SG11201601692PA - Structure based predictive modeling - Google Patents
Structure based predictive modelingInfo
- Publication number
- SG11201601692PA SG11201601692PA SG11201601692PA SG11201601692PA SG11201601692PA SG 11201601692P A SG11201601692P A SG 11201601692PA SG 11201601692P A SG11201601692P A SG 11201601692PA SG 11201601692P A SG11201601692P A SG 11201601692PA SG 11201601692P A SG11201601692P A SG 11201601692PA
- Authority
- SG
- Singapore
- Prior art keywords
- structure based
- predictive modeling
- based predictive
- modeling
- predictive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B10/00—ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/20—Protein or domain folding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/30—Drug targeting using structural data; Docking or binding prediction
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
- G16B35/20—Screening of libraries
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C10/00—Computational theoretical chemistry, i.e. ICT specially adapted for theoretical aspects of quantum chemistry, molecular mechanics, molecular dynamics or the like
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/30—Prediction of properties of chemical compounds, compositions or mixtures
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/50—Molecular design, e.g. of drugs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Evolutionary Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Computing Systems (AREA)
- Bioethics (AREA)
- Artificial Intelligence (AREA)
- Software Systems (AREA)
- Public Health (AREA)
- Evolutionary Computation (AREA)
- Epidemiology (AREA)
- Databases & Information Systems (AREA)
- Data Mining & Analysis (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Library & Information Science (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Ecology (AREA)
- Microbiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361883919P | 2013-09-27 | 2013-09-27 | |
| PCT/US2014/057900 WO2015048573A1 (en) | 2013-09-27 | 2014-09-26 | Structure based predictive modeling |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201601692PA true SG11201601692PA (en) | 2016-04-28 |
Family
ID=51743552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201601692PA SG11201601692PA (en) | 2013-09-27 | 2014-09-26 | Structure based predictive modeling |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20150134315A1 (en) |
| EP (1) | EP3049979B1 (en) |
| JP (1) | JP6309086B2 (en) |
| KR (1) | KR102341026B1 (en) |
| CN (2) | CN105814573B (en) |
| AU (1) | AU2014324670B2 (en) |
| BR (1) | BR112016006284B1 (en) |
| CA (1) | CA2923758C (en) |
| DK (1) | DK3049979T3 (en) |
| ES (1) | ES2774965T3 (en) |
| HU (1) | HUE048104T2 (en) |
| IL (1) | IL244458B (en) |
| NZ (1) | NZ717647A (en) |
| RU (1) | RU2694321C2 (en) |
| SG (1) | SG11201601692PA (en) |
| WO (1) | WO2015048573A1 (en) |
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102341026B1 (en) | 2013-09-27 | 2021-12-21 | 코덱시스, 인코포레이티드 | Structure based predictive modeling |
| SG11201601695WA (en) | 2013-09-27 | 2016-04-28 | Codexis Inc | Automated screening of enzyme variants |
| US9373059B1 (en) | 2014-05-05 | 2016-06-21 | Atomwise Inc. | Systems and methods for applying a convolutional network to spatial data |
| US10535008B1 (en) * | 2014-05-15 | 2020-01-14 | Pivotal Software, Inc. | Parallel time series analysis |
| DK3224354T3 (en) | 2014-11-25 | 2021-03-01 | Codexis Inc | MANIPULATED IMINREDUCTASES AND PROCEDURES FOR THE REDUCTIVE AMINATION OF KETONE AND AMIN COMPOUNDS |
| US20170360900A1 (en) | 2014-12-22 | 2017-12-21 | Codexis, Inc. | Human alpha-galactosidase variants |
