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SG11201603088RA - Specific anti-cd38 antibodies for treating human cancers - Google Patents

Specific anti-cd38 antibodies for treating human cancers

Info

Publication number
SG11201603088RA
SG11201603088RA SG11201603088RA SG11201603088RA SG11201603088RA SG 11201603088R A SG11201603088R A SG 11201603088RA SG 11201603088R A SG11201603088R A SG 11201603088RA SG 11201603088R A SG11201603088R A SG 11201603088RA SG 11201603088R A SG11201603088R A SG 11201603088RA
Authority
SG
Singapore
Prior art keywords
antibodies
specific anti
human cancers
treating human
treating
Prior art date
Application number
SG11201603088RA
Inventor
Antoine Deslandes
Krzysztof J Grzegorzewski
Marie-Laure Ozoux
Blake Tomkinson
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SG11201603088RA publication Critical patent/SG11201603088RA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11201603088RA 2013-10-31 2014-10-31 Specific anti-cd38 antibodies for treating human cancers SG11201603088RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361898309P 2013-10-31 2013-10-31
EP14306220 2014-07-31
PCT/US2014/063380 WO2015066450A1 (en) 2013-10-31 2014-10-31 Specific anti-cd38 antibodies for treating human cancers

Publications (1)

Publication Number Publication Date
SG11201603088RA true SG11201603088RA (en) 2016-05-30

Family

ID=51266255

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201603088RA SG11201603088RA (en) 2013-10-31 2014-10-31 Specific anti-cd38 antibodies for treating human cancers
SG10201803288RA SG10201803288RA (en) 2013-10-31 2014-10-31 Specific anti-cd38 antibodies for treating human cancers

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201803288RA SG10201803288RA (en) 2013-10-31 2014-10-31 Specific anti-cd38 antibodies for treating human cancers

Country Status (20)

