[go: up one dir, main page]

SG11201601181SA - Improved adenovirus formulations - Google Patents

Improved adenovirus formulations

Info

Publication number
SG11201601181SA
SG11201601181SA SG11201601181SA SG11201601181SA SG11201601181SA SG 11201601181S A SG11201601181S A SG 11201601181SA SG 11201601181S A SG11201601181S A SG 11201601181SA SG 11201601181S A SG11201601181S A SG 11201601181SA SG 11201601181S A SG11201601181S A SG 11201601181SA
Authority
SG
Singapore
Prior art keywords
improved adenovirus
adenovirus formulations
formulations
improved
adenovirus
Prior art date
Application number
SG11201601181SA
Inventor
Janik Adriaansen
Original Assignee
Crucell Holland Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49212683&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201601181S(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Crucell Holland Bv filed Critical Crucell Holland Bv
Publication of SG11201601181SA publication Critical patent/SG11201601181SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11201601181SA 2013-09-19 2014-09-16 Improved adenovirus formulations SG11201601181SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13185200 2013-09-19
PCT/EP2014/069654 WO2015040002A1 (en) 2013-09-19 2014-09-16 Improved adenovirus formulations

Publications (1)

Publication Number Publication Date
SG11201601181SA true SG11201601181SA (en) 2016-04-28

Family

ID=49212683

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201601181SA SG11201601181SA (en) 2013-09-19 2014-09-16 Improved adenovirus formulations

Country Status (33)

Country Link
US (3) US9974737B2 (en)
EP (1) EP3046536B1 (en)
JP (1) JP6013654B2 (en)
KR (1) KR102258348B1 (en)
CN (2) CN105530917B (en)
AP (1) AP2016009154A0 (en)
AU (1) AU2014323230B2 (en)
BR (1) BR112016005761B1 (en)
CA (1) CA2923352C (en)
CL (1) CL2016000621A1 (en)
CY (1) CY1122796T1 (en)
DK (1) DK3046536T3 (en)
EA (1) EA036046B1 (en)
ES (1) ES2711115T3 (en)
HR (1) HRP20182159T1 (en)
HU (1) HUE041791T2 (en)
IL (1) IL244572A (en)
LT (1) LT3046536T (en)
ME (1) ME03324B (en)
MX (1) MX369156B (en)
MY (1) MY181190A (en)
NZ (1) NZ717156A (en)
PE (1) PE20160527A1 (en)
PH (1) PH12016500316B1 (en)
PL (1) PL3046536T3 (en)
PT (1) PT3046536T (en)
RS (1) RS58393B1 (en)
SG (1) SG11201601181SA (en)
SI (1) SI3046536T1 (en)
SM (1) SMT201900092T1 (en)
TR (1) TR201900274T4 (en)
WO (1) WO2015040002A1 (en)
ZA (1) ZA201601919B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105188745B (en) 2013-04-25 2019-10-18 扬森疫苗与预防公司 Stabilized soluble pre-fusion RSV F polypeptides
EP3564379A1 (en) 2013-09-13 2019-11-06 California Institute of Technology Selective recovery
HRP20182159T1 (en) 2013-09-19 2019-02-22 Janssen Vaccines & Prevention B.V. IMPROVED ADENOVIRUS FORMULATIONS
KR20180026734A (en) 2015-07-07 2018-03-13 얀센 백신스 앤드 프리벤션 비.브이. Stabilized soluble fusion-pre-RSV F polypeptide
CA2991002C (en) 2015-07-07 2023-11-28 Janssen Vaccines & Prevention B.V. Vaccine against rsv
CN108135843B (en) * 2015-10-06 2021-11-02 扬森疫苗与预防公司 Method for preventing plastic-induced degradation of biological products
DK3387137T3 (en) 2015-12-11 2021-05-03 California Inst Of Techn TARGET TIPPID TIMES FOR MANAGING ADENO-ASSOCIATED VIRUSES (AAVs)
CN116063551A (en) 2016-04-05 2023-05-05 扬森疫苗与预防公司 Stabilized soluble pre-fusion RSV F proteins
US10729757B2 (en) 2016-04-05 2020-08-04 Janssen Vaccines & Prevention B.V. Vaccine against RSV
BR112018074483A2 (en) 2016-05-30 2019-03-19 Janssen Vaccines & Prevention B.V. stabilized pre-fusion rsv f proteins
WO2018210871A1 (en) 2017-05-17 2018-11-22 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against rsv infection
AU2018267971A1 (en) 2017-05-17 2019-11-07 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against RSV infection
JP2020533367A (en) 2017-09-15 2020-11-19 ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． Safe method of inducing immunity to RSV
CN113966399A (en) 2018-09-26 2022-01-21 加州理工学院 Adeno-associated virus compositions for targeted gene therapy
CA3114621A1 (en) 2018-09-28 2020-04-02 Voyager Therapeutics, Inc. Frataxin expression constructs having engineered promoters and methods of use thereof
CA3117275A1 (en) 2018-11-13 2020-05-22 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion rsv f proteins
WO2020145872A1 (en) * 2019-01-09 2020-07-16 Ziccum Ab Stabilized non-enveloped virus compositions
TW202237164A (en) * 2020-12-04 2022-10-01 美商磨石生物公司 Compositions and methods of use thereof
WO2023282796A2 (en) * 2021-07-08 2023-01-12 Limited Liability Company «ANABION» Pharmaceutical composition of non-enveloped virus
WO2023240196A1 (en) * 2022-06-08 2023-12-14 Gritstone Bio, Inc. Compositions and methods of use thereof
EP4338727A1 (en) 2022-09-14 2024-03-20 Roquette Freres Adenovirus formulations
KR20250078975A (en) * 2022-10-11 2025-06-04 메이라지티엑스 유케이 Ii 리미티드 Formulations for AAV gene therapy
WO2025218651A1 (en) * 2024-04-15 2025-10-23 康希诺生物股份公司 Recombinant adenovirus vector vaccine formulation and preparation method therefor

