[go: up one dir, main page]

SG11201703695VA - Microfluidic measurements of the response of an organism to a drug - Google Patents

Microfluidic measurements of the response of an organism to a drug

Info

Publication number
SG11201703695VA
SG11201703695VA SG11201703695VA SG11201703695VA SG11201703695VA SG 11201703695V A SG11201703695V A SG 11201703695VA SG 11201703695V A SG11201703695V A SG 11201703695VA SG 11201703695V A SG11201703695V A SG 11201703695VA SG 11201703695V A SG11201703695V A SG 11201703695VA
Authority
SG
Singapore
Prior art keywords
organism
drug
response
microfluidic measurements
microfluidic
Prior art date
Application number
SG11201703695VA
Inventor
Rustem Ismagilov
Eugenia Khorosheva
Travis Schlappi
Matthew S Curtis
Nathan Schoepp
Hedia Maamar
Feng Shen
Erik B Jue
Original Assignee
California Inst Of Techn
Slipchip Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn, Slipchip Corp filed Critical California Inst Of Techn
Publication of SG11201703695VA publication Critical patent/SG11201703695VA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
    • C12Q2545/114—Reactions characterised by their quantitative nature the purpose being quantitative analysis involving a quantitation step
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/629—Detection means characterised by use of a special device being a microfluidic device
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Algebra (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Physics (AREA)
  • Pure & Applied Mathematics (AREA)
SG11201703695VA 2014-11-05 2015-11-05 Microfluidic measurements of the response of an organism to a drug SG11201703695VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462075648P 2014-11-05 2014-11-05
PCT/US2015/059344 WO2016085632A2 (en) 2014-11-05 2015-11-05 Microfluidic measurements of the response of an organism to a drug

Publications (1)

Publication Number Publication Date
SG11201703695VA true SG11201703695VA (en) 2017-06-29

Family

ID=56075122

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201703695VA SG11201703695VA (en) 2014-11-05 2015-11-05 Microfluidic measurements of the response of an organism to a drug

Country Status (12)

