SG11201604993WA - A method for producing 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanine - Google Patents
A method for producing 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanineInfo
- Publication number
- SG11201604993WA SG11201604993WA SG11201604993WA SG11201604993WA SG11201604993WA SG 11201604993W A SG11201604993W A SG 11201604993WA SG 11201604993W A SG11201604993W A SG 11201604993WA SG 11201604993W A SG11201604993W A SG 11201604993WA SG 11201604993W A SG11201604993W A SG 11201604993WA
- Authority
- SG
- Singapore
- Prior art keywords
- borono
- phenylalanine
- fluoro
- precursor
- producing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013260451 | 2013-12-17 | ||
| PCT/JP2014/083243 WO2015093469A1 (en) | 2013-12-17 | 2014-12-16 | Production method for 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201604993WA true SG11201604993WA (en) | 2016-07-28 |
Family
ID=53402814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201604993WA SG11201604993WA (en) | 2013-12-17 | 2014-12-16 | A method for producing 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanine |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10005794B2 (en) |
| EP (1) | EP3085687B1 (en) |
| JP (2) | JP6227673B2 (en) |
| KR (1) | KR102137214B1 (en) |
| CN (1) | CN105916836B (en) |
| AU (1) | AU2014367825B9 (en) |
| CA (1) | CA2933846C (en) |
| MY (1) | MY183427A (en) |
| RU (1) | RU2668166C1 (en) |
| SG (1) | SG11201604993WA (en) |
| TW (1) | TWI640496B (en) |
| WO (1) | WO2015093469A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3085687B1 (en) | 2013-12-17 | 2020-06-17 | Stella Pharma Corporation | Production method for 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanine |
| JP6996443B2 (en) * | 2018-07-19 | 2022-02-04 | Jfeエンジニアリング株式会社 | 4-[18F] Fluoro-4-boronophenylalanine precursor production method, 2- [18F] Fluoro-4-boronophenylalanine production method |
| CN110835310B (en) * | 2018-08-17 | 2022-09-20 | 南京中硼联康医疗科技有限公司 | Intermediate, preparation method and application |
| CN112979684B (en) * | 2019-12-13 | 2023-11-03 | 南京江原安迪科正电子研究发展有限公司 | Preparation 18 F-BPA process |
| CN113045592A (en) * | 2019-12-26 | 2021-06-29 | 南京江原安迪科正电子研究发展有限公司 | 18Process for the preparation of F-BPA |
| CN113354669B (en) * | 2020-03-03 | 2022-07-08 | 北京大学 | Boron-carrying agent integrated in tumor diagnosis and treatment, its preparation method and use |
| CN113773337A (en) * | 2020-06-05 | 2021-12-10 | 南京中硼联康医疗科技有限公司 | Radiolabeled boron-containing compounds, methods of preparation and uses |
| EP4361159A4 (en) * | 2021-06-25 | 2025-03-12 | Stella Pharma Corporation | BORONO-PHENYLALANINE DERIVATIVE |
| CN115724866A (en) * | 2021-09-02 | 2023-03-03 | 北京大学 | Boron carrier for tumor diagnosis and treatment integration, preparation method and application thereof |
| US20230234973A1 (en) * | 2022-01-27 | 2023-07-27 | Heron Neutron Medical Corp. | Intermediate, preparing method thereof, and method of preparing drug |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US614100A (en) * | 1898-11-15 | Fiths | ||
| GB9323429D0 (en) * | 1993-11-12 | 1994-01-05 | Wellcome Found | Therapy |
| CN1160368C (en) * | 2000-06-21 | 2004-08-04 | 中国人民解放军军事医学科学院毒物药物研究所 | Endothelin antegon |
| JP3964417B2 (en) * | 2004-09-27 | 2007-08-22 | 国立大学法人金沢大学 | Α2 receptor blocker and vasodilator containing indole derivative as active ingredient |
| JP4931181B2 (en) * | 2006-01-31 | 2012-05-16 | 独立行政法人放射線医学総合研究所 | Synthesis method of radioligand having 18F-labeled fluorobenzene ring |
