SG11201606711UA - Monobactam organic compounds for the treatment of bacterial infections - Google Patents
Monobactam organic compounds for the treatment of bacterial infectionsInfo
- Publication number
- SG11201606711UA SG11201606711UA SG11201606711UA SG11201606711UA SG11201606711UA SG 11201606711U A SG11201606711U A SG 11201606711UA SG 11201606711U A SG11201606711U A SG 11201606711UA SG 11201606711U A SG11201606711U A SG 11201606711UA SG 11201606711U A SG11201606711U A SG 11201606711UA
- Authority
- SG
- Singapore
- Prior art keywords
- treatment
- organic compounds
- bacterial infections
- monobactam
- monobactam organic
- Prior art date
Links
- 208000035143 Bacterial infection Diseases 0.000 title 1
- -1 Monobactam organic compounds Chemical class 0.000 title 1
- 229960003644 aztreonam Drugs 0.000 title 1
- 208000022362 bacterial infectious disease Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461969735P | 2014-03-24 | 2014-03-24 | |
| US201462088304P | 2014-12-05 | 2014-12-05 | |
| PCT/US2015/022011 WO2015148379A1 (en) | 2014-03-24 | 2015-03-23 | Monobactam organic compounds for the treatment of bacterial infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201606711UA true SG11201606711UA (en) | 2016-10-28 |
Family
ID=52808201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201606711UA SG11201606711UA (en) | 2014-03-24 | 2015-03-23 | Monobactam organic compounds for the treatment of bacterial infections |
Country Status (37)
| Country | Link |
|---|---|
| US (4) | US9174978B2 (en) |
| EP (2) | EP3511328B1 (en) |
| JP (1) | JP6153674B2 (en) |
| KR (1) | KR101733441B1 (en) |
| CN (1) | CN106164072B (en) |
| AP (1) | AP2016009374A0 (en) |
| AU (1) | AU2015236369B2 (en) |
| BR (1) | BR112016020333B1 (en) |
| CA (1) | CA2939254C (en) |
| CL (1) | CL2016002285A1 (en) |
| CU (1) | CU24441B1 (en) |
| CY (1) | CY1121701T1 (en) |
| DK (2) | DK3122745T3 (en) |
| EA (1) | EA030850B1 (en) |
| EC (1) | ECSP16073620A (en) |
| ES (2) | ES2862203T3 (en) |
| GT (1) | GT201600183A (en) |
| HR (1) | HRP20190501T1 (en) |
| HU (1) | HUE042134T2 (en) |
| IL (1) | IL247259B (en) |
| LT (1) | LT3122745T (en) |
| MA (1) | MA39777B1 (en) |
| MX (1) | MX373444B (en) |
| MY (1) | MY179292A (en) |
| PE (1) | PE20161371A1 (en) |
| PH (1) | PH12016501577B1 (en) |
| PL (1) | PL3122745T3 (en) |
| PT (1) | PT3122745T (en) |
| RS (1) | RS58509B1 (en) |
| SG (1) | SG11201606711UA (en) |
| SI (1) | SI3122745T1 (en) |
| SM (1) | SMT201900218T1 (en) |
| SV (1) | SV2016005274A (en) |
| TW (1) | TWI714525B (en) |
| UA (1) | UA121383C2 (en) |
| WO (1) | WO2015148379A1 (en) |
| ZA (1) | ZA201605565B (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA202092620A1 (en) * | 2015-09-23 | 2021-06-30 | Новартис Аг | SALTS AND SOLID FORMS OF MONOBACTAM ANTIBIOTICS |
| WO2017081615A1 (en) | 2015-11-09 | 2017-05-18 | Wockhardt Limited | 7-oxo -6-(sulfooxy)- 1,6-diazabicyclo [3.2.1] octane containing compounds and their use in treatment of bacterial infections |
| CA3008006C (en) | 2015-12-15 | 2024-04-09 | Merck Sharp & Dohme Corp. | Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections |
| KR102408800B1 (en) | 2016-03-07 | 2022-06-13 | 머크 샤프 앤드 돔 코포레이션 | Bicyclic Aryl Monobactam Compounds and Methods of Their Use for Treatment of Bacterial Infections |