Country Link
US (1) US11542545B2 (en)
EP (1) EP3215631A4 (en)
JP (2) JP7055020B2 (en)
KR (1) KR20180040511A (en)
CN (2) CN113943773A (en)
AU (2) AU2015354693B2 (en)
CA (1) CA2966575A1 (en)
HK (1) HK1243466A1 (en)
IL (1) IL252031B (en)
SG (1) SG11201703695VA (en)
WO (1) WO2016085632A2 (en)
ZA (1) ZA201703412B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016085632A2 (en) 2014-11-05 2016-06-02 California Institute Of Technology Microfluidic measurements of the response of an organism to a drug
WO2018027185A1 (en) 2016-08-04 2018-02-08 Duke University Compositions and methods for measuring bacterial growth
WO2018058078A1 (en) * 2016-09-23 2018-03-29 California Institute Of Technology Digital quantification of dna replication and/or chromosome segregation based determination of antimicrobial susceptibility
US9851345B1 (en) * 2016-10-12 2017-12-26 Viasphere, Llc Compositions and methods for disease diagnosis using single cell analysis
EP3538668B8 (en) * 2016-11-10 2025-04-23 Talis Biomedical Corporation Polynucleotides for the amplification and detection of chlamydia trachomatis
WO2018111630A2 (en) * 2016-12-06 2018-06-21 Microbedx, Inc. Rnase for improved microbial detection and antimicrobial susceptibility testing
FI3601588T3 (en) * 2017-03-22 2023-08-31 Astrego Diagnostics Ab Phenotypic characterization of cells
US10947576B2 (en) * 2017-07-25 2021-03-16 Arizona Board Of Regents On Behalf Of Arizona State University Rapid antibiotic susceptibility testing by tracking sub-micron scale motion of single bacterial cells
US20200263224A1 (en) * 2017-08-18 2020-08-20 Microbedx, Inc. Methods for Antimicrobial Susceptibility Testing
CA3071462A1 (en) * 2017-08-30 2019-03-07 Microbedx, Inc. Device for optimization of microorganism growth in liquid culture
WO2019075264A1 (en) * 2017-10-11 2019-04-18 California Institute Of Technology Antibiotic susceptibility of microorganisms and related compositions, methods and systems
US12448655B2 (en) 2017-10-11 2025-10-21 California Institute Of Technology Antibiotic susceptibility of microorganisms and related methods and systems
CN108796123B (en) * 2018-05-04 2022-09-23 中农威特生物科技股份有限公司 Kit for rapidly detecting Seneca virus and detection method thereof
US10450616B1 (en) 2018-05-09 2019-10-22 Talis Biomedical Corporation Polynucleotides for the amplification and detection of Chlamydia trachomatis
WO2019241471A1 (en) * 2018-06-13 2019-12-19 Klaris Corporation Compositions and methods for cellular phenotype assessment of a sample using confined volume arrays
US11291997B2 (en) * 2018-08-02 2022-04-05 Colorado State University Research Foundation Rotary manifold for paper-based immunoassays
TWI679281B (en) * 2018-08-22 2019-12-11 國立清華大學 Method for detecting live Mycobacterium tuberculosis in a sample
WO2020061553A1 (en) * 2018-09-21 2020-03-26 Emory University Using multiple heteroresistance to guide combination antibiotic regimens
EP3861129A4 (en) * 2018-10-02 2022-07-20 BioFire Diagnostics, LLC BACTERIAL RESPONSE
US20220111378A1 (en) * 2019-01-17 2022-04-14 Genecapture, Inc. Methods and systems for determining target sensitivity to a therapeutic formula
ES2954784T3 (en) * 2019-05-08 2023-11-24 Dnae Diagnostics Ltd Combined solution phase and solid phase DNA amplification
US10954572B2 (en) 2019-07-25 2021-03-23 Talis Biomedical Corporation Polynucleotides for the amplification and detection of Neisseria gonorrhoeae
CN110849855A (en) * 2019-12-02 2020-02-28 杭州特隆基因技术有限公司 Artificial intelligence-based living bacterium quantitative detection method
US11891662B2 (en) 2019-12-02 2024-02-06 Talis Biomedical Corporation Polynucleotides for amplification and detection of human beta actin
KR102352898B1 (en) 2019-12-06 2022-01-18 광주과학기술원 Antibiotic Reaction Analysis Device
GB202001399D0 (en) * 2020-01-31 2020-03-18 Odx Innovations Ltd Centrifugally motivated fluidic systems, devices and methods
US12264365B2 (en) 2020-03-23 2025-04-01 Talis Biomedical Corporation Polynucleotides for amplification and detection of SARS-CoV-2
WO2022082025A1 (en) * 2020-10-16 2022-04-21 Biomems Analytics Llc Cellular response analysis method
CN120379765A (en) * 2022-06-24 2025-07-25 戴博创新有限公司 Test system, test apparatus, test method, and test preparation device
WO2024059305A1 (en) * 2022-09-15 2024-03-21 General Electric Company Method and apparatus for using lyophilized reagent beads for antimicrobial susceptibility testing
DE102023212142A1 (en) 2023-12-04 2025-06-05 Robert Bosch Gesellschaft mit beschränkter Haftung Device and method for culturing and testing tissue sections
US20250290117A1 (en) * 2024-03-14 2025-09-18 Bristol Whiles Molecular phenotypic antimicrobial susceptibility testing