| EP1842846A1 (en) * | 2006-04-07 | 2007-10-10 | Santhera Pharmaceuticals (Schweiz) AG | Phenylpiperidine derivatives as melanocortin-4 receptor modulators |
| RU2395489C2 (en) * | 2006-11-01 | 2010-07-27 | Институт элементоорганических соединений имени А.Н.Несмеянова Российской академии наук (ИНЭОС РАН) | [f-18] labelled l-glutamic acid, [f-18] labelled l-glutamine, derivatives thereof and use thereof, as well as synthesis method thereof |
| EA201070127A1 (en) * | 2007-07-11 | 2010-08-30 | Лексикон Фармасьютикалз , Инк. | METHODS OF TREATMENT OF PULMONARY HYPERTENSION, RELATED DISEASES AND DISORDERS AND COMPOSITIONS FOR THEIR IMPLEMENTATION |
| WO2010091164A1 (en) * | 2009-02-06 | 2010-08-12 | Exelixis, Inc. | Inhibitors of glucosylceramide synthase |
| CN102887913B (en) * | 2012-10-08 | 2015-02-25 | 南京江原安迪科正电子研究发展有限公司 | Method for synthesizing 4-dihydroxyborane-2-fluorophenylalanine |
| JP6248042B2 (en) * | 2012-10-15 | 2017-12-13 | ステラファーマ株式会社 | Chiral 4-boronophenylalanine (BPA) derivative and production method, and production method of 18F-labeled BPA using the derivative |
| US8877775B2 (en) | 2013-03-14 | 2014-11-04 | Boehringer Ingelheim International Gmbh | Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C |
| EP2970230B1 (en) | 2013-03-14 | 2019-05-22 | Boehringer Ingelheim International GmbH | Substituted bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c |
| EP3085687B1 (en) | 2013-12-17 | 2020-06-17 | Stella Pharma Corporation | Production method for 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanine |
-
2014
- 2014-12-16 EP EP14872762.1A patent/EP3085687B1/en active Active
- 2014-12-16 MY MYPI2016001113A patent/MY183427A/en unknown
- 2014-12-16 CN CN201480069329.1A patent/CN105916836B/en active Active
- 2014-12-16 SG SG11201604993WA patent/SG11201604993WA/en unknown
- 2014-12-16 JP JP2015553547A patent/JP6227673B2/en active Active
- 2014-12-16 CA CA2933846A patent/CA2933846C/en active Active
- 2014-12-16 WO PCT/JP2014/083243 patent/WO2015093469A1/en not_active Ceased
- 2014-12-16 US US15/105,401 patent/US10005794B2/en active Active
- 2014-12-16 AU AU2014367825A patent/AU2014367825B9/en active Active
- 2014-12-16 RU RU2016128963A patent/RU2668166C1/en active
- 2014-12-16 KR KR1020167019107A patent/KR102137214B1/en active Active
- 2014-12-17 TW TW103144087A patent/TWI640496B/en active
-
2017
- 2017-06-16 US US15/625,909 patent/US10344042B2/en active Active
- 2017-08-09 JP JP2017153811A patent/JP6455572B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6455572B2 (en) | 2019-01-23 |
| CN105916836B (en) | 2021-02-09 |
| US20160311836A1 (en) | 2016-10-27 |
| JPWO2015093469A1 (en) | 2017-03-16 |
| WO2015093469A1 (en) | 2015-06-25 |
| JP6227673B2 (en) | 2017-11-08 |
| RU2668166C1 (en) | 2018-09-27 |
| NZ720609A (en) | 2021-11-26 |
| AU2014367825B9 (en) | 2018-08-16 |
| US20170283441A1 (en) | 2017-10-05 |
| AU2014367825B2 (en) | 2018-08-09 |
| EP3085687A1 (en) | 2016-10-26 |
| CN105916836A (en) | 2016-08-31 |
| TW201609616A (en) | 2016-03-16 |
| US10005794B2 (en) | 2018-06-26 |
| JP2018024668A (en) | 2018-02-15 |
| KR102137214B1 (en) | 2020-07-23 |
| KR20160098449A (en) | 2016-08-18 |
| CA2933846C (en) | 2022-11-29 |
| MY183427A (en) | 2021-02-18 |
| CA2933846A1 (en) | 2015-06-25 |
| EP3085687A4 (en) | 2017-08-30 |
| US10344042B2 (en) | 2019-07-09 |
| TWI640496B (en) | 2018-11-11 |
| EP3085687B1 (en) | 2020-06-17 |
| AU2014367825A1 (en) | 2016-06-30 |
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