SG11201609497TA - Compounds for treating spinal muscular atrophy - Google Patents

Compounds for treating spinal muscular atrophy

Info

Publication number: SG11201609497TA
Authority: SG; Singapore
Prior art keywords: compounds; muscular atrophy; spinal muscular; treating spinal; treating
Prior art date: 2014-05-15

Application number

SG11201609497TA

Other languages

English (en)

Inventor

Hasane Ratni

Luke Green

Nikolai A Naryshkin

Marla L Weetall

Original Assignee

Hoffmann La Roche

Ptc Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-05-15

Filing date

2015-05-11

Publication date

2016-12-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53175048&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201609497T(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2015-05-11 Application filed by Hoffmann La Roche, Ptc Therapeutics Inc filed Critical Hoffmann La Roche

2016-12-29 Publication of SG11201609497TA publication Critical patent/SG11201609497TA/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SG11201609497TA 2014-05-15 2015-05-11 Compounds for treating spinal muscular atrophy SG11201609497TA (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201461993839P	2014-05-15	2014-05-15
PCT/EP2015/060343 WO2015173181A1 (fr)	2014-05-15	2015-05-11	Composés pour le traitement d'une amyotrophie spinale

Publications (1)

Publication Number	Publication Date
SG11201609497TA true SG11201609497TA (en)	2016-12-29

Family

ID=53175048

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG11201609497TA SG11201609497TA (en)	2014-05-15	2015-05-11	Compounds for treating spinal muscular atrophy

Country Status (36)

Country	Link
US (1)	US9969754B2 (fr)
EP (3)	EP4241772A3 (fr)
JP (1)	JP6236173B2 (fr)
KR (2)	KR102213740B1 (fr)
CN (1)	CN106459092B (fr)
AR (2)	AR100442A1 (fr)
AU (1)	AU2015261046C1 (fr)
BR (1)	BR112016026205B1 (fr)
CA (1)	CA2948561C (fr)
CL (1)	CL2016002836A1 (fr)
CR (1)	CR20160518A (fr)
DK (1)	DK3143025T3 (fr)
EA (2)	EA202090486A3 (fr)
ES (2)	ES2761423T3 (fr)
FR (1)	FR21C1039I2 (fr)
HR (2)	HRP20230637T1 (fr)
HU (2)	HUE046491T2 (fr)
IL (2)	IL248653B (fr)
LT (1)	LTC3143025I2 (fr)
MA (2)	MA51988A (fr)
MX (1)	MX371050B (fr)
MY (1)	MY174284A (fr)
NL (1)	NL301128I2 (fr)
NO (2)	NO2021035I1 (fr)
NZ (1)	NZ725008A (fr)
PE (1)	PE20170128A1 (fr)
PH (1)	PH12016502081B1 (fr)
PL (2)	PL3663296T3 (fr)
PT (1)	PT3143025T (fr)
RS (1)	RS59718B1 (fr)
SG (1)	SG11201609497TA (fr)
SI (2)	SI3143025T1 (fr)
TW (1)	TWI667239B (fr)
UA (1)	UA119670C2 (fr)
WO (1)	WO2015173181A1 (fr)
ZA (1)	ZA201607026B (fr)

