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SG11201610866PA - Inhibitors of lysine specific demethylase-1 - Google Patents

Inhibitors of lysine specific demethylase-1

Info

Publication number
SG11201610866PA
SG11201610866PA SG11201610866PA SG11201610866PA SG11201610866PA SG 11201610866P A SG11201610866P A SG 11201610866PA SG 11201610866P A SG11201610866P A SG 11201610866PA SG 11201610866P A SG11201610866P A SG 11201610866PA SG 11201610866P A SG11201610866P A SG 11201610866PA
Authority
SG
Singapore
Prior art keywords
inhibitors
specific demethylase
lysine specific
lysine
demethylase
Prior art date
Application number
SG11201610866PA
Inventor
Young K Chen
Toufike Kanouni
Jeffrey Alan Stafford
James Marvin Veal
Original Assignee
Celgene Quanticel Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54938856&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201610866P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Quanticel Res Inc filed Critical Celgene Quanticel Res Inc
Publication of SG11201610866PA publication Critical patent/SG11201610866PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polyamides (AREA)
SG11201610866PA 2014-06-27 2015-06-26 Inhibitors of lysine specific demethylase-1 SG11201610866PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462018365P 2014-06-27 2014-06-27
PCT/US2015/038089 WO2015200843A1 (en) 2014-06-27 2015-06-26 Inhibitors of lysine specific demethylase-1

Publications (1)

Publication Number Publication Date
SG11201610866PA true SG11201610866PA (en) 2017-01-27

Family

ID=54938856

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201610866PA SG11201610866PA (en) 2014-06-27 2015-06-26 Inhibitors of lysine specific demethylase-1
SG10201911220TA SG10201911220TA (en) 2014-06-27 2015-06-26 Inhibitors of lysine specific demethylase-1

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201911220TA SG10201911220TA (en) 2014-06-27 2015-06-26 Inhibitors of lysine specific demethylase-1

Country Status (28)

Country Link
US (3) US10011583B2 (en)
EP (1) EP3160956B1 (en)
JP (2) JP6587241B2 (en)
KR (1) KR102438302B1 (en)
CN (1) CN106660987B (en)
AU (2) AU2015279591A1 (en)
BR (1) BR112016030697B1 (en)
CA (1) CA2953810C (en)
CL (1) CL2016003350A1 (en)
CO (1) CO2017000362A2 (en)
CY (1) CY1123475T1 (en)
DK (1) DK3160956T3 (en)
EA (1) EA030946B1 (en)
EC (1) ECSP17005635A (en)
ES (1) ES2812626T3 (en)
HR (1) HRP20201337T1 (en)
HU (1) HUE050564T2 (en)
IL (1) IL249733B (en)
LT (1) LT3160956T (en)
MX (1) MX376632B (en)
PL (1) PL3160956T3 (en)
PT (1) PT3160956T (en)
RS (1) RS60658B1 (en)
SG (2) SG11201610866PA (en)
SI (1) SI3160956T1 (en)
SM (1) SMT202000443T1 (en)
WO (1) WO2015200843A1 (en)
ZA (1) ZA201700069B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX383590B (en) 2013-08-06 2025-03-11 Imago Biosciences Inc KDM1A INHIBITORS FOR THE TREATMENT OF DISEASES.
US10011583B2 (en) 2014-06-27 2018-07-03 Celgene Quanticel Research, Inc. Inhibitors of lysine specific demethylase-1
SI3511319T1 (en) * 2014-07-03 2023-10-30 Celgene Quanticel Research, Inc. Inhibitors of lysine specific demethylase-1
LT3256218T (en) 2015-02-12 2025-02-10 Imago Biosciences Inc. KDM1A INHIBITOR AND ITS USE IN THERAPY
CA2987876A1 (en) 2015-06-12 2016-12-15 Oryzon Genomics, S.A. Biomarkers associated with lsd1 inhibitors and uses thereof
WO2017013061A1 (en) 2015-07-17 2017-01-26 Oryzon Genomics, S.A. Biomarkers associated with lsd1 inhibitors and uses thereof
CN120661674A (en) 2016-03-15 2025-09-19 奥莱松基因组股份有限公司 Combination of LSD1 inhibitors for the treatment of solid tumors
ES3042059T3 (en) 2016-03-16 2025-11-18 Oryzon Genomics Sa Methods to determine kdm1a target engagement and chemoprobes useful therefor
US10150754B2 (en) 2016-04-19 2018-12-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
CN111194306B (en) 2016-08-16 2023-05-16 伊美格生物科学公司 Methods and processes for the preparation of KDM1A inhibitors
EP3535420A1 (en) 2016-11-03 2019-09-11 Oryzon Genomics, S.A. Biomarkers for determining responsiveness to lsd1 inhibitors
JP2020121925A (en) * 2017-04-10 2020-08-13 三井化学アグロ株式会社 Pest control composition containing pyridone compound and quinoline compound, pest control method, and novel quinoline compound
WO2018190323A1 (en) * 2017-04-10 2018-10-18 三井化学アグロ株式会社 Harmful organism control composition containing pyridone compound and harmful organism control agent, and harmful organism control method
WO2018190324A1 (en) * 2017-04-10 2018-10-18 三井化学アグロ株式会社 Antifungal agent containing pyridone compound as active component, and use method thereof
SI3661510T1 (en) 2017-08-03 2025-03-31 Oryzon Genomics, S.A. Methods of treating behavior alterations
KR102724968B1 (en) * 2018-03-21 2024-10-31 수조우 푸허 바이오파마 컴퍼니 리미티드 SHP2 inhibitors and uses thereof
CA3103392A1 (en) * 2018-05-11 2019-11-14 Imago Biosciences, Inc. Kdm1a inhibitors for the treatment of disease
MX2021011254A (en) 2019-03-20 2021-10-01 Oryzon Genomics Sa METHODS OF TREATMENT OF ATTENTION DEFICIT AND HYPERACTIVITY DISORDER.
KR20210141933A (en) 2019-03-20 2021-11-23 오리존 지노믹스 에스.에이. How to treat borderline personality disorder
EP3994280A1 (en) 2019-07-05 2022-05-11 Oryzon Genomics, S.A. Biomarkers and methods for personalized treatment of small cell lung cancer using kdm1a inhibitors
BR112023020554A2 (en) 2021-04-08 2023-12-05 Oryzon Genomics Sa LSD1 INHIBITOR COMBINATIONS FOR THE TREATMENT OF MYELOID CANCERS
EP4419504A4 (en) * 2021-10-18 2025-09-03 Imago Biosciences Inc KDM1A inhibitors for the treatment of diseases
JP2025516647A (en) 2022-05-09 2025-05-30 オリゾン・ゲノミクス・ソシエダッド・アノニマ Treatment of malignant peripheral nerve sheath tumors (MPNST) using LSD1 inhibitors
US20250295660A1 (en) 2022-05-09 2025-09-25 Oryzon Genomics, S.A. Methods of treating nf1-mutant tumors using lsd1 inhibitors
AU2023385514A1 (en) 2022-11-24 2025-07-10 Oryzon Genomics, S.A. Combinations of lsd1 inhibitors and menin inhibitors for treating cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7994325B2 (en) * 2005-03-14 2011-08-09 Merck Sharp & Dohme Corp. CGRP receptor antagonists
US20090186907A1 (en) 2006-06-21 2009-07-23 E.I. Dupont De Nemours And Company Pyrazinones As Cellular Proliferation Inhibitors
CN101842361B (en) * 2007-06-27 2013-06-05 阿斯利康(瑞典)有限公司 Pyrazinone derivatives and their use in the treatment of lung diseases
CL2008002793A1 (en) 2007-09-20 2009-09-04 Cgi Pharmaceuticals Inc Compounds derived from substituted amides, inhibitors of btk activity; pharmaceutical composition comprising them; Useful in the treatment of cancer, bone disorders, autoimmune diseases, among others
US9006449B2 (en) * 2010-07-29 2015-04-14 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as LSD1 inhibitors
SG11201408324QA (en) 2012-06-12 2015-01-29 Abbvie Inc Pyridinone and pyridazinone derivatives
LT3080100T (en) * 2013-12-11 2023-02-27 Celgene Quanticel Research, Inc. LYSINE-SPECIFIC DEMETHYLASE-1 INHIBITORS
CN103804312B (en) * 2014-02-17 2016-04-20 四川百利药业有限责任公司 Aza cyclic cpds and its production and use
US9255097B2 (en) * 2014-05-01 2016-02-09 Quanticel Pharmaceuticals, Inc. Inhibitors of lysine specific demethylase-1
US10011583B2 (en) 2014-06-27 2018-07-03 Celgene Quanticel Research, Inc. Inhibitors of lysine specific demethylase-1