| ES2966369T3 (en) | 2017-03-20 | 2024-04-22 | Broad Inst Inc | Compounds and methods for the treatment of parasitic diseases |
| CN111094281B (en) * | 2017-08-02 | 2023-08-29 | 诺华股份有限公司 | Chemical process for preparing monolactam antibiotics and intermediates thereof |
| WO2019058346A1 (en) * | 2017-09-22 | 2019-03-28 | Novartis Ag | Administration of monobactam in combination with antibiotic agent for the treatment of complicated intra-abdominal infection |
| SG11202002575UA (en) | 2017-10-02 | 2020-04-29 | Merck Sharp & Dohme | Chromane monobactam compounds for the treatment of bacterial infections |
| SG11202002300QA (en) * | 2017-10-02 | 2020-04-29 | Arixa Pharmaceuticals Inc | Aztreonam derivatives and uses thereof |
| WO2019092180A1 (en) * | 2017-11-10 | 2019-05-16 | Novartis Ag | Administration of monobactam for the treatment of urinary tract infection |
| US11459323B2 (en) | 2018-01-29 | 2022-10-04 | Medshine Discovery Inc. | Monocyclic β-lactam compound for treating bacterial infection |
| KR102017784B1 (en) * | 2018-04-11 | 2019-09-03 | 전북대학교산학협력단 | Medium composition with improved sensitivity and selectivity for detecting Campylobacter and detecting method using thereof |
| KR102017785B1 (en) * | 2018-05-17 | 2019-09-03 | 전북대학교산학협력단 | Broth composition with improved sensitivity and selectivity for selectively enriching Campylobacter and detecting method using thereof |
| US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| IL280770B2 (en) | 2018-08-09 | 2024-05-01 | Antabio Sas | Diazabicyclooctanone-type substances for use as serine inhibitors in cell-lactamase |
| TW202024068A (en) | 2018-11-13 | 2020-07-01 | 大陸商南京聖和藥業股份有限公司 | Monobactam compounds and use therefor |
| JP7179185B2 (en) * | 2018-12-18 | 2022-11-28 | メッドシャイン ディスカバリー インコーポレイテッド | Use of monocyclic β-lactam compounds in the manufacture of pharmaceuticals |
| KR102786898B1 (en) * | 2019-11-22 | 2025-03-25 | 쑤저우 얼예 파마슈티칼 컴퍼니 리미티드 | Sulfonylurea ring-substituted monocyclic β-lactam antibiotics |
| CN111303144B (en) * | 2019-12-13 | 2020-11-27 | 苏州信诺维医药科技有限公司 | Compound for treating bacterial infection |
| US12491180B2 (en) | 2019-12-19 | 2025-12-09 | Shenzhen Optimum Biological Technology Co., Ltd | Application of compound in treating pneumonia |
| EP3838266A1 (en) | 2019-12-20 | 2021-06-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Microfluidic production of biofunctionalized giant unilamellar vesicles for targeted intracellular cargo delivery |
| CN113754651B (en) * | 2020-06-02 | 2023-04-18 | 中国医学科学院医药生物技术研究所 | Beta-lactam compound, application and preparation method thereof |
| EP4165039B1 (en) * | 2020-07-16 | 2024-08-21 | Ningxia Academy of Agriculture and Forestry Sciences | Novel monobactam compounds, their preparation and use as antibacterial agents |
| WO2022185240A1 (en) | 2021-03-04 | 2022-09-09 | Bp Asset Vi, Inc. | Formulation of a monobactam antibiotic |
| WO2022185241A1 (en) | 2021-03-04 | 2022-09-09 | Bp Asset Vi, Inc. | Process for manufacturing a monobactam antibiotic |
| KR20240105442A (en) | 2021-11-18 | 2024-07-05 | 머크 샤프 앤드 돔 엘엘씨 | chromanamidine monobactam antibiotic |
