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SG11201708760PA - Nucleic acid-cationic polymer compositions and methods of making and using the same - Google Patents

Nucleic acid-cationic polymer compositions and methods of making and using the same

Info

Publication number
SG11201708760PA
SG11201708760PA SG11201708760PA SG11201708760PA SG11201708760PA SG 11201708760P A SG11201708760P A SG 11201708760PA SG 11201708760P A SG11201708760P A SG 11201708760PA SG 11201708760P A SG11201708760P A SG 11201708760PA SG 11201708760P A SG11201708760P A SG 11201708760PA
Authority
SG
Singapore
Prior art keywords
making
methods
nucleic acid
same
cationic polymer
Prior art date
Application number
SG11201708760PA
Inventor
Abraham Hochberg
Jennifer Gallula
Original Assignee
Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd filed Critical Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd
Publication of SG11201708760PA publication Critical patent/SG11201708760PA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0091Purification or manufacturing processes for gene therapy compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201708760PA 2015-05-05 2016-05-05 Nucleic acid-cationic polymer compositions and methods of making and using the same SG11201708760PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL23864315 2015-05-05
PCT/IL2016/050477 WO2016178233A1 (en) 2015-05-05 2016-05-05 Nucleic acid-cationic polymer compositions and methods of making and using the same

Publications (1)

Publication Number Publication Date
SG11201708760PA true SG11201708760PA (en) 2017-11-29

Family

ID=56134418

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201708760PA SG11201708760PA (en) 2015-05-05 2016-05-05 Nucleic acid-cationic polymer compositions and methods of making and using the same
SG10201909209R SG10201909209RA (en) 2015-05-05 2016-05-05 Nucleic acid-cationic polymer compositions and methods of making and using the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201909209R SG10201909209RA (en) 2015-05-05 2016-05-05 Nucleic acid-cationic polymer compositions and methods of making and using the same

Country Status (14)

Country Link
US (2) US20180154023A1 (en)
EP (1) EP3291799A1 (en)
JP (2) JP2018515479A (en)
KR (1) KR20180015145A (en)
CN (1) CN107735079A (en)
AU (1) AU2016258326A1 (en)
BR (1) BR112017023788A2 (en)
CA (1) CA2984879A1 (en)
IL (1) IL255254A0 (en)
MX (1) MX2017014060A (en)
PH (1) PH12017502216A1 (en)
RU (1) RU2017140065A (en)
SG (2) SG11201708760PA (en)
WO (1) WO2016178233A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016178233A1 (en) * 2015-05-05 2016-11-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Nucleic acid-cationic polymer compositions and methods of making and using the same
DE102017003004A1 (en) 2017-03-23 2018-09-27 Friedrich-Schiller-Universität Jena Cationic polymers with D-fructose substituents
CN115998757A (en) * 2017-05-17 2023-04-25 亮点医疗有限责任公司 Novel pharmaceutical composition comprising particles with complexes of double-stranded polyribonucleotides and polyethyleneimine
US11746360B2 (en) 2019-02-11 2023-09-05 Florian M. Wurm Eukaryotic cell transfection systems and related methods
CN111363761A (en) * 2020-03-17 2020-07-03 苏州吉恒基因科技有限公司 Method for promoting AAV-mediated gene expression by using cationic polymer DNA complex
KR20230036061A (en) * 2020-04-27 2023-03-14 주노 쎄러퓨티크스 인코퍼레이티드 Stabilization of polyethylenimine-deoxyribonucleic acid complex size and activity
TW202228727A (en) * 2020-10-01 2022-08-01 德商拜恩迪克公司 Preparation and storage of liposomal rna formulations suitable for therapy
US20240245720A1 (en) 2021-05-25 2024-07-25 Ramot At Tel-Aviv University Ltd. Compositions comprising extracellular vesicles and an active agent and uses thereof
CN113501889A (en) * 2021-07-06 2021-10-15 郑州大学 Preparation method and application of pseudo-ginseng polysaccharide cationic derivative
CN116549626A (en) * 2022-01-27 2023-08-08 深圳瑞吉生物科技有限公司 A nucleic acid-loaded lipid nanoparticle freeze-dried preparation and its preparation method and application
CN114762731B (en) * 2022-05-16 2024-08-23 常州大学 Method for prolonging storage time of gene medicine under mild condition
CN116036043A (en) * 2023-01-10 2023-05-02 深圳市乐土生物医药有限公司 Nucleic acid pharmaceutical preparation, freeze-dried powder and preparation method

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
FR2722506B1 (en) 1994-07-13 1996-08-14 Rhone Poulenc Rorer Sa COMPOSITION CONTAINING NUCLEIC ACIDS, PREPARATION AND USES
US6087164A (en) 1997-10-03 2000-07-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods and compositions for inducing tumor-specific cytotoxicity
US20040142474A1 (en) * 2000-09-14 2004-07-22 Expression Genetics, Inc. Novel cationic lipopolymer as a biocompatible gene delivery agent
ES2435774T3 (en) 2005-07-07 2013-12-23 Yissum Research Development Company, Of The Hebrew University Of Jerusalem Nucleic acid agents for the negative regulation of H19, and methods of use thereof
JP2009508516A (en) 2005-09-22 2009-03-05 イッサム リサーチ ディベロプメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム Nucleic acid constructs, pharmaceutical compositions, and methods of use thereof for cancer treatment
WO2008087642A2 (en) 2007-01-16 2008-07-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acid constructs and methods for specific silencing of h19
US20090042825A1 (en) * 2007-08-06 2009-02-12 Majed Matar Composition, method of preparation & application of concentrated formulations of condensed nucleic acids with a cationic lipopolymer
CN107049965A (en) * 2007-08-06 2017-08-18 Clsn实验室股份有限公司 Nucleic acid lipopolymer compositions
JP5486502B2 (en) 2007-10-25 2014-05-07 イッスム リサーチ デベロプメント カンパニー オブ ザ ヘブライ ユニバーシティ オブ エルサレム リミテッド Structures containing multiple expression cassettes for cancer therapy
JP2012501650A (en) * 2008-09-03 2012-01-26 セネスコ テクノロジーズ,インコーポレイティド Use of truncated EIF-5A1 polynucleotides to induce apoptosis in cancer cells
DE102009006606A1 (en) * 2009-01-29 2010-08-05 Philipps-Universität Marburg Non-viral transfection agent
WO2016178233A1 (en) * 2015-05-05 2016-11-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Nucleic acid-cationic polymer compositions and methods of making and using the same

Also Published As

Publication number Publication date
JP2021130671A (en) 2021-09-09
SG10201909209RA (en) 2019-11-28
BR112017023788A2 (en) 2018-10-16
RU2017140065A (en) 2019-06-05
RU2017140065A3 (en) 2019-09-27
AU2016258326A1 (en) 2017-11-23
WO2016178233A1 (en) 2016-11-10
CN107735079A (en) 2018-02-23
KR20180015145A (en) 2018-02-12
JP2018515479A (en) 2018-06-14
PH12017502216A1 (en) 2018-06-11
EP3291799A1 (en) 2018-03-14
IL255254A0 (en) 2017-12-31
US20180154023A1 (en) 2018-06-07
US20200138977A1 (en) 2020-05-07
CA2984879A1 (en) 2016-11-10
MX2017014060A (en) 2018-07-06

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