SG11201708480YA - Dual quencher probes - Google Patents
Dual quencher probesInfo
- Publication number
- SG11201708480YA SG11201708480YA SG11201708480YA SG11201708480YA SG11201708480YA SG 11201708480Y A SG11201708480Y A SG 11201708480YA SG 11201708480Y A SG11201708480Y A SG 11201708480YA SG 11201708480Y A SG11201708480Y A SG 11201708480YA SG 11201708480Y A SG11201708480Y A SG 11201708480YA
- Authority
- SG
- Singapore
- Prior art keywords
- quencher probes
- dual quencher
- dual
- probes
- quencher
- Prior art date
Links
- 230000009977 dual effect Effects 0.000 title 1
- 239000000523 sample Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/46—Phenazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Geophysics And Detection Of Objects (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562147695P | 2015-04-15 | 2015-04-15 | |
| PCT/US2016/027964 WO2016168750A1 (fr) | 2015-04-15 | 2016-04-15 | Sondes à désactivateur dual |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201708480YA true SG11201708480YA (en) | 2017-12-28 |
Family
ID=57127324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201708480YA SG11201708480YA (en) | 2015-04-15 | 2016-04-15 | Dual quencher probes |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10519485B2 (fr) |
| EP (1) | EP3283499B1 (fr) |
| JP (1) | JP2018512167A (fr) |
| CN (1) | CN107922454B (fr) |
| AU (1) | AU2016248347A1 (fr) |
| BR (1) | BR112017022117A2 (fr) |
| CA (1) | CA2982600A1 (fr) |
| CL (1) | CL2017002604A1 (fr) |
| DK (1) | DK3283499T5 (fr) |
| ES (1) | ES2924731T3 (fr) |
| MY (1) | MY181693A (fr) |
| PT (1) | PT3283499T (fr) |
| SG (1) | SG11201708480YA (fr) |
| WO (1) | WO2016168750A1 (fr) |
| ZA (1) | ZA201707679B (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI703158B (zh) | 2015-09-18 | 2020-09-01 | 美商希佛隆公司 | 特異性結合tl1a之抗體 |
| US9851359B2 (en) | 2016-04-06 | 2017-12-26 | Sony Corporation Of America | Ultra bright dimeric or polymeric dyes with spacing linker groups |
| US20190275179A1 (en) * | 2016-11-11 | 2019-09-12 | Memorial Sloan Kettering Cancer Center | Sonophore-labeled probes and related in vivo imaging techniques |
| JP7145517B2 (ja) | 2017-03-08 | 2022-10-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 分析物の検出 |
| CN107236815A (zh) * | 2017-07-18 | 2017-10-10 | 江西贤聚景欣医药生物科技有限公司 | 用于靶核酸序列检测的多重淬灭荧光探针及方法 |
| JP7580689B2 (ja) | 2018-06-27 | 2024-11-12 | ソニーグループ株式会社 | デオキシリボースを含むリンカー基を有するポリマー色素 |
| EP3844303A4 (fr) | 2018-08-27 | 2022-06-01 | The Regents of The University of California | Acides nucléiques rapporteurs pour une détection médiée par crispr de type v |
| US20220402963A1 (en) * | 2019-09-30 | 2022-12-22 | Sony Group Corporation | Nucleotide probes |
| CN112940713A (zh) * | 2019-12-10 | 2021-06-11 | 中国科学院大连化学物理研究所 | 一种用于细胞膜成像的荧光探针及其合成方法和应用 |
| CN111534576B (zh) * | 2020-07-08 | 2020-10-02 | 圣湘生物科技股份有限公司 | 用于荧光定量pcr的方法、组合物、试剂盒及其用途 |
| US20240132725A1 (en) | 2020-12-07 | 2024-04-25 | Sony Group Corporation | Spacing linker group design for brightness enhancement in dimeric or polymeric dyes |
| CN113652493A (zh) * | 2021-08-17 | 2021-11-16 | 厦门市妇幼保健院（厦门市计划生育服务中心） | 一种能减少三种荧光通道pcr竞争的生殖道pcr体系 |
