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SG11201609490QA - Polymer-flavonoid conjugate and uses thereof - Google Patents

Polymer-flavonoid conjugate and uses thereof

Info

Publication number
SG11201609490QA
SG11201609490QA SG11201609490QA SG11201609490QA SG11201609490QA SG 11201609490Q A SG11201609490Q A SG 11201609490QA SG 11201609490Q A SG11201609490Q A SG 11201609490QA SG 11201609490Q A SG11201609490Q A SG 11201609490QA SG 11201609490Q A SG11201609490Q A SG 11201609490QA
Authority
SG
Singapore
Prior art keywords
polymer
flavonoid conjugate
flavonoid
conjugate
Prior art date
Application number
SG11201609490QA
Inventor
Motoichi Kurisawa
Fan Lee
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Priority to SG11201609490QA priority Critical patent/SG11201609490QA/en
Publication of SG11201609490QA publication Critical patent/SG11201609490QA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728Hyaluronic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11201609490QA 2014-05-15 2015-05-15 Polymer-flavonoid conjugate and uses thereof SG11201609490QA (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SG11201609490QA SG11201609490QA (en) 2014-05-15 2015-05-15 Polymer-flavonoid conjugate and uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SG10201402361X 2014-05-15
SG11201609490QA SG11201609490QA (en) 2014-05-15 2015-05-15 Polymer-flavonoid conjugate and uses thereof
PCT/SG2015/050117 WO2015174934A1 (en) 2014-05-15 2015-05-15 Polymer-flavonoid conjugate and uses thereof

Publications (1)

Publication Number Publication Date
SG11201609490QA true SG11201609490QA (en) 2016-12-29

Family

ID=54480328

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201609490QA SG11201609490QA (en) 2014-05-15 2015-05-15 Polymer-flavonoid conjugate and uses thereof

Country Status (6)

Country Link
US (1) US10406175B2 (en)
EP (1) EP3142705B1 (en)
JP (1) JP6661546B2 (en)
CN (1) CN106456797A (en)
SG (1) SG11201609490QA (en)
WO (1) WO2015174934A1 (en)

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* Cited by examiner, † Cited by third party
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JP6484633B2 (en) * 2013-09-03 2019-03-13 エイジェンシー フォー サイエンス,テクノロジー アンド リサーチ Polymer-flavonoid conjugates and hydrogels for biomedical applications
CN105381470B (en) * 2015-11-27 2018-11-02 广东医科大学 A kind of modified dye lignin and its application
BR112019015891A2 (en) * 2017-02-02 2020-03-17 Amtixbio Co., Ltd. HYDROGEL USING AS A SUBSTRATE A MODIFIED HYALURONIC ACID DERIVATIVE WITH GALOL GROUP AND USE OF THE SAME
KR20190050416A (en) 2017-11-03 2019-05-13 전북대학교산학협력단 Composition for Gellan-gum Hydrogels Containing miRNA-140-5p and Composition for treatment of Cartilage Regeneration using it
EP3782613B1 (en) * 2018-04-02 2023-12-06 Optipharm Co., Ltd Alginate microcapsules for cell encapsulation and, manufacturing method therefor
KR102076769B1 (en) * 2018-04-24 2020-02-12 바이오스트림테크놀러지스(주) Hyaluronic acid-flavonoid conjugate, nanoparticle comprising same and manufacturing method thereof
KR102181502B1 (en) * 2018-08-17 2020-11-23 한양대학교 산학협력단 Preparation method of polymer complex coated with epigallocatechin gallate and the polymer complex prepared by the same method
KR102156602B1 (en) 2019-10-17 2020-09-16 전북대학교산학협력단 Composition for Gellan-gum Hydrogels Containing miRNA-140-5p and Composition for treatment of Cartilage Regeneration using it
KR102440783B1 (en) * 2020-06-15 2022-09-06 한양대학교 산학협력단 Preparation method of organic-inorganic complex coated with mineral particle based on polyphenol and organic-inorganic complex prepared by the method
CN115702937B (en) * 2021-08-04 2024-12-17 四川大学 Modified polyphenol carrier material, targeted nano delivery system, preparation method and application
CN118019750A (en) * 2021-09-16 2024-05-10 上海椿安生物医药科技有限公司 Drug delivery system for local delivery of therapeutic agents and uses thereof
CN114259602B (en) * 2021-12-29 2022-09-30 江苏江山聚源生物技术有限公司 Recombinant collagen hydrogel for injection and preparation method thereof
CN114366710B (en) * 2022-01-20 2023-11-17 苏州大学附属第一医院 Use of injectable burdock microcarriers in the treatment of advanced osteoarthritis
WO2024254192A2 (en) * 2023-06-05 2024-12-12 Suntec Medical, Inc. Method for treating neurodegenerative diseases
WO2025219934A1 (en) * 2024-04-18 2025-10-23 The Wave Innovation Group S.R.L. Composition based on hyaluronic acid, epigallocatechin-3-o- gallate and/or xanthohumol

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8713662D0 (en) 1987-06-11 1987-07-15 Skandigen Ab Hyaluronic acid derivatives
FR2699819B1 (en) * 1992-12-28 1995-02-24 Dolisos Lab Use of prodelphinidins for obtaining medicaments intended for the treatment of osteoarthritis.
JPH07238079A (en) 1994-02-25 1995-09-12 Lotte Co Ltd Catechin compound, its production and deodorant using the same
JP2003501381A (en) 1999-06-07 2003-01-14 ユニバーシティ・オブ・シェフィールド Arthritis treatment
US6428817B1 (en) * 1999-07-06 2002-08-06 Peter Donald Collin Companion animal therapeutic treat
US20050220753A1 (en) * 2002-03-22 2005-10-06 Beijing Jiankai Technology Co., Ltd Hydrophilic polymers-flavoids conjugates and pharmaceutical compositions comprising them
WO2006124000A1 (en) * 2005-05-20 2006-11-23 Agency For Science, Technology And Research Aldehyde conjugated flavonoid preparations
US7858080B2 (en) 2005-05-20 2010-12-28 Agency For Science, Technology And Research Aldehyde conjugated flavonoid preparations
EP2464388B1 (en) * 2009-08-11 2017-05-10 Agency for Science, Technology and Research Particulate hyaluronic acid formulations for cellular delivery of bioactive agents
EP2697648B1 (en) 2011-04-13 2018-08-22 Akonni Biosystems, Inc. Microarray based sample detection system
WO2013063086A1 (en) * 2011-10-24 2013-05-02 Intellect Neurosciences, Inc. Compositions and methods for treatment of proteinopathies
JP6484633B2 (en) 2013-09-03 2019-03-13 エイジェンシー フォー サイエンス,テクノロジー アンド リサーチ Polymer-flavonoid conjugates and hydrogels for biomedical applications
GB2518405A (en) 2013-09-20 2015-03-25 Zeiss Carl Meditec Ag Composition comprising at least one viscoelastic polymer

Also Published As

Publication number Publication date
WO2015174934A9 (en) 2016-06-09
EP3142705A4 (en) 2017-11-22
EP3142705B1 (en) 2020-08-19
JP2017515834A (en) 2017-06-15
US10406175B2 (en) 2019-09-10
US20170216446A1 (en) 2017-08-03
CN106456797A (en) 2017-02-22
EP3142705A1 (en) 2017-03-22
WO2015174934A1 (en) 2015-11-19
JP6661546B2 (en) 2020-03-11

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