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SG11201608438YA - Analogs of 4h-pyrazolo[1,5-α]benzimidazole compounds as parp inhibitors - Google Patents

Analogs of 4h-pyrazolo[1,5-α]benzimidazole compounds as parp inhibitors

Info

Publication number
SG11201608438YA
SG11201608438YA SG11201608438YA SG11201608438YA SG11201608438YA SG 11201608438Y A SG11201608438Y A SG 11201608438YA SG 11201608438Y A SG11201608438Y A SG 11201608438YA SG 11201608438Y A SG11201608438Y A SG 11201608438YA SG 11201608438Y A SG11201608438Y A SG 11201608438YA
Authority
SG
Singapore
Prior art keywords
pyrazolo
analogs
parp inhibitors
benzimidazole compounds
benzimidazole
Prior art date
Application number
SG11201608438YA
Inventor
Xuehai Wang
Zhaozhong Ding
Yong Xu
Shuhui Chen
Lie Li
Gang Li
Ronghua Tu
Cailin Wang
Yang Yue
Zhibo Zhang
Hailiang Chen
Wenjie Sun
Lu Huang
Original Assignee
Hubei Bio Pharmaceutical Ind Technological Inst Inc
Humanwell Healthcare Group Co Ltd
Medshine Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201410144173.0A external-priority patent/CN104974161B/en
Application filed by Hubei Bio Pharmaceutical Ind Technological Inst Inc, Humanwell Healthcare Group Co Ltd, Medshine Discovery Inc filed Critical Hubei Bio Pharmaceutical Ind Technological Inst Inc
Publication of SG11201608438YA publication Critical patent/SG11201608438YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41621,2-Diazoles condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/424Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG11201608438YA 2014-04-10 2015-03-30 Analogs of 4h-pyrazolo[1,5-α]benzimidazole compounds as parp inhibitors SG11201608438YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201410144173.0A CN104974161B (en) 2014-04-10 2014-04-10 The analog of 4H- pyrazolo [1,5- α] benzimidazole compound as PARP inhibitor
CN201510113090 2015-03-13
PCT/CN2015/075363 WO2015154630A1 (en) 2014-04-10 2015-03-30 Analogues of 4h-pyrazolo[1,5-α]benzimidazole compound as parp inhibitors

Publications (1)

Publication Number Publication Date
SG11201608438YA true SG11201608438YA (en) 2016-11-29

Family

ID=54287319

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201608438YA SG11201608438YA (en) 2014-04-10 2015-03-30 Analogs of 4h-pyrazolo[1,5-α]benzimidazole compounds as parp inhibitors

Country Status (22)

Country Link
US (1) US9856262B2 (en)
EP (1) EP3130592B1 (en)
JP (1) JP6359175B2 (en)
KR (1) KR101921486B1 (en)
CN (1) CN106459057B (en)
AU (1) AU2015245786B2 (en)
BR (1) BR112016023397B1 (en)
CA (1) CA2944801C (en)
DK (1) DK3130592T3 (en)
ES (1) ES2754590T3 (en)
HU (1) HUE047410T2 (en)
IL (1) IL248258B (en)
MX (1) MX368496B (en)
NZ (1) NZ725165A (en)
PL (1) PL3130592T3 (en)
PT (1) PT3130592T (en)
RU (1) RU2672722C2 (en)
SA (1) SA516380051B1 (en)
SG (1) SG11201608438YA (en)
TW (1) TWI671301B (en)
WO (1) WO2015154630A1 (en)
ZA (1) ZA201607736B (en)