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0822261B1 (en) 1996-07-29 2002-07-03 Academia Sinica Methods for rapid antimicrobial susceptibility testing
US6391577B1 (en) 1999-03-03 2002-05-21 Susan R. Mikkelsen Rapid electrochemical assay for antibiotic and cytotoxic drug susceptibility in microorganisms
US6153400A (en) 1999-03-12 2000-11-28 Akzo Nobel N.V. Device and method for microbial antibiotic susceptibility testing
EP1177448A2 (en) 1999-04-29 2002-02-06 Dade MicroScan Inc. A combined rapid anti-microbial susceptibility assay and microorganism identification system
AU2003254093A1 (en) 2002-07-19 2004-02-09 Isis Pharmaceuticals, Inc. Methods for mass spectrometry analysis utilizing an integrated microfluidics sample platform
AU2004273783A1 (en) 2003-07-12 2005-03-31 Accelr8 Technology Corporation Sensitive and rapid biodetection
US8206902B2 (en) 2003-12-25 2012-06-26 Riken Method of amplifying nucleic acid and method of detecting mutated nucleic acid using the same
CA2641271A1 (en) 2006-02-03 2008-03-13 Microchip Biotechnologies, Inc. Microfluidic devices
US9114398B2 (en) 2006-11-29 2015-08-25 Canon U.S. Life Sciences, Inc. Device and method for digital multiplex PCR assays
JP4410268B2 (en) 2007-03-28 2010-02-03 株式会社東芝 Nucleic acid primer set and nucleic acid probe for detecting the genotype of methylenetetrahydrofolate reductase (MTHFR)
US8557523B2 (en) 2007-10-19 2013-10-15 Eiken Kagaku Kabushiki Kaisha Method of nucleic acid amplification and measuring reagent and reagent kit therefor
US8911946B2 (en) * 2007-12-21 2014-12-16 Gen-Probe Incorporated Detection of antibiotic-resistant microorganisms
US20110269130A1 (en) 2008-10-24 2011-11-03 Song Shi Antibiotice Susceptibility Profiling Methods
WO2010091111A1 (en) 2009-02-03 2010-08-12 Biohelix Corporation Endonuclease-enhanced helicase-dependent amplification
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
CN104722342B (en) 2009-03-24 2017-01-11 芝加哥大学 Slip chip device and method
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
EP3998346A1 (en) 2009-03-30 2022-05-18 Illumina, Inc. Gene expression analysis in single cells
WO2011066449A1 (en) * 2009-11-24 2011-06-03 Sevident Devices for detection of analytes
WO2011106536A2 (en) 2010-02-24 2011-09-01 The Broad Institute, Inc Methods of diagnosing infectious disease pathogens and their drug sensitivity
EP2601307A4 (en) 2010-08-06 2014-01-01 Capitalbio Corp MICROPUICE-BASED ASSAY COMPRISING PARTICLES FOR ANALYZING MOLECULAR INTERACTIONS
EP2627781B1 (en) 2010-10-15 2017-02-22 Olink Bioscience AB Dynamic range methods
JP2012085605A (en) 2010-10-22 2012-05-10 Sony Corp Nucleic acid amplification reaction device, substrate used for nucleic acid amplification reaction device, and nucleic acid amplification reaction method
EP2673380B1 (en) 2011-02-09 2018-12-12 Bio-Rad Laboratories, Inc. Analysis of nucleic acids
US9050593B2 (en) 2011-11-23 2015-06-09 Wisconsin Alumni Research Foundation Self-loading microfluidic device and methods of use
KR101290648B1 (en) 2012-02-02 2013-07-29 서울대학교산학협력단 Rapid antibiotic susceptibility test (rast) system based on bacterial fixation, antibiotic diffusion and single cell growth tracking using gelling agents
AU2013225823A1 (en) 2012-02-29 2014-09-18 President And Fellows Of Harvard College Rapid antibiotic susceptibility testing
WO2013159116A1 (en) 2012-04-20 2013-10-24 University Of Chicago Fluidic devices for biospecimen preservation
JP6196661B2 (en) 2012-04-20 2017-09-13 スリップチップ， エルエルシー Fluidic devices and systems for sample preparation or autonomous analysis
US9803237B2 (en) 2012-04-24 2017-10-31 California Institute Of Technology Slip-induced compartmentalization
WO2014025337A1 (en) 2012-08-06 2014-02-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Methods and reagents for amplifying nucleic acids
CA2887206A1 (en) 2012-10-05 2014-04-10 Rustem F. Ismagilov Methods and systems for microfluidics imaging and analysis
RU2666988C2 (en) 2012-10-22 2018-09-13 Байер Кропсайенс Нв Methods, compositions and devices for amplification of nucleic acids
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
AU2014253749B2 (en) * 2013-04-19 2018-09-20 California Institute Of Technology Parallelized sample handling
WO2015009967A1 (en) 2013-07-19 2015-01-22 California Institute Of Technology Digital assay for quantifying and concentrating analytes
MX2016000811A (en) 2013-07-23 2016-10-13 Univ California Amdinocillin for rapid determination of susceptibility to beta-lactam antibiotics.
JP2016532075A (en) 2013-09-18 2016-10-13 カリフォルニア インスティテュート オブ テクノロジー System and method for movement and timing control
WO2015058008A2 (en) 2013-10-18 2015-04-23 California Institute Of Technology Enhanced nucleic acid identification and detection
EP3169793B1 (en) 2014-07-16 2022-07-06 Tangen Biosciences Inc. Isothermal methods for amplifying nucleic acid samples
US20170225161A1 (en) 2014-08-15 2017-08-10 California Institute Of Technology The pumping lid: devices and methods for programmable generation of positive and negative pressures
WO2016085632A2 (en) 2014-11-05 2016-06-02 California Institute Of Technology Microfluidic measurements of the response of an organism to a drug