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CN119528903A (zh)	2012-02-10	2025-02-28	Ptc医疗公司	用于治疗脊髓性肌萎缩的化合物
BR112015032718A2 (pt)	2013-08-19	2019-09-17	Hoffmann La Roche	composto de modificação de splicing do gene foxm1, uso do composto, formulação farmacêutica e métodos de triagem de compostos
US10882868B2 (en) *	2014-05-15	2021-01-05	Hoffmann-La Roche Inc.	Compounds for treating spinal muscular atrophy
JP6749343B2 (ja)	2015-05-20	2020-09-02	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	脊髄性筋萎縮症を処置するための化合物
US10668171B2 (en)	2015-05-30	2020-06-02	Ptc Therapeutics, Inc.	Methods for modulating RNA splicing
CN108289959B (zh)	2015-11-12	2021-07-16	豪夫迈·罗氏有限公司	用于治疗脊髓性肌萎缩的组合物
KR20180081520A (ko) *	2015-11-12	2018-07-16	에프. 호프만-라 로슈 아게	근위축성 측삭 경화증의 치료를 위한 화합물
EA201800367A1 (ru)	2015-12-10	2019-02-28	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	Способы лечения болезни хантингтона
EP3386978B1 (fr)	2015-12-10	2021-01-27	H. Hoffnabb-La Roche Ag	Dérivés de pipéridine pontés
US11702646B2 (en)	2016-11-28	2023-07-18	Ptc Therapeutics, Inc.	Methods for modulating RNA splicing
KR20200033249A (ko)	2017-06-05	2020-03-27	피티씨 테라퓨틱스, 인크.	헌팅턴병 치료 화합물
JP2020523365A (ja)	2017-06-14	2020-08-06	ピーティーシーセラピューティクス，インコーポレーテッド	Ｒｎａスプライシングを改変する方法
US11395822B2 (en)	2017-06-28	2022-07-26	Ptc Therapeutics, Inc.	Methods for treating Huntington's disease
CA3067591A1 (fr)	2017-06-28	2019-01-03	Ptc Therapeutics, Inc.	Procedes de traitement de la maladie de huntington
MX2020002711A (es) *	2017-09-22	2020-07-20	Hoffmann La Roche	Proceso para preparacion de 7-(4,7-diazaespiro[2.5]octan-7-il)-2-( 2,8-dimetilimidazo[1,2-b]piridazin-6-il)pirido[1,2-a]pirimidin-4- ona.
KR102761837B1 (ko) *	2017-10-03	2025-02-05	에프. 호프만-라 로슈 아게	척수성 근위축증의 새로운 치료법
US12103926B2 (en)	2018-03-27	2024-10-01	Ptc Therapeutics, Inc.	Compounds for treating huntington's disease
SG11202013088YA (en)	2018-06-27	2021-02-25	Reborna Biosciences Inc	Prophylactic or therapeutic agent for spinal muscular atrophy
BR112020026545A2 (pt)	2018-06-27	2021-03-23	Ptc Therapeutics, Inc.	Compostos heterocíclicos e de heteroarila para o tratamento da doença de huntington
