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SG11201607382TA - Apparatus and methods for fractionation of biological products - Google Patents

Apparatus and methods for fractionation of biological products

Info

Publication number
SG11201607382TA
SG11201607382TA SG11201607382TA SG11201607382TA SG11201607382TA SG 11201607382T A SG11201607382T A SG 11201607382TA SG 11201607382T A SG11201607382T A SG 11201607382TA SG 11201607382T A SG11201607382T A SG 11201607382TA SG 11201607382T A SG11201607382T A SG 11201607382TA
Authority
SG
Singapore
Prior art keywords
fractionation
methods
biological products
biological
products
Prior art date
Application number
SG11201607382TA
Inventor
Peter Stanley Gagnon
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of SG11201607382TA publication Critical patent/SG11201607382TA/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/58—Multistep processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/08—Polysaccharides
    • B01D71/10—Cellulose; Modified cellulose
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/66—Polymers having sulfur in the main chain, with or without nitrogen, oxygen or carbon only
    • B01D71/68—Polysulfones; Polyethersulfones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/08—Specific process operations in the concentrate stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/12—Addition of chemical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/25—Recirculation, recycling or bypass, e.g. recirculation of concentrate into the feed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/25—Recirculation, recycling or bypass, e.g. recirculation of concentrate into the feed
    • B01D2311/252—Recirculation of concentrate
    • B01D2311/2523—Recirculation of concentrate to feed side
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2623—Ion-Exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2626—Absorption or adsorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2697—Chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2317/00—Membrane module arrangements within a plant or an apparatus
    • B01D2317/04—Elements in parallel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B01D2325/0283—Pore size
    • B01D2325/02832—1-10 nm
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B01D2325/0283—Pore size
    • B01D2325/02833—Pore size more than 10 and up to 100 nm
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B01D2325/0283—Pore size
    • B01D2325/02834—Pore size more than 0.1 and up to 1 µm
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/42—Ion-exchange membranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Water Supply & Treatment (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
SG11201607382TA 2014-03-07 2015-03-09 Apparatus and methods for fractionation of biological products SG11201607382TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461949944P 2014-03-07 2014-03-07
PCT/SG2015/050031 WO2015133972A1 (en) 2014-03-07 2015-03-09 Apparatus and methods for fractionation of biological products

Publications (1)

Publication Number Publication Date
SG11201607382TA true SG11201607382TA (en) 2016-10-28

Family

ID=54055646

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201607382TA SG11201607382TA (en) 2014-03-07 2015-03-09 Apparatus and methods for fractionation of biological products

Country Status (7)