Also Published As

Publication number Publication date
AU2015354693A1 (en) 2017-05-18
ZA201703412B (en) 2021-08-25
JP2022028837A (en) 2022-02-16
JP2018500926A (en) 2018-01-18
EP3215631A4 (en) 2018-08-08
US11542545B2 (en) 2023-01-03
JP7055020B2 (en) 2022-04-15
KR20180040511A (en) 2018-04-20
WO2016085632A2 (en) 2016-06-02
CA2966575A1 (en) 2016-06-02
IL252031A0 (en) 2017-06-29
CN113943773A (en) 2022-01-18
IL252031B (en) 2022-03-01
WO2016085632A3 (en) 2016-09-15
EP3215631A2 (en) 2017-09-13
AU2015354693B2 (en) 2022-06-02
CN107636173A (en) 2018-01-26
HK1243466A1 (en) 2018-07-13
AU2022203175A1 (en) 2022-06-02
US20180274020A1 (en) 2018-09-27

Similar Documents

Publication Publication Date Title
ZA201703412B (en) Microfluidic measurements of the response of an organism to a drug
GB2526440B (en) Sensor arrangements
IL248431B (en) Syringe with rolling diaphragm
GB201403389D0 (en) Sensor
GB201405713D0 (en) Fluid sensor
ZA201707884B (en) Physiological measurement sensor
TWI563254B (en) Sensor
GB201409929D0 (en) Monitoring adherence to healthcare guidelines
EP3180618A4 (en) Noninvasive body fluid stress sensing
GB2529898B (en) Touch sensors
SI3174451T1 (en) Medical sensor assembly
GB2529749B (en) Monitoring the structural health of columns
EP3186664C0 (en) Measurement of acceleration
GB201515172D0 (en) Measurement of respiratory function
SG11201704325QA (en) Micro-cavity-based force sensor
GB201412136D0 (en) Sensor
GB201402316D0 (en) Provision of predetermined fluid
GB201420245D0 (en) Sensor manufacture
FI20145723A7 (en) Pressure sensor
GB2528159B (en) Sensor
GB2532746B (en) Temperature sensing
GB201410118D0 (en) Early diagnosis of leptospire
GB201411034D0 (en) Sensor
GB201407741D0 (en) Novel drug formulation
GB201400951D0 (en) Novel drug formulation