SG11201606545SA - Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising the same and use thereof - Google Patents
Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising the same and use thereofInfo
- Publication number
- SG11201606545SA SG11201606545SA SG11201606545SA SG11201606545SA SG11201606545SA SG 11201606545S A SG11201606545S A SG 11201606545SA SG 11201606545S A SG11201606545S A SG 11201606545SA SG 11201606545S A SG11201606545S A SG 11201606545SA SG 11201606545S A SG11201606545S A SG 11201606545SA
- Authority
- SG
- Singapore
- Prior art keywords
- pyrrole
- preparation
- composition
- same
- method therefor
- Prior art date
Links
- -1 Pyrrole-substituted indolone Chemical class 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410046278.2A CN104829596B (en) | 2014-02-10 | 2014-02-10 | Pyrrole-substituted indolinone derivative and preparation method thereof, composition including derivative, and application of derivative |
| PCT/CN2015/072230 WO2015117551A1 (en) | 2014-02-10 | 2015-02-04 | Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising same and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201606545SA true SG11201606545SA (en) | 2016-09-29 |
Family
ID=53777341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201606545SA SG11201606545SA (en) | 2014-02-10 | 2015-02-04 | Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising the same and use thereof |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9556154B2 (en) |
| EP (1) | EP3106459B1 (en) |
| JP (1) | JP6211205B2 (en) |
| KR (1) | KR101805693B1 (en) |
| CN (1) | CN104829596B (en) |
| AU (1) | AU2015215335B2 (en) |
| BR (1) | BR112016018371B1 (en) |
| CA (1) | CA2939012C (en) |
| ES (1) | ES2687418T3 (en) |
| MX (1) | MX369473B (en) |
| MY (1) | MY176521A (en) |
| PL (1) | PL3106459T3 (en) |
| PT (1) | PT3106459T (en) |
| RU (1) | RU2650682C2 (en) |
| SA (1) | SA516371644B1 (en) |
| SG (1) | SG11201606545SA (en) |
| WO (1) | WO2015117551A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10462491B2 (en) | 2015-11-02 | 2019-10-29 | Dolby Laboratories Licensing Corporation | Layered representation and delivery of high dynamic range video |
| CN108727341B (en) * | 2017-04-13 | 2021-02-19 | 勤浩医药(苏州)有限公司 | Pyrrole substituted indolone derivative or pharmaceutically acceptable salt thereof, and preparation method and application thereof |
| CN108191835A (en) * | 2018-01-09 | 2018-06-22 | 中国药科大学 | It is a kind of novel to contain pyrrole ring and indoline structure RIP1 kinase inhibitors and application thereof |
| US12018014B2 (en) * | 2018-09-19 | 2024-06-25 | Suzhou Genhouse Pharmaceutical Co., Ltd. | Pyrrole-substituted indolone derivative or pharmaceutically acceptable salts thereof, and preparation method therefor and application thereof |
| CN109232580A (en) * | 2018-11-14 | 2019-01-18 | 南阳师范学院 | A kind of synthetic method of 1H- pyrrolo- [1,2-a] indoles -2 (3-H) -one |
| CN112321568B (en) * | 2020-09-22 | 2023-02-17 | 南京中医药大学 | 4-methylpyrrole substituted indolone derivative, preparation method and medical application thereof |
| WO2025035486A1 (en) * | 2023-08-11 | 2025-02-20 | 勤浩医药(苏州)有限公司 | Pharmaceutically acceptable salt and crystalline form of tyrosine kinase inhibitor and preparation method therefor |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS50444B (en) * | 2000-02-15 | 2010-03-02 | Sugen Inc. | 2-INDOLINON PROTEIN KINASE INHIBITORS SUBSTITUTED BY PIROL |
| CA2432114A1 (en) * | 2000-12-20 | 2002-07-18 | Sugen, Inc. | 4-(hetero)aryl substituted indolinones |
| WO2002081466A1 (en) * | 2001-04-09 | 2002-10-17 | Sugen, Inc. | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| WO2003031438A1 (en) * | 2001-10-10 | 2003-04-17 | Sugen, Inc. | 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors |
| JP2005514368A (en) * | 2001-11-21 | 2005-05-19 | スージェン・インコーポレーテッド | Pharmaceutical formulations containing indolinone derivatives |
| TW200418836A (en) * | 2002-09-10 | 2004-10-01 | Pharmacia Italia Spa | Formulations comprising an indolinone compound |
| CN101007801A (en) * | 2006-01-27 | 2007-08-01 | 上海恒瑞医药有限公司 | Pyrrole substituted 2-dihydromolindone derivative, its preparation method and medical uses |
| JP5568304B2 (en) * | 2006-09-15 | 2014-08-06 | タイロジェネクス,インコーポレイテッド | Kinase inhibitor compounds |
| MX2010005556A (en) * | 2007-12-03 | 2010-08-11 | Boehringer Ingelheim Int | Process for the manufacture of an indolinone derivative. |
| US8829039B2 (en) * | 2008-05-23 | 2014-09-09 | Shanghai Institute Of Pharmaceutical Industry | Dihydroindolinone derivatives |