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2705686B1 (en) 1993-05-28 1995-08-18 Transgene Sa New defective adenoviruses and corresponding complementation lines.
CA2192442C (en) 1994-06-10 2007-09-25 Imre Kovesdi Complementary adenoviral vector systems and cell lines
US5851806A (en) 1994-06-10 1998-12-22 Genvec, Inc. Complementary adenoviral systems and cell lines
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US5965541A (en) 1995-11-28 1999-10-12 Genvec, Inc. Vectors and methods for gene transfer to cells
US5559099A (en) 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US5770442A (en) 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
PT833934E (en) 1995-06-15 2005-02-28 Crucell Holland Bv PACKAGING SYSTEMS FOR HUMAN RECOMBINANT ADENOVIVRUS INTENDED FOR GENETIC THERAPY
US5837511A (en) 1995-10-02 1998-11-17 Cornell Research Foundation, Inc. Non-group C adenoviral vectors
US6020191A (en) 1997-04-14 2000-02-01 Genzyme Corporation Adenoviral vectors capable of facilitating increased persistence of transgene expression
US5981225A (en) 1998-04-16 1999-11-09 Baylor College Of Medicine Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same
US6113913A (en) 1998-06-26 2000-09-05 Genvec, Inc. Recombinant adenovirus
US20030017138A1 (en) 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
US6689600B1 (en) * 1998-11-16 2004-02-10 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
WO2000029024A1 (en) * 1998-11-16 2000-05-25 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
US6225289B1 (en) * 1998-12-10 2001-05-01 Genvec, Inc. Methods and compositions for preserving adenoviral vectors
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
CA2399321C (en) * 2000-03-07 2013-04-30 Robert K. Evans Adenovirus formulations
US7456009B2 (en) * 2000-03-07 2008-11-25 Merck & Co., Inc. Adenovirus formulations
CA2469623C (en) * 2001-12-12 2012-05-29 F H Faulding & Co Limited Composition for the preservation of viruses
CA2470999C (en) * 2001-12-20 2017-02-21 Schering-Plough Corporation Syn3 compositions and methods
US20030180936A1 (en) * 2002-03-15 2003-09-25 Memarzadeh Bahram Eric Method for the purification, production and formulation of oncolytic adenoviruses
ATE447037T1 (en) 2002-04-25 2009-11-15 Crucell Holland Bv MEANS AND METHOD FOR PRODUCING ADENOVIRUS VECTORS
CA2507915C (en) 2002-12-17 2013-07-02 Crucell Holland B.V. Recombinant viral-based malaria vaccines
CN100429220C (en) * 2003-06-04 2008-10-29 坎基股份有限公司 Methods and compositions for interferon therapy
MXPA05013983A (en) * 2003-06-30 2006-03-02 Canji Inc Polymer encapsulation of adenoviruses.
WO2005052116A2 (en) * 2003-11-19 2005-06-09 Merck & Co., Inc. Preservative-containing virus formulations
US8137966B2 (en) 2004-03-04 2012-03-20 Dainippon Sumitomo Pharma Co., Ltd. Rat embryonic stem cell
EP1812580B1 (en) 2004-11-16 2014-12-17 Crucell Holland B.V. Multivalent vaccines comprising recombinant viral vectors
CN1883707A (en) * 2006-05-19 2006-12-27 吉林大学 Lyophilized preparation of recombinant adenovirus and preparation method thereof
GB0715723D0 (en) * 2007-08-11 2007-09-19 Ark Therapeutics Ltd Formulation
US20110059079A1 (en) * 2009-09-04 2011-03-10 Xoma Technology Ltd. Antibody Coformulations
GB201002419D0 (en) 2010-02-12 2010-03-31 Isis Innovation Stable live vaccine formulations
WO2012110971A2 (en) 2011-02-17 2012-08-23 Promed Exports Pvt. Ltd. Method and composition to retard sorption of preservatives to plastics
HRP20182159T1 (en) * 2013-09-19 2019-02-22 Janssen Vaccines & Prevention B.V. IMPROVED ADENOVIRUS FORMULATIONS
CN104027815A (en) 2014-06-12 2014-09-10 中国农业科学院兰州畜牧与兽药研究所 Tanshinone inclusion fluid as well as preparation method and application thereof
CN108135843B (en) 2015-10-06 2021-11-02 扬森疫苗与预防公司 Method for preventing plastic-induced degradation of biological products