| US10049128B1 (en) * | 2014-12-31 | 2018-08-14 | Symantec Corporation | Outlier detection in databases |
| US20180295927A1 (en) * | 2015-04-26 | 2018-10-18 | Samuel Lightstone | Method, device and system for fitness tracking |
| EP3298524A4 (en) | 2015-05-22 | 2019-03-20 | CSTS Health Care Inc. | THERMODYNAMIC MEASUREMENTS RELATING TO PROTEIN-PROTEIN INTERACTION NETWORKS FOR THE TREATMENT OF CANCER |
| US10542961B2 (en) | 2015-06-15 | 2020-01-28 | The Research Foundation For The State University Of New York | System and method for infrasonic cardiac monitoring |
| US10126262B2 (en) * | 2015-09-24 | 2018-11-13 | Genia Technologies, Inc. | Differential output of analog memories storing nanopore measurement samples |
| US11034929B2 (en) * | 2015-11-18 | 2021-06-15 | Thrive Bioscience, Inc. | Instrument resource scheduling |
| US10366779B2 (en) | 2015-12-30 | 2019-07-30 | International Business Machines Corporation | Scheme of new materials |
| WO2017213758A1 (en) | 2016-06-09 | 2017-12-14 | Codexis, Inc. | Biocatalysts and methods for hydroxylation of chemical compounds |
| WO2017218325A1 (en) | 2016-06-15 | 2017-12-21 | Codexis, Inc. | Engineered beta-glucosidases and glucosylation methods |
| WO2018031950A1 (en) * | 2016-08-12 | 2018-02-15 | Caribou Biosciences, Inc. | Protein engineering methods |
| JP7316662B2 (en) | 2016-08-26 | 2023-07-28 | コデクシス， インコーポレイテッド | Engineered imine reductases and methods for reductive amination of ketone and amine compounds |
| WO2018148633A1 (en) | 2017-02-13 | 2018-08-16 | Codexis, Inc. | Engineered phenylalanine ammonia lyase polypeptides |
| US10546237B2 (en) | 2017-03-30 | 2020-01-28 | Atomwise Inc. | Systems and methods for correcting error in a first classifier by evaluating classifier output in parallel |
| US11501034B2 (en) | 2017-05-18 | 2022-11-15 | Koninklijke Philips N.V. | System and method for providing prediction models for predicting changes to placeholder values |
| US11521712B2 (en) | 2017-05-19 | 2022-12-06 | Accutar Biotechnology Inc. | Computational method for classifying and predicting ligand docking conformations |
| JP7201981B2 (en) * | 2017-06-30 | 2023-01-11 | 学校法人 明治薬科大学 | Prediction device, prediction method and prediction program |
| AU2018292105B2 (en) | 2017-06-30 | 2024-12-12 | Codexis, Inc. | T7 RNA polymerase variants |
| RU2020103727A (en) | 2017-06-30 | 2021-07-30 | Кодексис, Инк. | VARIANTS OF RNA POLYMERASE T7 |
| US11139048B2 (en) | 2017-07-18 | 2021-10-05 | Analytics For Life Inc. | Discovering novel features to use in machine learning techniques, such as machine learning techniques for diagnosing medical conditions |
| US11062792B2 (en) | 2017-07-18 | 2021-07-13 | Analytics For Life Inc. | Discovering genomes to use in machine learning techniques |
| KR20200052298A (en) * | 2017-08-14 | 2020-05-14 | 소마젠 인크 | Targeted drugs related to trimethylamine and / or trimethylamine N-oxide |
| US10923214B2 (en) * | 2017-09-07 | 2021-02-16 | Accutar Biotechnology Inc. | Neural network for predicting drug property |
| US20190108311A1 (en) * | 2017-10-06 | 2019-04-11 | Grail, Inc. | Site-specific noise model for targeted sequencing |
| US11698936B2 (en) * | 2017-10-09 | 2023-07-11 | Home Depot Product Authority, Llc | System and methods for search engine parameter tuning using genetic algorithm |
| JP2021503899A (en) * | 2017-11-22 | 2021-02-15 | ジェルター， インコーポレイテッド | Methods and systems for manipulating collagen |
| CN109273047B (en) * | 2017-12-15 | 2022-09-16 | 武汉科技大学 | A Nucleic Acid Structure Prediction Method Based on Simulated Annealing |