| KR102644903B1 (ko) * | 2021-12-01 | 2024-03-06 | 서울시립대학교 산학협력단 | Dna 기반 생분해성 수지 조성물 |
| EP4453246A4 (fr) | 2021-12-20 | 2025-12-24 | Countable Labs Inc | Détection et quantification numérique de cibles multiples |
| CN114479102A (zh) * | 2022-01-24 | 2022-05-13 | 中国科学院兰州化学物理研究所 | 一种偶氮还原酶和谷胱甘肽双响应型超分子荧光探针及其制备和应用 |
| US20240036035A1 (en) * | 2022-07-15 | 2024-02-01 | The Regents Of The University Of Michigan | Analyte detection using fluorogenic probes or multiplex technologies |
| WO2025207981A1 (fr) * | 2024-03-27 | 2025-10-02 | 3D Medicines Biomedical Technologies, Inc. | Sondes attachées pour dosages d'amplification d'acides nucléiques multiplexés |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4351760A (en) | 1979-09-07 | 1982-09-28 | Syva Company | Novel alkyl substituted fluorescent compounds and polyamino acid conjugates |
| US4391904A (en) | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
| US4707352A (en) | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
| US4707440A (en) | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Nucleic acid hybridization assay and detectable molecules useful in such assay |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4739044A (en) | 1985-06-13 | 1988-04-19 | Amgen | Method for derivitization of polynucleotides |
| US4757141A (en) | 1985-08-26 | 1988-07-12 | Applied Biosystems, Incorporated | Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof |
| US5231191A (en) | 1987-12-24 | 1993-07-27 | Applied Biosystems, Inc. | Rhodamine phosphoramidite compounds |
| US4997928A (en) | 1988-09-15 | 1991-03-05 | E. I. Du Pont De Nemours And Company | Fluorescent reagents for the preparation of 5'-tagged oligonucleotides |
| EP0472648A4 (en) | 1989-05-18 | 1992-09-16 | Microprobe Corporation | Crosslinking oligonucleotides |
| CA2094803A1 (fr) | 1990-10-26 | 1992-04-27 | Robert E. Klem | Methode de synthese d'oligomeres |
| SE506700C2 (sv) | 1996-05-31 | 1998-02-02 | Mikael Kubista | Sond och förfaranden för analys av nukleinsyra |
| US6060242A (en) | 1997-02-27 | 2000-05-09 | Lorne Park Research, Inc. | PNA diagnostic methods |
| US5989823A (en) | 1998-09-18 | 1999-11-23 | Nexstar Pharmaceuticals, Inc. | Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction |
| EP1141409B2 (fr) | 1998-12-14 | 2009-05-27 | Pacific Biosciences of California, Inc. | Trousse et procede de sequencage d'acides nucleiques mono-moleculaires par synthese de polymerase |
| US6682887B1 (en) * | 1999-04-30 | 2004-01-27 | Aclara Biosciences, Inc. | Detection using degradation of a tagged sequence |
| US20070059752A1 (en) | 1999-06-09 | 2007-03-15 | Biosearch Technologies, Inc. | Fluorescence energy transfer probes with stabilized conformations |
| US7019129B1 (en) | 2000-05-09 | 2006-03-28 | Biosearch Technologies, Inc. | Dark quenchers for donor-acceptor energy transfer |
| US20030082547A1 (en) * | 2001-08-27 | 2003-05-01 | Ewing Gregory J. | Non-fluorescent quencher compounds and biomolecular assays |
| US7271265B2 (en) * | 2003-08-11 | 2007-09-18 | Invitrogen Corporation | Cyanine compounds and their application as quenching compounds |
