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SG11201606545SA - Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising the same and use thereof - Google Patents

Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising the same and use thereof

Info

Publication number
SG11201606545SA
SG11201606545SA SG11201606545SA SG11201606545SA SG11201606545SA SG 11201606545S A SG11201606545S A SG 11201606545SA SG 11201606545S A SG11201606545S A SG 11201606545SA SG 11201606545S A SG11201606545S A SG 11201606545SA SG 11201606545S A SG11201606545S A SG 11201606545SA
Authority
SG
Singapore
Prior art keywords
pyrrole
preparation
composition
same
method therefor
Prior art date
Application number
SG11201606545SA
Inventor
Lihong Hu
Shaohua Zhao
Peng Liu
Xiangjun Li
Junyong An
Mengxia Zhou
Lili Zhang
Zijian Yao
Original Assignee
Shijiazhuang Yiling Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shijiazhuang Yiling Pharmaceutical Co Ltd filed Critical Shijiazhuang Yiling Pharmaceutical Co Ltd
Publication of SG11201606545SA publication Critical patent/SG11201606545SA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG11201606545SA 2014-02-10 2015-02-04 Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising the same and use thereof SG11201606545SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410046278.2A CN104829596B (en) 2014-02-10 2014-02-10 Pyrrole-substituted indolinone derivative and preparation method thereof, composition including derivative, and application of derivative
PCT/CN2015/072230 WO2015117551A1 (en) 2014-02-10 2015-02-04 Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising same and use thereof

Publications (1)

Publication Number Publication Date
SG11201606545SA true SG11201606545SA (en) 2016-09-29

Family

ID=53777341

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201606545SA SG11201606545SA (en) 2014-02-10 2015-02-04 Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising the same and use thereof

Country Status (17)

Country Link
US (1) US9556154B2 (en)
EP (1) EP3106459B1 (en)
JP (1) JP6211205B2 (en)
KR (1) KR101805693B1 (en)
CN (1) CN104829596B (en)
AU (1) AU2015215335B2 (en)
BR (1) BR112016018371B1 (en)
CA (1) CA2939012C (en)
ES (1) ES2687418T3 (en)
MX (1) MX369473B (en)
MY (1) MY176521A (en)
PL (1) PL3106459T3 (en)
PT (1) PT3106459T (en)
RU (1) RU2650682C2 (en)
SA (1) SA516371644B1 (en)
SG (1) SG11201606545SA (en)
WO (1) WO2015117551A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10462491B2 (en) 2015-11-02 2019-10-29 Dolby Laboratories Licensing Corporation Layered representation and delivery of high dynamic range video
CN108727341B (en) * 2017-04-13 2021-02-19 勤浩医药(苏州)有限公司 Pyrrole substituted indolone derivative or pharmaceutically acceptable salt thereof, and preparation method and application thereof
CN108191835A (en) * 2018-01-09 2018-06-22 中国药科大学 It is a kind of novel to contain pyrrole ring and indoline structure RIP1 kinase inhibitors and application thereof
US12018014B2 (en) * 2018-09-19 2024-06-25 Suzhou Genhouse Pharmaceutical Co., Ltd. Pyrrole-substituted indolone derivative or pharmaceutically acceptable salts thereof, and preparation method therefor and application thereof
CN109232580A (en) * 2018-11-14 2019-01-18 南阳师范学院 A kind of synthetic method of 1H- pyrrolo- [1,2-a] indoles -2 (3-H) -one
CN112321568B (en) * 2020-09-22 2023-02-17 南京中医药大学 4-methylpyrrole substituted indolone derivative, preparation method and medical application thereof
WO2025035486A1 (en) * 2023-08-11 2025-02-20 勤浩医药(苏州)有限公司 Pharmaceutically acceptable salt and crystalline form of tyrosine kinase inhibitor and preparation method therefor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS50444B (en) * 2000-02-15 2010-03-02 Sugen Inc. 2-INDOLINON PROTEIN KINASE INHIBITORS SUBSTITUTED BY PIROL
CA2432114A1 (en) * 2000-12-20 2002-07-18 Sugen, Inc. 4-(hetero)aryl substituted indolinones
WO2002081466A1 (en) * 2001-04-09 2002-10-17 Sugen, Inc. Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
WO2003031438A1 (en) * 2001-10-10 2003-04-17 Sugen, Inc. 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors
JP2005514368A (en) * 2001-11-21 2005-05-19 スージェン・インコーポレーテッド Pharmaceutical formulations containing indolinone derivatives
TW200418836A (en) * 2002-09-10 2004-10-01 Pharmacia Italia Spa Formulations comprising an indolinone compound
CN101007801A (en) * 2006-01-27 2007-08-01 上海恒瑞医药有限公司 Pyrrole substituted 2-dihydromolindone derivative, its preparation method and medical uses
JP5568304B2 (en) * 2006-09-15 2014-08-06 タイロジェネクス,インコーポレイテッド Kinase inhibitor compounds
MX2010005556A (en) * 2007-12-03 2010-08-11 Boehringer Ingelheim Int Process for the manufacture of an indolinone derivative.
US8829039B2 (en) * 2008-05-23 2014-09-09 Shanghai Institute Of Pharmaceutical Industry Dihydroindolinone derivatives
CN102276584A (en) * 2010-06-08 2011-12-14 齐鲁制药有限公司 Pyrrole-substituted 2-dihydroindolone derivative and preparation method and application thereof
CN103130744B (en) 2012-08-28 2014-10-15 沈阳药科大学 Selenazole formic acid formic acid compound and preparation method and application thereof

Also Published As

Publication number Publication date
RU2650682C2 (en) 2018-04-17
PT3106459T (en) 2018-10-18
MX2016010272A (en) 2017-02-06
EP3106459A4 (en) 2017-07-12
SA516371644B1 (en) 2019-08-29
WO2015117551A1 (en) 2015-08-13
CA2939012A1 (en) 2015-08-13
ES2687418T3 (en) 2018-10-25
US20160347740A1 (en) 2016-12-01
EP3106459A1 (en) 2016-12-21
PL3106459T3 (en) 2018-11-30
JP2017505803A (en) 2017-02-23
BR112016018371A2 (en) 2017-10-17
KR20160117605A (en) 2016-10-10
AU2015215335B2 (en) 2017-07-27
AU2015215335A1 (en) 2016-09-01
MY176521A (en) 2020-08-13
BR112016018371B1 (en) 2022-06-14
EP3106459B1 (en) 2018-07-04
CN104829596A (en) 2015-08-12
RU2016136351A (en) 2018-03-15
KR101805693B1 (en) 2017-12-06
CN104829596B (en) 2017-02-01
JP6211205B2 (en) 2017-10-11
RU2016136351A3 (en) 2018-03-15
US9556154B2 (en) 2017-01-31
CA2939012C (en) 2018-11-06
MX369473B (en) 2019-11-08

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