| US10692605B2 (en) | 2018-01-08 | 2020-06-23 | International Business Machines Corporation | Library screening for cancer probability |
| CN108171336B (en) * | 2018-01-24 | 2018-12-28 | 清华大学 | The automatic sensing method and device of machine data model evolution |
| US11256244B2 (en) * | 2018-02-05 | 2022-02-22 | Inventus Holdings, Llc | Adaptive alarm and dispatch system using incremental regressive model development |
| WO2019173407A1 (en) | 2018-03-05 | 2019-09-12 | The Board Of Trustees Of The Leland Stanford Junior University | Machine learning and molecular simulation based methods for enhancing binding and activity prediction |
| WO2019173401A1 (en) * | 2018-03-05 | 2019-09-12 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for spatial graph convolutions with applications to drug discovery and molecular simulation |
| CN108388132B (en) * | 2018-03-19 | 2021-02-12 | 青岛理工大学 | Modeling method of polymerase chain reaction process system control model |
| CN108490776B (en) * | 2018-03-19 | 2021-02-12 | 青岛理工大学 | Polymerase chain reaction process control system control switching scheduling method |
| CN112334985B (en) * | 2018-03-19 | 2025-01-17 | 达索系统美国公司 | COSMOplex self-consistent simulation of self-organizing systems |
| US20190325986A1 (en) * | 2018-04-24 | 2019-10-24 | Samsung Electronics Co., Ltd. | Method and device for predicting amino acid substitutions at site of interest to generate enzyme variant optimized for biochemical reaction |
| TW202013385A (en) | 2018-06-07 | 2020-04-01 | 美商河谷控股Ｉｐ有限責任公司 | Difference-based genomic identity scores |
| US11175419B2 (en) * | 2018-06-28 | 2021-11-16 | Accenture Global Solutions Limited | Blast reconciliation for mines |
| IT201800007535A1 (en) * | 2018-07-26 | 2020-01-26 | Istituto Naz Fisica Nucleare | METHOD FOR IDENTIFYING INTERMEDIATES |
| EP3863757A4 (en) * | 2018-10-11 | 2022-07-20 | Berkeley Lights, Inc. | Systems and methods for identification of optimized protein production and kits therefor |
| KR20210084590A (en) | 2018-10-29 | 2021-07-07 | 코덱시스, 인코포레이티드 | engineered DNA polymerase variants |
| EP3893860A4 (en) | 2018-12-14 | 2023-03-29 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| US11427813B2 (en) | 2018-12-20 | 2022-08-30 | Codexis, Inc. | Human alpha-galactosidase variants |
| WO2020152750A1 (en) | 2019-01-21 | 2020-07-30 | Ｊｆｅスチール株式会社 | Design assistance method for metal material, prediction model generation method, metal material manufacturing method, and design assistance device |
| WO2020186109A2 (en) * | 2019-03-12 | 2020-09-17 | California Institute Of Technology | Systems and methods for determining molecular structures with molecular-orbital-based features |
| CN110444250A (en) * | 2019-03-26 | 2019-11-12 | 广东省微生物研究所（广东省微生物分析检测中心） | High-throughput drug virtual screening system based on molecular fingerprint and deep learning |
| US11591634B1 (en) * | 2019-04-03 | 2023-02-28 | The Trustees Of Boston College | Forecasting bacterial survival-success and adaptive evolution through multiomics stress-response mapping and machine learning |
| CN111785332B (en) * | 2019-04-04 | 2024-06-11 | 应急管理部化学品登记中心 | Chemical substance thermal stability prediction method based on genetic algorithm |
| CN111798935B (en) * | 2019-04-09 | 2024-07-05 | 南京药石科技股份有限公司 | Structure-property correlation prediction method of universal compound based on neural network |
| CN110070912B (en) * | 2019-04-15 | 2023-06-23 | 桂林电子科技大学 | Prediction method for CRISPR/Cas9 off-target effect |
| CN115989545A (en) * | 2019-06-12 | 2023-04-18 | 宽腾矽公司 | Techniques for protein identification using machine learning and related systems and methods |
