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SG11201604993WA - A method for producing 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanine - Google Patents

A method for producing 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanine

Info

Publication number
SG11201604993WA
SG11201604993WA SG11201604993WA SG11201604993WA SG11201604993WA SG 11201604993W A SG11201604993W A SG 11201604993WA SG 11201604993W A SG11201604993W A SG 11201604993WA SG 11201604993W A SG11201604993W A SG 11201604993WA SG 11201604993W A SG11201604993W A SG 11201604993WA
Authority
SG
Singapore
Prior art keywords
borono
phenylalanine
fluoro
precursor
producing
Prior art date
Application number
SG11201604993WA
Inventor
Hiroshi Takenaka
Yoichiro Ohta
Yusuke Taguchi
Sayuri Ueda
Yuko Ishino
Tomohiro Yoshikawa
Hideki Nakashima
Kohki Uehara
Mitsunori Kirihata
Original Assignee
Stella Pharma Corp
Univ Osaka Prefect Public Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stella Pharma Corp, Univ Osaka Prefect Public Corp filed Critical Stella Pharma Corp
Publication of SG11201604993WA publication Critical patent/SG11201604993WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/027Organoboranes and organoborohydrides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11201604993WA 2013-12-17 2014-12-16 A method for producing 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanine SG11201604993WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013260451 2013-12-17
PCT/JP2014/083243 WO2015093469A1 (en) 2013-12-17 2014-12-16 Production method for 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanine

Publications (1)

Publication Number Publication Date
SG11201604993WA true SG11201604993WA (en) 2016-07-28

Family

ID=53402814

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201604993WA SG11201604993WA (en) 2013-12-17 2014-12-16 A method for producing 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanine

Country Status (12)

Country Link
US (2) US10005794B2 (en)
EP (1) EP3085687B1 (en)
JP (2) JP6227673B2 (en)
KR (1) KR102137214B1 (en)
CN (1) CN105916836B (en)
AU (1) AU2014367825B9 (en)
CA (1) CA2933846C (en)
MY (1) MY183427A (en)
RU (1) RU2668166C1 (en)
SG (1) SG11201604993WA (en)
TW (1) TWI640496B (en)
WO (1) WO2015093469A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3085687B1 (en) 2013-12-17 2020-06-17 Stella Pharma Corporation Production method for 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanine
JP6996443B2 (en) * 2018-07-19 2022-02-04 Jfeエンジニアリング株式会社 4-[18F] Fluoro-4-boronophenylalanine precursor production method, 2- [18F] Fluoro-4-boronophenylalanine production method
CN110835310B (en) * 2018-08-17 2022-09-20 南京中硼联康医疗科技有限公司 Intermediate, preparation method and application
CN112979684B (en) * 2019-12-13 2023-11-03 南京江原安迪科正电子研究发展有限公司 Preparation 18 F-BPA process
CN113045592A (en) * 2019-12-26 2021-06-29 南京江原安迪科正电子研究发展有限公司 18Process for the preparation of F-BPA
CN113354669B (en) * 2020-03-03 2022-07-08 北京大学 Boron-carrying agent integrated in tumor diagnosis and treatment, its preparation method and use
CN113773337A (en) * 2020-06-05 2021-12-10 南京中硼联康医疗科技有限公司 Radiolabeled boron-containing compounds, methods of preparation and uses
EP4361159A4 (en) * 2021-06-25 2025-03-12 Stella Pharma Corporation BORONO-PHENYLALANINE DERIVATIVE
CN115724866A (en) * 2021-09-02 2023-03-03 北京大学 Boron carrier for tumor diagnosis and treatment integration, preparation method and application thereof
US20230234973A1 (en) * 2022-01-27 2023-07-27 Heron Neutron Medical Corp. Intermediate, preparing method thereof, and method of preparing drug

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
US614100A (en) * 1898-11-15 Fiths
GB9323429D0 (en) * 1993-11-12 1994-01-05 Wellcome Found Therapy
CN1160368C (en) * 2000-06-21 2004-08-04 中国人民解放军军事医学科学院毒物药物研究所 Endothelin antegon
JP3964417B2 (en) * 2004-09-27 2007-08-22 国立大学法人金沢大学 Α2 receptor blocker and vasodilator containing indole derivative as active ingredient
JP4931181B2 (en) * 2006-01-31 2012-05-16 独立行政法人放射線医学総合研究所 Synthesis method of radioligand having 18F-labeled fluorobenzene ring
EP1842846A1 (en) * 2006-04-07 2007-10-10 Santhera Pharmaceuticals (Schweiz) AG Phenylpiperidine derivatives as melanocortin-4 receptor modulators
RU2395489C2 (en) * 2006-11-01 2010-07-27 Институт элементоорганических соединений имени А.Н.Несмеянова Российской академии наук (ИНЭОС РАН) [f-18] labelled l-glutamic acid, [f-18] labelled l-glutamine, derivatives thereof and use thereof, as well as synthesis method thereof
EA201070127A1 (en) * 2007-07-11 2010-08-30 Лексикон Фармасьютикалз , Инк. METHODS OF TREATMENT OF PULMONARY HYPERTENSION, RELATED DISEASES AND DISORDERS AND COMPOSITIONS FOR THEIR IMPLEMENTATION
WO2010091164A1 (en) * 2009-02-06 2010-08-12 Exelixis, Inc. Inhibitors of glucosylceramide synthase
CN102887913B (en) * 2012-10-08 2015-02-25 南京江原安迪科正电子研究发展有限公司 Method for synthesizing 4-dihydroxyborane-2-fluorophenylalanine
JP6248042B2 (en) * 2012-10-15 2017-12-13 ステラファーマ株式会社 Chiral 4-boronophenylalanine (BPA) derivative and production method, and production method of 18F-labeled BPA using the derivative
US8877775B2 (en) 2013-03-14 2014-11-04 Boehringer Ingelheim International Gmbh Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C
EP2970230B1 (en) 2013-03-14 2019-05-22 Boehringer Ingelheim International GmbH Substituted bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c
EP3085687B1 (en) 2013-12-17 2020-06-17 Stella Pharma Corporation Production method for 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanine

Also Published As

Publication number Publication date
JP6455572B2 (en) 2019-01-23
CN105916836B (en) 2021-02-09
US20160311836A1 (en) 2016-10-27
JPWO2015093469A1 (en) 2017-03-16
WO2015093469A1 (en) 2015-06-25
JP6227673B2 (en) 2017-11-08
RU2668166C1 (en) 2018-09-27
NZ720609A (en) 2021-11-26
AU2014367825B9 (en) 2018-08-16
US20170283441A1 (en) 2017-10-05
AU2014367825B2 (en) 2018-08-09
EP3085687A1 (en) 2016-10-26
CN105916836A (en) 2016-08-31
TW201609616A (en) 2016-03-16
US10005794B2 (en) 2018-06-26
JP2018024668A (en) 2018-02-15
KR102137214B1 (en) 2020-07-23
KR20160098449A (en) 2016-08-18
CA2933846C (en) 2022-11-29
MY183427A (en) 2021-02-18
CA2933846A1 (en) 2015-06-25
EP3085687A4 (en) 2017-08-30
US10344042B2 (en) 2019-07-09
TWI640496B (en) 2018-11-11
EP3085687B1 (en) 2020-06-17
AU2014367825A1 (en) 2016-06-30

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