| CN102276584A (en) * | 2010-06-08 | 2011-12-14 | 齐鲁制药有限公司 | Pyrrole-substituted 2-dihydroindolone derivative and preparation method and application thereof |
| CN103130744B (en) | 2012-08-28 | 2014-10-15 | 沈阳药科大学 | Selenazole formic acid formic acid compound and preparation method and application thereof |
-
2014
- 2014-02-10 CN CN201410046278.2A patent/CN104829596B/en active Active
-
2015
- 2015-02-04 PL PL15746066T patent/PL3106459T3/en unknown
- 2015-02-04 US US15/117,400 patent/US9556154B2/en active Active
- 2015-02-04 MX MX2016010272A patent/MX369473B/en active IP Right Grant
- 2015-02-04 KR KR1020167024807A patent/KR101805693B1/en active Active
- 2015-02-04 AU AU2015215335A patent/AU2015215335B2/en active Active
- 2015-02-04 SG SG11201606545SA patent/SG11201606545SA/en unknown
- 2015-02-04 PT PT15746066T patent/PT3106459T/en unknown
- 2015-02-04 ES ES15746066.8T patent/ES2687418T3/en active Active
- 2015-02-04 JP JP2016552314A patent/JP6211205B2/en active Active
- 2015-02-04 RU RU2016136351A patent/RU2650682C2/en active
- 2015-02-04 CA CA2939012A patent/CA2939012C/en active Active
- 2015-02-04 WO PCT/CN2015/072230 patent/WO2015117551A1/en not_active Ceased
- 2015-02-04 MY MYPI2016702887A patent/MY176521A/en unknown
- 2015-02-04 EP EP15746066.8A patent/EP3106459B1/en active Active
- 2015-02-04 BR BR112016018371-1A patent/BR112016018371B1/en active IP Right Grant
-
2016
- 2016-08-09 SA SA516371644A patent/SA516371644B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2650682C2 (en) | 2018-04-17 |
| PT3106459T (en) | 2018-10-18 |
| MX2016010272A (en) | 2017-02-06 |
| EP3106459A4 (en) | 2017-07-12 |
| SA516371644B1 (en) | 2019-08-29 |
| WO2015117551A1 (en) | 2015-08-13 |
| CA2939012A1 (en) | 2015-08-13 |
| ES2687418T3 (en) | 2018-10-25 |
| US20160347740A1 (en) | 2016-12-01 |
| EP3106459A1 (en) | 2016-12-21 |
| PL3106459T3 (en) | 2018-11-30 |
| JP2017505803A (en) | 2017-02-23 |
| BR112016018371A2 (en) | 2017-10-17 |
| KR20160117605A (en) | 2016-10-10 |
| AU2015215335B2 (en) | 2017-07-27 |
| AU2015215335A1 (en) | 2016-09-01 |
| MY176521A (en) | 2020-08-13 |
| BR112016018371B1 (en) | 2022-06-14 |
| EP3106459B1 (en) | 2018-07-04 |
| CN104829596A (en) | 2015-08-12 |
| RU2016136351A (en) | 2018-03-15 |
| KR101805693B1 (en) | 2017-12-06 |
| CN104829596B (en) | 2017-02-01 |
| JP6211205B2 (en) | 2017-10-11 |
| RU2016136351A3 (en) | 2018-03-15 |
| US9556154B2 (en) | 2017-01-31 |
| CA2939012C (en) | 2018-11-06 |
| MX369473B (en) | 2019-11-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3215147A4 (en) | Neuro-attenuating ketamine and norketamine compounds, derivatives thereof, and methods | |
| PL3643709T3 (en) | Isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof | |
| EP3183349A4 (en) | Methods for preparing rebaudioside i and uses | |
| EP3109302A4 (en) | Composition for heat cycle system, and heat cycle system | |
| EP3109301A4 (en) | Composition for heat cycle system, and heat cycle system | |
| EP3109304A4 (en) | Composition for heat cycle system, and heat cycle system | |
| EP3109291A4 (en) | Composition for heat cycle system, and heat cycle system | |
| EP3109303A4 (en) | Composition for heat cycle system, and heat cycle system | |
| EP3109298A4 (en) | Composition for heat cycle system, and heat cycle system | |
| EP3040326A4 (en) | Halo-olefin composition | |
| EP3112437A4 (en) | Composition for heat cycle system, and heat cycle system | |
| IL287645A (en) | Cytotoxic and anti-mitotic compounds, and methods of using the same | |
| EP3115361A4 (en) | Heterocyclic compounds, and preparation method and use thereof | |
| PL3157901T3 (en) | Formulations, the production and use thereof, and suitable components | |
| EP3067338A4 (en) | Water-settable composition | |
| PT3552017T (en) | Compounds, compositions and methods | |
| SG11201606545SA (en) | Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising the same and use thereof | |
| SI3220893T1 (en) | Composition based on coq10 | |
| EP3231430A4 (en) | Composition | |
| PT3157912T (en) | Parasiticidal compositions comprising indole derivatives, methods and uses thereof | |
| EP3125321A4 (en) | Organic-semiconductor-film-forming composition | |
| EP3237399A4 (en) | Compounds, compositions and methods | |
| EP3241823A4 (en) | Pyrrole amide compound, preparation method therefor, and use thereof | |
| RO130539B8 (en) | Herbicidal composition, preparation process and use thereof | |
| EP3169670A4 (en) | Quinoxaline compounds, method for preparing the same and use thereof |