| IT201900009531A1 (en) * | 2019-06-19 | 2020-12-19 | Torino Politecnico | METHOD FOR OPTIMIZING THE PHYSICAL-CHEMICAL PROPERTIES OF THE BIOLOGICAL SEQUENCES IMPLEMENTABLE VIA COMPUTER |
| US10515715B1 (en) | 2019-06-25 | 2019-12-24 | Colgate-Palmolive Company | Systems and methods for evaluating compositions |
| US11475790B2 (en) * | 2019-06-28 | 2022-10-18 | Fortinet, Inc. | Gamified network security training using dedicated virtual environments simulating a deployed network topology of network security products |
| US11412016B2 (en) * | 2019-06-28 | 2022-08-09 | Fortinet, Inc. | Gamified virtual conference with network security training of network security products |
| WO2021040821A1 (en) * | 2019-08-23 | 2021-03-04 | Board Of Trustees Of Michigan State University | System and methods for electrostatic analysis with machine learning model |
| WO2021050923A1 (en) * | 2019-09-13 | 2021-03-18 | The University Of Chicago | Method and apparatus using machine learning for evolutionary data-driven design of proteins and other sequence defined biomolecules |
| CN110647628B (en) * | 2019-09-16 | 2022-09-23 | 北京电子工程总体研究所 | Automatic marking and detecting method and system |
| US20210134389A1 (en) * | 2019-10-31 | 2021-05-06 | Pharmcadd Co., Ltd. | Method for training protein structure prediction apparatus, protein structure prediction apparatus and method for predicting protein structure based on molecular dynamics |
| US12094576B2 (en) * | 2019-12-16 | 2024-09-17 | John McDevitt | System and method for improved genetic modifications to support beneficial adaptation to unanticipated conditions and unintended consequences by utilizing randomization |
| CA3165484A1 (en) | 2019-12-20 | 2021-06-24 | Codexis, Inc. | Engineered acid alpha-glucosidase variants |
| WO2021158686A1 (en) | 2020-02-04 | 2021-08-12 | Codexis, Inc. | Engineered leucine decarboxylases |
| US11049590B1 (en) | 2020-02-12 | 2021-06-29 | Peptilogics, Inc. | Artificial intelligence engine architecture for generating candidate drugs |
| US20210366580A1 (en) * | 2020-05-21 | 2021-11-25 | International Business Machines Corporation | Filtering artificial intelligence designed molecules for laboratory testing |
| US11174289B1 (en) | 2020-05-21 | 2021-11-16 | International Business Machines Corporation | Artificial intelligence designed antimicrobial peptides |
| US12079730B2 (en) | 2020-05-28 | 2024-09-03 | International Business Machines Corporation | Transfer learning for molecular structure generation |
| CA3187366A1 (en) * | 2020-07-31 | 2022-02-03 | Arc Bio, Llc | Systems, methods, and media for determining relative quality of oligonucleotide preparations |
| US12229639B2 (en) * | 2020-10-23 | 2025-02-18 | EMC IP Holding Company LLC | Acceptance status classification of product-related data structures using models with multiple training periods |
| US11403316B2 (en) | 2020-11-23 | 2022-08-02 | Peptilogics, Inc. | Generating enhanced graphical user interfaces for presentation of anti-infective design spaces for selecting drug candidates |
| CN114822717A (en) * | 2021-01-28 | 2022-07-29 | 腾讯科技（深圳）有限公司 | Artificial intelligence-based drug molecule processing method, device, equipment and storage medium |
| US11439159B2 (en) | 2021-03-22 | 2022-09-13 | Shiru, Inc. | System for identifying and developing individual naturally-occurring proteins as food ingredients by machine learning and database mining combined with empirical testing for a target food function |
| US20220351808A1 (en) * | 2021-04-29 | 2022-11-03 | Uchicago Argonne, Llc | Systems and methods for reinforcement learning molecular modeling |