EP3814360B8 (fr)	2018-06-27	2024-11-06	PTC Therapeutics, Inc.	Composés hétéroaryl pour traiter la maladie de huntington
EA202092899A1 (ru)	2018-06-27	2021-05-14	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	Гетероарильные соединения для лечения болезни гентингтона
KR102705600B1 (ko)	2018-10-19	2024-09-12	에프. 호프만-라 로슈 아게	피리도[1,2-a]피리미딘-4-온 유도체의 형태, 그의 제형 및 그의 제조 방법
CN113966219A (zh)	2019-06-12	2022-01-21	豪夫迈·罗氏有限公司	Sma的新治疗方法
US12492214B2 (en)	2019-07-31	2025-12-09	Assia Chemical Industries Ltd.	Solid state forms of Risdiplam and process for preparation thereof
BR112022020418A2 (pt) *	2020-04-08	2023-05-02	Remix Therapeutics Inc	Compostos e métodos para modulação de splicing
WO2022048675A1 (fr) *	2020-09-07	2022-03-10	苏州科睿思制药有限公司	Forme cristalline du risdiplam, son procédé de préparation et son utilisation
WO2022162107A1 (fr)	2021-02-01	2022-08-04	Sandoz Ag	Forme cristalline de risdiplam
EP4308577B1 (fr) *	2021-03-17	2024-12-25	F. Hoffmann-La Roche AG	Nouveaux dérivés de thiadiazolopyrimidone
KR20230157367A (ko)	2021-03-17	2023-11-16	에프. 호프만-라 로슈 아게	신규 티아졸로피리미디논 유도체
AU2022237836B2 (en) *	2021-03-18	2024-07-04	F. Hoffmann-La Roche Ag	Process for preparing risdiplam
CN118055767A (zh)	2021-10-06	2024-05-17	豪夫迈·罗氏有限公司	新颖的组合施用
WO2023202501A1 (fr) *	2022-04-18	2023-10-26	深圳市塔吉瑞生物医药有限公司	Composé de pyridopyrimidinone substitué, composition le comprenant et son utilisation
WO2023240236A1 (fr)	2022-06-10	2023-12-14	Voyager Therapeutics, Inc.	Compositions et procédés pour le traitement de troubles liés à l'amyotrophie spinale
WO2024069646A1 (fr) *	2022-09-26	2024-04-04	Natco Pharma Limited	Procédé amélioré pour la préparation de risdiplam et de ses intermédiaires
IL319859A (en)	2022-10-14	2025-05-01	Genentech Inc	Methods for treating spinal muscular atrophy
CN120530115A (zh) *	2023-01-21	2025-08-22	哈曼菲诺化学有限公司	利司扑兰的制备方法、新型中间体及其制备方法
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AU2024286618A1 (en)	2023-06-09	2025-10-30	F. Hoffmann-La Roche Ag	Inducible gene expression system
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TW202525295A (zh)	2023-10-27	2025-07-01	瑞士商赫孚孟拉羅股份公司	治療脊髓性肌肉萎縮症之新穎組成物