Country Link
US (2) US20150118251A1 (en)
EP (2) EP3805266A1 (en)
JP (3) JP2016536314A (en)
KR (1) KR20160077155A (en)
CN (1) CN106103481A (en)
AU (1) AU2014342103B2 (en)
BR (1) BR112016009403A2 (en)
CA (1) CA2927099A1 (en)
CR (1) CR20160186A (en)
EA (1) EA035098B1 (en)
IL (1) IL245196B (en)
MA (2) MA39070A1 (en)
MX (1) MX373301B (en)
NZ (1) NZ719784A (en)
PL (1) PL3063173T3 (en)
PT (1) PT3063173T (en)
SG (2) SG11201603088RA (en)
TN (1) TN2016000142A1 (en)
TW (1) TW201522378A (en)
WO (1) WO2015066450A1 (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA112170C2 (en) 2010-12-10 2016-08-10 Санофі ANTI-TUMOR COMBINATION CONTAINING AN ANTIBODY SPECIFICALLY RECOGNIZING CD38 AND BORTESOMB
JOP20210044A1 (en) 2010-12-30 2017-06-16 Takeda Pharmaceuticals Co Anti-CD38 . antibody
US10342869B2 (en) * 2012-12-07 2019-07-09 The Regents Of The University Of California Compositions comprising anti-CD38 antibodies and lenalidomide
EP3769783A1 (en) * 2013-03-13 2021-01-27 Sanofi Compositions comprising anti-cd38 antibodies and carfilzomib
US9732154B2 (en) 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
US9603927B2 (en) 2014-02-28 2017-03-28 Janssen Biotech, Inc. Combination therapies with anti-CD38 antibodies
EA035979B1 (en) 2014-09-09 2020-09-08 Янссен Байотек, Инк. Combination therapies with anti-cd38 antibodies
KR102597989B1 (en) 2014-12-04 2023-11-02 얀센 바이오테크 인코포레이티드 Anti-cd38 antibodies for treatment of acute myeloid leukemia
PL3294769T3 (en) * 2015-05-13 2021-07-05 Morphosys Ag Treatment for multiple myeloma (mm)
IL319936A (en) * 2015-05-20 2025-05-01 Janssen Biotech Inc Anti-cd38 antibodies for treatment of light chain amyloidosis and other cd38-positive hematological malignancies
MX2017015493A (en) 2015-05-30 2018-02-09 Molecular Templates Inc De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same.
WO2016201337A1 (en) * 2015-06-12 2016-12-15 Immungene, Inc. Engineered antibody-interferon fusion molecules for the treatment of glucose-regulated protein 94 (grp94) expressing cancers
WO2016209921A1 (en) 2015-06-22 2016-12-29 Janssen Biotech, Inc. Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors
US20170044265A1 (en) 2015-06-24 2017-02-16 Janssen Biotech, Inc. Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
US10781261B2 (en) 2015-11-03 2020-09-22 Janssen Biotech, Inc. Subcutaneous formulations of anti-CD38 antibodies and their uses
EP4516319A3 (en) * 2015-11-03 2025-05-07 Janssen Biotech, Inc. Subcutaneous formulations of anti-cd38 antibodies and their uses
JP7362250B2 (en) 2016-03-04 2023-10-17 モルフォシス・アーゲー Clinical evaluation of M protein response in multiple myeloma
KR20190053835A (en) 2016-06-21 2019-05-20 테네오바이오, 인코포레이티드 CD3 binding antibody
CN109689690B (en) 2016-07-15 2023-10-03 武田药品工业株式会社 Methods and materials for assessing response to plasmacytoid and plasma cell depleting therapies
CN114395048B (en) 2016-09-14 2025-01-28 特纳奥尼股份有限公司 CD3 binding antibodies
CN116284402A (en) 2016-12-21 2023-06-23 特尼奥生物股份有限公司 Heavy chain-only anti-BCMA antibodies
CA3065951A1 (en) 2017-06-20 2018-12-27 Teneoone, Inc. Anti-bcma heavy chain-only antibodies
KR102742528B1 (en) 2017-06-20 2024-12-16 테네오바이오, 인코포레이티드 Anti-BCMA heavy chain-only antibody
JPWO2019031444A1 (en) * 2017-08-07 2020-08-27 国立大学法人九州大学 Method for measuring occupancy of specific binding substance in cell population
WO2019035938A1 (en) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. Multispecific molecules that bind to bcma and uses thereof
BR112020004846A2 (en) * 2017-09-13 2020-09-15 Teneobio, Inc. heavy chain antibodies that bind to ectoenzymes
MA50514A (en) 2017-10-31 2020-09-09 Janssen Biotech Inc HIGH-RISK MULTIPLE MYELOMA TREATMENT METHODS
CA3080109A1 (en) 2017-11-03 2019-05-09 Sorrento Therapeutics, Inc. Cd38-directed chimeric antigen receptor constructs
CA3088199A1 (en) 2018-01-12 2019-07-18 Takeda Pharmaceutical Company Limited Subcutaneous dosing of anti-cd38 antibodies
AU2019244478B2 (en) * 2018-03-28 2025-11-06 Takeda Pharmaceutical Company Limited Subcutaneous dosing of anti-CD38 antibodies
CN112703038B (en) * 2018-07-10 2025-07-29 赛诺菲 Anticancer combination therapies targeting CD38 and TGF-beta
AU2019395841B2 (en) 2018-12-14 2025-02-27 Morphosys Ag Antibody formulations
EP3941489A4 (en) * 2019-03-21 2022-12-28 Gamida-Cell Ltd. EXPANDED NK CELL FRACTIONS FOR TRANSPLANTATION IN COMBINATION THERAPY
MX2021012205A (en) 2019-04-05 2022-02-21 Teneobio Inc Heavy chain antibodies binding to psma.
US11655302B2 (en) 2019-06-10 2023-05-23 Sanofi Anti-CD38 antibodies and formulations
JP7665538B2 (en) 2019-06-14 2025-04-21 テネオバイオ, インコーポレイテッド Multispecific heavy chain antibodies that bind to CD22 and CD3
CN112876563B (en) * 2019-11-29 2022-08-16 康诺亚生物医药科技(成都)有限公司 Pharmaceutical composition, preparation method and application thereof
IL293563A (en) 2019-12-05 2022-08-01 Sanofi Aventis Us Llc Formulations of anti-cd38 antibodies for subcutaneous administration
BR112022010907A2 (en) * 2019-12-06 2022-10-18 Sanofi Aventis Us Llc USE OF ISATUXIMAB FOR THE TREATMENT OF RECURRING AND/OR REFRACTORY MULTIPLE MYELOMA
EP4169949A4 (en) * 2020-06-23 2024-08-21 Jiangsu Kanion Pharmaceutical Co., Ltd. ANTI-CD38 ANTIBODIES AND USE THEREOF
WO2022117572A2 (en) 2020-12-02 2022-06-09 Oncurious Nv An ltbr agonist in combination therapy against cancer
TW202432177A (en) * 2022-10-31 2024-08-16 丹麥商珍美寶股份有限公司 Cd38 antibodies and uses thereof