| CN115304594B (en) | 2022-10-12 | 2023-02-14 | 苏州二叶制药有限公司 | Salt form of sulfonylurea ring-substituted compound and crystal form thereof |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ196202A (en) | 1980-02-07 | 1984-07-31 | Squibb & Sons Inc | Beta-lactam antibiotics (of azetidine-sulphonic acid type) |
| US4775670A (en) | 1980-09-29 | 1988-10-04 | E. R. Squibb & Sons, Inc. | 2-oxo-1-azetidinesulfonic acid salts |
| EP0048953B1 (en) | 1980-09-29 | 1988-03-09 | E.R. Squibb & Sons, Inc. | Beta-lactam antibiotics |
| WO1982001873A1 (en) * | 1980-12-05 | 1982-06-10 | Takeda Chemical Industries Ltd | 1-sulfo-2-oxoazetidine derivatives and process for their preparation |
| JPS58210061A (en) * | 1982-05-31 | 1983-12-07 | Takeda Chem Ind Ltd | 1-sulfo-2-oxoazetidine derivative, its preparation and use |
| US4782147A (en) * | 1980-12-05 | 1988-11-01 | Takeda Chemical Industries, Ltd. | 1-sulfo-2-oxoazetidine derivatives and their production |
| JPS58189176A (en) * | 1982-04-30 | 1983-11-04 | Takeda Chem Ind Ltd | 1-sulfo-2-azetidinone derivative and its preparation |
| CA1262128A (en) | 1981-08-27 | 1989-10-03 | Christian N. Hubschwerlen | .beta.-lactams |
| IL67451A (en) | 1981-12-25 | 1987-10-20 | Takeda Chemical Industries Ltd | 4-cyano-2-azetidinones and production thereof and process for the preparation of 4-carbamoyl-2-azetidinones using them |
| GB2116183B (en) | 1982-03-03 | 1985-06-05 | Genentech Inc | Human antithrombin iii dna sequences therefore expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby a process for expressing human antithrombin iii and pharmaceutical compositions comprising it |
| AU564150B2 (en) * | 1982-04-30 | 1987-08-06 | Takeda Chemical Industries Ltd. | 1-sulfo-2-azetidinone derivatives |
| HU189290B (en) | 1982-05-31 | 1986-06-30 | Banyu Pharmaceutical Co Ltd,Jp | Process for preparing new 2-oxo-1-azetidine-sulphonic acid derivatives and pharmaceutically acceptable salts thereof, further pharmaceutical compositions containing such derivatives as active substances |
| EP0096297B1 (en) | 1982-06-03 | 1988-06-15 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Process for the preparation of 1-sulfo-2-oxoazetidine derivatives |
| JPS6153282A (en) | 1984-08-22 | 1986-03-17 | Banyu Pharmaceut Co Ltd | Monocyclic beta-lactam derivative |
| JPS6153283A (en) | 1984-08-24 | 1986-03-17 | Banyu Pharmaceut Co Ltd | 2-oxo-1-azetidinesulfonic acid derivative |
| US4610824A (en) | 1984-10-09 | 1986-09-09 | E. R. Squibb & Sons, Inc. | Hydrazide derivatives of monocyclic beta-lactam antibiotics |
| US5112968A (en) | 1989-07-28 | 1992-05-12 | E. R. Squibb & Sons, Inc. | Monobactam hydrazide derivatives |
| US6111090A (en) | 1996-08-16 | 2000-08-29 | Schering Corporation | Mammalian cell surface antigens; related reagents |
| DE69738749D1 (en) | 1996-08-16 | 2008-07-17 | Schering Corp | CELL SURFACE ANTIGEN FROM MAMMALS AND RELATED REAGENTS |
| JP2001520039A (en) | 1997-10-21 | 2001-10-30 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | Human tumor necrosis factor receptor-like proteins, TR11, TR11SV1 and TR11SV2 |
| WO1999040196A1 (en) | 1998-02-09 | 1999-08-12 | Genentech, Inc. | Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same |