Country Link
US (1) US20170173537A1 (en)
EP (1) EP3113865A4 (en)
JP (1) JP2017510452A (en)
KR (1) KR20160133489A (en)
CN (1) CN106457153B (en)
SG (1) SG11201607382TA (en)
WO (1) WO2015133972A1 (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015195453A2 (en) 2014-06-16 2015-12-23 Emd Millipore Corporation Methods for increasing the capacity of flow-through processes
WO2015195452A2 (en) 2014-06-16 2015-12-23 Emd Millipore Corporation Single-pass filtration systems and processes
CN106132517B (en) 2014-06-25 2019-12-13 Emd 密理博公司 Filter elements, tangential flow filtration systems, liquid filtration processes
SG10202006102UA (en) 2014-08-29 2020-07-29 Emd Millipore Corp Processes For Filtering Liquids Using Single Pass Tangential Flow Filtration Systems AndTangential Flow Filtration Systems With Recirculation of Retentate
SG10201901555UA (en) 2014-08-29 2019-03-28 Emd Millipore Corp Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems withRecirculation of Retentate
US11291931B2 (en) 2014-12-15 2022-04-05 Akadeum Life Sciences, Inc. Method and system for buoyant separation
CN107873055B (en) 2015-05-29 2021-09-17 库瑞瓦格房地产有限公司 Method for producing and purifying RNA comprising at least one tangential flow filtration step
GB201600287D0 (en) 2016-01-07 2016-02-24 Fujifilm Diosynth Biotechnologies Uk Ltd Process
GB201600290D0 (en) * 2016-01-07 2016-02-24 Fujifilm Diosynth Biotechnologies Uk Ltd Process
EP3468698B1 (en) 2016-06-09 2022-06-29 EMD Millipore Corporation Radial-path filter elements, systems and methods of using same
RU2755065C2 (en) * 2016-11-11 2021-09-13 Байер Акциенгезельшафт Method for sampling from fluid flow to track contaminant in continuous mode
AU2018207260B2 (en) * 2017-01-13 2021-12-09 Minh Khoi LE Alternating flow column chromatography apparatus and method of use
HRP20230345T1 (en) 2017-01-16 2023-06-09 Spectrum Solutions L.L.C. Nucleic acid preservation solution and methods of use
WO2018208875A1 (en) 2017-05-09 2018-11-15 Vitality Biopharma, Inc. Antimicrobial compositions comprising cannabinoids and methods of using the same
CN111246930B (en) * 2017-11-13 2022-12-02 Emd密理博公司 Continuous diafiltration with tank circulation
RU2745613C1 (en) * 2017-12-26 2021-03-29 Общество с ограниченной ответственностью "Простагност" (ООО "Простагност") Method and device for recovering extracellular vesicles from biological fluids by means of cascade ultrafiltration
JP7319487B2 (en) * 2018-01-12 2023-08-02 フォーミュラトリクス・インターナショナル・ホールディング・リミテッド A disposable TFF unit containing a tangential flow filtration (TFF) system and an integrated pumping device
SG11202009622PA (en) * 2018-03-30 2020-10-29 Fujifilm Electronic Materials Usa Inc Chemical liquid manufacturing apparatus
TWI898645B (en) 2018-05-04 2025-09-21 美商健臻公司 Perfusion cell culture apparatus
US10792618B2 (en) 2018-06-19 2020-10-06 Sartorius Stedim Biotech Gmbh Particle separation and/or purification of a fluid
EP3816177A4 (en) * 2018-06-29 2021-12-01 Mitsubishi Chemical Corporation POLYPEPTIDE ISOLATION METHOD, POLYPEPTIDE MANUFACTURING METHOD, AND POLYPEPTIDE PURIFYING DEVICE
WO2020014273A1 (en) 2018-07-09 2020-01-16 Akadeum Life Sciences, Inc. System and method for buoyant particle processing
US12195715B2 (en) * 2018-09-21 2025-01-14 Cytiva Sweden Ab Perfusion bioprocessing system and method of operating the same
US10864483B2 (en) * 2018-11-16 2020-12-15 Integrated Protein Technologies, Snc. Molecular weight filtration system and apparatus
CN111318077A (en) * 2018-12-13 2020-06-23 中国科学院青岛生物能源与过程研究所 A multiplexed convection chromatography system and method for purifying protein
GB201911686D0 (en) * 2019-08-15 2019-10-02 Fujifilm Diosynth Biotechnologies Uk Ltd Process for purifying target substances
CN114341152B (en) * 2019-09-06 2025-06-13 赛多利斯比亚分离有限责任公司 Compositions and methods for reducing the chromatin content of biological products
AU2020385637A1 (en) * 2019-11-20 2022-06-09 Csl Behring Ag Method for extracting a protein from a precipitate and method for precipitating impurities
CN113559712A (en) * 2020-04-29 2021-10-29 上海药明生物技术有限公司 Tangential flow filtration system and method
EP4165197A4 (en) * 2020-06-11 2024-07-03 Regeneron Pharmaceuticals, Inc. Methods for manufacturing viral vectors
CN114574355A (en) * 2020-11-30 2022-06-03 中国科学院大连化学物理研究所 Exosome purification device and application
WO2022126028A1 (en) * 2020-12-11 2022-06-16 Graphium Biosciences, Inc. Continuous enzymatic perfusion reactor system
WO2023220336A1 (en) * 2022-05-13 2023-11-16 Herzlinger Regina E Methods, systems, and apparatus for administering an antibody treatment via infusion
US12133966B2 (en) * 2020-12-22 2024-11-05 Regina E. HERZLINGER Methods, systems, and apparatus for administering an antibody treatment via infusion
US11819842B2 (en) 2021-08-26 2023-11-21 Akadeum Life Sciences, Inc. Method and system for buoyant separation
KR102896125B1 (en) * 2021-10-15 2025-12-08 주식회사 아모그린텍 Exosome extraction System
US20240408520A1 (en) * 2021-10-15 2024-12-12 Amogreentech Co., Ltd. Exosome extraction system
EP4504367A1 (en) 2022-04-01 2025-02-12 Akadeum Life Sciences, Inc. Method and system for buoyant-particle-assisted cell therapy
CA3255748A1 (en) * 2022-05-26 2023-11-30 Eli Lilly And Company Continuous tangential flow filtration system
EP4299156A1 (en) * 2022-06-29 2024-01-03 Sartorius Stedim Biotech GmbH Tangential flow filtration/chromatography systems, use thereof, and methods of separation
US12099050B2 (en) 2023-02-14 2024-09-24 Akadeum Life Sciences, Inc. Method and system for partially or fully automated buoyancy-assisted separation
CN116217709A (en) * 2023-03-08 2023-06-06 中科森辉微球技术（苏州）有限公司 Preparation method of human intravenous injection immunoglobulin