| US11512345B1 (en) | 2021-05-07 | 2022-11-29 | Peptilogics, Inc. | Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids |
| CN113255770B (en) * | 2021-05-26 | 2023-10-27 | 北京百度网讯科技有限公司 | Compound attribute prediction model training method and compound attribute prediction method |
| CN113488114B (en) * | 2021-07-13 | 2024-03-01 | 南京邮电大学 | Prediction method for intermolecular non-covalent bond weak interaction energy in fluorenyl molecular crystal containing spiro and prediction model training method thereof |
| US20230034425A1 (en) * | 2021-07-22 | 2023-02-02 | Pythia Labs, Inc. | Systems and methods for artificial intelligence-guided biomolecule design and assessment |
| US20230081439A1 (en) * | 2021-09-10 | 2023-03-16 | X Development Llc | Generative tna sequence design with experiment-in-the-loop training |
| WO2023064938A1 (en) | 2021-10-15 | 2023-04-20 | Codexis, Inc. | Engineered dna polymerase variants |
| CN114093415B (en) * | 2021-11-19 | 2022-06-03 | 中国科学院数学与系统科学研究院 | Peptide segment detectability prediction method and system |
| US20230169564A1 (en) * | 2021-11-29 | 2023-06-01 | Taudata Co., Ltd. | Artificial intelligence-based shopping mall purchase prediction device |
| CN114334030B (en) * | 2021-12-20 | 2025-02-21 | 郑州信大先进技术研究院 | Evaluation method of polymer polymerization products based on quantum support vector machine |
| CN114708931B (en) * | 2022-04-22 | 2023-01-24 | 中国海洋大学 | Method for improving prediction precision of drug-target activity by combining machine learning and conformation calculation |
| WO2023220038A1 (en) * | 2022-05-10 | 2023-11-16 | Amgen Inc. | Machine learning techniques for predicting thermostability |
| CN115206438A (en) * | 2022-05-26 | 2022-10-18 | 上海合全药业股份有限公司 | Enzyme directed evolution data storage and retrieval method, device and storage medium |
| CN115631784B (en) * | 2022-10-26 | 2024-04-23 | 苏州立妙达药物科技有限公司 | Gradient-free flexible molecular docking method based on multi-scale discrimination |
| WO2024097291A2 (en) * | 2022-11-02 | 2024-05-10 | Synvitrobio, Inc. | Methods for predicting cell-free protein synthesis |
| WO2024186382A1 (en) * | 2023-03-03 | 2024-09-12 | Ge Infrastructure Technology Llc | Artificial intelligence-guided molecular screening for coordination framework compounds |
| CN116421726A (en) * | 2023-04-14 | 2023-07-14 | 中国海洋大学 | A molecular prediction-based approach for the development of nanomedicine targeting PLK1 |
| JP7461678B1 (en) | 2023-04-18 | 2024-04-04 | 竹本油脂株式会社 | Estimation method, estimation program, and estimation device |
| JPWO2024236722A1 (en) * | 2023-05-16 | 2024-11-21 | ||
| WO2025036438A1 (en) * | 2023-08-15 | 2025-02-20 | 上海金斯康生物科技有限公司 | Prediction for influence of mutation on protease activity |
| CN117831625B (en) * | 2023-12-19 | 2024-07-19 | 苏州沃时数字科技有限公司 | Enzyme directional mutation sequence prediction method, system and medium based on graph neural network |
| US12368503B2 (en) | 2023-12-27 | 2025-07-22 | Quantum Generative Materials Llc | Intent-based satellite transmit management based on preexisting historical location and machine learning |
| WO2025154977A1 (en) * | 2024-01-19 | 2025-07-24 | 주식회사 인세리브로 | Method and device for obtaining binding pose between protein receptor and ligand by using artificial intelligence model |
| WO2025235589A1 (en) | 2024-05-08 | 2025-11-13 | Codexis, Inc. | Dna polymerase variants |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04179495A (en) * | 1990-11-14 | 1992-06-26 | M D Res Kk | Fused protein, and method for producing peptide or protein |