| ES2295040T3 (en) | 1999-07-12 | 2008-04-16 | Genentech, Inc. | PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION BY LEGEND / RECEIVER OF TUMOR NECROSIS FACTOR. |
| BR0316880A (en) | 2002-12-23 | 2005-10-25 | Wyeth Corp | Pd-1 Antibodies and Uses |
| JP2007524596A (en) | 2003-02-28 | 2007-08-30 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | Co-crystal pharmaceutical composition |
| US7618632B2 (en) | 2003-05-23 | 2009-11-17 | Wyeth | Method of treating or ameliorating an immune cell associated pathology using GITR ligand antibodies |
| EP1660126A1 (en) | 2003-07-11 | 2006-05-31 | Schering Corporation | Agonists or antagonists of the clucocorticoid-induced tumour necrosis factor receptor (gitr) or its ligand for the treatment of immune disorders, infections and cancer |
| WO2005055808A2 (en) | 2003-12-02 | 2005-06-23 | Genzyme Corporation | Compositions and methods to diagnose and treat lung cancer |
| GB0409799D0 (en) | 2004-04-30 | 2004-06-09 | Isis Innovation | Method of generating improved immune response |
| EP1765402A2 (en) | 2004-06-04 | 2007-03-28 | Duke University | Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity |
| CA2602777C (en) | 2005-03-25 | 2018-12-11 | Tolerrx, Inc. | Gitr binding molecules and uses therefor |
| EP2439273B1 (en) | 2005-05-09 | 2019-02-27 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
| KR101888321B1 (en) | 2005-07-01 | 2018-08-13 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | Human monoclonal antibodies to programmed death ligand 1(pd-l1) |
| US20110212086A1 (en) | 2006-01-19 | 2011-09-01 | Genzyme Corporation | GITR Antibodies For The Treatment of Cancer |
| EP2069347A2 (en) | 2006-09-27 | 2009-06-17 | Merck & Co., Inc. | Novel inhibitors of beta-lactamase |
| NZ600758A (en) | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| DK2175884T3 (en) | 2007-07-12 | 2016-09-26 | Gitr Inc | Combination USING GITR BINDING MOLECULES |
| DK2231667T3 (en) | 2008-01-18 | 2013-12-16 | Merck Sharp & Dohme | Beta-lactamase INHIBITORS |
| RU2531758C2 (en) | 2008-02-11 | 2014-10-27 | Куретек Лтд. | Monoclonal antibodies for tumour treatment |
| US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
| US20110177070A1 (en) | 2008-07-02 | 2011-07-21 | Emergent Product Development Seatlle, LLC | TGF-Beta Antagonist Multi-Target Binding Proteins |
| AR072999A1 (en) | 2008-08-11 | 2010-10-06 | Medarex Inc | HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE |
| MX2011002250A (en) | 2008-08-25 | 2011-08-17 | Amplimmune Inc | Pd-1 antagonists and methods of use thereof. |
| RS54233B1 (en) | 2008-08-25 | 2015-12-31 | Amplimmune Inc. | PD-1 ANTAGONIST COMPOSITIONS AND PROCEDURES FOR THEIR APPLICATION |
| US8586023B2 (en) | 2008-09-12 | 2013-11-19 | Mie University | Cell capable of expressing exogenous GITR ligand |
| KR101655961B1 (en) | 2008-10-31 | 2016-09-08 | 시오노기세야쿠 가부시키가이샤 | Cephalosporin having catechol group |
| US8217149B2 (en) | 2008-12-09 | 2012-07-10 | Genentech, Inc. | Anti-PD-L1 antibodies, compositions and articles of manufacture |
| JP5844159B2 (en) | 2009-02-09 | 2016-01-13 | ユニヴェルシテ デクス−マルセイユＵｎｉｖｅｒｓｉｔｅ Ｄ’Ａｉｘ−Ｍａｒｓｅｉｌｌｅ | PD-1 antibody and PD-L1 antibody and use thereof |
| US20120053350A1 (en) | 2009-04-30 | 2012-03-01 | Ian Mangion | Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids |
| SG178991A1 (en) | 2009-09-03 | 2012-04-27 | Schering Corp | Anti-gitr antibodies |
| GB0919054D0 (en) | 2009-10-30 | 2009-12-16 | Isis Innovation | Treatment of obesity |
| WO2011061760A1 (en) | 2009-11-18 | 2011-05-26 | Cadila Healthcare Limited | Novel antithrombotic agents |
| JP2013512251A (en) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Simultaneous inhibition of PD-L1 / PD-L2 |
| PT2519543T (en) | 2009-12-29 | 2016-10-07 | Emergent Product Dev Seattle | Heterodimer binding proteins and uses thereof |
| JP2012027846A (en) | 2010-07-27 | 2012-02-09 | Sony Corp | Information processing unit, information display method and computer program |
| DK2646436T3 (en) | 2010-11-29 | 2015-06-29 | Pfizer | monobactams |
| PL2748151T3 (en) | 2011-08-25 | 2016-09-30 | Pyrimidine pde10 inhibitors | |
| EP3052497B1 (en) | 2011-09-13 | 2017-06-28 | Wockhardt Limited | Nitrogen containing compounds and their use |
| WO2013039954A1 (en) | 2011-09-14 | 2013-03-21 | Sanofi | Anti-gitr antibodies |
| LT2785375T (en) | 2011-11-28 | 2020-11-10 | Merck Patent Gmbh | ANTI-PD-L1 ANTIBODIES AND THEIR USE |
| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
| UY34585A (en) | 2012-01-24 | 2013-09-02 | Aicuris Gmbh & Co Kg | B-LACTAMIC COMPOUNDS REPLACED WITH AMIDINE, ITS PREPARATION AND USE |
| EP2814483A2 (en) | 2012-02-15 | 2014-12-24 | Rempex Pharmaceuticals, Inc. | Methods of treating bacterial infections |
| UY34632A (en) | 2012-02-24 | 2013-05-31 | Novartis Ag | OXAZOLIDIN- 2- ONA COMPOUNDS AND USES OF THE SAME |
| AU2013237939A1 (en) | 2012-03-30 | 2014-10-30 | Cubist Pharmaceuticals, Inc. | 1,3,4-oxadiazole and 1,3,4-thiadiazole beta-lactamase inhibitors |
| MX2014011825A (en) | 2012-03-30 | 2015-02-20 | Cubist Pharm Inc | Isoxazole î²-lactamase inhibitors. |
| UY34887A (en) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES |
| AU2013308127B2 (en) | 2012-08-25 | 2015-08-13 | Wockhardt Limited | 1,6- Diazabicyclo [3,2,1] octan- 7- one derivatives and their use in the treatment of bacterial infections |
| CN103044416A (en) | 2012-12-17 | 2013-04-17 | 浙江华方药业有限责任公司 | Synthetic method of Carumonam sodium |
| WO2014141132A1 (en) | 2013-03-14 | 2014-09-18 | Naeja Pharmaceutical Inc. | NEW HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS |
| US20160326157A1 (en) | 2014-01-06 | 2016-11-10 | President And Fellows Of Harvard College | Monobactams and methods of their synthesis and use |
-
2015
- 2015-03-23 WO PCT/US2015/022011 patent/WO2015148379A1/en not_active Ceased
- 2015-03-23 HR HRP20190501TT patent/HRP20190501T1/en unknown
- 2015-03-23 PE PE2016001601A patent/PE20161371A1/en unknown
- 2015-03-23 AU AU2015236369A patent/AU2015236369B2/en active Active
- 2015-03-23 HU HUE15714147A patent/HUE042134T2/en unknown
- 2015-03-23 UA UAA201608977A patent/UA121383C2/en unknown
- 2015-03-23 CU CU2016000131A patent/CU24441B1/en unknown
- 2015-03-23 CA CA2939254A patent/CA2939254C/en active Active
- 2015-03-23 SI SI201530680T patent/SI3122745T1/en unknown
- 2015-03-23 PL PL15714147T patent/PL3122745T3/en unknown
- 2015-03-23 PT PT15714147T patent/PT3122745T/en unknown
- 2015-03-23 KR KR1020167024716A patent/KR101733441B1/en active Active
