SG11201804856VA - C-terminal lysine conjugated immunoglobulins - Google Patents
C-terminal lysine conjugated immunoglobulinsInfo
- Publication number
- SG11201804856VA SG11201804856VA SG11201804856VA SG11201804856VA SG11201804856VA SG 11201804856V A SG11201804856V A SG 11201804856VA SG 11201804856V A SG11201804856V A SG 11201804856VA SG 11201804856V A SG11201804856V A SG 11201804856VA SG 11201804856V A SG11201804856V A SG 11201804856VA
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- SG
- Singapore
- Prior art keywords
- international
- rule
- pct
- applicant
- english
- Prior art date
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/528—CH4 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization M1111101110101011111 HO 11111 0111010110111100 11111 00 111110111011# 11 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... ..or::,„, 22 June 2017(22.06.2017) WIPO I PCT WO 2017/106643 Al (51) International Patent Classification: KP, C07K 16/00 (2006.01) MD, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (21) International Application Number: RU, PCT/US2016/067165 TH, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (22) International Filing Date: ZA, ZM, ZW. 16 December 2016 (16.12.2016) (84) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind GM, of regional protection available): ARIPO (BW, GH, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (26) Publication Language: English TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (30) Priority Data: TJ, 62/269,138 18 December 2015 (18.12.2015) US DK, LV, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (71) Applicant: MORPHOTEK, INC. [US/US]; 210 Welsh SM, Pool Road, Exton, PA 19341 (US). GW, KM, ML, MR, NE, SN, TD, TG). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: SPIDEL, Jared; 100 Wildbrier Road, Down- Declarations under Rule 4.17: ingtown, PA 19335 (US). ALBONE, Earl; 2105 Whitpain — as to Hills, Blue Bell, PA 19422 (US). applicant's entitlement to apply for and be granted a patent (Rule 4.1700) (74) Agents: ZACHARAKIS, Maria, Laccotripe et al.; Mc- as to the applicant's entitlement to claim the priority of the Carter & English, LLP, 265 Franklin Street, Boston, MA application (Rule 4.17(iii)) earlier 02110 (US). Published: (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, — with international search report (Art. 21(3)) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, _ before the expiration of the time limit for amending the BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, claims and to be republished in the event of receipt of DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, amendments (Rule 48.2(h)) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 1-1 M 7r © 11 IN 11 © \" (54) Title: C-TERMINAL LYSINE CONJUGATED IMMUNOGLOBULINS C ) „,.. (57) : Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.
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| US201562269138P | 2015-12-18 | 2015-12-18 | |
| PCT/US2016/067165 WO2017106643A1 (en) | 2015-12-18 | 2016-12-16 | C-terminal lysine conjugated immunoglobulins |
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| US11130818B2 (en) * | 2015-08-07 | 2021-09-28 | Merck Patent Gmbh | Transglutamine tag for efficient site-specific bioconjugation |
| MY192987A (en) | 2015-12-18 | 2022-09-20 | Eisai R&D Man Co Ltd | C-terminal lysine conjugated immunoglobulins |
| SMT202200173T1 (en) | 2016-06-01 | 2022-05-12 | Athira Pharma Inc | COMPOUNDS |
| PE20190340A1 (en) * | 2016-06-10 | 2019-03-07 | Eisai Randd Man Co Ltd | IMMUNGLOBULINS CONJUGATED WITH LYSINE |
| EP3272864A1 (en) * | 2016-07-20 | 2018-01-24 | Paul Scherrer Institut | Solid-phase immobilization of microbial transglutaminase mtg on microbeads for protein conjugation |
| CN110637036A (en) | 2017-04-28 | 2019-12-31 | 味之素株式会社 | Compound or salt thereof having affinity substance, cleavage moiety and reactive group for soluble protein |