| US6969763B1 (en) | 1999-05-12 | 2005-11-29 | Isis Pharmaceuticals, Inc. | Molecular interaction sites of interleukin-2 RNA and methods of modulating the same |
| WO2001071347A1 (en) | 2000-03-23 | 2001-09-27 | California Institute Of Technology | Method and apparatus for predicting ligand binding interactions |
| US20020133297A1 (en) | 2001-01-17 | 2002-09-19 | Jinn-Moon Yang | Ligand docking method using evolutionary algorithm |
| US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
| EP1570407A2 (en) | 2002-10-28 | 2005-09-07 | Commissariat A L'energie Atomique | A method for performing restrained dynamics docking of one or multiple substrates on multi-specific enzymes |
| US20060121455A1 (en) | 2003-04-14 | 2006-06-08 | California Institute Of Technology | COP protein design tool |
| CN1468959A (en) | 2003-06-02 | 2004-01-21 | 复旦大学 | Spatial conformational model of atypical pneumonia coronavirus protein and its application |
| US8005620B2 (en) * | 2003-08-01 | 2011-08-23 | Dna Twopointo Inc. | Systems and methods for biopolymer engineering |
| JP2005309877A (en) * | 2004-04-22 | 2005-11-04 | National Institute Of Advanced Industrial & Technology | Method for sequence analysis of functional biomolecules |
| WO2006044378A2 (en) * | 2004-10-12 | 2006-04-27 | University Of Iowa Research Foundation | Rapid computational identification of targets |
| WO2006121455A1 (en) | 2005-05-10 | 2006-11-16 | The Salk Institute For Biological Studies | Dynamic signal processing |
| AU2007208340B2 (en) | 2006-01-23 | 2012-11-01 | Joseph P. Errico | Methods and compositions of targeted drug development |
| RU2008140858A (en) | 2006-03-15 | 2010-04-20 | Ксир (Za) | METHOD FOR SCREENING COMPOUNDS POSSESSING THE ACTIVITY OF A GLUTAMINE SYNTHETIS INHIBITOR |
| KR20090031938A (en) * | 2006-07-05 | 2009-03-30 | 더 스크립스 리서치 인스티튜트 | Chimeric Zinc Finger Recombinase Optimizes Catalysis by Directional Evolution |
| US7814234B2 (en) | 2006-10-30 | 2010-10-12 | Microsoft Corporation | Offline execution of web based applications |
| EP2118281A2 (en) * | 2007-02-12 | 2009-11-18 | Codexis, Inc. | Structure-activity relationships |
| WO2009064015A1 (en) * | 2007-11-12 | 2009-05-22 | In-Silico Sciences, Inc. | In silico screening system and in silico screening method |
| SI2315773T1 (en) * | 2008-07-25 | 2016-12-30 | Glaxosmithkline Biologicals S.A. | Polypeptides, polynucleotides and compositions for use in the treatment of latent tubeculosis |
| WO2010077470A2 (en) | 2008-11-19 | 2010-07-08 | University Of Washington | Enzyme catalysts for diels-alder reactions |
| US8704041B2 (en) * | 2009-12-30 | 2014-04-22 | Pioneer Hi Bred International Inc | Methods and compositions for targeted polynucleotide modification |
| CN102156823B (en) | 2011-02-18 | 2015-04-22 | 复旦大学 | Method for screening compound with targeted action on inactive conformation of protein kinase |
| KR20150030673A (en) * | 2012-06-29 | 2015-03-20 | 위스콘신 얼럼나이 리서어치 화운데이션 | USE OF 2-METHYLENE-19-NOR-(20S)-1α,25-DIHYDROXYVITAMIN D₃ TO TREAT SECONDARY HYPERPARATHYROIDISM |
| US20140303952A1 (en) * | 2013-04-08 | 2014-10-09 | City University Of Hong Kong | Protein-ligand docking |
| CN103265635A (en) | 2013-04-28 | 2013-08-28 | 中山大学附属第一医院 | Construction method of universal targeted protein chimeric molecular compound |
| CN103324861B (en) | 2013-07-10 | 2016-07-20 | 南京大学 | Virtual screening method based on the nuclear receptor mediating endocrine interfering material of molecular dynamics simulation |
| KR102341026B1 (en) | 2013-09-27 | 2021-12-21 | 코덱시스, 인코포레이티드 | Structure based predictive modeling |