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
US4716111A (en) 1982-08-11 1987-12-29 Trustees Of Boston University Process for producing human antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
ATE139258T1 (en) 1990-01-12 1996-06-15 Cell Genesys Inc GENERATION OF XENOGENE ANTIBODIES
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
DE69233482T2 (en) 1991-05-17 2006-01-12 Merck & Co., Inc. Method for reducing the immunogenicity of antibody variable domains
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
EP0822830B1 (en) 1995-04-27 2008-04-02 Amgen Fremont Inc. Human anti-IL-8 antibodies, derived from immunized xenomice
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc Human antibodies derived from immunized xenomice
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
EP1500329B1 (en) 1996-12-03 2012-03-21 Amgen Fremont Inc. Human antibodies that specifically bind human TNF alpha
DE69800716T2 (en) 1997-04-14 2001-09-20 Micromet Gesellschaft Fuer Biomedizinische Forschung Mbh NEW METHOD FOR PRODUCING ANTI-HUMAN ANTIGENT RECEPTORS AND THEIR USE
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
CN1976950B (en) * 2004-02-06 2012-08-29 莫佛塞斯公司 Anti-CD38 human antibodies and uses therefor.
SG10201912554TA (en) 2005-03-23 2020-02-27 Genmab As Antibodies against cd38 for treatment of multiple myeloma
TW200745162A (en) * 2005-05-24 2007-12-16 Morphosys Ag Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human CD38
PL2081595T3 (en) * 2006-09-26 2019-11-29 Genmab As Anti-cd38 plus corticosteroids plus a non-corticosteroid chemotherapeutic for treating tumors
EP1914242A1 (en) * 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
EP2191840A1 (en) 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan
EP2191842A1 (en) * 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine
EP2191841A1 (en) * 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine
EP2191843A1 (en) * 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and cyclophosphamide
UA112170C2 (en) * 2010-12-10 2016-08-10 Санофі ANTI-TUMOR COMBINATION CONTAINING AN ANTIBODY SPECIFICALLY RECOGNIZING CD38 AND BORTESOMB
JOP20210044A1 (en) * 2010-12-30 2017-06-16 Takeda Pharmaceuticals Co Anti-CD38 . antibody
KR102096224B1 (en) * 2011-10-28 2020-04-03 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 Polypeptide constructs and uses thereof
US10342869B2 (en) * 2012-12-07 2019-07-09 The Regents Of The University Of California Compositions comprising anti-CD38 antibodies and lenalidomide
EP3769783A1 (en) * 2013-03-13 2021-01-27 Sanofi Compositions comprising anti-cd38 antibodies and carfilzomib

Also Published As

Publication number Publication date
SG10201803288RA (en) 2018-05-30
WO2015066450A1 (en) 2015-05-07
CA2927099A1 (en) 2015-05-07
MX2016005666A (en) 2016-07-14
AU2014342103B2 (en) 2020-06-04
KR20160077155A (en) 2016-07-01
EP3063173A1 (en) 2016-09-07
EA201690905A1 (en) 2016-08-31
EP3063173B1 (en) 2020-07-29
US20150118251A1 (en) 2015-04-30
IL245196A0 (en) 2016-06-30
MA44560B2 (en) 2021-01-29
PT3063173T (en) 2020-10-20
NZ719784A (en) 2022-02-25
CN106103481A (en) 2016-11-09
US20180022814A1 (en) 2018-01-25
TW201522378A (en) 2015-06-16
MA39070A1 (en) 2017-11-30
TN2016000142A1 (en) 2017-10-06
EA035098B1 (en) 2020-04-27
IL245196B (en) 2021-04-29
PL3063173T3 (en) 2021-01-11
BR112016009403A2 (en) 2017-09-19
EP3805266A1 (en) 2021-04-14
MA44560A1 (en) 2019-09-30
JP2016536314A (en) 2016-11-24
MX373301B (en) 2020-04-24
JP2023109927A (en) 2023-08-08
AU2014342103A1 (en) 2016-05-26
CR20160186A (en) 2016-06-13
MA44560B1 (en) 2020-06-30
JP2025139586A (en) 2025-09-26

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