| WO2019035681A2 (en) | 2017-08-17 | 2019-02-21 | 주식회사 엘지화학 | Electrode for solid-state battery and manufacturing method therefor |
| CN111163809B (en) | 2017-09-19 | 2024-07-02 | 保罗·谢勒学院 | Transglutaminase conjugation method and linker |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| US12097263B2 (en) | 2018-08-02 | 2024-09-24 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| WO2020028832A1 (en) | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| EA202190416A1 (en) | 2018-08-02 | 2021-06-23 | Дайн Терапьютикс, Инк. | MUSCULAR-SPECIFIC COMPLEXES AND THEIR APPLICATION FOR THE TREATMENT OF SHOULDER-SCAPULAR-FACIAL MUSCULAR DYSTROPHY |
| US12370264B1 (en) | 2018-08-02 | 2025-07-29 | Dyne Therapeutics, Inc. | Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US20210324101A1 (en) * | 2018-08-02 | 2021-10-21 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating hypertrophic cardiomyopathy |
| JP7657213B2 (en) | 2019-11-07 | 2025-04-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Anti-mesothelin eribulin antibody-drug conjugates and methods of use |
| US12043670B2 (en) | 2020-06-05 | 2024-07-23 | Eisai R&D Management Co., Ltd. | Anti-BCMA antibody-drug conjugates and methods of use |
| KR20230096052A (en) | 2020-10-25 | 2023-06-29 | 아라리스 바이오테크 아게 | Means and methods for generating antibody-linker conjugates |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| JP2024525608A (en) | 2021-07-09 | 2024-07-12 | ダイン セラピューティクス,インコーポレーテッド | Muscle-targeting complexes and formulations for treating dystrophinopathy |
| CN119183457A (en) | 2022-04-15 | 2024-12-24 | 达因疗法公司 | Muscle-targeted compounds and formulations for the treatment of myotonic dystrophy |
| IL322523A (en) | 2023-02-28 | 2025-10-01 | Eisai R&D Man Co Ltd | Anti-psma antibodies, conjugates, and methods of use |
| WO2025198987A1 (en) * | 2024-03-21 | 2025-09-25 | Merck Sharp & Dohme Llc | Polypeptides for bioconjugation |
| WO2025199464A1 (en) | 2024-03-22 | 2025-09-25 | Eisai R&D Management Co., Ltd. | Anti-trop2 antibody-drug conjugates and methods of use |
| CN120779021A (en) * | 2024-04-08 | 2025-10-14 | 菲鹏生物股份有限公司 | Antibody conjugates and uses thereof |
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| ES2642214T3 (en) | 2004-01-21 | 2017-11-15 | Novo Nordisk Health Care Ag | Conjugation of peptides by transglutaminase |
| AT503902B1 (en) * | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | METHOD FOR MANIPULATING IMMUNE LOBULINS |
| US8426179B2 (en) * | 2007-08-30 | 2013-04-23 | Northwestern University | Synthetic peptide and peptide conjugates and related tissue coupling methods via transglutaminase enzyme |
| MX2010003718A (en) * | 2007-10-19 | 2010-04-21 | Genentech Inc | Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates. |
| EP2635310A2 (en) * | 2010-11-05 | 2013-09-11 | Rinat Neuroscience Corp. | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| WO2013176516A1 (en) | 2012-05-24 | 2013-11-28 | 한화케미칼 주식회사 | Antibody-drug conjugate prepared by using transglutaminase and use thereof |
| US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
| US9359400B2 (en) * | 2013-07-11 | 2016-06-07 | Novartis Ag | Site-specific chemoenzymatic protein modifications |
| WO2015015488A1 (en) * | 2013-07-29 | 2015-02-05 | Microsemi Corp. - Analog Mixed Signal Group, Ltd. | Integrated limiter and active filter |
| WO2015015448A2 (en) * | 2013-07-31 | 2015-02-05 | Rinat Neuroscience Corp. | Engineered polypeptide conjugates |
| EP3134127B1 (en) | 2014-04-25 | 2020-02-26 | Rinat Neuroscience Corp. | Antibody-drug conjugates with high drug loading |
| MY192987A (en) | 2015-12-18 | 2022-09-20 | Eisai R&D Man Co Ltd | C-terminal lysine conjugated immunoglobulins |
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