| SG11201601695WA (en) | 2013-09-27 | 2016-04-28 | Codexis Inc | Automated screening of enzyme variants |
-
2014
- 2014-09-26 KR KR1020167010659A patent/KR102341026B1/en not_active Expired - Fee Related
- 2014-09-26 ES ES14786396T patent/ES2774965T3/en active Active
- 2014-09-26 CN CN201480065176.3A patent/CN105814573B/en active Active
- 2014-09-26 CN CN201910165028.3A patent/CN109872771A/en active Pending
- 2014-09-26 BR BR112016006284-1A patent/BR112016006284B1/en active IP Right Grant
- 2014-09-26 HU HUE14786396A patent/HUE048104T2/en unknown
- 2014-09-26 AU AU2014324670A patent/AU2014324670B2/en active Active
- 2014-09-26 EP EP14786396.3A patent/EP3049979B1/en active Active
- 2014-09-26 JP JP2016516871A patent/JP6309086B2/en not_active Expired - Fee Related
- 2014-09-26 SG SG11201601692PA patent/SG11201601692PA/en unknown
- 2014-09-26 NZ NZ717647A patent/NZ717647A/en unknown
- 2014-09-26 WO PCT/US2014/057900 patent/WO2015048573A1/en not_active Ceased
- 2014-09-26 US US14/498,881 patent/US20150134315A1/en not_active Abandoned
- 2014-09-26 CA CA2923758A patent/CA2923758C/en active Active
- 2014-09-26 RU RU2016116261A patent/RU2694321C2/en active
- 2014-09-26 DK DK14786396.3T patent/DK3049979T3/en active
-
2016
- 2016-03-06 IL IL244458A patent/IL244458B/en active IP Right Grant
-
2019
- 2019-06-06 US US16/434,138 patent/US11342046B2/en active Active
-
2022
- 2022-04-12 US US17/719,321 patent/US20220238179A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112016006284A2 (en) | 2017-08-01 |
| US11342046B2 (en) | 2022-05-24 |
| KR20160062079A (en) | 2016-06-01 |
| IL244458B (en) | 2020-04-30 |
| IL244458A0 (en) | 2016-04-21 |
| CN105814573B (en) | 2019-03-29 |
| AU2014324670B2 (en) | 2019-11-21 |
| CN109872771A (en) | 2019-06-11 |
| BR112016006284B1 (en) | 2022-07-26 |
| CA2923758A1 (en) | 2015-04-02 |
| US20150134315A1 (en) | 2015-05-14 |
| RU2016116261A (en) | 2017-11-01 |
| CA2923758C (en) | 2022-08-30 |
| RU2016116261A3 (en) | 2018-03-02 |
| DK3049979T3 (en) | 2020-02-17 |
| JP6309086B2 (en) | 2018-04-11 |
| HUE048104T2 (en) | 2020-05-28 |
| EP3049979A1 (en) | 2016-08-03 |
| NZ717647A (en) | 2020-06-26 |
| US20200020415A1 (en) | 2020-01-16 |
| EP3049979B1 (en) | 2020-01-01 |
| US20220238179A1 (en) | 2022-07-28 |
| RU2694321C2 (en) | 2019-07-11 |
| WO2015048573A1 (en) | 2015-04-02 |
| ES2774965T3 (en) | 2020-07-23 |
| CN105814573A (en) | 2016-07-27 |
| AU2014324670A1 (en) | 2016-03-24 |
| KR102341026B1 (en) | 2021-12-21 |
| JP2016537699A (en) | 2016-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL244458A0 (en) | Structure based predictive modeling | |
| IL245573A0 (en) | Cell | |
| AU355447S (en) | Case | |
| AU354443S (en) | Case | |
| AU354395S (en) | Case | |
| PL2984837T3 (en) | Inter-component prediction | |
| GB201313245D0 (en) | Parallel tree based prediction | |
| AU354606S (en) | Keyboard | |
| SG11201508333RA (en) | Basin-to-reservoir modeling | |
| GB201319565D0 (en) | Storage case | |
| IL242744B (en) | Shape change structure | |
| PL3044389T3 (en) | Mullion-transom structure | |
| SG11201506993TA (en) | Tube-fastening structure | |
| GB201310031D0 (en) | Cell | |
| GB201312332D0 (en) | Cell locations | |
| EP2979746A4 (en) | Structure | |
| GB201517306D0 (en) | Modeling social behavior | |
| GB201310730D0 (en) | New structure | |
| SG11201510465YA (en) | Floating construction | |
| SG11201504474VA (en) | Case unit | |
| EP2959773A4 (en) | Floating structure | |
| DK3049043T3 (en) | Indirekte tryk- og temperaturmåling i et totalt væskeventilationssystem | |
| SG2013064209A (en) | Creet model | |
| GB201311130D0 (en) | Greensleeves I | |
| GB2533896B (en) | Geocellular modeling |