Also Published As

Publication number Publication date
RS60658B1 (en) 2020-09-30
SG10201911220TA (en) 2020-02-27
EP3160956B1 (en) 2020-05-27
BR112016030697A2 (en) 2018-07-17
CA2953810C (en) 2022-07-12
ECSP17005635A (en) 2017-03-31
CY1123475T1 (en) 2022-03-24
CL2016003350A1 (en) 2018-05-11
AU2019261771B2 (en) 2020-09-24
EA030946B1 (en) 2018-10-31
SMT202000443T1 (en) 2020-09-10
JP6587241B2 (en) 2019-10-09
IL249733B (en) 2020-07-30
IL249733A0 (en) 2017-02-28
EP3160956A1 (en) 2017-05-03
US20170137402A1 (en) 2017-05-18
KR20170018913A (en) 2017-02-20
BR112016030697B1 (en) 2023-03-21
CN106660987B (en) 2020-11-06
JP2019167345A (en) 2019-10-03
HRP20201337T1 (en) 2020-11-27
PL3160956T3 (en) 2020-11-30
US20200172506A1 (en) 2020-06-04
SI3160956T1 (en) 2020-11-30
MX376632B (en) 2025-03-07
MX2017000179A (en) 2017-05-01
CA2953810A1 (en) 2015-12-30
EA201692513A1 (en) 2017-05-31
ES2812626T3 (en) 2021-03-17
HUE050564T2 (en) 2020-12-28
CO2017000362A2 (en) 2017-04-10
US10011583B2 (en) 2018-07-03
PT3160956T (en) 2020-09-01
ZA201700069B (en) 2018-04-25
AU2015279591A1 (en) 2017-01-19
US10597376B2 (en) 2020-03-24
AU2019261771A1 (en) 2019-11-28
JP2017519781A (en) 2017-07-20
US11028066B2 (en) 2021-06-08
US20180273505A1 (en) 2018-09-27
LT3160956T (en) 2020-09-10
KR102438302B1 (en) 2022-08-30
JP6851418B2 (en) 2021-03-31
WO2015200843A1 (en) 2015-12-30
CN106660987A (en) 2017-05-10
DK3160956T3 (en) 2020-08-31
EP3160956A4 (en) 2018-01-10

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