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CN104974161B (en) * 2014-04-10 2019-11-01 湖北生物医药产业技术研究院有限公司 The analog of 4H- pyrazolo [1,5- α] benzimidazole compound as PARP inhibitor
CN108137598B (en) 2015-09-30 2021-02-12 湖北生物医药产业技术研究院有限公司 Salt form and crystal form of 4H-pyrazolo [1, 5-alpha ] benzimidazole compound, and preparation method and intermediate thereof
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
WO2018197401A1 (en) 2017-04-27 2018-11-01 Bayer Animal Health Gmbh New bicyclic pyrazole derivatives
CN115028641B (en) * 2022-07-19 2024-05-28 湖南大学 A method for synthesizing 5,8-difunctional substituted imidazo[1,2-a]pyrazine compounds using cobalt catalyst
WO2024229406A1 (en) 2023-05-04 2024-11-07 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
WO2025056690A1 (en) 2023-09-12 2025-03-20 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Parp1- and immune-checkpoint inhibitors for the treatment of cancer patients overexpressing ubqln1 and/or ubqln4
CN116969954B (en) * 2023-09-21 2023-11-28 广东省农业科学院农业质量标准与监测技术研究所 Tricyclic fused heterocyclic compounds containing lactam and application thereof
TW202530228A (en) 2023-10-12 2025-08-01 美商銳新醫藥公司 Ras inhibitors
CN117534677B (en) * 2024-01-09 2024-03-12 广东省农业科学院农业质量标准与监测技术研究所 Imine-containing tricyclic fused heterocyclic compound and application thereof
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025217307A1 (en) 2024-04-09 2025-10-16 Revolution Medicines, Inc. Methods for predicting response to a ras(on) inhibitor and combination therapies
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder

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US4916051A (en) * 1987-04-07 1990-04-10 Konica Corporation Silver halide color photographic light-sensitive material
MY143499A (en) * 2003-12-22 2011-05-31 Sb Pharmco Inc Crf receptor antagonist and methods relating thereto
EP1973909A2 (en) * 2005-12-22 2008-10-01 Biogen Idec MA Inc. Transforming growth factor modulators
WO2007144669A1 (en) 2006-06-15 2007-12-21 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Pyrazolo[1,5-a]quinazolin-5(4h)-ones as inhibitors of poly(adp-ribose)polymerase (parp)
EP2069351B1 (en) 2006-06-20 2015-10-28 AbbVie Inc. Pyrazoloquinazolinones as parp inhibitors
GB0701273D0 (en) 2007-01-24 2007-02-28 Angeletti P Ist Richerche Bio New compounds
PT2656843E (en) 2012-04-26 2015-04-14 Helmut Schickaneder Esters of bendamustine and related compounds, and medical use thereof
PT2844659T (en) * 2012-05-04 2016-08-31 Merck Patent Gmbh Pyrrolotriazinone derivatives
EP2666775A1 (en) * 2012-05-21 2013-11-27 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
CA2873723A1 (en) 2012-06-07 2013-12-12 F. Hoffmann-La Roche Ag Pyrrolopyrimidone and pyrrolopyridone inhibitors of tankyrase
IN2015MN00002A (en) * 2012-07-09 2015-10-16 Lupin Ltd
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CN104974161B (en) 2014-04-10 2019-11-01 湖北生物医药产业技术研究院有限公司 The analog of 4H- pyrazolo [1,5- α] benzimidazole compound as PARP inhibitor

Also Published As

Publication number Publication date
EP3130592B1 (en) 2019-08-14
BR112016023397B1 (en) 2022-08-16
WO2015154630A1 (en) 2015-10-15
PL3130592T3 (en) 2020-05-18
AU2015245786B2 (en) 2018-03-15
US9856262B2 (en) 2018-01-02
SA516380051B1 (en) 2020-05-17
EP3130592A1 (en) 2017-02-15
DK3130592T3 (en) 2019-11-04
RU2016144202A (en) 2018-05-15
RU2672722C2 (en) 2018-11-19
CA2944801A1 (en) 2015-10-15
KR20170005807A (en) 2017-01-16
CN106459057B (en) 2019-06-07
HUE047410T2 (en) 2020-04-28
TWI671301B (en) 2019-09-11
TW201620913A (en) 2016-06-16
RU2016144202A3 (en) 2018-05-15
BR112016023397A2 (en) 2017-08-15
JP2017510653A (en) 2017-04-13
AU2015245786A1 (en) 2016-11-03
PT3130592T (en) 2019-11-21
NZ725165A (en) 2018-04-27
JP6359175B2 (en) 2018-07-18
ES2754590T3 (en) 2020-04-20
CA2944801C (en) 2019-02-12
CN106459057A (en) 2017-02-22
KR101921486B1 (en) 2018-11-26
MX368496B (en) 2019-10-04
EP3130592A4 (en) 2017-09-06
US20170029430A1 (en) 2017-02-02
IL248258B (en) 2018-11-29
ZA201607736B (en) 2017-09-27
MX2016013265A (en) 2017-05-03

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