- 2015-03-23 MX MX2016011822A patent/MX373444B/en active IP Right Grant
- 2015-03-23 ES ES18215940T patent/ES2862203T3/en active Active
- 2015-03-23 LT LTEP15714147.4T patent/LT3122745T/en unknown
- 2015-03-23 EP EP18215940.0A patent/EP3511328B1/en active Active
- 2015-03-23 JP JP2016558569A patent/JP6153674B2/en active Active
- 2015-03-23 EP EP15714147.4A patent/EP3122745B1/en active Active
- 2015-03-23 US US14/665,245 patent/US9174978B2/en active Active
- 2015-03-23 AP AP2016009374A patent/AP2016009374A0/en unknown
- 2015-03-23 MY MYPI2016702871A patent/MY179292A/en unknown
- 2015-03-23 SM SM20190218T patent/SMT201900218T1/en unknown
- 2015-03-23 BR BR112016020333-0A patent/BR112016020333B1/en active IP Right Grant
- 2015-03-23 TW TW104109243A patent/TWI714525B/en active
- 2015-03-23 SG SG11201606711UA patent/SG11201606711UA/en unknown
- 2015-03-23 MA MA39777A patent/MA39777B1/en unknown
- 2015-03-23 DK DK15714147.4T patent/DK3122745T3/en active
- 2015-03-23 ES ES15714147T patent/ES2719136T3/en active Active
- 2015-03-23 DK DK18215940.0T patent/DK3511328T3/en active
- 2015-03-23 EA EA201691766A patent/EA030850B1/en not_active IP Right Cessation
- 2015-03-23 CN CN201580015867.7A patent/CN106164072B/en active Active
- 2015-03-23 PH PH1/2016/501577A patent/PH12016501577B1/en unknown
- 2015-03-23 RS RS20190406A patent/RS58509B1/en unknown
- 2015-09-22 US US14/861,797 patent/US10369138B2/en active Active
-
2016
- 2016-08-11 ZA ZA2016/05565A patent/ZA201605565B/en unknown
- 2016-08-14 IL IL247259A patent/IL247259B/en active IP Right Grant
- 2016-09-09 CL CL2016002285A patent/CL2016002285A1/en unknown
- 2016-09-12 SV SV2016005274A patent/SV2016005274A/en unknown
- 2016-09-12 EC ECIEPI201673620A patent/ECSP16073620A/en unknown
- 2016-09-12 GT GT201600183A patent/GT201600183A/en unknown
-
2019
- 2019-04-03 CY CY20191100371T patent/CY1121701T1/en unknown
- 2019-04-10 US US16/380,243 patent/US20190231752A1/en not_active Abandoned
-
2020
- 2020-03-19 US US16/823,485 patent/US20200276169A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL247259A0 (en) | Monobactam organic compounds for the treatment of bacterial infections | |
| HUS2100037I1 (en) | Compounds for the treatment of spinal muscular atrophy | |
| ZA202001721B (en) | Chromane monobactam compounds for the treatment of bacterial infections | |
| EP3125893A4 (en) | Organic compounds | |
| EP3125892A4 (en) | Organic compounds | |
| EP3157565A4 (en) | Treatment of polybacterials infections | |
| ZA201703245B (en) | Combination therapy for treatment of resistant bacterial infections | |
| EP3226862A4 (en) | Organic compounds | |
| EP3177627A4 (en) | Organic compounds | |
| EP3157926A4 (en) | Organic compounds | |
| EP3091982A4 (en) | Organic compounds | |
| EP3226870A4 (en) | Organic compounds | |
| IL249616A0 (en) | Methods for treating infections | |
| AU2014901912A0 (en) | Compounds for the treatment of bacterial infections | |
| AU2014901885A0 (en) | Compounds for the treatment of antibacterial infections | |
| ZA201704589B (en) | Compounds for the treatment of cancer | |
| TH1501004125A (en) | Compounds and methods for treating bacterial infections | |
| GB201404621D0 (en) | Organic transistors | |
| GB201401087D0 (en) | Organic compounds |