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WO2009042907A1 (fr)	2007-09-27	2009-04-02	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Composés d'isoindoline pour le traitement d'une amyotrophie spinale et autres utilisations
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CN119528903A (zh)	2012-02-10	2025-02-28	Ptc医疗公司	用于治疗脊髓性肌萎缩的化合物
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CN108289959B (zh)	2015-11-12	2021-07-16	豪夫迈·罗氏有限公司	用于治疗脊髓性肌萎缩的组合物

2015
- 2015-05-11 PL PL19200058.6T patent/PL3663296T3/pl unknown
- 2015-05-11 EP EP23169721.0A patent/EP4241772A3/fr not_active Withdrawn
- 2015-05-11 KR KR1020167034983A patent/KR102213740B1/ko active Active
- 2015-05-11 SG SG11201609497TA patent/SG11201609497TA/en unknown
- 2015-05-11 JP JP2016567816A patent/JP6236173B2/ja active Active
- 2015-05-11 CA CA2948561A patent/CA2948561C/fr active Active
- 2015-05-11 UA UAA201612716A patent/UA119670C2/uk unknown
- 2015-05-11 EA EA202090486A patent/EA202090486A3/ru unknown
- 2015-05-11 RS RS20191541A patent/RS59718B1/sr unknown
- 2015-05-11 EP EP15721701.9A patent/EP3143025B1/fr active Active
- 2015-05-11 DK DK15721701T patent/DK3143025T3/da active
- 2015-05-11 CR CR20160518A patent/CR20160518A/es unknown
- 2015-05-11 WO PCT/EP2015/060343 patent/WO2015173181A1/fr not_active Ceased
- 2015-05-11 SI SI201531021T patent/SI3143025T1/sl unknown
- 2015-05-11 ES ES15721701T patent/ES2761423T3/es active Active
- 2015-05-11 EP EP19200058.6A patent/EP3663296B1/fr active Active
- 2015-05-11 KR KR1020217002966A patent/KR102256013B1/ko active Active
- 2015-05-11 MX MX2016014547A patent/MX371050B/es active IP Right Grant
- 2015-05-11 PT PT157217019T patent/PT3143025T/pt unknown
- 2015-05-11 BR BR112016026205-0A patent/BR112016026205B1/pt active IP Right Grant
- 2015-05-11 ES ES19200058T patent/ES2949660T3/es active Active
- 2015-05-11 PL PL15721701T patent/PL3143025T3/pl unknown
- 2015-05-11 NZ NZ72500815A patent/NZ725008A/en unknown
- 2015-05-11 MY MYPI2016001903A patent/MY174284A/en unknown
- 2015-05-11 PE PE2016002128A patent/PE20170128A1/es unknown
- 2015-05-11 SI SI201531952T patent/SI3663296T1/sl unknown
- 2015-05-11 PH PH1/2016/502081A patent/PH12016502081B1/en unknown
- 2015-05-11 MA MA051988A patent/MA51988A/fr unknown
- 2015-05-11 CN CN201580027306.9A patent/CN106459092B/zh active Active
- 2015-05-11 HR HRP20230637TT patent/HRP20230637T1/hr unknown
- 2015-05-11 HR HRP20192159TT patent/HRP20192159T1/hr unknown
- 2015-05-11 EA EA201692280A patent/EA035068B1/ru active Protection Beyond IP Right Term
- 2015-05-11 MA MA39995A patent/MA39995B1/fr unknown
- 2015-05-11 HU HUE15721701A patent/HUE046491T2/hu unknown
- 2015-05-11 AU AU2015261046A patent/AU2015261046C1/en active Active
- 2015-05-14 AR ARP150101500A patent/AR100442A1/es not_active Application Discontinuation
- 2015-05-14 TW TW104115433A patent/TWI667239B/zh active
2016
- 2016-10-12 ZA ZA2016/07026A patent/ZA201607026B/en unknown
- 2016-10-31 IL IL24865316A patent/IL248653B/en active IP Right Grant
- 2016-11-08 CL CL2016002836A patent/CL2016002836A1/es unknown
- 2016-11-14 US US15/351,267 patent/US9969754B2/en active Active
2019
- 2019-10-17 IL IL270027A patent/IL270027B/en active IP Right Grant
2021
- 2021-09-09 FR FR21C1039C patent/FR21C1039I2/fr active Active
- 2021-09-10 NO NO2021035C patent/NO2021035I1/no unknown
- 2021-09-14 LT LTPA2021010C patent/LTC3143025I2/lt unknown
- 2021-09-14 HU HUS2100037C patent/HUS2100037I1/hu unknown
- 2021-09-15 NL NL301128C patent/NL301128I2/nl unknown
2023
- 2023-12-01 AR ARP230103289A patent/AR131260A2/es unknown
2025
- 2025-08-14 NO NO2025038C patent/NO2025038I1/no unknown