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0352699A (en) * 1989-07-18 1991-03-06 Ebara Infilco Co Ltd Treatment of sewage of night soil system
US5256294A (en) * 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
EP0853123A1 (en) * 1997-01-10 1998-07-15 Roche Diagnostics GmbH Purification of DNA by 'cross-flow-filtration'
US6406623B2 (en) * 1997-05-15 2002-06-18 Millipore Corporation Tangential flow filtration apparatus
FR2785200B1 (en) * 1998-10-30 2001-03-30 Centre Nat Rech Scient USE OF AN ADSORBENT GEL TO ELIMINATE AND PURIFY BIOMOLECULES
US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
ITRM20010468A1 (en) * 2001-08-01 2003-02-03 Consiglio Nazionale Ricerche MOLECULAR VECTOR FOR THE GENOPHENOTYPIC CHARACTERIZATION OF SEQUENCES V3 OF THE HIV-1 GP120 AND RELATED PROCEDURE.
AU2003261387A1 (en) * 2003-02-24 2004-09-17 Gtc Biotherapeutics, Inc. Methods of tangential flow filtration and an apparatus therefore
US20050197496A1 (en) * 2004-03-04 2005-09-08 Gtc Biotherapeutics, Inc. Methods of protein fractionation using high performance tangential flow filtration
CN101027080A (en) * 2004-03-04 2007-08-29 Gtc生物治疗有限公司 Methods of protein fractionation using high performance tangential flow filtration
EP1878791A1 (en) * 2006-07-11 2008-01-16 Bia Separations D.O.O. Method for influenza virus purification
US9433922B2 (en) * 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
US8863323B2 (en) * 2009-10-21 2014-10-21 Kohler Co. Wall-entry bathtub
CA2813747A1 (en) * 2010-10-11 2012-04-19 Chen Wang Processes for purification of proteins
EP2649088A4 (en) * 2010-12-10 2014-09-03 Tracy Thompson Compositions for separation methods

Also Published As

Publication number Publication date
KR20160133489A (en) 2016-11-22
WO2015133972A1 (en) 2015-09-11
US20170173537A1 (en) 2017-06-22
EP3113865A4 (en) 2017-11-01
CN106457153A (en) 2017-02-22
EP3113865A1 (en) 2017-01-11
CN106457153B (en) 2019-03-29
JP2017510452A (en) 2017-04-13

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