Also Published As

Publication number Publication date
EA036046B1 (en) 2020-09-18
HUE041791T2 (en) 2019-05-28
IL244572A (en) 2017-02-28
LT3046536T (en) 2019-03-12
CN111514314A (en) 2020-08-11
WO2015040002A1 (en) 2015-03-26
JP6013654B2 (en) 2016-10-25
CN105530917A (en) 2016-04-27
EP3046536B1 (en) 2018-11-28
US11484494B2 (en) 2022-11-01
TR201900274T4 (en) 2019-02-21
CY1122796T1 (en) 2021-05-05
PL3046536T3 (en) 2019-06-28
AU2014323230A1 (en) 2016-03-17
ES2711115T3 (en) 2019-04-30
US10272032B2 (en) 2019-04-30
CL2016000621A1 (en) 2016-11-25
US20160199426A1 (en) 2016-07-14
PE20160527A1 (en) 2016-05-20
PT3046536T (en) 2019-02-25
SMT201900092T1 (en) 2019-02-28
MX2016003414A (en) 2016-06-30
MX369156B (en) 2019-10-30
CN105530917B (en) 2020-06-05
BR112016005761B1 (en) 2022-09-20
KR102258348B1 (en) 2021-05-31
HRP20182159T1 (en) 2019-02-22
US20190240146A1 (en) 2019-08-08
MY181190A (en) 2020-12-21
EA201690613A1 (en) 2016-08-31
RS58393B1 (en) 2019-04-30
BR112016005761A2 (en) 2017-08-01
DK3046536T3 (en) 2019-03-11
US9974737B2 (en) 2018-05-22
IL244572A0 (en) 2016-04-21
CA2923352C (en) 2022-05-03
KR20160055180A (en) 2016-05-17
CA2923352A1 (en) 2015-03-26
PH12016500316A1 (en) 2016-05-02
ME03324B (en) 2019-10-20
AP2016009154A0 (en) 2016-04-30
PH12016500316B1 (en) 2019-02-01
AU2014323230B2 (en) 2017-05-25
NZ717156A (en) 2022-04-29
JP2016530220A (en) 2016-09-29
ZA201601919B (en) 2017-06-28
SI3046536T1 (en) 2019-05-31
US20180235871A1 (en) 2018-08-23
EP3046536A1 (en) 2016-07-27

Similar Documents

Publication Publication Date Title
ZA201601919B (en) Improved adenovirus formulations
IL279395A (en) Vaccine composition
GB201319791D0 (en) Formulations
SG11201507393TA (en) Oncolytic adenovirus compositions
GB201319792D0 (en) Formulations
EP3006525A4 (en) Asphalt-urethane composition
IL245420A0 (en) Novel formulations
GB201306984D0 (en) Composition
GB201320432D0 (en) Novel formulation
SG11201509194SA (en) Radiomitigating pharmaceutical formulations
PL2821061T3 (en) Novel inhalation formulations
GB201322948D0 (en) Improved formulation
GB201317718D0 (en) Novel formulation
GB2517232B (en) Formulation
GB201301774D0 (en) Composition
GB201313688D0 (en) Improved cyanoacrylate compositions
GB201305622D0 (en) Composition
SG11201604136PA (en) Improved formulations for virosomes
PT3041488T (en) Honey compositions
GB201318880D0 (en) Adenovirus
GB201318885D0 (en) Adenovirus
GB201319352D0 (en) Formulation
GB201312347D0 (en) Formulation
EP2986109A4 (en) Improved ectoparasiticidal formulations
GB201317717D0 (en) Novel formulation