| US7344701B2 (en) * | 2004-02-03 | 2008-03-18 | Biosearch Technologies, Inc. | Xanthene dyes |
| US7705150B2 (en) | 2004-02-04 | 2010-04-27 | Biosearch Technologies, Inc. | Cyanine dyes |
| EP1844161A4 (fr) | 2005-02-04 | 2010-10-27 | Berry & Associates Inc | Extincteurs sombres, sondes et autres conjugues les contenant, et utilisation associee |
| EP1907560B1 (fr) * | 2005-05-20 | 2013-01-23 | Integrated DNA Technologies, Inc. | Composes et procedes de marquage d'oligonucleotides |
| US8354523B2 (en) * | 2006-07-19 | 2013-01-15 | Allelogic Biosciences Corporation | Oligonucleotide probes and uses thereof |
| EP2268608A4 (fr) | 2008-04-01 | 2012-01-11 | Biosearch Technologies Inc | Sondes de désactiveur-fluorophore sombres d acide nucléique stabilisé |
| WO2010147673A2 (fr) * | 2009-06-19 | 2010-12-23 | University Of Florida Research Foundation, Inc. | Nanomoteur à molécule d'adn unique régulé par des photons |
| CA2794485C (fr) | 2010-03-26 | 2018-05-22 | Integrated Dna Technologies, Inc. | Procedes pour ameliorer l'hybridation des acides nucleiques |
| US8815509B2 (en) | 2011-06-14 | 2014-08-26 | University Of Southern California | Fluorescence-based assay for the rapid detection and quantification of deoxyribonucleoside triphosphates |
-
2016
- 2016-04-15 DK DK16780937.5T patent/DK3283499T5/da active
- 2016-04-15 AU AU2016248347A patent/AU2016248347A1/en not_active Abandoned
- 2016-04-15 EP EP16780937.5A patent/EP3283499B1/fr active Active
- 2016-04-15 BR BR112017022117-9A patent/BR112017022117A2/pt not_active Application Discontinuation
- 2016-04-15 WO PCT/US2016/027964 patent/WO2016168750A1/fr not_active Ceased
- 2016-04-15 ES ES16780937T patent/ES2924731T3/es active Active
- 2016-04-15 US US15/130,858 patent/US10519485B2/en active Active
- 2016-04-15 JP JP2017554397A patent/JP2018512167A/ja active Pending
- 2016-04-15 CN CN201680034415.8A patent/CN107922454B/zh active Active
- 2016-04-15 PT PT167809375T patent/PT3283499T/pt unknown
- 2016-04-15 CA CA2982600A patent/CA2982600A1/fr active Pending
- 2016-04-15 MY MYPI2017001524A patent/MY181693A/en unknown
- 2016-04-15 SG SG11201708480YA patent/SG11201708480YA/en unknown
-
2017
- 2017-10-13 CL CL2017002604A patent/CL2017002604A1/es unknown
- 2017-11-13 ZA ZA2017/07679A patent/ZA201707679B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3283499A4 (fr) | 2019-02-20 |
| NZ737214A (en) | 2024-07-26 |
| JP2018512167A (ja) | 2018-05-17 |
| ZA201707679B (en) | 2021-03-31 |
| BR112017022117A2 (pt) | 2018-07-10 |
| CN107922454B (zh) | 2021-10-22 |
| EP3283499A1 (fr) | 2018-02-21 |
| ES2924731T3 (es) | 2022-10-10 |
| US10519485B2 (en) | 2019-12-31 |
| CL2017002604A1 (es) | 2018-04-20 |
| WO2016168750A1 (fr) | 2016-10-20 |
| MY181693A (en) | 2021-01-01 |
| DK3283499T5 (da) | 2024-09-16 |
| PT3283499T (pt) | 2022-08-23 |
| CN107922454A (zh) | 2018-04-17 |
| AU2016248347A1 (en) | 2017-11-30 |
| EP3283499B1 (fr) | 2022-07-06 |
| CA2982600A1 (fr) | 2016-10-20 |
| US20160326576A1 (en) | 2016-11-10 |
| HK1243423A1 (en) | 2018-07-13 |
| DK3283499T3 (da) | 2022-08-08 |
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