Also Published As

Publication number	Publication date
PL3143025T3 (pl)	2020-03-31
FR21C1039I1 (fr)	2021-10-15
FR21C1039I2 (fr)	2022-09-02
IL248653A0 (en)	2017-01-31
BR112016026205A8 (pt)	2021-07-20
AU2015261046C1 (en)	2019-07-25
KR102213740B1 (ko)	2021-02-09
IL270027B (en)	2020-08-31
CN106459092B (zh)	2019-10-15
HRP20230637T1 (hr)	2023-09-29
JP6236173B2 (ja)	2017-11-22
EP3143025A1 (fr)	2017-03-22
HRP20192159T1 (hr)	2020-02-21
ZA201607026B (en)	2022-05-25
ES2761423T3 (es)	2020-05-19
JP2017515863A (ja)	2017-06-15
MA39995B1 (fr)	2019-11-29
AR100442A1 (es)	2016-10-05
EP4241772A2 (fr)	2023-09-13
PT3143025T (pt)	2019-12-03
EA202090486A3 (ru)	2020-08-31
WO2015173181A1 (fr)	2015-11-19
ES2949660T3 (es)	2023-10-02
NO2025038I1 (no)	2025-08-14
MX2016014547A (es)	2017-02-23
US9969754B2 (en)	2018-05-15
KR20170003687A (ko)	2017-01-09
SI3663296T1 (sl)	2023-08-31
NL301128I2 (nl)	2021-10-25
US20170197990A1 (en)	2017-07-13
RS59718B1 (sr)	2020-01-31
MX371050B (es)	2020-01-14
AR131260A2 (es)	2025-03-05
CA2948561A1 (fr)	2015-11-19
NO2021035I1 (no)	2021-09-10
EP3663296B1 (fr)	2023-05-17
PH12016502081B1 (en)	2022-11-23
AU2015261046B2 (en)	2019-04-18
MA51988A (fr)	2021-01-20
EA201692280A1 (ru)	2018-07-31
PH12016502081A1 (en)	2017-01-09
CR20160518A (es)	2017-02-21
CA2948561C (fr)	2019-10-22
KR20210014219A (ko)	2021-02-08
MY174284A (en)	2020-04-01
UA119670C2 (uk)	2019-07-25
CL2016002836A1 (es)	2017-04-21
KR102256013B1 (ko)	2021-05-26
SI3143025T1 (sl)	2020-01-31
BR112016026205A2 (pt)	2017-08-15
IL248653B (en)	2019-11-28
CN106459092A (zh)	2017-02-22
EA035068B1 (ru)	2020-04-23
TW201609738A (zh)	2016-03-16
EP3663296A1 (fr)	2020-06-10
EP3143025B1 (fr)	2019-10-09
DK3143025T3 (da)	2019-12-09
PL3663296T3 (pl)	2023-08-07
NL301128I1 (fr)	2021-09-22
HUS2100037I1 (hu)	2021-10-28
EA202090486A2 (ru)	2020-06-30
PE20170128A1 (es)	2017-03-16
EP4241772A3 (fr)	2023-11-15
TWI667239B (zh)	2019-08-01
NZ725008A (en)	2019-11-29
LTC3143025I2 (fr)	2023-11-10
HUE046491T2 (hu)	2020-03-30
LTPA2021010I1 (fr)	2021-10-11
AU2015261046A1 (en)	2016-10-27
BR112016026205B1 (pt)	2021-12-07

Publication	Publication Date	Title
HUS2100037I1 (hu)	2021-10-28	Vegyületek gerinc eredetû izomsorvadás kezelésére
IL258497B (en)	2021-07-29	Preparations for the treatment of sma muscular dystrophy
IL258211A (en)	2018-05-31	Methods for treating muscular dystrophy
EP3354288C0 (fr)	2023-10-11	Dispositif de stérilisation
IL254393A0 (en)	2017-11-30	Methods for treating diseases associated with pathological changes in protein
IL251790B (en)	2019-08-29	Compounds include thiazole for the treatment of culture diseases
EP3302695B8 (fr)	2024-05-29	Dispositifs de traitement des muscles
GB201715519D0 (en)	2017-11-08	Hand treatment apparatus
GB201405132D0 (en)	2014-05-07	Fixation apparatus
GB201719105D0 (en)	2018-01-03	Orthopedic apparatus
IL231816A (en)	2015-06-30	Bone fracture treatment devices
GB201604658D0 (en)	2016-05-04	Treatment for pain
ZA201800752B (en)	2019-07-31	Improved prosthesis for osteosynthesis
SG11201802292UA (en)	2018-04-27	Composition for treating pain
PT3250218T (pt)	2021-05-14	Péptido natkide para o tratamento da obesidade
HUE047940T2 (hu)	2020-05-28	Eritromelalgia kezelése
GB2534681B (en)	2017-08-02	Treatment apparatus
PL3129031T3 (pl)	2019-01-31	Kompozycja do terapii zaburzeń żołądkowych
ZA201607027B (en)	2019-05-29	Method for treating or enhancing muscle tissue
PL3194551T3 (pl)	2021-03-08	Stała kompozycja do traktowania tekstyliów
ZA201805215B (en)	2019-07-31	Preparation for nasal-nasopharyngeal treatment
GB201507044D0 (en)	2015-06-10	Waste treatment
GB201505205D0 (en)	2015-05-13	Treatment for pain
GB201504688D0 (en)	2015-05-06	Treatment for pain
GB201418676D0 (en)	2014-12-03	Compounds for use