful in cryo-preservation, -storage, -transport, and application of therapeutic mammalian cells
SG11201909915PA (en) Electrosurgical instrument for performing ablation or electroporation of biological tissue
SG11201903155XA (en) Pharmaceutical compounds
SG11201908919XA (en) Combination therapies targeting pd-1, tim-3, and lag-3
SG11201809614VA (en) Method for the fabrication of three-dimensional objects and apparatus for same
SG11201806969VA (en) Control device for a surgical instrument
SG11201908790PA (en) Glucocorticoid receptor modulators to treat cervical cancer
SG11201809850QA (en) Systems and methods for cosmetic ultrasound treatment of skin
SG11201804694SA (en) Dual controls for therapeutic cell activation or elimination
SG11201908530QA (en) Treatment methods
SG11201808724SA (en) Anti-tim-3 antibodies and compositions
SG11201808157SA (en) Electrosurgical cutting tool